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Article

Caspase‑10, matrix metalloproteinase‑9 and total laminin are correlated with the tumor malignancy of clear cell renal cell carcinoma

  • Authors:
    • Hua Qian
    • Xiaoguang Li
    • Wei Zhang
    • Liang Ma
    • Junfeng Sun
    • Xianling Tang
    • Yongsheng Chen
    • Lichen Teng
    • Wentao Wang
    • Dechao Li
    • Yongpeng Xu
    • Changfu Li
    • Yan Cao
  • View Affiliations / Copyright

    Affiliations: Academician Workstation, Harbin Medical University and Heilongjiang Academy of Medical Sciences, Harbin, Heilongjiang 150081, P.R. China, Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, Heilongjiang 150081, P.R. China, Department of Cardiovascular Medicine, First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Eye Hospital, First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Department of Urology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150001, P.R. China
  • Pages: 2039-2045
    |
    Published online on: May 30, 2018
       https://doi.org/10.3892/ol.2018.8845
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Abstract

Clear cell renal cell carcinoma (ccRCC) is a common malignant kidney tumor, the pathogenesis of which remains unclear. The aim of the present study was to investigate whether caspase‑10, matrix metalloproteinase‑9 (MMP‑9) and total laminin (LM) were involved into the pathogenesis of ccRCC. The levels of caspase‑10, MMP‑9 and total LM were analyzed by ELISA in tumor tissues and adjacent non‑malignant tissues of 27 patients with ccRCC. The results revealed that caspase‑10 levels in the tumor tissues were significantly higher than those in the adjacent non‑malignant tissues (P<0.05). The MMP‑9 levels in the tumor tissues were significantly lower than those in adjacent non‑malignant tissues (P<0.01). The total LM levels in tumor tissues revealed no statistical difference with those in the adjacent non‑malignant tissues (P=0.757). Additionally, caspase‑10 levels were positively correlated with MMP‑9 levels (P<0.001), but negatively correlated with total LM levels (P<0.05) in tumor tissues. Correlation analyses with clinical data of patients with ccRCC, revealed that caspase‑10 levels (P<0.05) and MMP‑9 levels (P<0.001) in tumor tissues were positively correlated with tumor grades of ccRCC, whereas total LM levels were positively correlated with tumor size (P<0.05). The results of the present study suggested that interactions between caspase‑10, MMP‑9 and LM are likely involved in the pathogenesis of ccRCC. A deeper understanding of the correlation between caspase‑10, MMP‑9 and LM would aid the clarification of pathogenesis of ccRCC.
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Copy and paste a formatted citation
Spandidos Publications style
Qian H, Li X, Zhang W, Ma L, Sun J, Tang X, Chen Y, Teng L, Wang W, Li D, Li D, et al: Caspase‑10, matrix metalloproteinase‑9 and total laminin are correlated with the tumor malignancy of clear cell renal cell carcinoma. Oncol Lett 16: 2039-2045, 2018.
APA
Qian, H., Li, X., Zhang, W., Ma, L., Sun, J., Tang, X. ... Cao, Y. (2018). Caspase‑10, matrix metalloproteinase‑9 and total laminin are correlated with the tumor malignancy of clear cell renal cell carcinoma. Oncology Letters, 16, 2039-2045. https://doi.org/10.3892/ol.2018.8845
MLA
Qian, H., Li, X., Zhang, W., Ma, L., Sun, J., Tang, X., Chen, Y., Teng, L., Wang, W., Li, D., Xu, Y., Li, C., Cao, Y."Caspase‑10, matrix metalloproteinase‑9 and total laminin are correlated with the tumor malignancy of clear cell renal cell carcinoma". Oncology Letters 16.2 (2018): 2039-2045.
Chicago
Qian, H., Li, X., Zhang, W., Ma, L., Sun, J., Tang, X., Chen, Y., Teng, L., Wang, W., Li, D., Xu, Y., Li, C., Cao, Y."Caspase‑10, matrix metalloproteinase‑9 and total laminin are correlated with the tumor malignancy of clear cell renal cell carcinoma". Oncology Letters 16, no. 2 (2018): 2039-2045. https://doi.org/10.3892/ol.2018.8845
Copy and paste a formatted citation
x
Spandidos Publications style
Qian H, Li X, Zhang W, Ma L, Sun J, Tang X, Chen Y, Teng L, Wang W, Li D, Li D, et al: Caspase‑10, matrix metalloproteinase‑9 and total laminin are correlated with the tumor malignancy of clear cell renal cell carcinoma. Oncol Lett 16: 2039-2045, 2018.
APA
Qian, H., Li, X., Zhang, W., Ma, L., Sun, J., Tang, X. ... Cao, Y. (2018). Caspase‑10, matrix metalloproteinase‑9 and total laminin are correlated with the tumor malignancy of clear cell renal cell carcinoma. Oncology Letters, 16, 2039-2045. https://doi.org/10.3892/ol.2018.8845
MLA
Qian, H., Li, X., Zhang, W., Ma, L., Sun, J., Tang, X., Chen, Y., Teng, L., Wang, W., Li, D., Xu, Y., Li, C., Cao, Y."Caspase‑10, matrix metalloproteinase‑9 and total laminin are correlated with the tumor malignancy of clear cell renal cell carcinoma". Oncology Letters 16.2 (2018): 2039-2045.
Chicago
Qian, H., Li, X., Zhang, W., Ma, L., Sun, J., Tang, X., Chen, Y., Teng, L., Wang, W., Li, D., Xu, Y., Li, C., Cao, Y."Caspase‑10, matrix metalloproteinase‑9 and total laminin are correlated with the tumor malignancy of clear cell renal cell carcinoma". Oncology Letters 16, no. 2 (2018): 2039-2045. https://doi.org/10.3892/ol.2018.8845
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