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Ellagic acid and Sennoside B inhibit osteosarcoma cell migration, invasion and growth by repressing the expression of c‑Jun

  • Authors:
    • Wei Xu
    • Jinjin Xu
    • Ting Wang
    • Weibo Liu
    • Haifeng Wei
    • Xinghai Yang
    • Wangjun Yan
    • Wang Zhou
    • Jianru Xiao
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China, Shanghai Key Laboratory of Regulatory Biology, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Biomedical Sciences, East China Normal University, Shanghai 200241, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 898-904
    |
    Published online on: May 16, 2018
       https://doi.org/10.3892/ol.2018.8712
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Abstract

Osteosarcoma is a mesenchymally derived, high‑grade bone sarcoma that is the most frequently diagnosed primary malignant bone tumor. Today, chemoprevention is regarded as a promising and realistic approach in the prevention of human cancer. Previous studies have suggested ellagic acid (EA) and Sennoside B have potential in this regard. The aim of the present study was to elucidate the anti‑osteosarcoma effects of EA and Sennoside B by using Saos‑2 and MG63 osteosarcoma cells. It was identified that EA or Sennoside B treatment could inhibit the growth, migration and invasion of the cells, and induce G1 cell cycle arrest by repressing the transcription of c‑Jun. These results may provide a cellular basis for the application of EA or Sennoside B in the treatment of patients with osteosarcoma.
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Copy and paste a formatted citation
Spandidos Publications style
Xu W, Xu J, Wang T, Liu W, Wei H, Yang X, Yan W, Zhou W and Xiao J: Ellagic acid and Sennoside B inhibit osteosarcoma cell migration, invasion and growth by repressing the expression of c‑Jun. Oncol Lett 16: 898-904, 2018.
APA
Xu, W., Xu, J., Wang, T., Liu, W., Wei, H., Yang, X. ... Xiao, J. (2018). Ellagic acid and Sennoside B inhibit osteosarcoma cell migration, invasion and growth by repressing the expression of c‑Jun. Oncology Letters, 16, 898-904. https://doi.org/10.3892/ol.2018.8712
MLA
Xu, W., Xu, J., Wang, T., Liu, W., Wei, H., Yang, X., Yan, W., Zhou, W., Xiao, J."Ellagic acid and Sennoside B inhibit osteosarcoma cell migration, invasion and growth by repressing the expression of c‑Jun". Oncology Letters 16.1 (2018): 898-904.
Chicago
Xu, W., Xu, J., Wang, T., Liu, W., Wei, H., Yang, X., Yan, W., Zhou, W., Xiao, J."Ellagic acid and Sennoside B inhibit osteosarcoma cell migration, invasion and growth by repressing the expression of c‑Jun". Oncology Letters 16, no. 1 (2018): 898-904. https://doi.org/10.3892/ol.2018.8712
Copy and paste a formatted citation
x
Spandidos Publications style
Xu W, Xu J, Wang T, Liu W, Wei H, Yang X, Yan W, Zhou W and Xiao J: Ellagic acid and Sennoside B inhibit osteosarcoma cell migration, invasion and growth by repressing the expression of c‑Jun. Oncol Lett 16: 898-904, 2018.
APA
Xu, W., Xu, J., Wang, T., Liu, W., Wei, H., Yang, X. ... Xiao, J. (2018). Ellagic acid and Sennoside B inhibit osteosarcoma cell migration, invasion and growth by repressing the expression of c‑Jun. Oncology Letters, 16, 898-904. https://doi.org/10.3892/ol.2018.8712
MLA
Xu, W., Xu, J., Wang, T., Liu, W., Wei, H., Yang, X., Yan, W., Zhou, W., Xiao, J."Ellagic acid and Sennoside B inhibit osteosarcoma cell migration, invasion and growth by repressing the expression of c‑Jun". Oncology Letters 16.1 (2018): 898-904.
Chicago
Xu, W., Xu, J., Wang, T., Liu, W., Wei, H., Yang, X., Yan, W., Zhou, W., Xiao, J."Ellagic acid and Sennoside B inhibit osteosarcoma cell migration, invasion and growth by repressing the expression of c‑Jun". Oncology Letters 16, no. 1 (2018): 898-904. https://doi.org/10.3892/ol.2018.8712
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