Open Access

Global lipidomics reveals two plasma lipids as novel biomarkers for the detection of squamous cell lung cancer: A pilot study

  • Authors:
    • Zongtao Yu
    • Hankui Chen
    • Yong Zhu
    • Junmei Ai
    • Yan Li
    • Wei Gu
    • Jeffrey A. Borgia
    • Jicai Zhang
    • Bin Jiang
    • Wei Chen
    • Youping Deng
  • View Affiliations

  • Published online on: May 18, 2018     https://doi.org/10.3892/ol.2018.8740
  • Pages: 761-768
  • Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lipids are known to serve important roles in energy storage, membrane structure and signal transduction as well as in human cancers. In the present study, lipidomics was employed in order to identify plasma lipid markers for the early detection of lung cancer. Mass spectrometry was performed to profile 390 individual lipids in 44 plasma samples obtained from a training discovery cohort, which included 22 patients with squamous cell lung carcinoma (SqCC) and 22 high‑risk individuals. An additional cohort that included 22 high‑risk individuals and 22 patients with SqCC was further used for validation. During the training stage, a total of 20 distinct lipids that were significantly distributed between the high‑risk and SqCC cases, were identified. A panel of 2 lipid markers (C18:2 cholesterol esters and sphingomyelin 22:0) were then further defined using the training accuracy values of 95.5% sensitivity, 90.9% specificity and 95.2% area under the receiver operating characteristic curve (AUC). The validation accuracy values applied for the additional cohort were 93.9% sensitivity, 92.9% specificity and 98.7% AUC. Thus, in the present study, 2 lipid markers that were able to discern SqCC patients from high‑risk individuals with a high sensitivity, specificity and accuracy, were identified. These results may provide vital information for the development of a quick and safe blood test for the early diagnosis of SqCC.
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July-2018
Volume 16 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yu Z, Chen H, Zhu Y, Ai J, Li Y, Gu W, Borgia JA, Zhang J, Jiang B, Chen W, Chen W, et al: Global lipidomics reveals two plasma lipids as novel biomarkers for the detection of squamous cell lung cancer: A pilot study. Oncol Lett 16: 761-768, 2018
APA
Yu, Z., Chen, H., Zhu, Y., Ai, J., Li, Y., Gu, W. ... Deng, Y. (2018). Global lipidomics reveals two plasma lipids as novel biomarkers for the detection of squamous cell lung cancer: A pilot study. Oncology Letters, 16, 761-768. https://doi.org/10.3892/ol.2018.8740
MLA
Yu, Z., Chen, H., Zhu, Y., Ai, J., Li, Y., Gu, W., Borgia, J. A., Zhang, J., Jiang, B., Chen, W., Deng, Y."Global lipidomics reveals two plasma lipids as novel biomarkers for the detection of squamous cell lung cancer: A pilot study". Oncology Letters 16.1 (2018): 761-768.
Chicago
Yu, Z., Chen, H., Zhu, Y., Ai, J., Li, Y., Gu, W., Borgia, J. A., Zhang, J., Jiang, B., Chen, W., Deng, Y."Global lipidomics reveals two plasma lipids as novel biomarkers for the detection of squamous cell lung cancer: A pilot study". Oncology Letters 16, no. 1 (2018): 761-768. https://doi.org/10.3892/ol.2018.8740