Correlation between ultrasonic features and expression levels of C-erbB-2, VEGF and nm23 in breast cancer

Nie,Min; Qin,Yongchun; Zhu,Jiafeng; Li,Yanzhi; Wang,Zhibin

doi:10.3892/ol.2018.8777

Correlation between ultrasonic features and expression levels of C-erbB-2, VEGF and nm23 in breast cancer

Authors:
- Min Nie
- Yongchun Qin
- Jiafeng Zhu
- Yanzhi Li
- Zhibin Wang
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Affiliations: Department of Medical Imaging, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266001, P.R. China, Department of Medical Imaging, People's Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China, ICU, People's Hospital of Zhangqiu, Jinan, Shandong 250000, P.R. China
Published online on: May 22, 2018 https://doi.org/10.3892/ol.2018.8777
Pages: 1701-1707

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Abstract

Breast cancer is one of the most common female malignancies in clinical practice, which ranks number one in terms of its high incidence. We investigated the relevance of ultrasonic features of breast cancer and expression levels of C-erbB-2, vascular endothelial growth factor (VEGF) and nm23 and its clinical significance. A total of 76 patients with breast cancer were recruited who were admitted to The Affiliated Hospital of Qingdao University from January, 2016 to August, 2017. All patients underwent color Doppler ultrasonic imaging, and expression levels of C-erbB-2, VEGF and nm23 in their tumor tissues were measured by immunohistochemistry. The ultrasonic features were evaluated and compared with the expression levels of C-erbB-2, VEGF and nm23 for each patient. Ultrasonography showed a tumor mass with spiculated margins, abnormal vasculature, and a diameter no less than 3 cm, as well as lymph node metastasis. The above signs were associated with high expression of C-erbB-2, VEGF and nm23 (p<0.05), but calcification was not associated with high expression of these biomarkers (p>0.05). For patients with highly expressed C-erbB-2 and VEGF, the time to peak (TTP) of the time‑intensity curve obtained by contrast enhanced ultrasound was shorter, while the peak intensity (PI) was higher. On the contrary, for patients with highly expressed nm23, the TTP was apparently longer, while the PI was lower (p<0.05). The ultrasonic features of breast cancer were relevant to the expression levels of C-erbB-2, VEGF and nm23. Thus, the expression levels of C-erbB-2, VEGF and nm23 were predictable indirectly according to the ultrasonic features of the patient, which can be used as a reference for breast cancer treatment and prognosis prediction.

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