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A risk score staging system based on the expression of seven genes predicts the outcome of bladder cancer

  • Authors:
    • Jianfeng Chu
    • Ning Li
    • Fengguang Li
  • View Affiliations / Copyright

    Affiliations: Department of Urinary Surgery, Yantaishan Hospital, Yantai, Shandong 264000, P.R. China
    Copyright: © Chu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2091-2096
    |
    Published online on: June 5, 2018
       https://doi.org/10.3892/ol.2018.8904
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Abstract

Bladder cancer (BLCA) is among the most malignant types of cancer. At present, the prognostic tools available for this disease are insufficient. In the present study, the transcriptome of 1,049 BLCA samples from four datasets from the Gene Expression Omnibus and The Cancer Genome Atlas (TCGA) were analyzed. By utilizing the RNA‑seq data provided by TCGA, a risk score staging system model was built to predict the outcome of patients with BLCA using random forest variable hunting and Cox multivariate regression. A total of 7 genes, including zinc finger protein 230, Bcl2‑like 14, AHNAK, transmembrane protein 109, apolipoprotein L2, advanced glycation end‑product specific receptor and amine oxidase, copper containing 2 were identified as predicting the survival time of patients with BLCA. The patients with a low risk score had a significantly higher survival rate than those with a high‑risk score both in the training and validation datasets. Association analyses between risk score and other clinical information were additionally performed; it was demonstrated that the risk score was significantly associated with pathological stage. A nomogram was plotted to compare risk score and other clinical information. The risk score spanned the greatest range of points, indicating the relative accuracy of risk score. In summary, the risk staging model based on the expression of 7 genes is robust and performs more effectively than other clinical information in predicting a prognosis.
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1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Siegel R, Miller K and Jemal A: Cancer statistics, 2015. CA Cancer J Clin. 65:5–29. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Funt SA and Rosenberg JE: Systemic, perioperative management of muscle-invasive bladder cancer and future horizons. Nat Rev Clin Oncol. 14:221–234. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Santoni M, Catanzariti F, Minardi D, Burattini L, Nabissi M, Muzzonigro G, Cascinu S and Santoni G: Pathogenic and diagnostic potential of BLCA-1 and BLCA-4 nuclear proteins in urothelial cell carcinoma of human bladder. Adv Urol. 2012:3974122012. View Article : Google Scholar : PubMed/NCBI

5 

Salomaa V, Havulinna A, Saarela O, Zeller T, Jousilahti P, Jula A, Muenzel T, Aromaa A, Evans A, Kuulasmaa K and Blankenberg S: Thirty-one novel biomarkers as predictors for clinically incident diabetes. PLoS One. 5:e101002010. View Article : Google Scholar : PubMed/NCBI

6 

Izadi F, Zarrini HN, Kiani G and Jelodar NB: A comparative analytical assay of gene regulatory networks inferred using microarray and RNA-seq datasets. Bioinformation. 12:340–346. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Deandrés-Galiana EJ, Fernández-Martínez JL, Saligan LN and Sonis ST: Impact of microarray preprocessing techniques in unraveling biological pathways. J Comput Biol. 23:957–968. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Colantuoni C, Henry G, Zeger S and Pevsner J: SNOMAD (Standardization and NOrmalization of MicroArray Data): web-accessible gene expression data analysis. Bioinformatics. 18:1540–1541. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Gautier L, Cope L, Bolstad BM and Irizarry RA: Affy-analysis of Affymetrix GeneChip data at the probe level. Bioinformatics. 20:307–315. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Dazard JE, Choe M, LeBlanc M and Rao JS: R package PRIMsrc: Bump hunting by patient rule induction method for survival, regression and classification. Proc Am Stat Assoc. 2015:650–664. 2015.PubMed/NCBI

11 

Robin X, Turck N, Hainard A, Tiberti N, Lisacek F, Sanchez JC and Müller M: pROC: An open-source package for R and S+ to analyze and compare ROC curves. BMC bioinformatics. 12:772011. View Article : Google Scholar : PubMed/NCBI

12 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES and Mesirov JP: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 102:15545–15550. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Zhao M, He XL and Teng XD: Understanding the molecular pathogenesis and prognostics of bladder cancer: An overview. Chin J Cancer Res. 28:92–98. 2016.PubMed/NCBI

14 

Dadhania V, Czerniak B and Guo CC: Adenocarcinoma of the urinary bladder. Am J Clin Exp Urol. 3:51–63. 2015.PubMed/NCBI

15 

Boustead GB, Fowler S, Swamy R, Kocklebergh R and Hounsome L: Stage, grade and pathological characteristics of bladder cancer in the UK: British association of urological surgeons (BAUS) urological tumour registry. BJU Int. 113:924–930. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Hong Z, Li H, Li L, Wang W and Xu T: Different expression patterns of histone H3K27 demethylases in renal cell carcinoma and bladder cancer. Cancer Biomark. 18:125–131. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Nandagopal L and Sonpavde G: Circulating biomarkers in bladder cancer. Bladder Cancer. 2:369–379. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Yang J, Platt LT, Maity B, Ahlers KE, Luo Z, Lin Z, Chakravarti B, Ibeawuchi SR, Askeland RW, Bondaruk J, et al: RGS6 is an essential tumor suppressor that prevents bladder carcinogenesis by promoting p53 activation and DNMT1 downregulation. Oncotarget. 7:69159–69172. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Wang J, Zhang X, Wang L, Dong Z, Du L, Yang Y, Guo Y and Wang C: Downregulation of urinary cell-free microRNA-214 as a diagnostic and prognostic biomarker in bladder cancer. J Surg Oncol. 111:992–999. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Gogalic S, Sauer U, Doppler S, Heinzel A, Perco P, Lukas A, Simpson G, Pandha H, Horvath A and Preininger C: Validation of a protein panel for the non-invasive detection of recurrent non-muscle invasive bladder cancer. Biomarkers. 22:674–681. 2017.PubMed/NCBI

21 

Urquidi V, Netherton M, Gomes-Giacoia E, Serie DJ, Eckel-Passow J, Rosser CJ and Goodison S: A microRNA biomarker panel for the non-invasive detection of bladder cancer. Oncotarget. 7:86290–86299. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Li Y, Huang J, Sun J, Xiang S, Yang D, Ying X, Lu M, Li H and Ren G: The transcription levels and prognostic values of seven proteasome alpha subunits in human cancers. Oncotarget. 8:4501–4519. 2017.PubMed/NCBI

23 

Kavalieris L, O'Sullivan P, Frampton C, Guilford P, Darling D, Jacobson E, Suttie J, Raman JD, Shariat SF and Lotan Y: Performance characteristics of a multigene urine biomarker test for monitoring for recurrent urothelial carcinoma in a multicenter study. J Urol. 197:1419–1426. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Lin ML, Park JH, Nishidate T, Nakamura Y and Katagiri T: Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family. Breast Cancer Res. 9:R172007. View Article : Google Scholar : PubMed/NCBI

25 

Spitz MR, Gorlov IP, Dong Q, Wu X, Chen W, Chang DW, Etzel CJ, Caporaso NE, Zhao Y, Christiani DC, et al: Multistage analysis of variants in the inflammation pathway and lung cancer risk in smokers. Cancer Epidemiol Biomarkers Prev. 21:1213–1221. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Davis TA, Loos B and Engelbrecht AM: AHNAK: The giant jack of all trades. Cell Signal. 26:2683–2693. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Sheppard HM, Feisst V, Chen J, Print C and Dunbar PR: AHNAK is downregulated in melanoma, predicts poor outcome, and may be required for the expression of functional cadherin-1. Melanoma Res. 26:108–116. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Sudo H, Tsuji AB, Sugyo A, Abe M, Hino O and Saga T: AHNAK is highly expressed and plays a key role in cell migration and invasion in mesothelioma. Int J Oncol. 44:530–538. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chu J, Li N and Li F: A risk score staging system based on the expression of seven genes predicts the outcome of bladder cancer. Oncol Lett 16: 2091-2096, 2018.
APA
Chu, J., Li, N., & Li, F. (2018). A risk score staging system based on the expression of seven genes predicts the outcome of bladder cancer. Oncology Letters, 16, 2091-2096. https://doi.org/10.3892/ol.2018.8904
MLA
Chu, J., Li, N., Li, F."A risk score staging system based on the expression of seven genes predicts the outcome of bladder cancer". Oncology Letters 16.2 (2018): 2091-2096.
Chicago
Chu, J., Li, N., Li, F."A risk score staging system based on the expression of seven genes predicts the outcome of bladder cancer". Oncology Letters 16, no. 2 (2018): 2091-2096. https://doi.org/10.3892/ol.2018.8904
Copy and paste a formatted citation
x
Spandidos Publications style
Chu J, Li N and Li F: A risk score staging system based on the expression of seven genes predicts the outcome of bladder cancer. Oncol Lett 16: 2091-2096, 2018.
APA
Chu, J., Li, N., & Li, F. (2018). A risk score staging system based on the expression of seven genes predicts the outcome of bladder cancer. Oncology Letters, 16, 2091-2096. https://doi.org/10.3892/ol.2018.8904
MLA
Chu, J., Li, N., Li, F."A risk score staging system based on the expression of seven genes predicts the outcome of bladder cancer". Oncology Letters 16.2 (2018): 2091-2096.
Chicago
Chu, J., Li, N., Li, F."A risk score staging system based on the expression of seven genes predicts the outcome of bladder cancer". Oncology Letters 16, no. 2 (2018): 2091-2096. https://doi.org/10.3892/ol.2018.8904
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