Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2018 Volume 16 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2018 Volume 16 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Clinical significance of decoy receptor 3 upregulation in patients with hepatitis B and liver fibrosis

  • Authors:
    • Xiaoli Lou
    • Yanqiang Hou
    • Hui Cao
    • Jingjing Zhao
    • Fengting Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Central Laboratory, Songjiang Hospital Affiliated First People's Hospital, Shanghai Jiao Tong University, Shanghai 201600, P.R. China
  • Pages: 1147-1154
    |
    Published online on: May 21, 2018
       https://doi.org/10.3892/ol.2018.8762
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Decoy receptor 3 (DcR3) is a tumor necrosis factor receptor, which may inhibit apoptosis. The aim of the present study was to investigate the clinical significance of DcR3 upregulation in patients with chronic hepatitis B (CHB) and hepatic fibrosis. A total of 128 patients with a clinical diagnosis of CHB who underwent liver biopsy were included in the present study. The expression levels of DcR3, hyaluronic acid (HA), type III procollagen, type IV collagen (IV‑C) and laminin protein were assessed. The diagnostic value of DcR3 in patients with CHB with hepatic fibrosis was determined using receiver operating characteristic (ROC) curve analysis. DcR3 was significantly upregulated in patients with CHB, particularly in patients with active CHB. The expression of DcR3 was significantly increased in patients with CHB with liver fibrosis and liver cirrhosis, compared with patients with CHB without liver fibrosis. The area under the ROC curve for the diagnosis of CHB liver fibrosis based on DcR3 or DcR3 combined with IV‑C/HA was 0.807 or 0.869, with a sensitivity and specificity of 76.9 and 77.8% or 84.6 and 81.2%, respectively. DcR3 is a marker for liver fibrosis in patients with hepatitis B infection. The use of DcR3 in combination with IV‑C and HA may further increase its diagnostic value for liver fibrosis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Lu FM and Zhuang H: Management of hepatitis B in China. Chin Med J (EngI). 122:3–4. 2009.

2 

Liang X, Bi S, Yang W, Wang L, Cui G, Cui F, Zhang Y, Liu J, Gong X, Chen Y, et al: EpidemioIogicaI serosurvey of hepatitis B in China-decIining HBV prevaIence due to hepatitis B vaccination. Vaccine. 27:6550–6557. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Seeger C and Mason WS: Molecular biology of hepatitis B virus infection. Virology. 479–480:672–686. 2015. View Article : Google Scholar

4 

Meng N, Gao X, Yan W, Wang M, Liu P, Lu XD, Zhang SJ, Lu YQ and Tang WX: Efficacy of telbivudine in the treatment of chronic hepatitis b and liver cirrhosis and its effect on immunological responses. J Huazhong Univ Sci Technolog Med Sci. 35:230–234. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Neuman MG, Cohen LB and Nanau RM: Hyaluronic acid as a non-invasive biomarker of liver fibrosis. Clin Biochem. 49:302–15. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Jiang YF, Ma J, He B, Li NP, Tang W and Gong GZ: The therapeutic effect of Anluohuaxian capsule combined with adefovir dipivoxil on patients with chronic hepatitis B and influence on hepatic histology. Zhonghua Gan Zang Bing Za Zhi. 20:344–347. 2012.(In Chinese). PubMed/NCBI

7 

You SP, Zhao J, Ma L, Tudimat M, Zhang SL and Liu T: Preventive effects of phenylethanol glycosides from Cistanche tubulosa on bovine serum albumin-induced hepatic fibrosis in rats. Daru. 23:522015. View Article : Google Scholar : PubMed/NCBI

8 

Oztas E, Kuzu UB, Zengin NI, Kalkan IH, Onder FO, Yildiz H, Celik HT, Akdogan M, Kilic MY, Koksal AS, et al: Can Serum ST2 levels be used as a marker of fibrosis in chronic Hepatitis B infection? Medicine (Baltimore). 94:e18892015. View Article : Google Scholar : PubMed/NCBI

9 

Zhang Z, Wang G, Kang K, Wu G and Wang P: The diagnostic accuracy and clinical utility of three noninvasive models for predicting liver fibrosis in patients with HBV Infection. PLoS One. 11:e01527572016. View Article : Google Scholar : PubMed/NCBI

10 

Lok AS and McMahon BJ: Chronic hepatitis B. Hepatology. 45:507–539. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Hou YQ, Xu P, Zhang M, Han D, Peng L, Liang DY, Yang S, Zhang Z, Hong J, Lou XL, et al: Serum decoy receptor 3, a potential new biomarker for sepsis. Clin Chim Acta. 413:744–748. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Liang D, Hou Y, Lou X and Chen H: Decoy receptor 3 improves survival in experimental sepsis by suppressing the inflammatory response and lymphocyte apoptosis. PLoS One. 10:e01316802015. View Article : Google Scholar : PubMed/NCBI

13 

Easterbrook PJ, Roberts T, Sands A and Peeling R: Diagnosis of viral hepatitis. Curr Opin HIV AIDS. 12:302–314. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Lambrecht J, Verhulst S, Mannaerts I, Reynaert H and van Grunsven LA: Prospects in non-invasive assessment of liver fibrosis: Liquid biopsy as the future goldstandard? Biochim Biophys Acta. 1864:1024–1036. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Liu J, Ji Y, Ai H, Ning B, Zhao J, Zhang Y and Dun G: Liver shear-wave velocity and serum fibrosis markers to diagnosis hepatic fibrosis in patients with chronic vial Hepatitis B. Korean J Radiol. 17:396–404. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Cho HJ, Kim SS, Ahn SJ, Park JH, Kim DJ, Kim YB, Cho SW and Cheong JY: Serum transferrin as a liver fibrosis biomarker in patients with chronic hepatitis B. Clin Mol Hepatol. 20:347–354. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Alempijević T, Štulić M, Popovic D, Culafic D, Dragasevic S and Milosavljevic T: The role of fecal calprotectin in assessment of hepatic encephalopathy in patients with liver cirrhosis. Acta Gastroenterol Belg. 77:302–305. 2014.PubMed/NCBI

18 

Lin WW and Hsieh SL: Decoy receptor 3: A pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmube diseases and cancer. Biochem Pharmacol. 81:838–847. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Siakavellas SI, Sfikakis PP and Bamias G: The TL1A/DR3/DcR3 pathway in autoimmune rheumatic diseases. Semin Arthritis Rheum. 45:1–8. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Kim S, Kotoula V, Hytiroglou P, Zardavas D and Zhang L: Significance of increased expression of decoy receptor 3 in chronic liver disease. Dig Liver Dis. 41:591–598. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Bamias G, Kaltsa G, Siakavellas SI, Papaxoinis K, Zampeli E, Michopoulos S, Zouboulis-Vafiadis I and Ladas SD: High intestinal and systemic levels of decoy receptor 3 (DcR3)and its ligand TL1A in active ulcerative colitis. Chin Immunol. 137:242–249. 2010. View Article : Google Scholar

22 

Hou Y, Xu P, Lou X, Liang D, Zhang M, Zhang Z and Zhang L: Serum decoy receptor 3 is a useful predictor for the active status of chronic hepatitis B in hepatitis B e antigen-negative patients. Tohoku J Exp Med. 230:227–232. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Yang M, Chen G, Dang Y and Luo D: Significance of decoy receptor 3 in sera of hepatocellular carcinoma patients. Ups J Med Sci. 115:232–237. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Yoo S, Jang J, Kim S, Cho H and Lee MS: Expression of DcR3 and its effects in kaposi's sarcoma-associated herpesvirus-infected human endothelial cells. Intervirology. 55:45–52. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Bamias G, Evangelou K, Vergou T, Tsimaratou K, Kaltsa G, Antoniou C, Kotsinas A, Kim S, Gorgoulis V, Stratigos AJ and Sfikakis PP: Upregulation and nuclear localization of TNF-like cytokine 1A (TL1A) and its receptors DR3 and DcR3 in psoriatic skin lesions. Exp Dermatol. 20:725–731. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Hsieh SL and Lin WW: Decoy receptor 3: An endogenous immubomudulator in cancer growth and inflammatory reactions. J Biomed Sci. 24:392017. View Article : Google Scholar : PubMed/NCBI

27 

Ho CH, Hsu CF, Fong PF, Tai SK, Hsieh SL and Chen CJ: Epstein-Barr virus transcription activator Rta upregulates decoy receptor 3 expression by binding to its promoter. J Virol. 81:4837–4847. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Ho CH, Chen CL, Li WY and Chen CJ: Decoy receptor 3, upregulated by Epstein-Barr virus latent membrane protein 1, enhances nasopharyngeal carcinoma cell migration and invasion. Carcinogenesis. 30:1443–1451. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Xia L, Tian D, Huang W, Zhu H, Wang J, Zhang Y, Hu H, Nie Y, Fan D and Wu K: Upregulation of IL-23 expression in patients with chronic hepatitis B is mediated by the HBx/ERK/NF-κB pathway. J Immunol. 188:753–764. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lou X, Hou Y, Cao H, Zhao J and Zhu F: Clinical significance of decoy receptor 3 upregulation in patients with hepatitis B and liver fibrosis. Oncol Lett 16: 1147-1154, 2018.
APA
Lou, X., Hou, Y., Cao, H., Zhao, J., & Zhu, F. (2018). Clinical significance of decoy receptor 3 upregulation in patients with hepatitis B and liver fibrosis. Oncology Letters, 16, 1147-1154. https://doi.org/10.3892/ol.2018.8762
MLA
Lou, X., Hou, Y., Cao, H., Zhao, J., Zhu, F."Clinical significance of decoy receptor 3 upregulation in patients with hepatitis B and liver fibrosis". Oncology Letters 16.1 (2018): 1147-1154.
Chicago
Lou, X., Hou, Y., Cao, H., Zhao, J., Zhu, F."Clinical significance of decoy receptor 3 upregulation in patients with hepatitis B and liver fibrosis". Oncology Letters 16, no. 1 (2018): 1147-1154. https://doi.org/10.3892/ol.2018.8762
Copy and paste a formatted citation
x
Spandidos Publications style
Lou X, Hou Y, Cao H, Zhao J and Zhu F: Clinical significance of decoy receptor 3 upregulation in patients with hepatitis B and liver fibrosis. Oncol Lett 16: 1147-1154, 2018.
APA
Lou, X., Hou, Y., Cao, H., Zhao, J., & Zhu, F. (2018). Clinical significance of decoy receptor 3 upregulation in patients with hepatitis B and liver fibrosis. Oncology Letters, 16, 1147-1154. https://doi.org/10.3892/ol.2018.8762
MLA
Lou, X., Hou, Y., Cao, H., Zhao, J., Zhu, F."Clinical significance of decoy receptor 3 upregulation in patients with hepatitis B and liver fibrosis". Oncology Letters 16.1 (2018): 1147-1154.
Chicago
Lou, X., Hou, Y., Cao, H., Zhao, J., Zhu, F."Clinical significance of decoy receptor 3 upregulation in patients with hepatitis B and liver fibrosis". Oncology Letters 16, no. 1 (2018): 1147-1154. https://doi.org/10.3892/ol.2018.8762
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team