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Article

Performance of Gd‑EOB‑DTPA‑enhanced MRI for the diagnosis of LI‑RADS 4 category hepatocellular carcinoma nodules with different diameters

  • Authors:
    • Qi Tang
    • Cong Ma
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, The Second XiangYa Hospital of Central South University, Changsha, Hunan 410011, P.R. China, Department of Radiology, The Second XiangYa Hospital of Central South University, Changsha, Hunan 410011, P.R. China
  • Pages: 2725-2731
    |
    Published online on: June 4, 2018
       https://doi.org/10.3892/ol.2018.8884
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Abstract

In 2011, the American College of Radiology released a standardized reporting and data collection system, named Liver Imaging Reporting and Data System (LI‑RADS), to improve the consistency of diagnostic imaging examinations of hepatocellular carcinoma (HCC). When the LI‑RADS guideline was updated in 2014, hepatobiliary contrast agents, including gadoxetate acid (Gd‑EOB‑DTPA), were incorporated into the system. However, the diagnostic performance of Gd‑EOB‑DTPA‑enhanced magnetic resonance imaging (MRI) for nodules of different diameters has not been addressed. In the present study, a total of 263 LI‑RADS 4 category hepatic nodules were examined blindly and independently by two radiologists. All nodules were divided into two datasets: Set 1 (n=86) that included nodules with iso/hypo‑intensity in the arterial phase (HCC, n=42; non‑HCC, n=44) and set 2 (n=177) that included nodules with hyper‑intensity in the arterial phase (HCC, n=131; non‑HCC, n=46). The diagnostic performance of Gd‑EOB‑DTPA‑enhanced MRI for evaluation of nodules with different diameters was evaluated. The present study revealed that the diagnostic performance of Gd‑EOB‑enhanced MRI of larger nodules (>2 cm) was higher compared with (<2 cm) smaller nodules. The FPR of large nodules (>2 cm) with a hypervascular pattern was lower compared with smaller nodules (<2 cm) with hypovascular pattern. In conclusion, Gd‑EOB‑enhanced MRI is useful for the diagnosis of HCC where hypervascular LI‑RADS 4 nodules are >2 cm in diameter. However, Gd‑EOB‑enhanced MRI may be of limited use for the assessment of nodules that <20 mm due to low diagnostic performance and high FPR.
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1 

Purysko AS, Remer EM, Coppa CP, Leao HM, Thupili CR and Veniero JC: LI-RADS: A case-based review of the new categorization of liver findings in patients with end-stage liver disease. Radiographics. 32:1977–1995. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Wallace MC, Preen D, Jeffrey GP and Adams LA: The evolving epidemiology of hepatocellular carcinoma: A global perspective. Expert Rev Gastroenterol Hepatol. 9:765–779. 2015.PubMed/NCBI

3 

Yan M, Ha J, Aguilar M, Bhuket T, Liu B, Gish RG, Cheung R and Wong RJ: Birth cohort-specific disparities in hepatocellular carcinoma stage at diagnosis, treatment, and long-term survival. J Hepatol. 64:326–332. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Goldberg DS, Valderrama A, Kamalakar R, Sansgiry SS, Babajanyan S and Lewis JD: Hepatocellular carcinoma surveillance among cirrhotic patients with commercial health insurance. J Clin Gastroenterol. 50:258–265. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Bruix J and Sherman M: Management of hepatocellular carcinoma: An update. Hepatology. 53:1020–1022. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Davenport MS, Khalatbari S, Liu PS, Maturen KE, Kaza RK, Wasnik AP, Al-Hawary MM, Glazer DI, Stein EB, Patel J, et al: Repeatability of diagnostic features and scoring systems for hepatocellular carcinoma by using MR imaging. Radiology. 272:132–142. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Leoni S, Piscaglia F, Golfieri R, Camaggi V, Vidili G, Pini P and Bolondi L: The impact of vascular and nonvascular findings on the noninvasive diagnosis of small hepatocellular carcinoma based on the EASL and AASLD criteria. Am J Gastroenterol. 105:599–609. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Khalili K, Kim TK, Jang HJ, Haider MA, Khan L, Guindi M and Sherman M: Optimization of imaging diagnosis of 1–2 cm hepatocellular carcinoma: An analysis of diagnostic performance and resource utilization. J Hepatol. 54:723–728. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Santillan C, Chernyak V and Sirlin C: LI-RADS categories: Concepts, definitions, and criteria. Abdom Radiol (NY). 43:101–110. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Santillan C, Fowler K, Kono Y and Chernyak V: LI-RADS major features: CT, MRI with extracellular agents, and MRI with hepatobiliary agents. Abdom Radiol (NY). 43:75–81. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Cha DI, Jang KM, Kim SH, Kang TW and Song KD: Liver imaging reporting and data system on CT and gadoxetic acid-enhanced MRI with diffusion-weighted imaging. Eur Radiol. 27:4394–4405. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Granata V, Fusco R, Avallone A, Catalano O, Filice F, Leongito M, Palaia R, Izzo F and Petrillo A: Major and ancillary magnetic resonance features of LI-RADS to assess HCC: An overview and update. Infect Agent Cancer. 12:232017. View Article : Google Scholar : PubMed/NCBI

13 

Chen NX, Motosugi U, Morisaka H, Ichikawa S, Sano K, Ichikawa T Matsuda M, Fujii H and Onishi H: Added value of a gadoxetic acid-enhanced hepatocyte-phase image to the LI-RADS system for diagnosing hepatocellular carcinoma. Magn Reson Med Sci. 15:49–59. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Abd Alkhalik Basha M, Abd El, Aziz El, Sammak D and El Sammak AA: Diagnostic efficacy of the liver imaging-reporting and data system (LI-RADS) with CT imaging in categorising small nodules (10–20 mm) detected in the cirrhotic liver at screening ultrasound. Clin Radiol. 72:901.e1–901.e11. 2017. View Article : Google Scholar

15 

Mitchell DG, Bruix J, Sherman M and Sirlin CB: LI-RADS (Liver Imaging Reporting and Data System): Summary, discussion, and consensus of the LI-RADS management working group and future directions. Hepatology. 61:1056–1065. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Santillan CS, Tang A, Cruite I, Shah A and Sirlin CB: Understanding LI-RADS: A primer for practical use. Magn Reson Imaging Clin N Am. 22:337–352. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Elsayes KM, Hooker JC, Agrons MM, Kielar AZ, Tang A, Fowler KJ, Chernyak V, Bashir MR, Kono Y, Do RK, et al: 2017 Version of LI-RADS for CT and MR Imaging: An Update. Radiographics. 37:1994–2017. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Qian H, Li S, Ji M and Lin G: MRI characteristics for the differential diagnosis of benign and malignant small solitary hypovascular hepatic nodules. Eur J Gastroen Hepat. 28:749–756. 2016. View Article : Google Scholar

19 

Joo I, Lee JM, Lee SM, Lee JS, Park JY and Han JK: Diagnostic accuracy of liver imaging reporting and data system (LI-RADS) v2014 for intrahepatic mass-forming cholangiocarcinomas in patients with chronic liver disease on gadoxetic acid-enhanced MRI. J Magn Reson Imaging. 76:1330–1338. 2016. View Article : Google Scholar

20 

Motosugi U, Ichikawa T, Onohara K, Sou H, Sano K, Muhi A and Araki T: Distinguishing hepatic metastasis from hemangioma using gadoxetic acid-enhanced magnetic resonance imaging. Invest Radiol. 46:359–365. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Darnell A, Forner A, Rimola J, Reig M, Garcia-Criado A, Ayuso C and Bruix J: Liver imaging reporting and data system with MR imaging: Evaluation in nodules 20 mm or smaller detected in cirrhosis at screening US. Radiology. 275:698–707. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Di Pietropaolo M, Briani C, Federici GF, Marignani M, Begini P, Delle Fave G and Iannicelli E: Comparison of diffusion-weighted imaging and gadoxetic acid-enhanced MR images in the evaluation of hepatocellular carcinoma and hypovascular hepatocellular nodules. Clin Imag. 39:468–475. 2015. View Article : Google Scholar

23 

Motosugi U, Bannas P, Sano K and Reeder SB: Hepatobiliary MR contrast agents in hypovascular hepatocellular carcinoma. J Magn Reson Imaging. 41:251–265. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Ichikawa S, Ichikawa T, Motosugi U, Sano K, Morisaka H, Enomoto N, Matsuda M, Fujii H and Araki T: Presence of a hypovascular hepatic nodule showing hypointensity on hepatocyte-phase image is a risk factor for hypervascular hepatocellular carcinoma. J Magn Reson Imaging. 39:293–297. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Golfieri R, Renzulli M, Lucidi V, Corcioni B, Trevisani F and Bolondi L: Contribution of the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI to dynamic MRI in the detection of hypovascular small (<=2 cm) HCC in cirrhosis. Eur Radiol. 21:1233–1242. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Quaia E, de Paoli L, Pizzolato R, Angileri R, Pantano E, Degrassi F, Ukmar M and Cova MA: Predictors of dysplastic nodule diagnosis in patients with liver cirrhosis on unenhanced and gadobenate dimeglumine-enhanced MRI with dynamic and hepatobiliary phase. AJR Am J Roentgenol. 200:553–562. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Kang Y, Lee JM, Kim SH, Han JK and Choi BI: Intrahepatic mass-forming cholangiocarcinoma: Enhancement patterns on gadoxetic acid-enhanced MR images. Radiology. 264:751–760. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Xu J, Igarashi S, Sasaki M, Matsubara T, Yoneda N, Kozaka K, Ikeda H, Kim J, Yu E, Matsui O, et al: Intrahepatic cholangiocarcinomas in cirrhosis are hypervascular in comparison with those in normal livers. Liver Int. 32:1156–1164. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Rimola J, Forner A, Reig M, Vilana R, de Lope CR, Ayuso C and Bruix J: Cholangiocarcinoma in cirrhosis: Absence of contrast washout in delayed phases by magnetic resonance imaging avoids misdiagnosis of hepatocellular carcinoma. Hepatology. 50:791–798. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Joo I, Lee JM, Lee DH, Jeon JH, Han JK and Choi BI: Noninvasive diagnosis of hepatocellular carcinoma on gadoxetic acid-enhanced MRI: Can hypointensity on the hepatobiliary phase be used as an alternative to washout? Eur Radiol. 25:2859–2868. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Loyer EM, Chin H, DuBrow RA, David CL, Eftekhari F and Charnsangavej C: Hepatocellular carcinoma and intrahepatic peripheral cholangiocarcinoma: Enhancement patterns with quadruple phase helical CT-a comparative study. Radiology. 212:866–875. 1999. View Article : Google Scholar : PubMed/NCBI

32 

Goshima S, Kanematsu M, Kondo H, Yokoyama R, Kajita K, Tsuge Y, Shiratori Y, Onozuka M and Moriyama N: Hepatic hemangioma: Correlation of enhancement types with diffusion-weighted MR findings and apparent diffusion coefficients. Eur J Radiol. 70:325–330. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Tateyama A, Fukukura Y, Takumi K, Shindo T, Kumagae Y and Nakamura F: Hepatic hemangiomas: factors associated with pseudo washout sign on Gd-EOB-DTPA-enhanced MR imaging. Magn Reson Med Sci. 15:73–82. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Kim B, Byun JH, Kim HJ, Won HJ, Kim SY, Shin YM and Kim PN: Enhancement patterns and pseudo-washout of hepatic haemangiomas on gadoxetate disodium-enhanced liver MRI. Eur Radiol. 26:191–198. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Grazioli L, Ambrosini R, Frittoli B, Grazioli M and Morone M: Primary benign liver lesions. Eur J Radiol. 95:378–398. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Kumar R and Indrayan A: Receiver operating characteristic (ROC) curve for medical researchers. Indian Pediatr. 48:277–287. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tang Q and Ma C: Performance of Gd‑EOB‑DTPA‑enhanced MRI for the diagnosis of LI‑RADS 4 category hepatocellular carcinoma nodules with different diameters. Oncol Lett 16: 2725-2731, 2018.
APA
Tang, Q., & Ma, C. (2018). Performance of Gd‑EOB‑DTPA‑enhanced MRI for the diagnosis of LI‑RADS 4 category hepatocellular carcinoma nodules with different diameters. Oncology Letters, 16, 2725-2731. https://doi.org/10.3892/ol.2018.8884
MLA
Tang, Q., Ma, C."Performance of Gd‑EOB‑DTPA‑enhanced MRI for the diagnosis of LI‑RADS 4 category hepatocellular carcinoma nodules with different diameters". Oncology Letters 16.2 (2018): 2725-2731.
Chicago
Tang, Q., Ma, C."Performance of Gd‑EOB‑DTPA‑enhanced MRI for the diagnosis of LI‑RADS 4 category hepatocellular carcinoma nodules with different diameters". Oncology Letters 16, no. 2 (2018): 2725-2731. https://doi.org/10.3892/ol.2018.8884
Copy and paste a formatted citation
x
Spandidos Publications style
Tang Q and Ma C: Performance of Gd‑EOB‑DTPA‑enhanced MRI for the diagnosis of LI‑RADS 4 category hepatocellular carcinoma nodules with different diameters. Oncol Lett 16: 2725-2731, 2018.
APA
Tang, Q., & Ma, C. (2018). Performance of Gd‑EOB‑DTPA‑enhanced MRI for the diagnosis of LI‑RADS 4 category hepatocellular carcinoma nodules with different diameters. Oncology Letters, 16, 2725-2731. https://doi.org/10.3892/ol.2018.8884
MLA
Tang, Q., Ma, C."Performance of Gd‑EOB‑DTPA‑enhanced MRI for the diagnosis of LI‑RADS 4 category hepatocellular carcinoma nodules with different diameters". Oncology Letters 16.2 (2018): 2725-2731.
Chicago
Tang, Q., Ma, C."Performance of Gd‑EOB‑DTPA‑enhanced MRI for the diagnosis of LI‑RADS 4 category hepatocellular carcinoma nodules with different diameters". Oncology Letters 16, no. 2 (2018): 2725-2731. https://doi.org/10.3892/ol.2018.8884
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