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Identification of potential target genes in pancreatic ductal adenocarcinoma by bioinformatics analysis

  • Authors:
    • Yuchen Tang
    • Zixiang Zhang
    • Yaocheng Tang
    • Xinyu Chen
    • Jian Zhou
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China
    Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2453-2461
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    Published online on: June 6, 2018
       https://doi.org/10.3892/ol.2018.8912
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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most complicated and fatally pathogenic human malignancies. Therefore, there is an urgent need to improve our understanding of the underlying molecular mechanism that drives the initiation, progression, and metastasis of PDAC. The aim of the present study was to identify the key genes and signaling pathways associated with PDAC using bioinformatics analysis. Four transcriptome microarray datasets (GSE15471, GSE55643, GSE62165 and GSE91035) were acquired from Gene Expression Omnibus datasets, which included 226 PDAC samples and 65 normal pancreatic tissue samples. We screened differentially expressed genes (DEGs) with GEO2R and investigated their biological function by Gene Ontology (GO) and Kyoto Encyclopedia of Genes (KEGG) analysis. The overall survival data was obtained from UALCAN, which calculated the data shared with The Cancer Genome Atlas. In addition, a protein‑protein interaction (PPI) network of the DEGs was constructed by STRING and Cytoscape software. The four sets of DEGs exhibited an intersection consisting of 205 genes (142 up‑regulated and 63 down‑regulated), which may be associated with PDAC. GO analysis showed that the 205 DEGs were significantly enriched in the plasma membrane, cell adhesion molecule activity and the Energy pathways, and glycine, serine, threonine metabolism were the most enriched pathways according to KEGG pathway analysis. Kaplan‑Meier survival analysis revealed that 22 of 205 common genes were significantly associated with the overall survival of pancreatic cancer patients. In the PPI network and sub‑network, DKK1 and HMGA2 were considered as hub genes with high connectivity degrees. DKK1 and HMGA2 are strongly associated with WNT3A and TP53 separately, which indicates that they may play an important role in the Wnt and P53 signaling pathways. Using integrated bioinformatics analysis, we identified DKK1 and HMGA2 as candidate genes in PDAC, which may improve our understanding of the mechanisms of the pathogenesis and integration; the two genes may be therapeutic targets and prognostic markers for PDAC.
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View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI

2 

DeSantis CE, Lin CC, Mariotto AB, Siegel RL, Stein KD, Kramer JL, Alteri R, Robbins AS and Jemal A: Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin. 64:252–271. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Kamisawa T, Wood LD, Itoi T and Takaori K: Pancreatic cancer. Lancet. 388:73–85. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Wang P, Zhang J, Zhang L, Zhu Z, Fan J, Chen L, Zhuang L, Luo J, Chen H, Liu L, et al: MicroRNA 23b regulates autophagy associated with radioresistance of pancreatic cancer cells. Gastroenterology. 145:1133–1143.e12. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Adamska A, Elaskalani O, Emmanouilidi A, Kim M, Abdol Razak NB, Metharom P and Falasca M: Molecular and cellular mechanisms of chemoresistance in pancreatic cancer. Adv Biol Regul. Nov 22. 2017, (Epub ahead of print). PubMed/NCBI

6 

Mazarico JM, Sánchez-Arévalo Lobo VJ, Favicchio R, Greenhalf W, Costello E, Carrillo-de Santa Pau E, Marqués M, Lacal JC, Aboagye E and Real FX: Choline Kinase Alpha (CHKα) as a therapeutic target in pancreatic ductal adenocarcinoma: Expression, predictive value, and sensitivity to inhibitors. Mol Cancer Ther. 15:323–333. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Alhasan SF, Haugk B, Ogle LF, Beale GS, Long A, Burt AD, Tiniakos D, Televantou D, Coxon F, Newell DR, et al: Sulfatase-2: A prognostic biomarker and candidate therapeutic target in patients with pancreatic ductal adenocarcinoma. Br J Cancer. 115:797–804. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, et al: NCBI GEO: Archive for functional genomics data sets-update. Nucleic Acids Res. 41:(Database Issue):. D991–D995. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Cancer Genome Atlas Research Network; Weinstein JN, Collisson EA, Mills GB, Shaw KR, Ozenberger BA, Ellrott K, Shmulevich I, Sander C and Stuart JM: The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet. 45:1113–1120. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Cancer Genome Atlas Research Network. Electronic address: andrew_aguirre@dfci.harvard.edu; Cancer Genome Atlas Research Network: Integrated genomic characterization of pancreatic ductal adenocarcinoma. Cancer Cell. 32:185–203.e13. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Gautier L, Cope L, Bolstad BM and Irizarry RA: affy-analysis of Affymetrix GeneChip data at the probe level. Bioinformatics. 20:307–315. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 25:25–29. 2000.

13 

Kanehisa M, Goto S, Sato Y, Furumichi M and Tanabe M: KEGG for integration and interpretation of large-scale molecular data sets. Nucleic Acids Res. 40:(Database Issue):. D109–D114. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Pathan M, Keerthikumar S, Ang CS, Gangoda L, Quek CY, Williamson NA, Mouradov D, Sieber OM, Simpson RJ, Salim A, et al: FunRich: An open access standalone functional enrichment and interaction network analysis tool. Proteomics. 15:2597–2601. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Chandrashekar DS, Bashel B, Balasubramanya SAH, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BVSK and Varambally S: UALCAN: A portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 19:649–658. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, et al: STRING v10: Protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 43:(Database Issue):. D447–D452. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Calvo MB, Figueroa A, Pulido EG, Campelo RG and Aparicio LA: Potential role of sugar transporters in cancer and their relationship with anticancer therapy. Int J Endocrinol. 2010(pii): 2053572010.PubMed/NCBI

19 

Jiang H, Hegde S, Knolhoff BL, Zhu Y, Herndon JM, Meyer MA, Nywening TM, Hawkins WG, Shapiro IM, Weaver DT, et al: Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy. Nat Med. 22:851–860. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Morris JP IV, Wang SC and Hebrok M: KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma. Nat Rev Cancer. 10:683–695. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Ahn VE, Chu ML, Choi HJ, Tran D, Abo A and Weis WI: Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6. Dev Cell. 21:862–873. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Qi L, Sun B, Liu Z, Li H, Gao J and Leng X: Dickkopf-1 inhibits epithelial-mesenchymal transition of colon cancer cells and contributes to colon cancer suppression. Cancer Sci. 103:828–835. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Sato N, Yamabuki T, Takano A, Koinuma J, Aragaki M, Masuda K, Ishikawa N, Kohno N, Ito H, Miyamoto M, et al: Wnt inhibitor Dickkopf-1 as a target for passive cancer immunotherapy. Cancer Res. 70:5326–5336. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Zhang J, Zhang X, Zhao X, Jiang M, Gu M, Wang Z and Yue W: DKK1 promotes migration and invasion of non-small cell lung cancer via β-catenin signaling pathway. Tumour Biol. 39:10104283177038202017. View Article : Google Scholar : PubMed/NCBI

25 

González-Sancho JM, Aguilera O, García JM, Pendás-Franco N, Peña C, Cal S, García de Herreros A, Bonilla F and Muñoz A: The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer. Oncogene. 24:1098–1103. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Takahashi N, Fukushima T, Yorita K, Tanaka H, Chijiiwa K and Kataoka H: Dickkopf-1 is overexpressed in human pancreatic ductal adenocarcinoma cells and is involved in invasive growth. Int J Cancer. 126:1611–1620. 2010.PubMed/NCBI

27 

Shen Q, Fan J, Yang XR, Tan Y, Zhao W, Xu Y, Wang N, Niu Y, Wu Z, Zhou J, et al: Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: A large-scale, multicentre study. Lancet Oncol. 13:817–826. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Kimura H, Fumoto K, Shojima K, Nojima S, Osugi Y, Tomihara H, Eguchi H, Shintani Y, Endo H, Inoue M, et al: CKAP4 is a Dickkopf1 receptor and is involved in tumor progression. J Clin Invest. 126:2689–2705. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Hinton J, Callan R, Bodine C, Glasgow W, Brower S, Jiang SW and Li J: Potential epigenetic biomarkers for the diagnosis and prognosis of pancreatic ductal adenocarcinomas. Expert Rev Mol Diagn. 13:431–443. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Are C, Chowdhury S, Ahmad H, Ravipati A, Song T, Shrikandhe S and Smith L: Predictive global trends in the incidence and mortality of pancreatic cancer based on geographic location, socio-economic status, and demographic shift. J Surg Oncol. 114:736–742. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Perera RM and Bardeesy N: Ready, set, go: The EGF receptor at the pancreatic cancer starting line. Cancer Cell. 22:281–282. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Li Y, Peng L and Seto E: Histone deacetylase 10 regulates the cell cycle G2/M phase transition via a Novel Let-7-HMGA2-Cyclin A2 pathway. Mol Cell Biol. 35:3547–3565. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Watanabe S, Ueda Y, Akaboshi S, Hino Y, Sekita Y and Nakao M: HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cells. Am J Pathol. 174:854–868. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Strell C, Norberg KJ, Mezheyeuski A, Schnittert J, Kuninty PR, Moro CF, Paulsson J, Schultz NA, Calatayud D, Löhr JM, et al: Stroma-regulated HMGA2 is an independent prognostic marker in PDAC and AAC. Br J Cancer. 117:65–77. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Haselmann V, Kurz A, Bertsch U, Hübner S, Olempska-Müller M, Fritsch J, Häsler R, Pickl A, Fritsche H, Annewanter F, et al: Nuclear death receptor TRAIL-R2 inhibits maturation of let-7 and promotes proliferation of pancreatic and other tumor cells. Gastroenterology. 146:278–290. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Wei JJ, Wu J, Luan C, Yeldandi A, Lee P, Keh P and Liu J: HMGA2: A potential biomarker complement to P53 for detection of early-stage high-grade papillary serous carcinoma in fallopian tubes. Am J Surg Pathol. 34:18–26. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Mahajan A, Liu Z, Gellert L, Zou X, Yang G, Lee P, Yang X and Wei JJ: HMGA2: A biomarker significantly overexpressed in high-grade ovarian serous carcinoma. Mod Pathol. 23:673–681. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Italiano A, Bianchini L, Keslair F, Bonnafous S, Cardot-Leccia N, Coindre JM, Dumollard JM, Hofman P, Leroux A, Mainguené C, et al: HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon. Int J Cancer. 122:2233–2241. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Iwai A, Marusawa H, Matsuzawa S, Fukushima T, Hijikata M, Reed JC, Shimotohno K and Chiba T: Siah-1L, a novel transcript variant belonging to the human Siah family of proteins, regulates beta-catenin activity in a p53-dependent manner. Oncogene. 23:7593–7600. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Lee KH, Li M, Michalowski AM, Zhang X, Liao H, Chen L, Xu Y, Wu X and Huang J: A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells. Proc Natl Acad Sci USA. 107:69–74. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Wang J, Shou J and Chen X: Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53. Oncogene. 19:1843–1848. 2000. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tang Y, Zhang Z, Tang Y, Chen X and Zhou J: Identification of potential target genes in pancreatic ductal adenocarcinoma by bioinformatics analysis. Oncol Lett 16: 2453-2461, 2018.
APA
Tang, Y., Zhang, Z., Tang, Y., Chen, X., & Zhou, J. (2018). Identification of potential target genes in pancreatic ductal adenocarcinoma by bioinformatics analysis. Oncology Letters, 16, 2453-2461. https://doi.org/10.3892/ol.2018.8912
MLA
Tang, Y., Zhang, Z., Tang, Y., Chen, X., Zhou, J."Identification of potential target genes in pancreatic ductal adenocarcinoma by bioinformatics analysis". Oncology Letters 16.2 (2018): 2453-2461.
Chicago
Tang, Y., Zhang, Z., Tang, Y., Chen, X., Zhou, J."Identification of potential target genes in pancreatic ductal adenocarcinoma by bioinformatics analysis". Oncology Letters 16, no. 2 (2018): 2453-2461. https://doi.org/10.3892/ol.2018.8912
Copy and paste a formatted citation
x
Spandidos Publications style
Tang Y, Zhang Z, Tang Y, Chen X and Zhou J: Identification of potential target genes in pancreatic ductal adenocarcinoma by bioinformatics analysis. Oncol Lett 16: 2453-2461, 2018.
APA
Tang, Y., Zhang, Z., Tang, Y., Chen, X., & Zhou, J. (2018). Identification of potential target genes in pancreatic ductal adenocarcinoma by bioinformatics analysis. Oncology Letters, 16, 2453-2461. https://doi.org/10.3892/ol.2018.8912
MLA
Tang, Y., Zhang, Z., Tang, Y., Chen, X., Zhou, J."Identification of potential target genes in pancreatic ductal adenocarcinoma by bioinformatics analysis". Oncology Letters 16.2 (2018): 2453-2461.
Chicago
Tang, Y., Zhang, Z., Tang, Y., Chen, X., Zhou, J."Identification of potential target genes in pancreatic ductal adenocarcinoma by bioinformatics analysis". Oncology Letters 16, no. 2 (2018): 2453-2461. https://doi.org/10.3892/ol.2018.8912
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