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Review Open Access

The role of chemokine receptor 9/chemokine ligand 25 signaling: From immune cells to cancer cells (Review)

  • Authors:
    • Cong Wang
    • Zhenghuan Liu
    • Zhihui Xu
    • Xian Wu
    • Dongyang Zhang
    • Ziqi Zhang
    • Jianqin Wei
  • View Affiliations / Copyright

    Affiliations: Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai University, Xining, Qinghai 810001, P.R. China, Department of Urology, West China School of Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan 610041, P.R. China, Department of Ultrasound, West China School of Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China, The University of Miami Leonard M. Miller School of Medicine, University of Miami, Coral Gables, FL 33136, USA
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2071-2077
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    Published online on: June 4, 2018
       https://doi.org/10.3892/ol.2018.8896
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Abstract

Chemokine ligand 25 (CCL25) and chemokine receptor 9 (CCR9) are important regulators of migration, proliferation and apoptosis in leukocytes and cancer cells. Blocking of the CCR9/CCL25 signal has been demonstrated to be a potential novel cancer therapy. Research into CCR9 and CCL25 has revealed their associated upstream and downstream signaling pathways; CCR9 is regulated by several immunological factors, including NOTCH, interleukin 2, interleukin 4 and retinoic acid. NOTCH in particular, has been revealed to be a crucial upstream regulator of CCR9. Furthermore, proteins including matrix metalloproteinases, P‑glycoprotein, Ezrin/Radixin/Moesin and Livin are regulated via phosphatidylinositol‑3 kinase/ protein kinase B, which are in turn stimulated by CCR9/CCL25. This is a review of the current literature on the functions and signaling pathways of CCR9/CCL25.
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Copy and paste a formatted citation
Spandidos Publications style
Wang C, Liu Z, Xu Z, Wu X, Zhang D, Zhang Z and Wei J: The role of chemokine receptor 9/chemokine ligand 25 signaling: From immune cells to cancer cells (Review). Oncol Lett 16: 2071-2077, 2018.
APA
Wang, C., Liu, Z., Xu, Z., Wu, X., Zhang, D., Zhang, Z., & Wei, J. (2018). The role of chemokine receptor 9/chemokine ligand 25 signaling: From immune cells to cancer cells (Review). Oncology Letters, 16, 2071-2077. https://doi.org/10.3892/ol.2018.8896
MLA
Wang, C., Liu, Z., Xu, Z., Wu, X., Zhang, D., Zhang, Z., Wei, J."The role of chemokine receptor 9/chemokine ligand 25 signaling: From immune cells to cancer cells (Review)". Oncology Letters 16.2 (2018): 2071-2077.
Chicago
Wang, C., Liu, Z., Xu, Z., Wu, X., Zhang, D., Zhang, Z., Wei, J."The role of chemokine receptor 9/chemokine ligand 25 signaling: From immune cells to cancer cells (Review)". Oncology Letters 16, no. 2 (2018): 2071-2077. https://doi.org/10.3892/ol.2018.8896
Copy and paste a formatted citation
x
Spandidos Publications style
Wang C, Liu Z, Xu Z, Wu X, Zhang D, Zhang Z and Wei J: The role of chemokine receptor 9/chemokine ligand 25 signaling: From immune cells to cancer cells (Review). Oncol Lett 16: 2071-2077, 2018.
APA
Wang, C., Liu, Z., Xu, Z., Wu, X., Zhang, D., Zhang, Z., & Wei, J. (2018). The role of chemokine receptor 9/chemokine ligand 25 signaling: From immune cells to cancer cells (Review). Oncology Letters, 16, 2071-2077. https://doi.org/10.3892/ol.2018.8896
MLA
Wang, C., Liu, Z., Xu, Z., Wu, X., Zhang, D., Zhang, Z., Wei, J."The role of chemokine receptor 9/chemokine ligand 25 signaling: From immune cells to cancer cells (Review)". Oncology Letters 16.2 (2018): 2071-2077.
Chicago
Wang, C., Liu, Z., Xu, Z., Wu, X., Zhang, D., Zhang, Z., Wei, J."The role of chemokine receptor 9/chemokine ligand 25 signaling: From immune cells to cancer cells (Review)". Oncology Letters 16, no. 2 (2018): 2071-2077. https://doi.org/10.3892/ol.2018.8896
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