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Article

Overexpression of MTH1 and OGG1 proteins in ulcerative colitis‑associated carcinogenesis

  • Authors:
    • Yoshiteru Kumagae
    • Minako Hirahashi
    • Katsumi Takizawa
    • Hidetaka Yamamoto
    • Masaki Gushima
    • Motohiro Esaki
    • Takayuki Matsumoto
    • Masafumi Nakamura
    • Takanari Kitazono
    • Yoshinao Oda
  • View Affiliations / Copyright

    Affiliations: Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka 812‑8582, Japan, Department of Medical Gastroenterology, Shimonoseki Hospital, Yamaguchi, Yamaguchi 750‑8520, Japan, Department of Medicine and Clinical Science, Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka 812‑8582, Japan, Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Iwate 020‑8505, Japan
  • Pages: 1765-1776
    |
    Published online on: May 25, 2018
       https://doi.org/10.3892/ol.2018.8812
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Abstract

Oxidative stress, demonstrated by an accumulation of 8‑hydroxy‑2'‑deoxyguanosine (8‑OHdG), results in DNA damage, which is normally repaired by base excision repair enzymes including 8‑OHdG DNA glycosylase (OGG1) and human MutY homolog (MUTYH), in addition to nucleotide pool sanitizing enzymes including MutT Homolog 1 (MTH1). Abnormalities of this repair system are present in various cancer types. The present study aimed to elucidate the clinicopathological significance of altered expression levels of inducible nitric oxide synthase (iNOS), 8‑OHdG, OGG1, MTH1 and MUTYH in ulcerative colitis (UC) and UC‑associated neoplasms. Immunohistochemical staining for these markers and p53 in 23 cases of UC‑associated neoplasm (Group A, 14 carcinomas and nine dysplasias), 16 cases of UC without neoplasm (Group B) and 17 cases of normal colon specimens (Group C) was performed. Mutation analyses was conducted for KRAS proto‑oncogene, GTPase (K‑ras), tumor protein P53 (TP53) and isocitrate dehydrogenase (NADP (+)) 1, cytosolic (IDH1) genes. Immunohistochemically, the iNOS, 8‑OHdG, OGG1 and MTH1 expression levels were increased in Groups A and B compared with Group C. The OGG1 and MTH1 expression levels in Group A were also increased compared with Group B. Group A and Group B exhibited increased cytoplasmic expression and decreased nuclear expression of MUTYH compared with Group C. Mutations of K‑ras and TP53 were detected in 2/21 (9.5%) and 10/22 (45.5%) cases of Group A, respectively. IDH1 mutation was not detected in any cases. These findings suggest that, as a response to oxidative damage, OGG1 and MTH1 may be upregulated in UC through an inflammatory condition that progresses to cancer formation. Persisting oxidative damage stress may play a role in the pathogenesis of UC‑associated tumors.
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1 

Jess T, Rungoe C and Peyrin-Biroulet L: Risk of colorectal cancer in patients with ulcerative colitis: A meta-analysis of population-based cohort studies. Clin Gastroenterol Hepatol. 10:639–645. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Jess T, LoftusEV Jr, Velayos FS, Harmsen WS, Zinsmeister AR, Smyrk TC, Tremaine WJ, Melton LJ III, Munkholm P and Sandborn WJ: Incidence and prognosis of colorectal dysplasia in inflammatory bowel disease: A population-based study from Olmsted County, Minnesota. Inflamm Bowel Dis. 12:669–676. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Brentnall TA, Haggitt RC, Rabinovitch PS, Kimmey MB, Bronner MP, Levine DS, Kowdley KV, Stevens AC, Crispin DA, Emond M and Rubin CE: Risk and natural histoy of colonic neoplasia in patients with primary sclerosing cholangitis and ulcerative colitis. Gastroenterology. 110:331–338. 1996. View Article : Google Scholar : PubMed/NCBI

4 

Nuako KW, Ahlquist DA, Mahoney DW, Schaid DJ, Siems DM and Lindor NM: Familial predisposition for colorectal cancer in chronic ulcerative colitis: A case-control study. Gastroenterology. 115:1079–1083. 1998. View Article : Google Scholar : PubMed/NCBI

5 

Devroede GJ, Taylor WF, Sauer WG, Jackman RJ and Stickler GB: Cancer risk and life expectancy of children with ulcerative colitis. N Engl J Med. 285:17–21. 1971. View Article : Google Scholar : PubMed/NCBI

6 

D'Incà R, Cardin R, Benazzato L, Angriman I, Martines D and Sturniolo GC: Oxidative DNA damage in the mucosa of ulcerative colitis increases with disease duration and dysplasia. Inflamm Bowel Dis. 10:23–27. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Kojima M, Morisaki T, Tsukahara Y, Uchiyama A, Matsunari Y, Mibu R and Tanaka M: Nitric oxide synthase expression and nitric oxide production in human colon carcinoma tissue. J Surg Oncol. 70:222–229. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Choudhari SK, Chaudhary M, Bagde S, Gadbail AR and Joshi V: Nitric oxide and cancer: A review. World J Surg Oncol. 11:1182013. View Article : Google Scholar : PubMed/NCBI

9 

Vannini F, Kashfi K and Nath N: The dual role of iNOS in cancer. Redox Biol. 6:334–343. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Nakabeppu Y, Tsuchimoto D, Ichinoe A, Ohno M, Ide Y, Hirano S, Yoshimura D, Tominaga Y, Furuichi M and Sakumi K: Biological significance of the defense mechanisms against oxidative damage in nucleic acids caused by reactive oxygen species: From mitochondria to nuclei. Ann N Y Acad Sci. 1011:101–111. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Shibutani S, Takeshita M and Grollman AP: Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature. 349:431–434. 1991. View Article : Google Scholar : PubMed/NCBI

12 

Vakakanidis A, Vlachogianni T and Fiotakis C: 8-hydroxy-2′-deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 27:120–139. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Kondo S, Toyokuni S, Tanaka T, Hiai H, Onodera H, Kasai H and Imamura M: Overexpression of the hOGG1 gene and high 8-hydroxy-2′-deoxyguanosine (8-OHdG) lyase activity in human colorectal carcinoma: Regulation mechanism of the 8-OHdG level in DNA. Clin Cancer Res. 6:1394–1400. 2000.PubMed/NCBI

14 

Sekiguchi M and Tsuzuki T: Oxidative nucleotide damage: Consequences and prevention. Oncogene. 21:8895–8904. 2002. View Article : Google Scholar : PubMed/NCBI

15 

García-Quispes WA, Pérez-Machado G, Akdi A, Pastor S, Galofré P, Biarnés F, Castell J, Velázquez A and Marcos R: Association studies of OGG1, XRCC1, XRCC2 and XRCC3 polymorphisms with differentiated thyroid cancer. Mutat Res. 709–710:67–72. 2011. View Article : Google Scholar

16 

Kubo N, Morita M, Nakashima Y, Kitao H, Egashira A, Saeki H, Oki E, Kakeji Y, Oda Y and Maehara Y: Oxidative DNA damage in human esophageal cancer: Clinicopathological analysis of 8-hydroxydeoxyguanosine and its repair enzyme. Dis Esophagus. 27:285–293. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Karihtala P, Kauppila S, Puistola U and Jukkola-Vuorinen A: Absence of the DNA repair enzyme human 8-oxoguanine glycosylase is associated with an aggressive breast cancer phenotype. Br J Cancer. 106:344–347. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Gushima M, Hirahashi M, Matsumoto T, Fujita K, Fujisawa R, Mizumoto K, Nakabeppu Y, Iida M, Yao T and Tsuneyoshi M: Altered expression of MUTYH and an increase in 8-hydroxydeoxyguanosine are early events in ulcerative colitis-associated carcinogenesis. J Pathol. 219:77–86. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Grasso F, Di Meo S, de Luca G, Pasquini L, Rossi S, Boirivant M, Biffoni M, Bignami M and Di Carlo E: The MUTYH base excision repair gene protects against inflammation-associated colorectal carcinogenesis. Oncotarget. 6:19671–19684. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Scarpa M, Castagliuolo I, Castoro C, Pozza A, Scarpa M, Kotsafti A and Angriman I: Inflammatory colonic carcinogenesis: A review on pathogenesis and immunosurveillance mechanisms in ulcerative colitis. World J Gastroenterol. 20:6774–6785. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Yin J, Harpaz N, Tong Y, Huang Y, Laurin J, Greenwald BD, Hontanosas M, Newkirk C and Meltzer SJ: p53 point mutations in dysplastic and cancerous ulcerative colitis lesions. Gastroenterology. 104:1633–1639. 1993. View Article : Google Scholar : PubMed/NCBI

22 

Borger DR, Tanabe KK, Fan KC, Lopez HU, Fantin VR, Straley KS, Schenkein DP, Hezel AF, Ancukiewicz M Liebman HM, et al: Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping. Oncologist. 17:72–79. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Hartman DJ, Binion D, Regueiro M, Schraut W, Bahary N, Sun W, Nikiforova M and Pai RK: Isocitrate dehydrogenase-1 is mutated in inflammatory bowel disease-associated intestinal adenocarcinoma with low-grade tubuloglandular histology but not in sporadic intestinal adenocarcinoma. Am J Surg Pathol. 38:1147–1156. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Riddell RH, Goldman H, Ransohoff DF, Appelman HD, Fenoglio CM, Haggitt RC, Ahren C, Correa P, Hamilton SR, Morson BC, et al: Dysplasia in inflammatory bowel disease: Standardized classification with provisional clinical applications. Human Pathol. 11:931–968. 1983. View Article : Google Scholar

25 

Brennan PA, Palacios-Callender M, Zaki GA, Spedding AV and Langdon JD: Type II nitric oxide synthase (NOS2) expression correlates with lymph node status in oral squamous cell carcinoma. J Oral Pathol Med. 30:129–134. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Maehara Y, Tomoda M, Hasuda S, Kabashima A, Tokunaga E, Kakeji Y and Sugimachi K: Prognostic value of p53 protein expression for patients with gastric cancer- a multivariate analysis. Br J Cancer. 79:1255–1261. 1999. View Article : Google Scholar : PubMed/NCBI

27 

Feng CW, Wang LD, Jiao LH, Liu B, Zheng S and Xie XJ: Expression of p53, inducible nitric oxide synthase and vascular endothelial growth factor in gastric precancerous and cancerous lesions: Correlation with clinical features. BMC Cancer. 2:82002. View Article : Google Scholar : PubMed/NCBI

28 

Oda Y, Sakamoto A, Satio T, Kawauchi S, Iwamoto Y and Tsuneyoshi M: Molecular abnormalities of p53, MDM2 and H-ras in synovial sarcoma. Mod Pathol. 13:994–1004. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Fujita K, Yamamoto H, Matsumoto T, Hirahashi M, Gushima M, Kishimoto J, Nishiyama K, Taguchi T, Yao T and Oda Y: Sessile serrated adenoma with early neoplastic progression: A clinicopathologic and molecular study. Am J Surg Pathol. 35:295–304. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Kajitani K, Yamaguchi H, Dan Y, Furuichi M, Kang D and Nakabeppu Y: MTH1, an oxidized purine nucleoside triphosphatase, suppresses the accumulation of oxidative damage of nucleic acids in the hippocampal microglia during kainate-induced excitotoxicity. J Neurosci. 26:1688–1698. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Liao J, Seril DN, Lu GG, Zhang M, Toyokuni S, Yang AL and Yang GY: Increased susceptibility of chronic ulcerative colitis-induced carcinoma development in DNA repair enzyme Ogg1 deficient mice. Mol Carcinog. 47:638–646. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Nakabeppu Y: Cellular levels of 8-oxoguanine in either DNA or the nucleotide pool play pivotal roles in carcinogenesis and survival of cancer cells. Int J Mol Sci. 15:12543–12557. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Tsuzuki T, Egashira A, Igarashi H, Iwakuma T, Nakatsuru Y, Tominaga Y, Kawate H, Nakao K, Nakamura K, Ide F, et al: Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase. Proc Natl Acad Sci USA. 98:11456–11461. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Song WJ, Jiang P, Cai JP and Zheng ZQ: Expression of cytoplasmic 8-oxo-Gsn and MTH1 correlates with pathological grading in human gastric cancer. Asian Pac J Cancer Prev. 16:6335–6338. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Gad H, Koolmeister T, Jemth AS, Eshtad S, Jacques SA, Ström CE, Svensson LM, Schultz N, Lundbäck T, Einarsdottir BO, et al: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 508:215–221. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Huber KV, Salah E, Radic B, Gridling M, Elkins JM, Stukalov A, Jemth AS, Göktürk C, Sanjiv K, Strömberg K, et al: Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature. 508:222–227. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Chaubert P, Benhattar J, Saraga E and Costa J: K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis. Am J Pathol. 144:767–775. 1994.PubMed/NCBI

38 

Oka S, Leon J, Tsuchimoto D, Sakumi K and Nakabeppu Y: MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death. Oncogenesis. 4:e1422015. View Article : Google Scholar : PubMed/NCBI

39 

Chatterjee A..Mambo E, Osada M, Upadhyay S and Sidransky D: The effect of p53-RNAi and p53 knockout on human 8-oxoguanine DNA glycosylase (hOgg1) activity. FASEB J. 20:112–114. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kumagae Y, Hirahashi M, Takizawa K, Yamamoto H, Gushima M, Esaki M, Matsumoto T, Nakamura M, Kitazono T, Oda Y, Oda Y, et al: Overexpression of MTH1 and OGG1 proteins in ulcerative colitis‑associated carcinogenesis. Oncol Lett 16: 1765-1776, 2018.
APA
Kumagae, Y., Hirahashi, M., Takizawa, K., Yamamoto, H., Gushima, M., Esaki, M. ... Oda, Y. (2018). Overexpression of MTH1 and OGG1 proteins in ulcerative colitis‑associated carcinogenesis. Oncology Letters, 16, 1765-1776. https://doi.org/10.3892/ol.2018.8812
MLA
Kumagae, Y., Hirahashi, M., Takizawa, K., Yamamoto, H., Gushima, M., Esaki, M., Matsumoto, T., Nakamura, M., Kitazono, T., Oda, Y."Overexpression of MTH1 and OGG1 proteins in ulcerative colitis‑associated carcinogenesis". Oncology Letters 16.2 (2018): 1765-1776.
Chicago
Kumagae, Y., Hirahashi, M., Takizawa, K., Yamamoto, H., Gushima, M., Esaki, M., Matsumoto, T., Nakamura, M., Kitazono, T., Oda, Y."Overexpression of MTH1 and OGG1 proteins in ulcerative colitis‑associated carcinogenesis". Oncology Letters 16, no. 2 (2018): 1765-1776. https://doi.org/10.3892/ol.2018.8812
Copy and paste a formatted citation
x
Spandidos Publications style
Kumagae Y, Hirahashi M, Takizawa K, Yamamoto H, Gushima M, Esaki M, Matsumoto T, Nakamura M, Kitazono T, Oda Y, Oda Y, et al: Overexpression of MTH1 and OGG1 proteins in ulcerative colitis‑associated carcinogenesis. Oncol Lett 16: 1765-1776, 2018.
APA
Kumagae, Y., Hirahashi, M., Takizawa, K., Yamamoto, H., Gushima, M., Esaki, M. ... Oda, Y. (2018). Overexpression of MTH1 and OGG1 proteins in ulcerative colitis‑associated carcinogenesis. Oncology Letters, 16, 1765-1776. https://doi.org/10.3892/ol.2018.8812
MLA
Kumagae, Y., Hirahashi, M., Takizawa, K., Yamamoto, H., Gushima, M., Esaki, M., Matsumoto, T., Nakamura, M., Kitazono, T., Oda, Y."Overexpression of MTH1 and OGG1 proteins in ulcerative colitis‑associated carcinogenesis". Oncology Letters 16.2 (2018): 1765-1776.
Chicago
Kumagae, Y., Hirahashi, M., Takizawa, K., Yamamoto, H., Gushima, M., Esaki, M., Matsumoto, T., Nakamura, M., Kitazono, T., Oda, Y."Overexpression of MTH1 and OGG1 proteins in ulcerative colitis‑associated carcinogenesis". Oncology Letters 16, no. 2 (2018): 1765-1776. https://doi.org/10.3892/ol.2018.8812
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