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Case Report Open Access

Bilateral breast fibromatosis after silicone prosthetics in a patient with classic familial adenomatous polyposis: A case report

  • Authors:
    • Sara Silva
    • Pedro Lage
    • Francisco Cabral
    • Rui Alves
    • Ana Catarino
    • Ana Félix
    • Saudade André
  • View Affiliations / Copyright

    Affiliations: NOVA Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, 1169‑056 Lisbon, Portugal, Department of Gastroenterology, Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), 1099‑023 Lisbon, Portugal, Department of Surgery, Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), 1099‑023 Lisbon, Portugal
    Copyright: © Silva et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1449-1454
    |
    Published online on: May 31, 2018
       https://doi.org/10.3892/ol.2018.8853
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Abstract

Breast fibromatosis is a benign fibroblastic proliferation accounting for less than 0.2% of breast tumors. It presents sporadically or as a manifestation of familial adenomatous polyposis (FAP). Fibromatosis in FAP may develop in patients with adenomatous polyposis coli (APC) gene mutations at any location through the gene. Notably, there is an increased risk if mutation is downstream codon 1400. The present case report described a 33‑year‑old woman with recurrent bilateral breast fibromatosis after breast implants in a context of classic FAP. APC mutation (codon‑935) was detected at the age of 16. In the same year, a thyroidectomy for a cribriform-morular papillary thyroid carcinoma (pT1) was performed. Seven years later, a prophylactic total colectomy with >100 adenomas without invasive carcinoma was performed and the patient was kept under surveillance. At the age of 30 years old, she underwent breast silicone implantation for cosmetic reasons. One year later, bilateral breast tumors were diagnosed in core biopsy as fibromatosis (nuclear β‑catenin+, estrogen receptors‑). After no success with medical treatment with tamoxifen, bilateral mastectomy was performed. The patient relapsed one year later and a fibromatosis lesion in the right thoracic wall was excised again. The patient demonstrated no signs of relapse 24 months after the surgery. This rare case illustrates that the increased risk of developing fibromatosis in patients with FAP, even in the classic form, should be considered before deciding to place breast implants.
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1 

Calvert GT, Monument MJ, Burt RW, Jones KB and Randall RL: Extra-abdominal desmoid tumors associated with familial adenomatous polyposis. Sarcoma. 2012:7265372012. View Article : Google Scholar : PubMed/NCBI

2 

Plawski A, Banasiewicz T, Borun P, Kubaszewski L, Krokowicz P, Skrzypczak-Zielinska M and Lubinski J: Familial adenomatous polyposis of the colon. Hered Cancer Clin Pract. 11:152013. View Article : Google Scholar : PubMed/NCBI

3 

Colaco RJ, Menasce LP, Ranson M, Sobrinho Simoes M, Cameselle Teijeiro J, Vinjamuri S and Yap BK: A clinical case report of cribriform-morular variant of papillary thyroid carcinoma with neuroendocrine differentiation and aggressive behaviour in a patient with familial adenomatous polyposis coli. Thyroid Sci. 4:1–3. 2009.

4 

Escobar C, Munker R, Thomas JO, Li BD and Burton GV: Update on desmoid tumors. Ann Oncol. 23:562–569. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Ebrahim L, Parry J and Taylor DB: Fibromatosis of the breast: A pictorial review of the imaging and histopathology findings. Clin Radiol. 69:1077–1083. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Balzer BL and Weiss SW: Do biomaterials cause implant-associated mesenchymal tumors of the breast? Analysis of 8 new cases and review of the literature. Hum Pathol. 40:1564–1570. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Ünal B, Erdoğan G and Karaveli FŞ: Step by step approach to rare breast lesions containing spindle cells. Springerplus. 4:6782015. View Article : Google Scholar : PubMed/NCBI

8 

Mátrai Z, Tóth L, Gulyás G, Szabó E, Szentirmay Z and Kásler M: A desmoid tumor associated with a ruptured silicone breast implant. Plast Reconstr Surg. 127:1e–4e. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Jeong WS, Oh TS, Sim HB and Eom JS: Desmoid tumor following augmentation mammoplasty with silicone implants. Arch Plast Surg. 40:470–472. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Amourak S, Alaoui FF, Jayi S, Chaara H and Melhouf MA: Desmoid fibromatosis of the breast: A case report on and a review of the literature. Pan Afr Med J. 21:882015.(In French). PubMed/NCBI

11 

Abraham SC, Reynolds C, Lee JH, Montgomery EA, Baisden BL, Krasinskas AM and Wu TT: Fibromatosis of the breast and mutations involving the APC/beta-catenin pathway. Hum Pathol. 33:39–46. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Haggitt RC and Booth JL: Bilateral fibromatosis of the breast in Gardner syndrome. Cancer. 25:161–166. 1970. View Article : Google Scholar : PubMed/NCBI

13 

Filipe B, Baltazar C, Albuquerque C, Fragoso S, Lage P, Vitoriano I, Mão de Ferro S, Claro I, Rodrigues P, Fidalgo P, et al: APC or MUTYH mutations account for the majority of clinically well-characterized families with FAP and AFAP phenotype and patients with more than 30 adenomas. Clin Genet. 76:242–255. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Albuquerque C, Cravo M, Cruz C, Lage P, Chaves P, Fidalgo P, Suspiro A and Nobre Leitão C: Genetic characterisation of patients with multiple colonic polyps. J Med Genet. 39:297–302. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Perea Del Pozo E, Ramirez Plaza C, Padillo Ruiz J and Martos Martínez JM: Cribiform variant of papillary thyroid cancer and familial adenomatous polyposis. Int J Surg Case Rep. 16:192–194. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Cao X, Eu KW, Seow-Choen F, Zao Y and Cheah PY: APC mutation and phenotypic spectrum of Singapore familial adenomatous polyposis patients. Eur J Hum Genet. 8:42–48. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Bonvalot S, Desai A, Coppola S, Le Péchoux C, Terrier P, Dômont J and Le Cesne A: The treatment of desmoid tumors: A stepwise clinical approach. Ann Oncol. 23(Suppl 10): x158–x166. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Roussin S, Mazouni C, Rimareix F, Honoré C, Terrier P, Mir O, Dômont J, Le Péchoux C, Le Cesne A and Bonvalot S: Toward a new strategy in desmoid of the breast? Eur J Surg Oncol. 41:571–576. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Bonvalot S, Ternès N, Fiore M, Bitsakou G, Colombo C, Honoré C, Marrari A, Le Cesne A, Perrone F, Dunant A and Gronchi A: Spontaneous regression of primary abdominal wall desmoid tumors: More common than previously thought. Ann Surg Oncol. 20:4096–4102. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Kasper B, Baumgarten C, Bonvalot S, Haas R, Haller F, Hohenberger P, Moreau G, van der Graaf WT and Gronchi A; Desmoid Working Group: Management of sporadic desmoid-type fibromatosis: A European consensus approach based on patients' and professionals' expertise-a sarcoma patients EuroNet and European Organisation for research and treatment of cancer/soft tissue and bone sarcoma group initiative. Eur J Cancer. 51:127–136. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Bocale D, Rotelli MT, Cavallini A and Altomare DF: Anti-oestrogen therapy in the treatment of desmoid tumours: A systematic review. Colorectal Dis. 13:e388–e395. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Silva S, Lage P, Cabral F, Alves R, Catarino A, Félix A and André S: Bilateral breast fibromatosis after silicone prosthetics in a patient with classic familial adenomatous polyposis: A case report. Oncol Lett 16: 1449-1454, 2018.
APA
Silva, S., Lage, P., Cabral, F., Alves, R., Catarino, A., Félix, A., & André, S. (2018). Bilateral breast fibromatosis after silicone prosthetics in a patient with classic familial adenomatous polyposis: A case report. Oncology Letters, 16, 1449-1454. https://doi.org/10.3892/ol.2018.8853
MLA
Silva, S., Lage, P., Cabral, F., Alves, R., Catarino, A., Félix, A., André, S."Bilateral breast fibromatosis after silicone prosthetics in a patient with classic familial adenomatous polyposis: A case report". Oncology Letters 16.2 (2018): 1449-1454.
Chicago
Silva, S., Lage, P., Cabral, F., Alves, R., Catarino, A., Félix, A., André, S."Bilateral breast fibromatosis after silicone prosthetics in a patient with classic familial adenomatous polyposis: A case report". Oncology Letters 16, no. 2 (2018): 1449-1454. https://doi.org/10.3892/ol.2018.8853
Copy and paste a formatted citation
x
Spandidos Publications style
Silva S, Lage P, Cabral F, Alves R, Catarino A, Félix A and André S: Bilateral breast fibromatosis after silicone prosthetics in a patient with classic familial adenomatous polyposis: A case report. Oncol Lett 16: 1449-1454, 2018.
APA
Silva, S., Lage, P., Cabral, F., Alves, R., Catarino, A., Félix, A., & André, S. (2018). Bilateral breast fibromatosis after silicone prosthetics in a patient with classic familial adenomatous polyposis: A case report. Oncology Letters, 16, 1449-1454. https://doi.org/10.3892/ol.2018.8853
MLA
Silva, S., Lage, P., Cabral, F., Alves, R., Catarino, A., Félix, A., André, S."Bilateral breast fibromatosis after silicone prosthetics in a patient with classic familial adenomatous polyposis: A case report". Oncology Letters 16.2 (2018): 1449-1454.
Chicago
Silva, S., Lage, P., Cabral, F., Alves, R., Catarino, A., Félix, A., André, S."Bilateral breast fibromatosis after silicone prosthetics in a patient with classic familial adenomatous polyposis: A case report". Oncology Letters 16, no. 2 (2018): 1449-1454. https://doi.org/10.3892/ol.2018.8853
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