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Article Open Access

Treatment effect of conversion therapy and its correlation with VEGF expression in unresectable rectal cancer with liver metastasis

  • Authors:
    • Ge Hou
    • Rui Song
    • Jun Yang
    • Yanling Zhang
    • Chenhu Xiao
    • Cheng Wang
    • Jinjin Yuan
    • Ting Chai
    • Zongwen Liu
  • View Affiliations / Copyright

    Affiliations: Department of Tumor Radiotherapy, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450014, P.R. China, Department of Oncology, The Third People's Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China
    Copyright: © Hou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 749-754
    |
    Published online on: May 21, 2018
       https://doi.org/10.3892/ol.2018.8758
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Abstract

To investigate the therapeutic effect of conversion therapy and its correlation with vascular endothelial growth factor (VEGF) expression in unresectable rectal cancer with liver metastasis. A total of 116 cases of unresectable rectal cancer patients with liver metastasis were randomly divided into control and observation group, 58 cases in each group, all of these patients were treated by conversion therapy, patients in control were treated by FOLFOXIRI treatment program, and in observation group were treated by FOLFOXIRI program treatment and bevacizumab. Efficacy and adverse reactions were compared between the two groups, the levels of VEGF in portal vein and the expression of VEGF in cancer tissue were compared, after 5 years of follow-up, the prognosis of the two groups were observed. Objective efficiency and conversion rate of observation was significantly higher than the control group, survival rate of postoperative observation was significantly higher than that of control group (P>0.05). There was no significant difference in adverse reactions between the two groups (P>0.05). The positive rate of VEGF in portal vein blood and the expression of VEGF in the observation was significantly lower than that in the control group (P<0.05). The 5-year survival rate of VEGF high expression was significantly lower than that of VEGF low expression group (P<0.05). FOLFOXIRI combined with bevacizumab in patients with unresectable hepatic metastasis of rectal cancer can provide higher conversion rate and hepatectomy opportunities, and reduce VEGF expression in patients with unresectable rectal cancer, which is closely related to VEGF expression, therefore it is beneficial to better local control and to improve long-term survival.
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1 

Brenner H, Kloor M and Pox CP: Colorectal cancer. Lancet. 383:1490–1502. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Kahi CJ, Boland CR, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Lieberman D, Levin TR, Robertson DJ and Rex DK: Colonoscopy surveillance after colorectal cancer resection: Recommendations of the US multi-society task force on colorectal cancer. Gastrointest Endosc. 83:489–98.e10. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Page AJ, Weiss MJ and Pawlik TM: Surgical management of noncolorectal cancer liver metastases. Cancer. 120:3111–3121. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Sotirchos VS, Petrovic LM, Gönen M, Klimstra DS, Do RK, Petre EN, Garcia AR, Barlas A, Erinjeri JP, Brown KT, et al: Colorectal cancer liver metastases: Biopsy of the ablation zone and margins can be used to predict oncologic outcome. Radiology. 280:949–959. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Fulong W and Pan Z: Operation time of colorectal liver metastasis and choice of operation after convertible therapy. Chin J Pract Surg. 33:656–659. 2013.

6 

Corley DA, Jensen CD, Marks AR, Zhao WK, Lee JK, Doubeni CA, Zauber AG, de Boer J, Fireman BH, Schottinger JE, et al: Adenoma detection rate and risk of colorectal cancer and death. N Engl J Med. 370:1298–1306. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Li J, Hao D, Wang L, Wang H, Wang Y, Zhao Z, Li P, Deng C and Di LJ: Epigenetic targeting drugs potentiate chemotherapeutic effects in solid tumor therapy. Sci Rep. 7:40352017. View Article : Google Scholar : PubMed/NCBI

8 

Jagadish N, Parashar D, Gupta N, Agarwal S, Sharma A, Fatima R, Suri V, Kumar R, Gupta A, Lohiya NK, et al: A novel cancer testis antigen target A-kinase anchor protein (AKAP4) for the early diagnosis and immunotherapy of colon cancer. OncoImmunology. 5:e10789652016. View Article : Google Scholar : PubMed/NCBI

9 

Dunet V, Halkic N, Prior JO, Anaye A, Meuli RA, Sempoux C, Denys A and Schmidt S: Detection and viability of colorectal liver metastases after neoadjuvant chemotherapy: A multiparametric PET/CT-MRI study. Clin Nucl Med. 42:258–263. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Truant S, Séquier C, Leteurtre E, Boleslawski E, Elamrani M, Huet G, Duhamel A, Hebbar M and Pruvot FR: Tumour biology of colorectal liver metastasis is a more important factor in survival than surgical margin clearance in the era of modern chemotherapy regimens. HPB. 17:176–184. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Venderbosch S, Nagtegaal ID, Maughan TS, Smith CG, Cheadle JP, Fisher D, Kaplan R, Quirke P, Seymour MT, Richman SD, et al: Mismatch repair status and BRAF mutation status in metastatic colorectal cancer patients: A pooled analysis of the CAIRO, CAIRO2, COIN, and FOCUS studies. Clin Cancer Res. 20:5322–5330. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Alexandrescu S, Diaconescu A and Popescu I.: Surg options synchronous liver metastases colorectal cancer. Transl. J. Med. Res. 22:10–21. 2017.

13 

Wagner M, Ronot M, Doblas S, Giraudeau C, van Beers B, Belghiti J, Paradis V and Vilgrain V: Assessment of the residual tumour of colorectal liver metastases after chemotherapy: Diffusion-weighted MR magnetic resonance imaging in the peripheral and entire tumour. Eur Radiol. 26:206–215. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Bregendahl S, Emmertsen KJ, Fassov J, Krogh K, Zhao J, Gregersen H and Laurberg S: Neorectal hyposensitivity after neoadjuvant therapy for rectal cancer. Radiother Oncol. 108:331–336. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Glimelius B, Ristamäki R, Kjaer M, Pfeiffer P, Skovsgaard T, Tveit KM, Linné T, Frödin JE, Boussard B, Oulid-Aïssa D, et al: Irinotecan combined with bolus 5-fluorouracil and folinic acid Nordic schedule as first-line therapy in advanced colorectal cancer. Ann Oncol. 13:1868–1873. 2002. View Article : Google Scholar : PubMed/NCBI

16 

van Cutsem E, Lenz HJ, Köhne CH, Heinemann V, Tejpar S, Melezínek I, Beier F, Stroh C, Rougier P, van Krieken JH, et al: Fluorouracil, leucovorin, and irinotecan plus cetuximab treatment and RAS mutations in colorectal cancer. J Clin Oncol. 33:692–700. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Heinemann V, von Weikersthal LF, Decker T, Kiani A, Vehling-Kaiser U, Al-Batran SE, Heintges T, Lerchenmüller C, Kahl C, Seipelt G, et al: FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): A randomised, open-label, phase 3 trial. Lancet Oncol. 15:1065–1075. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Hamnvik OPR, Choueiri TK, Turchin A, McKay RR, Goyal L, Davis M, Kaymakcalan MD and Williams JS: Clinical risk factors for the development of hypertension in patients treated with inhibitors of the VEGF signaling pathway. Cancer. 121:311–319. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Ciamporcero E, Miles KM, Adelaiye R, Ramakrishnan S, Shen L, Ku S, Pizzimenti S, Sennino B, Barrera G and Pili R: Combination strategy targeting VEGF and HGF/c-met in human renal cell carcinoma models. Mol Cancer Ther. 14:101–110. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Jannuzzi AT, Özhan G, Yanar HT and Alpertunga B: VEGF gene polymorphisms and susceptibility to colorectal cancer. Genet Test Mol Biomarkers. 19:133–137. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hou G, Song R, Yang J, Zhang Y, Xiao C, Wang C, Yuan J, Chai T and Liu Z: Treatment effect of conversion therapy and its correlation with VEGF expression in unresectable rectal cancer with liver metastasis. Oncol Lett 16: 749-754, 2018.
APA
Hou, G., Song, R., Yang, J., Zhang, Y., Xiao, C., Wang, C. ... Liu, Z. (2018). Treatment effect of conversion therapy and its correlation with VEGF expression in unresectable rectal cancer with liver metastasis. Oncology Letters, 16, 749-754. https://doi.org/10.3892/ol.2018.8758
MLA
Hou, G., Song, R., Yang, J., Zhang, Y., Xiao, C., Wang, C., Yuan, J., Chai, T., Liu, Z."Treatment effect of conversion therapy and its correlation with VEGF expression in unresectable rectal cancer with liver metastasis". Oncology Letters 16.1 (2018): 749-754.
Chicago
Hou, G., Song, R., Yang, J., Zhang, Y., Xiao, C., Wang, C., Yuan, J., Chai, T., Liu, Z."Treatment effect of conversion therapy and its correlation with VEGF expression in unresectable rectal cancer with liver metastasis". Oncology Letters 16, no. 1 (2018): 749-754. https://doi.org/10.3892/ol.2018.8758
Copy and paste a formatted citation
x
Spandidos Publications style
Hou G, Song R, Yang J, Zhang Y, Xiao C, Wang C, Yuan J, Chai T and Liu Z: Treatment effect of conversion therapy and its correlation with VEGF expression in unresectable rectal cancer with liver metastasis. Oncol Lett 16: 749-754, 2018.
APA
Hou, G., Song, R., Yang, J., Zhang, Y., Xiao, C., Wang, C. ... Liu, Z. (2018). Treatment effect of conversion therapy and its correlation with VEGF expression in unresectable rectal cancer with liver metastasis. Oncology Letters, 16, 749-754. https://doi.org/10.3892/ol.2018.8758
MLA
Hou, G., Song, R., Yang, J., Zhang, Y., Xiao, C., Wang, C., Yuan, J., Chai, T., Liu, Z."Treatment effect of conversion therapy and its correlation with VEGF expression in unresectable rectal cancer with liver metastasis". Oncology Letters 16.1 (2018): 749-754.
Chicago
Hou, G., Song, R., Yang, J., Zhang, Y., Xiao, C., Wang, C., Yuan, J., Chai, T., Liu, Z."Treatment effect of conversion therapy and its correlation with VEGF expression in unresectable rectal cancer with liver metastasis". Oncology Letters 16, no. 1 (2018): 749-754. https://doi.org/10.3892/ol.2018.8758
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