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miR‑205‑5p inhibits cell migration and invasion in prostatic carcinoma by targeting ZEB1

  • Authors:
    • Lianpeng Li
    • Shouqiang Li
  • View Affiliations / Copyright

    Affiliations: Department of Urological Surgery, Binzhou Central Hospital, Binzhou, Shandong 251700, P.R. China, Department of Urological Surgery, People's Hospital of Dongying District, Dongying, Shandong 257000, P.R. China
  • Pages: 1715-1721
    |
    Published online on: May 31, 2018
       https://doi.org/10.3892/ol.2018.8862
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Abstract

Many studies have demonstrated that miRNAs have influence on tumorigenesis and progression of human cancers, including invasion and migration. Thus, the role of miR‑205/ZEB1 axis for the migration and invasion of prostate cancer cells was explored in the present study. The miR‑205‑5p and zinc finger E‑box binding homeobox 1 (ZEB1) mRNA expression levels were observed in prostate cancer tissues or cell lines via reverse transcription-quantitative PCR (RT‑qPCR), and the protein level of ZEB1 was measured by western blotting. Dual‑Luciferase Reporter Assay was used to verify the relationship between miR‑205‑5p and ZEB1. In addition, cell migration and invasion was measured by Transwell assay. The results revealed that, compared with the control, downregulation of miR‑205‑5p was detected in prostate cancer tissues and cell lines, and miR‑205‑5p overexpression was found to inhibit cell migration and invasion. Moreover, miR‑205‑5p was confirmed to directly target ZEB1 in prostate cancer. Importantly, ZEB1 was identified to weaken the inhibitory effect of miR‑205‑5p in prostate cancer. In conclusion, miR‑205‑5p inhibited cell migration and invasion in prostatic carcinoma by targeting ZEB1 and miR‑205‑5p/ZEB1 axis shows potential to be developed in therapeutic strategies for prostate cancer.
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1 

Tao ZQ, Shi AM, Wang KX and Zhang WD: Epidemiology of prostate cancer: Current status. Eur Rev Med Pharmacol Sci. 19:805–812. 2015.PubMed/NCBI

2 

Debebe Z and Rathmell WK: Ror2 as a therapeutic target in cancer. Pharmacol Ther. 150:143–148. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Croce CM and Calin GA: miRNAs, cancer, and stem cell division. Cell. 122:6–7. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Liu X, Fortin K and Mourelatos Z: MicroRNAs: Biogenesis and molecular functions. Brain Pathol. 18:113–121. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Zhao N, Lin T, Zhao C, Zhao S, Zhou S and Li Y: MicroRNA-588 is upregulated in human prostate cancer with prognostic and functional implications. J Cell Biochem. Oct 5. 2017, (Epub ahead of print). View Article : Google Scholar

6 

Zhou YJ, Yang HQ, Xia W, Cui L, Xu RF, Lu H, Xue Z, Zhang B, Tian ZN, Cao YJ, et al: Down-regulation of miR-605 promotes the proliferation and invasion of prostate cancer cells by up-regulating EN2. Life Sci. 190:7–14. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Song XL, Tang Y, Lei XH, Zhao SC and Wu ZQ: miR-618 inhibits prostate cancer migration and invasion by targeting FOXP2. J Cancer. 8:2501–2510. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Luo B, Kang N, Chen Y, Liu L and Zhang Y: Oncogene miR-106a promotes proliferation and metastasis of prostate cancer cells by directly targeting PTEN in vivo and in vitro. Minerva Med. 109:24–30. 2018.PubMed/NCBI

9 

Qu F, Zheng J, Gan W, Lian H, He H, Li W, Yuan T, Yang Y, Li X, Ji C, et al: MiR-199a-3p suppresses proliferation and invasion of prostate cancer cells by targeting Smad1. Oncotarget. 8:52465–52473. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Yang ZG, Ma XD, He ZH and Guo YX: miR-483-5p promotes prostate cancer cell proliferation and invasion by targeting RBM5. Int Braz J Urol. 43:1060–1067. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Pang H and Yue X: MiR-205 serves as a prognostic factor and suppresses proliferation and invasion by targeting insulin-like growth factor receptor 1 in human cervical cancer. Tumour Biol. 39:10104283177013082017. View Article : Google Scholar : PubMed/NCBI

12 

Duan B, Guo T, Sun H, Cai R, Rui Q and Xi Z: miR-205 as a biological marker in non-small cell lung cancer. Biomed Pharmacother. 91:823–830. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Verdoodt B, Neid M, Vogt M, Kuhn V, Liffers ST, Palisaar RJ, Noldus J, Tannapfel A and Mirmohammadsadegh A: MicroRNA-205, a novel regulator of the anti-apoptotic protein Bcl2, is downregulated in prostate cancer. Int J Oncol. 43:307–314. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Pazos MC, Abramovich D, Bechis A, Accialini P, Parborell F, Tesone M and Irusta G: Gamma secretase inhibitor impairs epithelial-to-mesenchymal transition induced by TGF-β in ovarian tumor cell lines. Mol Cell Endocrinol. 440:125–137. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Jiang R, Zhang C, Liu G, Gu R and Wu H: MicroRNA-126 inhibits proliferation, migration, invasion and EMT in osteosarcoma by targeting ZEB1. J Cell Biochem. 118:3765–3774. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Hu Y, Xie H, Liu Y, Liu W, Liu M and Tang H: miR-484 suppresses proliferation and epithelial-mesenchymal transition by targeting ZEB1 and SMAD2 in cervical cancer cells. Cancer Cell Int. 17:362017. View Article : Google Scholar : PubMed/NCBI

17 

Cha YJ, Lee JH, Han HH, Kim BG, Kang S, Choi YD and Cho NH: MicroRNA alteration and putative target genes in high-grade prostatic intraepithelial neoplasia and prostate cancer: STAT3 and ZEB1 are upregulated during prostate carcinogenesis. Prostate. 76:937–947. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Sun X, Li Y, Yu J, Pei H, Luo P and Zhang J: miR-128 modulates chemosensitivity and invasion of prostate cancer cells through targeting ZEB1. Jpn J Clin Oncol. 45:474–482. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Volinia S, Visone R, Galasso M, Rossi E and Croce CM: Identification of microRNA activity by Targets' Reverse EXpression. Bioinformatics. 26:91–97. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Wei J, Zhang L, Li J, Zhu S, Tai M, Mason CW, Chapman JA, Reynolds EA, Weiner CP and Zhou HH: MicroRNA-205 promotes cell invasion by repressing TCF21 in human ovarian cancer. J Ovarian Res. 10:332017. View Article : Google Scholar : PubMed/NCBI

22 

Niu K, Shen W, Zhang Y, Zhao Y and Lu Y: MiR-205 promotes motility of ovarian cancer cells via targeting ZEB1. Gene. 574:330–336. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Zhang C, Long F, Wan J, Hu Y and He H: MicroRNA-205 acts as a tumor suppressor in osteosarcoma via targeting RUNX2. Oncol Rep. 35:3275–3284. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Chen S, Jin L, Nie S, Han L, Lu N and Zhou Y: MiR-205 inhibits growth and invasion of neuroblastoma by targeting cAMP responsive element binding protein 1. Oncol Res. Jun 26. 2017, (Epub ahead of print). View Article : Google Scholar

25 

Zhuo Z and Yu H: miR-205 inhibits cell growth by targeting AKT-mTOR signaling in progesterone-resistant endometrial cancer Ishikawa cells. Oncotarget. 8:28042–28051. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Nie G, Duan H, Li X, Yu Z, Luo L, Lu R, Ji Z and Zhang W: MicroRNA-205 promotes the tumorigenesis of nasopharyngeal carcinoma through targeting tumor protein p53-inducible nuclear protein 1. Mol Med Rep. 12:5715–5722. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Dou J, He X, Liu Y, Wang Y, Zhao F, Wang X, Chen D, Shi F and Wang J: Effect of downregulation of ZEB1 on vimentin expression, tumour migration and tumourigenicity of melanoma B16F10 cells and CSCs. Cell Biol Int. 38:452–461. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Wang Y, Yan S, Liu X, Zhang W, Li Y, Dong R, Zhang Q, Yang Q, Yuan C, Shen K, et al: miR-1236-3p represses the cell migration and invasion abilities by targeting ZEB1 in high-grade serous ovarian carcinoma. Oncol Rep. 31:1905–1910. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Ma J, Zhan Y, Xu Z, Li Y, Luo A, Ding F, Cao X, Chen H and Liu Z: ZEB1 induced miR-99b/let-7e/miR-125a cluster promotes invasion and metastasis in esophageal squamous cell carcinoma. Cancer Lett. 398:37–45. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Deng Y, Luan F, Zeng L, Zhang Y and Ma K: MiR-429 suppresses the progression and metastasis of osteosarcoma by targeting ZEB1. EXCLI J. 16:618–627. 2017.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li L and Li S: miR‑205‑5p inhibits cell migration and invasion in prostatic carcinoma by targeting ZEB1. Oncol Lett 16: 1715-1721, 2018.
APA
Li, L., & Li, S. (2018). miR‑205‑5p inhibits cell migration and invasion in prostatic carcinoma by targeting ZEB1. Oncology Letters, 16, 1715-1721. https://doi.org/10.3892/ol.2018.8862
MLA
Li, L., Li, S."miR‑205‑5p inhibits cell migration and invasion in prostatic carcinoma by targeting ZEB1". Oncology Letters 16.2 (2018): 1715-1721.
Chicago
Li, L., Li, S."miR‑205‑5p inhibits cell migration and invasion in prostatic carcinoma by targeting ZEB1". Oncology Letters 16, no. 2 (2018): 1715-1721. https://doi.org/10.3892/ol.2018.8862
Copy and paste a formatted citation
x
Spandidos Publications style
Li L and Li S: miR‑205‑5p inhibits cell migration and invasion in prostatic carcinoma by targeting ZEB1. Oncol Lett 16: 1715-1721, 2018.
APA
Li, L., & Li, S. (2018). miR‑205‑5p inhibits cell migration and invasion in prostatic carcinoma by targeting ZEB1. Oncology Letters, 16, 1715-1721. https://doi.org/10.3892/ol.2018.8862
MLA
Li, L., Li, S."miR‑205‑5p inhibits cell migration and invasion in prostatic carcinoma by targeting ZEB1". Oncology Letters 16.2 (2018): 1715-1721.
Chicago
Li, L., Li, S."miR‑205‑5p inhibits cell migration and invasion in prostatic carcinoma by targeting ZEB1". Oncology Letters 16, no. 2 (2018): 1715-1721. https://doi.org/10.3892/ol.2018.8862
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