Correlation between CT features of adrenocortical and adrenal medullary tumors and expression of miR‑96 in serum

Xu,Yongyun; Wang,Zhenfang; Bi,Yangang; Duan,Zuyun; Yue,Xuewang

doi:10.3892/ol.2018.8863

Correlation between CT features of adrenocortical and adrenal medullary tumors and expression of miR‑96 in serum

Authors:
- Yongyun Xu
- Zhenfang Wang
- Yangang Bi
- Zuyun Duan
- Xuewang Yue
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Affiliations: CT Room, Dongying People's Hospital, The Second People's Hospital of Dongying, Dongying, Shandong 257091, P.R. China, Department of Imaging, The Second People's Hospital of Dongying, Dongying, Shandong 257091, P.R. China
Published online on: May 31, 2018 https://doi.org/10.3892/ol.2018.8863
Pages: 2053-2057

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Abstract

Correlation between CT features of adrenocortical and adrenal medullary tumors and the expression of miR‑96 in serum were investigated. A total of 230 patients with adrenocortical tumors and 194 patients with adrenal medullary tumors were selected in Dongying People's Hospital from August 2013 to August 2017. The two groups of patients underwent CT examination, and the signs and symptoms were recorded. The expression of miR‑96 in the serum of the two groups was detected by RT‑PCR, and the correlation between the expression of serum miR‑96 and CT features was analyzed. In patients with adrenocortical tumor, serum miR‑96 expression levels were significantly higher in patients with tumor diameter ≥5 cm than those with tumor diameter <5 cm (p<0.001). In patients with adrenal medullary tumor, serum miR‑96 expression levels were significantly higher in patients with tumor diameter ≥3 cm than those with tumor diameter <3 cm (p<0.001). In patients with adrenocortical or adrenal medullary tumor, serum miR‑96 expression levels were significantly higher in patients with peripheral infiltration than those without peripheral infiltration (p<0.001), and serum miR‑96 expression levels were also significantly higher in patients with distant metastasis than those without distant metastasis (p<0.001). Serum levels of miR‑96 in patients with benign adrenocortical and adrenal medullary tumors were significantly lower than those with malignant tumors in the same group (p<0.001). miR‑96 may have oncogenic functions in patients with adrenocortical or adrenal medullary tumors. Increased expression level of miR‑96 may promote proliferation, invasion and metastasis of tumors, and serum levels of miR‑96 provide references for the diagnosis of adrenocortical and adrenal medullary tumors.

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