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Global lipidomics reveals two plasma lipids as novel biomarkers for the detection of squamous cell lung cancer: A pilot study

  • Authors:
    • Zongtao Yu
    • Hankui Chen
    • Yong Zhu
    • Junmei Ai
    • Yan Li
    • Wei Gu
    • Jeffrey A. Borgia
    • Jicai Zhang
    • Bin Jiang
    • Wei Chen
    • Youping Deng
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, Affiliated Taihe Hospital of Xi'an Jiaotong University Health Science Center, Shiyan, Hubei 442000, P.R. China, Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA, National Center of Colorectal Disease, Nanjing Municipal Hospital of Chinese Medicine, The Third Affiliated Hospital, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 21001, P.R. China, Department of Respiration, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 21001, P.R. China, Department of Pathology, Rush University Medical Center, Chicago, IL 60612, USA, Center for Laboratory Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi 710061, P.R. China, Department of Laboratory Medicine, Shiyan Taihe Hospital, College of Biomedical Engineering, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 761-768
    |
    Published online on: May 18, 2018
       https://doi.org/10.3892/ol.2018.8740
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Abstract

Lipids are known to serve important roles in energy storage, membrane structure and signal transduction as well as in human cancers. In the present study, lipidomics was employed in order to identify plasma lipid markers for the early detection of lung cancer. Mass spectrometry was performed to profile 390 individual lipids in 44 plasma samples obtained from a training discovery cohort, which included 22 patients with squamous cell lung carcinoma (SqCC) and 22 high‑risk individuals. An additional cohort that included 22 high‑risk individuals and 22 patients with SqCC was further used for validation. During the training stage, a total of 20 distinct lipids that were significantly distributed between the high‑risk and SqCC cases, were identified. A panel of 2 lipid markers (C18:2 cholesterol esters and sphingomyelin 22:0) were then further defined using the training accuracy values of 95.5% sensitivity, 90.9% specificity and 95.2% area under the receiver operating characteristic curve (AUC). The validation accuracy values applied for the additional cohort were 93.9% sensitivity, 92.9% specificity and 98.7% AUC. Thus, in the present study, 2 lipid markers that were able to discern SqCC patients from high‑risk individuals with a high sensitivity, specificity and accuracy, were identified. These results may provide vital information for the development of a quick and safe blood test for the early diagnosis of SqCC.
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1 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Beadsmoore CJ and Screaton NJ: Classification, staging and prognosis of lung cancer. Eur J Radiol. 45:8–17. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Papi A, Casoni G, Caramori G, Guzzinati I, Boschetto P, Ravenna F, Calia N, Petruzzelli S, Corbetta L, Cavallesco G, et al: COPD increases the risk of squamous histological subtype in smokers who develop non-small cell lung carcinoma. Thorax. 59:679–681. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Janssen-Heijnen ML and Coebergh JW: Trends in incidence and prognosis of the histological subtypes of lung cancer in North America, Australia, New Zealand and Europe. Lung Cancer. 31:123–137. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Edwards BK, Brown ML, Wingo PA, Howe HL, Ward E, Ries LA, Schrag D, Jamison PM, Jemal A, Wu XC, et al: Annual report to the nation on the status of cancer, 1975–2002, featuring population-based trends in cancer treatment. J Natl Cancer Inst. 97:1407–1427. 2005. View Article : Google Scholar : PubMed/NCBI

6 

International Early Lung Cancer Action Program Investigators1, . Henschke CI, Yankelevitz DF, Libby DM, Pasmantier MW, Smith JP and Miettinen OS: Survival of patients with stage I lung cancer detected on CT screening. N Engl J Med. 355:1763–1771. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Roth JA and Ramsey SD: Computed tomography screening for lung cancer: A high-value proposition? JAMA. 315:77–78. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Sleeman MW, Wortley KE, Lai KM, Gowen LC, Kintner J, Kline WO, Garcia K, Stitt TN, Yancopoulos GD, Wiegand SJ and Glass DJ: Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity. Nat Med. 11:199–205. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Cutler RG, Kelly J, Storie K, Pedersen WA, Tammara A, Hatanpaa K, Troncoso JC and Mattson MP: Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease. Proc Natl Acad Sci USA. 101:2070–2075. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Nguyen NT, Magno CP, Lane KT, Hinojosa MW and Lane JS: Association of hypertension, diabetes, dyslipidemia, and metabolic syndrome with obesity: Findings from the National Health and Nutrition Examination Survey, 1999 to 2004. J Am Coll Surg. 207:928–934. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Pendaries C, Tronchère H, Plantavid M and Payrastre B: Phosphoinositide signaling disorders in human diseases. FEBS Lett. 546:25–31. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Ogretmen B and Hannun YA: Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer. 4:604–616. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Görke R1, Meyer-Bäse A, Wagner D, He H, Emmett MR and Conrad CA: Determining and interpreting correlations in lipidomic networks found in glioblastoma cells. BMC Syst Biol. 4:1262010. View Article : Google Scholar : PubMed/NCBI

14 

Lee GK, Lee HS, Park YS, Lee JH, Lee SC, Lee JH, Lee SJ, Shanta SR, Park HM, Kim HR, et al: Lipid MALDI profile classifies non-small cell lung cancers according to the histologic type. Lung Cancer. 76:197–203. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Suarna C, Dean RT, May J and Stocker R: Human atherosclerotic plaque contains both oxidized lipids and relatively large amounts of alpha-tocopherol and ascorbate. Arterioscler Thromb Vasc Biol. 15:1616–1624. 1995. View Article : Google Scholar : PubMed/NCBI

16 

Miyoshi N, Iwasaki N, Tomono S, Higashi T and Ohshima H: Occurrence of cytotoxic 9-oxononanoyl secosterol aldehydes in human low-density lipoprotein. Free Radic Biol Med. 60:73–79. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Fhaner CJ, Liu S, Ji H, Simpson RJ and Reid GE: Comprehensive lipidome profiling of isogenic primary and metastatic colon adenocarcinoma cell lines. Anal Chem. 84:8917–8926. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Ishikawa S, Tateya I, Hayasaka T, Masaki N, Takizawa Y, Ohno S, Kojima T, Kitani Y, Kitamura M, Hirano S, et al: Increased expression of phosphatidylcholine (16:0/18:1) and (16:0/18:2) in thyroid papillary cancer. PLoS One. 7:e488732012. View Article : Google Scholar : PubMed/NCBI

19 

Zhou X, Mao J, Ai J, Deng Y, Roth MR, Pound C, Henegar J, Welti R and Bigler SA: Identification of plasma lipid biomarkers for prostate cancer by lipidomics and bioinformatics. PLoS One. 7:e488892012. View Article : Google Scholar : PubMed/NCBI

20 

Yu Z, Chen H, Ai J, Zhu Y, Li Y, Borgia JA, Yang JS, Zhang J, Jiang B, Gu W and Deng Y: Global lipidomics identified plasma lipids as novel biomarkers for early detection of lung cancer. Oncotarget. 8:107899–107906. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Devaiah SP, Roth MR, Baughman E, Li M, Tamura P, Jeannotte R, Welti R and Wang X: Quantitative profiling of polar glycerolipid species from organs of wild-type Arabidopsis and a phospholipase Dalpha1 knockout mutant. Phytochemistry. 67:1907–1924. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Smith TC and Frank E: Introducing machine learning concepts with WEKA. Springer; New York, NY: pp. 353–378. 2016

23 

Weir IM, Wong G, Barlow CK, Greeve MA, Kowalczyk A, Almasy L, Comuzzie AG, Mahaney MC, Jowett JB, Shaw J, et al: Plasma lipid profiling in a large population-based cohort. J Lipid Res. 54:2898–2908. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Kolesnick R: Signal transduction through the sphingomyelin pathway. Mol Chem Neuropathol. 21:287–297. 1994. View Article : Google Scholar : PubMed/NCBI

25 

Green DR: Apoptosis and sphingomyelin hydrolysis. The flip side. J Cell Biol. 150:F5–F7. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Gangoiti P, Granado MH, Alonso A, Goñi FM and Gomez-Munoz A: Implication of ceramide, ceramide 1-phosphate and sphingosine 1-phosphate in tumorigenesis. Transl Oncogenomics. 3:81–98. 2008.PubMed/NCBI

27 

Alberg AJ, Armeson K, Pierce JS, Bielawski J, Bielawska A, Visvanathan K, Hill EG and Ogretmen B: Plasma sphingolipids and lung cancer: A population-based, nested case-control study. Cancer Epidemiol Biomarkers Prev. 22:1374–1382. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Goldkorn T, Chung S and Filosto S: Lung cancer and lung injury: The dual role of ceramide. Handb Exp Pharmacol. 93–113. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Goldkorn T and Filosto S: Lung injury and cancer: Mechanistic insights into ceramide and EGFR signaling under cigarette smoke. Am J Respir Cell Mol Biol. 43:259–268. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yu Z, Chen H, Zhu Y, Ai J, Li Y, Gu W, Borgia JA, Zhang J, Jiang B, Chen W, Chen W, et al: Global lipidomics reveals two plasma lipids as novel biomarkers for the detection of squamous cell lung cancer: A pilot study. Oncol Lett 16: 761-768, 2018.
APA
Yu, Z., Chen, H., Zhu, Y., Ai, J., Li, Y., Gu, W. ... Deng, Y. (2018). Global lipidomics reveals two plasma lipids as novel biomarkers for the detection of squamous cell lung cancer: A pilot study. Oncology Letters, 16, 761-768. https://doi.org/10.3892/ol.2018.8740
MLA
Yu, Z., Chen, H., Zhu, Y., Ai, J., Li, Y., Gu, W., Borgia, J. A., Zhang, J., Jiang, B., Chen, W., Deng, Y."Global lipidomics reveals two plasma lipids as novel biomarkers for the detection of squamous cell lung cancer: A pilot study". Oncology Letters 16.1 (2018): 761-768.
Chicago
Yu, Z., Chen, H., Zhu, Y., Ai, J., Li, Y., Gu, W., Borgia, J. A., Zhang, J., Jiang, B., Chen, W., Deng, Y."Global lipidomics reveals two plasma lipids as novel biomarkers for the detection of squamous cell lung cancer: A pilot study". Oncology Letters 16, no. 1 (2018): 761-768. https://doi.org/10.3892/ol.2018.8740
Copy and paste a formatted citation
x
Spandidos Publications style
Yu Z, Chen H, Zhu Y, Ai J, Li Y, Gu W, Borgia JA, Zhang J, Jiang B, Chen W, Chen W, et al: Global lipidomics reveals two plasma lipids as novel biomarkers for the detection of squamous cell lung cancer: A pilot study. Oncol Lett 16: 761-768, 2018.
APA
Yu, Z., Chen, H., Zhu, Y., Ai, J., Li, Y., Gu, W. ... Deng, Y. (2018). Global lipidomics reveals two plasma lipids as novel biomarkers for the detection of squamous cell lung cancer: A pilot study. Oncology Letters, 16, 761-768. https://doi.org/10.3892/ol.2018.8740
MLA
Yu, Z., Chen, H., Zhu, Y., Ai, J., Li, Y., Gu, W., Borgia, J. A., Zhang, J., Jiang, B., Chen, W., Deng, Y."Global lipidomics reveals two plasma lipids as novel biomarkers for the detection of squamous cell lung cancer: A pilot study". Oncology Letters 16.1 (2018): 761-768.
Chicago
Yu, Z., Chen, H., Zhu, Y., Ai, J., Li, Y., Gu, W., Borgia, J. A., Zhang, J., Jiang, B., Chen, W., Deng, Y."Global lipidomics reveals two plasma lipids as novel biomarkers for the detection of squamous cell lung cancer: A pilot study". Oncology Letters 16, no. 1 (2018): 761-768. https://doi.org/10.3892/ol.2018.8740
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