Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2018 Volume 16 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2018 Volume 16 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Effect of allogeneic blood transfusion on levels of IL‑6 and sIL‑R2 in peripheral blood of children with acute lymphocytic leukemia

  • Authors:
    • Hui Zhao
    • Huayou Zhou
    • Qiong Cao
    • Chunyan Wang
    • Jing Bai
    • Piao Lv
    • Fang Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Blood Transfusion, Nanfang Hospital, Southern Medical University/The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Clinical Laboratory, Nanfang Hospital, Southern Medical University/The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Pediatrics, Nanfang Hospital, Southern Medical University/The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Stomatology, Nanfang Hospital, Southern Medical University/The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
  • Pages: 849-852
    |
    Published online on: May 21, 2018
       https://doi.org/10.3892/ol.2018.8760
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Effect of allogeneic blood transfusion on the expression of interleukin‑6 (IL‑6) and soluble interleukin‑2 receptor (sIL‑2R) in peripheral blood of children with acute lymphoblastic leukemia (ALL) was investigated. A total of 91 ALL children admitted to Nanfang Hospital from June 2014 to January 2017 were selected as the study group. Patients were randomly divided into allogeneic blood transfusion group (n=38) and non‑transfusion group (n=53). In addition, a total of 64 healthy children were also selected from June 2014 to January 2017 as the control group. Patients in allogeneic blood transfusion group were transfused with red blood cell suspension and machine‑collected platelets, while patients in non‑transfusion group were not treated with blood transfusion. Peripheral venous blood was collected before and at 4, 8 and 12 weeks after blood transfusion to prepare serum. Serum IL‑6 and sIL‑2R levels were measured by enzyme‑linked immunosorbent assay (ELISA). Before transfusion, serum levels of IL‑6 and sIL‑2R were significantly lower in the study group than those in control group (p<0.05), and no significant differences in serum levels of IL‑6 and sIL‑2R were found between the allogeneic blood transfusion and non‑transfusion group. After transfusion, serum levels of IL‑6 and sIL‑2R were stable for 12 weeks in the non‑transfusion group, while IL‑6 and sIL‑2R levels were significantly increased in the allogeneic blood transfusion group. The results showed that serum level of IL‑6 and sIL‑2R was increased in ALL patients with allogeneic blood transfusion, which resulted in reduced antibody production and decreased cellular immunity. The patients had low immunity, and attention should be paid on the pathogen infection prevention.
View Figures
View References

1 

Sanders JE, Im HJ, Hoffmeister PA, Gooley TA, Woolfrey AE, Carpenter PA, Andrews RG, Bryant EM and Appelbaum FR: Allogeneic hematopoietic cell transplantation for infants with acute lymphoblastic leukemia. Blood. 105:3749–3756. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Pieters R and Carroll WL: Biology and treatment of acute lymphoblastic leukemia. Pediatr Clin North Am. 55:1–20, ix. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Izbicki G, Rudensky B, Na'amad M, Hershko C, Huerta M and Hersch M: Transfusion-related leukocytosis in critically ill patients. Crit Care Med. 32:439–442. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Deng CH and Zhang QP: Leukemia stem cells in drug resistance and metastasis. Chin Med J (Eng1). 123:954–960. 2010.

5 

Bhojwani D and Pui CH: Relapsed childhood acute lymphoblastic leukaemia. Lancet Oncol. 14:e205–e217. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Pui C-H, Gaynon PS, Boyett JM, Chessells JM, Baruchel A, Kamps W, Silverman LB, Biondi A, Harms DO, Vilmer E, et al: Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal region. Lancet. 359:1909–1915. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Tzounakas VL, Seghatchian J, Grouzi E, Kokoris S and Antonelou MH: Red blood cell transfusion in surgical cancer patients: Targets, risks, mechanistic understanding and further therapeutic opportunities. Transfus Apheresis Sci. 56:291–304. 2017. View Article : Google Scholar

8 

Cata JP, Wang H, Gottumukkala V, Reuben J and Sessler DI: Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusions. Br J Anaesth. 110:690–701. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Koehl U, Sörensen J, Esser R, Zimmermann S, Grüttner HP, Tonn T, Seidl C, Seifried E, Klingebiel T and Schwabe D: IL-2 activated NK cell immunotherapy of three children after haploidentical stem cell transplantation. Blood Cells Mol Dis. 33:261–266. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Tvedt TH, Lie SA, Reikvam H, Rye KP, Lindås R, Gedde-Dahl T, Ahmed AB and Bruserud Ø: Pretransplant levels of CRP and interleukin-6 family cytokines; effects on outcome after allogeneic stem cell transplantation. Int J Mol Sci. 17:E18232016. View Article : Google Scholar : PubMed/NCBI

11 

Jordan SC, Choi J, Kim I, Wu G, Toyoda M, Shin B and Vo A: Interleukin-6, a cytokine critical to mediation of inflammation, autoimmunity and allograft rejection: Therapeutic implications of IL-6 receptor blockade. Transplantation. 101:32–44. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Murakami S: Soluble interleukin-2 receptor in cancer. Front Biosci. 9:3085–3090. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Katsuya H, Yamanaka T, Ishitsuka K, Utsunomiya A, Sasaki H, Hanada S, Eto T, Moriuchi Y, Saburi Y, Miyahara M, et al: Prognostic index for acute- and lymphoma-type adult T-cell leukemia/lymphoma. J Clin Oncol. 30:1635–1640. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Goto H, Tsurumi H, Takemura M, Ino-Shimomura Y, Kasahara S, Sawada M, Yamada T, Hara T, Fukuno K, Goto N, et al: Serum-soluble interleukin-2 receptor (sIL-2R) level determines clinical outcome in patients with aggressive non-Hodgkin's lymphoma: In combination with the International Prognostic Index. J Cancer Res Clin Oncol. 131:73–79. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Goto N, Tsurumi H, Goto H, Shimomura YI, Kasahara S, Hara T, Yasuda I, Shimizu M, Murakami N, Yoshikawa T, et al: Serum soluble interleukin-2 receptor (sIL-2R) level is associated with the outcome of patients with diffuse large B cell lymphoma treated with R-CHOP regimens. Ann Hematol. 91:705–714. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Bhojwani D, Yang JJ and Pui CH: Biology of childhood acute lymphoblastic leukemia. Pediatr Clin North Am. 62:47–60. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Pape A, Stein P, Horn O and Habler O: Clinical evidence of blood transfusion effectiveness. Blood Transfus. 7:250–258. 2009.PubMed/NCBI

18 

Smolen JS and Maini RN: Interleukin-6: A new therapeutic target. Arthritis Res Ther. 8(Suppl 2): S52006. View Article : Google Scholar : PubMed/NCBI

19 

Soker M, Colpan L, Ece A, Devecioğlu C and Haspolat K: Serum levels of IL-1 beta, sIL-2R, IL-6, IL-8, and TNF-alpha in febrile children with cancer and neutropenia. Med Oncol. 18:51–57. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Stachura A, Król R, Poplawski T, Michalik D, Pomianowski S, Jacobsson M, Aberg M and Bengtsson A: Transfusion of intra-operative autologous whole blood: Influence on complement activation and interleukin formation. Vox Sang. 100:239–246. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Yoshida N, Oda M, Kuroda Y, Katayama Y, Okikawa Y, Masunari T, Fujiwara M, Nishisaka T, Sasaki N, Sadahira Y, et al: Clinical significance of sIL-2R levels in B-cell lymphomas. PLoS One. 8:e787302013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhao H, Zhou H, Cao Q, Wang C, Bai J, Lv P and Zhao F: Effect of allogeneic blood transfusion on levels of IL‑6 and sIL‑R2 in peripheral blood of children with acute lymphocytic leukemia. Oncol Lett 16: 849-852, 2018.
APA
Zhao, H., Zhou, H., Cao, Q., Wang, C., Bai, J., Lv, P., & Zhao, F. (2018). Effect of allogeneic blood transfusion on levels of IL‑6 and sIL‑R2 in peripheral blood of children with acute lymphocytic leukemia. Oncology Letters, 16, 849-852. https://doi.org/10.3892/ol.2018.8760
MLA
Zhao, H., Zhou, H., Cao, Q., Wang, C., Bai, J., Lv, P., Zhao, F."Effect of allogeneic blood transfusion on levels of IL‑6 and sIL‑R2 in peripheral blood of children with acute lymphocytic leukemia". Oncology Letters 16.1 (2018): 849-852.
Chicago
Zhao, H., Zhou, H., Cao, Q., Wang, C., Bai, J., Lv, P., Zhao, F."Effect of allogeneic blood transfusion on levels of IL‑6 and sIL‑R2 in peripheral blood of children with acute lymphocytic leukemia". Oncology Letters 16, no. 1 (2018): 849-852. https://doi.org/10.3892/ol.2018.8760
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao H, Zhou H, Cao Q, Wang C, Bai J, Lv P and Zhao F: Effect of allogeneic blood transfusion on levels of IL‑6 and sIL‑R2 in peripheral blood of children with acute lymphocytic leukemia. Oncol Lett 16: 849-852, 2018.
APA
Zhao, H., Zhou, H., Cao, Q., Wang, C., Bai, J., Lv, P., & Zhao, F. (2018). Effect of allogeneic blood transfusion on levels of IL‑6 and sIL‑R2 in peripheral blood of children with acute lymphocytic leukemia. Oncology Letters, 16, 849-852. https://doi.org/10.3892/ol.2018.8760
MLA
Zhao, H., Zhou, H., Cao, Q., Wang, C., Bai, J., Lv, P., Zhao, F."Effect of allogeneic blood transfusion on levels of IL‑6 and sIL‑R2 in peripheral blood of children with acute lymphocytic leukemia". Oncology Letters 16.1 (2018): 849-852.
Chicago
Zhao, H., Zhou, H., Cao, Q., Wang, C., Bai, J., Lv, P., Zhao, F."Effect of allogeneic blood transfusion on levels of IL‑6 and sIL‑R2 in peripheral blood of children with acute lymphocytic leukemia". Oncology Letters 16, no. 1 (2018): 849-852. https://doi.org/10.3892/ol.2018.8760
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team