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Programmed death‑ligand 1 positivity can predict improved survival and a lower risk of brain metastasis in patients with resectable small cell lung cancer

  • Authors:
    • Jin Liu
    • Zhong Lu
    • Wenhao Wang
    • Xiumei Sun
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261000, P.R. China, Department of Oncology, Weifang Medical University, Weifang, Shandong 261000, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2373-2381
    |
    Published online on: June 4, 2018
       https://doi.org/10.3892/ol.2018.8895
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Abstract

The present study aimed to investigate the expression of programmed death‑ligand 1 (PD‑L1) in resectable small cell lung cancer (SCLC) and investigate its predictive value for survival and brain metastasis (BM). Postoperative SCLC specimens were immunostained with the SP142 antibody against PD‑L1. Positive PD‑L1 expression was defined as PD‑L1 expression in ≥5% of tumor cells. A total of 80 patients were recruited between January 2010 and December 2012. PD‑L1 was expressed in 65.0% (52/80) of all patients and 59.3% (16/27) of patients with BM. The median survival time (MST) was longer in the PD‑L1(+) group (46.4 vs. 28.5 months, ­P=0.002). There was no significant difference in the MST between patients with PD‑L1(+) or (‑) BM (P=0.55). The 3‑year risk of BM in the PD‑L1(+) group was lower than that in the PD‑L1(‑) group (24.1 vs. 48.4%, P=0.046). PD‑L1 was an independent factor for overall survival (OS) [hazard ratio (HR)=0.485, P=0.011] and BM (HR=0.335, P=0.024). The present study concludes that PD‑L1 is commonly expressed in SCLC and is associated with OS and BM.
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Copy and paste a formatted citation
Spandidos Publications style
Liu J, Lu Z, Wang W and Sun X: Programmed death‑ligand 1 positivity can predict improved survival and a lower risk of brain metastasis in patients with resectable small cell lung cancer. Oncol Lett 16: 2373-2381, 2018.
APA
Liu, J., Lu, Z., Wang, W., & Sun, X. (2018). Programmed death‑ligand 1 positivity can predict improved survival and a lower risk of brain metastasis in patients with resectable small cell lung cancer. Oncology Letters, 16, 2373-2381. https://doi.org/10.3892/ol.2018.8895
MLA
Liu, J., Lu, Z., Wang, W., Sun, X."Programmed death‑ligand 1 positivity can predict improved survival and a lower risk of brain metastasis in patients with resectable small cell lung cancer". Oncology Letters 16.2 (2018): 2373-2381.
Chicago
Liu, J., Lu, Z., Wang, W., Sun, X."Programmed death‑ligand 1 positivity can predict improved survival and a lower risk of brain metastasis in patients with resectable small cell lung cancer". Oncology Letters 16, no. 2 (2018): 2373-2381. https://doi.org/10.3892/ol.2018.8895
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Lu Z, Wang W and Sun X: Programmed death‑ligand 1 positivity can predict improved survival and a lower risk of brain metastasis in patients with resectable small cell lung cancer. Oncol Lett 16: 2373-2381, 2018.
APA
Liu, J., Lu, Z., Wang, W., & Sun, X. (2018). Programmed death‑ligand 1 positivity can predict improved survival and a lower risk of brain metastasis in patients with resectable small cell lung cancer. Oncology Letters, 16, 2373-2381. https://doi.org/10.3892/ol.2018.8895
MLA
Liu, J., Lu, Z., Wang, W., Sun, X."Programmed death‑ligand 1 positivity can predict improved survival and a lower risk of brain metastasis in patients with resectable small cell lung cancer". Oncology Letters 16.2 (2018): 2373-2381.
Chicago
Liu, J., Lu, Z., Wang, W., Sun, X."Programmed death‑ligand 1 positivity can predict improved survival and a lower risk of brain metastasis in patients with resectable small cell lung cancer". Oncology Letters 16, no. 2 (2018): 2373-2381. https://doi.org/10.3892/ol.2018.8895
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