Anticancer effect of HOTTIP regulates human pancreatic cancer via the metabotropic glutamate receptor 1 pathway

  • Authors:
    • Yibiao Ye
    • Yanshan Li
    • Yunping Wei
    • Yunxiuxiu Xu
    • Ruomei Wang
    • Zhiqiang Fu
    • Shangyou Zheng
    • Quanbo Zhou
    • Yu Zhou
    • Rufu Chen
    • Tao Chen
  • View Affiliations

  • Published online on: June 1, 2018     https://doi.org/10.3892/ol.2018.8870
  • Pages: 1937-1942
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Abstract

The present study aimed to determine how the expression and function of HOTTIP modifies, and regulates the metabotropic glutamate receptor 1 (mGluR1) to affect human pancreatic cancer cell viability. HOTTIP expression was higher in human pancreatic cancer tissue compared with in para‑carcinoma tissue. However, downregulation of HOTTIP expression was revealed to significantly reduce cell viability, induce apoptosis, promote caspase‑3 and caspase‑8 activities and increase Bax expression in pancreatic cancer cells. Additionally, downregulation of HOTTIP expression significantly suppressed mGluR1 and mitigated activation of the phosphoinositide 3‑kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) pathway in pancreatic cancer cells. To the best of our knowledge, the present study is the first to identify that the anticancer effect of HOTTIP against human pancreatic cancer functions the mGluR1 pathway.
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August-2018
Volume 16 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Ye Y, Li Y, Wei Y, Xu Y, Wang R, Fu Z, Zheng S, Zhou Q, Zhou Y, Chen R, Chen R, et al: Anticancer effect of HOTTIP regulates human pancreatic cancer via the metabotropic glutamate receptor 1 pathway. Oncol Lett 16: 1937-1942, 2018
APA
Ye, Y., Li, Y., Wei, Y., Xu, Y., Wang, R., Fu, Z. ... Chen, T. (2018). Anticancer effect of HOTTIP regulates human pancreatic cancer via the metabotropic glutamate receptor 1 pathway. Oncology Letters, 16, 1937-1942. https://doi.org/10.3892/ol.2018.8870
MLA
Ye, Y., Li, Y., Wei, Y., Xu, Y., Wang, R., Fu, Z., Zheng, S., Zhou, Q., Zhou, Y., Chen, R., Chen, T."Anticancer effect of HOTTIP regulates human pancreatic cancer via the metabotropic glutamate receptor 1 pathway". Oncology Letters 16.2 (2018): 1937-1942.
Chicago
Ye, Y., Li, Y., Wei, Y., Xu, Y., Wang, R., Fu, Z., Zheng, S., Zhou, Q., Zhou, Y., Chen, R., Chen, T."Anticancer effect of HOTTIP regulates human pancreatic cancer via the metabotropic glutamate receptor 1 pathway". Oncology Letters 16, no. 2 (2018): 1937-1942. https://doi.org/10.3892/ol.2018.8870