Open Access

Disabled homolog 2 interactive protein functions as a tumor suppressor in osteosarcoma cells

  • Authors:
    • Jianan He
    • Shuai Huang
    • Zhenhua Lin
    • Jiqin Zhang
    • Jialin Su
    • Weidong Ji
    • Xingmo Liu
  • View Affiliations

  • Published online on: May 22, 2018     https://doi.org/10.3892/ol.2018.8776
  • Pages: 703-712
  • Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The disabled homolog 2 interactive protein (DAB2IP) gene is a member of the family of Ras GTPases and functions as a tumor suppressor in many types of carcinoma; however, its function in osteosarcoma remains unclear. The aim of the present study was to determine the function of DAB2IP in osteosarcoma and normal bone cells in vitro. The expression of DAB2IP protein was assessed in osteoblast and osteosarcoma cell lines by western blot analysis. The effects of DAB2IP expression on cell proliferation, colony formation, apoptosis, cell cycle, and cell migration and invasion were evaluated by in vitro studies. DAB2IP expression was lower in osteosarcoma cell lines than in normal osteoblast cell lines. DAB2IP expression affected cell proliferation, apoptosis and cell cycle distribution. In addition, DAB2IP inhibited the migration and invasion of osteosarcoma and normal osteoblast cells. Therefore, DAB2IP may function as a tumor suppressor in osteosarcoma cell lines by inhibiting cell proliferation and invasion.
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July-2018
Volume 16 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
He J, Huang S, Lin Z, Zhang J, Su J, Ji W and Liu X: Disabled homolog 2 interactive protein functions as a tumor suppressor in osteosarcoma cells. Oncol Lett 16: 703-712, 2018
APA
He, J., Huang, S., Lin, Z., Zhang, J., Su, J., Ji, W., & Liu, X. (2018). Disabled homolog 2 interactive protein functions as a tumor suppressor in osteosarcoma cells. Oncology Letters, 16, 703-712. https://doi.org/10.3892/ol.2018.8776
MLA
He, J., Huang, S., Lin, Z., Zhang, J., Su, J., Ji, W., Liu, X."Disabled homolog 2 interactive protein functions as a tumor suppressor in osteosarcoma cells". Oncology Letters 16.1 (2018): 703-712.
Chicago
He, J., Huang, S., Lin, Z., Zhang, J., Su, J., Ji, W., Liu, X."Disabled homolog 2 interactive protein functions as a tumor suppressor in osteosarcoma cells". Oncology Letters 16, no. 1 (2018): 703-712. https://doi.org/10.3892/ol.2018.8776