Wermers RA, Tiegs RD, Atkinson EJ, Achenbach SJ and Melton LJ III: Morbidity and mortality associated with Paget's disease of bone: A population-based study. J Bone Miner Res. 23:819–825. 2008. View Article : Google Scholar : PubMed/NCBI

Mirabello L, Troisi RJ and Savage SA: Osteosarcoma incidence and survival rates from 1973 to 2004: Data from the surveillance, epidemiology and end results program. Cancer. 115:1531–1543. 2009. View Article : Google Scholar : PubMed/NCBI

Liao CL, Lai KC, Huang AC, Yang JS, Lin JJ, Wu SH, Wood Gibson W, Lin JG and Chung JG: Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways. Food Chem Toxicol. 50:1734–1740. 2012. View Article : Google Scholar : PubMed/NCBI

Hong WK and Sporn MB: Recent advances in chemoprevention of cancer. Science. 278:1073–1077. 1997. View Article : Google Scholar : PubMed/NCBI

Ishibashi K, Kumamoto K, Kuwabara K, Hokama N, Ishiguro T, Ohsawa T, Okada N, Miyazaki T, Yokoyama M, Tsuji Y, et al: Usefulness of sennoside as an agent for mechanical bowel preparation prior to elective colon cancer surgery. Asian J Surg. 35:81–87. 2012. View Article : Google Scholar : PubMed/NCBI

Hussein RH and Khalifa FK: The protective role of ellagitannins flavonoids pretreatment against N-nitrosodiethylamine induced-hepatocellular carcinoma. Saudi J Biol Sci. 21:589–596. 2014. View Article : Google Scholar : PubMed/NCBI

Sohn EH, Koo HJ, Hang DTT, Jang SA, Namkoong S, Lim JD and Kang SC: Protective effects of ellagic acid on ethanol-induced toxicity in hepatic HepG2 cells. Mol Cell Toxicol. 9:249–256. 2013. View Article : Google Scholar

Li TM, Chen GW, Su CC, Lin JG, Yeh CC, Cheng KC and Chung JG: Ellagic acid induced p53/p21 expression, G1 arrest and apoptosis in human bladder cancer T24 cells. Anticancer Res. 25:971–979. 2005.PubMed/NCBI

Mertens-Talcott SU and Percival SS: Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells. Cancer Lett. 218:141–151. 2005. View Article : Google Scholar : PubMed/NCBI

Narayanan BA, Geoffroy O, Willingham MC, Re GG and Nixon DW: p53/p21(WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells. Cancer Lett. 136:215–221. 1999. View Article : Google Scholar : PubMed/NCBI

Päivärinta E, Pajari AM, Törrönen R and Mutanen M: Ellagic acid and natural sources of ellagitannins as possible chemopreventive agents against intestinal tumorigenesis in the Min mouse. Nutr Cancer. 54:79–83. 2006. View Article : Google Scholar : PubMed/NCBI

Whitmarsh AJ and Davis RJ: Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J Mol Med (Berl). 74:589–607. 1996. View Article : Google Scholar : PubMed/NCBI

Papachristou DJ, Batistatou A, Sykiotis GP, Varakis I and Papavassiliou AG: Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas. Bone. 32:364–371. 2003. View Article : Google Scholar : PubMed/NCBI

Angel P and Karin M: The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta. 1072:129–157. 1991.PubMed/NCBI

Hipskind RA and Bilbe G: MAP kinase signaling cascades and gene expression in osteoblasts. Front Biosci. 3:d804–d816. 1998. View Article : Google Scholar : PubMed/NCBI

Liu B and Shuai K: Induction of apoptosis by protein inhibitor of activated Stat1 through c-Jun NH2-terminal kinase activation. J Biol Chem. 276:36624–36631. 2001. View Article : Google Scholar : PubMed/NCBI

Suzuki A, Guicheux J, Palmer G, Miura Y, Oiso Y, Bonjour JP and Caverzasio J: Evidence for a role of p38 MAP kinase in expression of alkaline phosphatase during osteoblastic cell differentiation. Bone. 30:91–98. 2002. View Article : Google Scholar : PubMed/NCBI

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

Umesalma S, Nagendraprabhu P and Sudhandiran G: Ellagic acid inhibits proliferation and induced apoptosis via the Akt signaling pathway in HCT-15 colon adenocarcinoma cells. Mol Cell Biochem. 399:303–313. 2015. View Article : Google Scholar : PubMed/NCBI

Hanahan D and Weinberg RA: The hallmarks of cancer. Cell. 100:57–70. 2000. View Article : Google Scholar : PubMed/NCBI

Chambers AF and Matrisian LM: Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst. 89:1260–1270. 1997. View Article : Google Scholar : PubMed/NCBI

Pitchakarn P, Chewonarin T, Ogawa K, Suzuki S, Asamoto M, Takahashi S, Shirai T and Limtrakul P: Ellagic acid inhibits migration and invasion by prostate cancer cell lines. Asian Pac J Cancer Prev. 14:2859–2863. 2013. View Article : Google Scholar : PubMed/NCBI

Chakraborti S, Mandal M, Das S, Mandal A and Chakraborti T: Regulation of matrix metalloproteinases: An overview. Mol Cell Biochem. 253:269–285. 2003. View Article : Google Scholar : PubMed/NCBI

Bakiri L, Lallemand D, Bossy-Wetzel E and Yaniv M: Cell cycle-dependent variations in c-Jun and JunB phosphorylation: A role in the control of cyclin D1 expression. EMBO J. 19:2056–2068. 2000. View Article : Google Scholar : PubMed/NCBI

Huang J, Shi Y, Li H, Tan D, Yang M and Wu X: Knockdown of receptor tyrosine kinase-like orphan receptor 2 inhibits cell proliferation and colony formation in osteosarcoma cells by inducing arrest in cell cycle progression. Oncol Lett. 10:3705–3711. 2015. View Article : Google Scholar : PubMed/NCBI

Ge L, Zheng B, Li M, Niu L and Li Z: MicroRNA-497 suppresses osteosarcoma tumor growth in vitro and in vivo. Oncol Lett. 11:2207–2212. 2016. View Article : Google Scholar : PubMed/NCBI