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Article

Loss of skeletal muscle mass after curative gastrectomy is a poor prognostic factor

  • Authors:
    • Naruji Kugimiya
    • Eijiro Harada
    • Kazuhito Oka
    • Daichi Kawamura
    • Yuki Suehiro
    • Yoshihiro Takemoto
    • Kimikazu Hamano
  • View Affiliations / Copyright

    Affiliations: Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755‑8505, Japan, Department of Surgery, Saiseikai Shimonoseki General Hospital, Shimonoseki, Yamaguchi 759‑6603, Japan
  • Pages: 1341-1347
    |
    Published online on: May 18, 2018
       https://doi.org/10.3892/ol.2018.8747
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Abstract

Sarcopenia has been reported to relate to poor prognosis in various malignant cancer types. The present study aimed to clarify the prognostic impact of skeletal muscle mass (SMM) loss after curative gastrectomy in patients with gastric cancer. A total of 119 patients who underwent curative gastrectomy for gastric cancer between 2009 and 2016 were analyzed. The SMM loss at 6 months postoperatively compared with the SMM prior to surgery was calculated using the hospital records. The median loss of SMM was 3.8%. Multivariate logistic regression analysis demonstrated that total gastrectomy was a significant and independent risk factor for SMM loss of ≥5% (odds ratio=2.58; P=0.02). Results from multivariate analysis using stepwise Cox proportional hazards regression indicated that the following factors were significantly associated with shorter overall survival after curative gastrectomy: Age [>70 years; hazard ratio (HR)=2.46, P=0.04], TNM stage (≥2; HR=2.65, P=0.04) and loss of SMM (≥5%; HR=2.57, P=0.03). The present findings suggested that loss of SMM after curative gastrectomy for gastric cancer is an independent predictive factor for poor prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Kugimiya N, Harada E, Oka K, Kawamura D, Suehiro Y, Takemoto Y and Hamano K: Loss of skeletal muscle mass after curative gastrectomy is a poor prognostic factor. Oncol Lett 16: 1341-1347, 2018.
APA
Kugimiya, N., Harada, E., Oka, K., Kawamura, D., Suehiro, Y., Takemoto, Y., & Hamano, K. (2018). Loss of skeletal muscle mass after curative gastrectomy is a poor prognostic factor. Oncology Letters, 16, 1341-1347. https://doi.org/10.3892/ol.2018.8747
MLA
Kugimiya, N., Harada, E., Oka, K., Kawamura, D., Suehiro, Y., Takemoto, Y., Hamano, K."Loss of skeletal muscle mass after curative gastrectomy is a poor prognostic factor". Oncology Letters 16.1 (2018): 1341-1347.
Chicago
Kugimiya, N., Harada, E., Oka, K., Kawamura, D., Suehiro, Y., Takemoto, Y., Hamano, K."Loss of skeletal muscle mass after curative gastrectomy is a poor prognostic factor". Oncology Letters 16, no. 1 (2018): 1341-1347. https://doi.org/10.3892/ol.2018.8747
Copy and paste a formatted citation
x
Spandidos Publications style
Kugimiya N, Harada E, Oka K, Kawamura D, Suehiro Y, Takemoto Y and Hamano K: Loss of skeletal muscle mass after curative gastrectomy is a poor prognostic factor. Oncol Lett 16: 1341-1347, 2018.
APA
Kugimiya, N., Harada, E., Oka, K., Kawamura, D., Suehiro, Y., Takemoto, Y., & Hamano, K. (2018). Loss of skeletal muscle mass after curative gastrectomy is a poor prognostic factor. Oncology Letters, 16, 1341-1347. https://doi.org/10.3892/ol.2018.8747
MLA
Kugimiya, N., Harada, E., Oka, K., Kawamura, D., Suehiro, Y., Takemoto, Y., Hamano, K."Loss of skeletal muscle mass after curative gastrectomy is a poor prognostic factor". Oncology Letters 16.1 (2018): 1341-1347.
Chicago
Kugimiya, N., Harada, E., Oka, K., Kawamura, D., Suehiro, Y., Takemoto, Y., Hamano, K."Loss of skeletal muscle mass after curative gastrectomy is a poor prognostic factor". Oncology Letters 16, no. 1 (2018): 1341-1347. https://doi.org/10.3892/ol.2018.8747
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