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Article Open Access

REV‑ERBα reduction is associated with clinicopathological features and prognosis in human gastric cancer

  • Authors:
    • Xiaoshan Wang
    • Nana Wang
    • Xiang Wei
    • Haoyuan Yu
    • Zhengguang Wang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. China, Laboratory of Pathophysiology, School of Life Sciences, Anhui Medical University, Hefei, Anhui 230032, P.R. China, Laboratory of Molecular Biology, Department of Biochemistry, Anhui Medical University, Hefei, Anhui 230032, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1499-1506
    |
    Published online on: May 25, 2018
       https://doi.org/10.3892/ol.2018.8809
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Abstract

Gastric cancer is a serious threat to human health. Nuclear receptor subfamily 1 group D member 1 (REV‑ERBα) is a member of the nuclear hormone receptor family that regulates lipid metabolism, inflammatory responses and circadian rhythms. However, the role of REV‑ERBα in the pathogenesis of human gastric cancer is unclear. The present study employed gastric cancer tissues from 74 patients and determined the association between REV‑ERBα expression with clinicopathological variables and prognosis. Furthermore, the association between REV‑ERBα and apoptosis in undifferentiated and moderately differentiated human gastric cancer cells was determined. It was identified that REV‑ERBα expression was decreased in gastric cancer, which was positively associated with poor differentiation (P=0.009), T stage (P=0.001), Tumor‑Node‑Metastasis (TMN) stage (P=0.001) and lymph node metastasis (P=0.007). In the survival analysis, the 3‑ and 5‑year survival times of patients were significantly associated with REV‑ERBα expression (P=0.009 and P=0.002, respectively). Low REV‑ERBα expression was associated with poor prognosis (P<0.05). Concurrently, cleaved caspase‑3 expression was downregulated, whereas expression levels of Bcl‑2 and the Bcl‑2/Bax ratio were upregulated in gastric cancer tissues compared with normal tissues. REV‑ERBα activator GSK4112 caused apoptosis in SGC‑7901 and BGC‑823 cell lines. REV‑ERBα levels were decreased in human gastric cancer, which was associated with poor differentiation, TMN stages and poor prognosis. REV‑ERBα is a potential biomarker for tumor development and prognosis, and a potential therapeutic target for gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Wang N, Wei X, Yu H and Wang Z: REV‑ERBα reduction is associated with clinicopathological features and prognosis in human gastric cancer. Oncol Lett 16: 1499-1506, 2018.
APA
Wang, X., Wang, N., Wei, X., Yu, H., & Wang, Z. (2018). REV‑ERBα reduction is associated with clinicopathological features and prognosis in human gastric cancer. Oncology Letters, 16, 1499-1506. https://doi.org/10.3892/ol.2018.8809
MLA
Wang, X., Wang, N., Wei, X., Yu, H., Wang, Z."REV‑ERBα reduction is associated with clinicopathological features and prognosis in human gastric cancer". Oncology Letters 16.2 (2018): 1499-1506.
Chicago
Wang, X., Wang, N., Wei, X., Yu, H., Wang, Z."REV‑ERBα reduction is associated with clinicopathological features and prognosis in human gastric cancer". Oncology Letters 16, no. 2 (2018): 1499-1506. https://doi.org/10.3892/ol.2018.8809
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Wang N, Wei X, Yu H and Wang Z: REV‑ERBα reduction is associated with clinicopathological features and prognosis in human gastric cancer. Oncol Lett 16: 1499-1506, 2018.
APA
Wang, X., Wang, N., Wei, X., Yu, H., & Wang, Z. (2018). REV‑ERBα reduction is associated with clinicopathological features and prognosis in human gastric cancer. Oncology Letters, 16, 1499-1506. https://doi.org/10.3892/ol.2018.8809
MLA
Wang, X., Wang, N., Wei, X., Yu, H., Wang, Z."REV‑ERBα reduction is associated with clinicopathological features and prognosis in human gastric cancer". Oncology Letters 16.2 (2018): 1499-1506.
Chicago
Wang, X., Wang, N., Wei, X., Yu, H., Wang, Z."REV‑ERBα reduction is associated with clinicopathological features and prognosis in human gastric cancer". Oncology Letters 16, no. 2 (2018): 1499-1506. https://doi.org/10.3892/ol.2018.8809
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