Open Access

Association between EGFR/KRAS mutation and expression of VEGFA, VEGFR and VEGFR2 in lung adenocarcinoma

  • Authors:
    • Xiao‑Han Yuan
    • Jie Yang
    • Xin‑Yue Wang
    • Xiao‑Ling Zhang
    • Ting‑Ting Qin
    • Kai Li
  • View Affiliations

  • Published online on: June 5, 2018     https://doi.org/10.3892/ol.2018.8901
  • Pages: 2105-2112
  • Copyright: © Yuan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene homolog (KRAS) are two of the most notable driver genes in lung cancer, whilst vascular endothelial growth factor (VEGF) signaling serves a critical function in tumor angiogenesis. However, few studies have focused on the potential connection between EGFR/KRAS mutational status, and VEGFA, VEGF receptor (VEGFR)1 and VEGFR2 expression in lung adenocarcinoma. EGFR (exon 19, 20 and 21) and KRAS (exon 2) mutations were detected using an amplification refractory mutation system technique, and the expression of VEGFA, VEGFR1 and VEGFR2 was analyzed using immunohistochemistry in 204 patients with lung adenocarcinoma. Associations between EGFR/KRAS mutational status and VEGFA, VEGFR1, and VEGFR2 expression was analyzed using Pearson χ² tests. It was revealed that EGFR 21 exon (P=0.033) and EGFR 20 exon (P=0.002) mutated tumors exhibited a significantly higher level of expression of VEGFA. EGFR 21 exon mutant tumors additionally demonstrated a significantly higher level of co‑expression of VEGFA and VEGFR1 (P<0.001). EGFR 19 exon mutation was significantly associated with low levels of VEGFR1 (P=0.008). KRAS mutation was significantly associated with a high level of co‑expression of VEGFA, VEGFR1 and VEGFR2 (P=0.035), but no such association with the individual expression of VEGFA, VEGFR1 or VEGFR2 was identified. However, neither KRAS or EGFR mutations exhibited an association with the expression of VEGFR2. The present study may help in the treatment of various patients with KRAS or subtype of EGFR mutation with anti‑angiogenesis therapy.
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August-2018
Volume 16 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yuan XH, Yang J, Wang XY, Zhang XL, Qin TT and Li K: Association between EGFR/KRAS mutation and expression of VEGFA, VEGFR and VEGFR2 in lung adenocarcinoma. Oncol Lett 16: 2105-2112, 2018
APA
Yuan, X., Yang, J., Wang, X., Zhang, X., Qin, T., & Li, K. (2018). Association between EGFR/KRAS mutation and expression of VEGFA, VEGFR and VEGFR2 in lung adenocarcinoma. Oncology Letters, 16, 2105-2112. https://doi.org/10.3892/ol.2018.8901
MLA
Yuan, X., Yang, J., Wang, X., Zhang, X., Qin, T., Li, K."Association between EGFR/KRAS mutation and expression of VEGFA, VEGFR and VEGFR2 in lung adenocarcinoma". Oncology Letters 16.2 (2018): 2105-2112.
Chicago
Yuan, X., Yang, J., Wang, X., Zhang, X., Qin, T., Li, K."Association between EGFR/KRAS mutation and expression of VEGFA, VEGFR and VEGFR2 in lung adenocarcinoma". Oncology Letters 16, no. 2 (2018): 2105-2112. https://doi.org/10.3892/ol.2018.8901