Open Access

BRAF V600E mutation and BRAF VE1 immunoexpression profiles in different types of glioblastoma

  • Authors:
    • Zeynep Tosuner
    • Melin Özgün Geçer
    • Mustafa Aziz Hatiboğlu
    • Anas Abdallah
    • Seval Turna
  • View Affiliations

  • Published online on: June 6, 2018     https://doi.org/10.3892/ol.2018.8919
  • Pages: 2402-2408
  • Copyright: © Tosuner et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Abnormalities in proto‑oncogene B‑Raf (BRAF) are typical in several subgroups of gliomas, including pilocytic astrocytomas, optic nerve gliomas, pleomorphic xanthoastrocytomas (PXA), anaplastic PXAs and gangliogliomas. However, they are rarely reported in adult gliomas. BRAF alterations are frequent in a distinct variant of glioblastomas (GBMs) known as epithelioid GBMs (E‑GBMs). There are limited studies on whether immunohistochemistry (IHC) can be used to determine the presence of BRAF VE1 mutations in these tumors. The aim of the current study was to examine BRAF V600E mutations in 20 GBMs, including GBMs with epithelioid features, giant cell GBMs and conventional GBMs. V600 mutations were detected using the Cobas 4800 BRAF V600 Mutation Test, and IHC analysis was also performed. Of the 6 cases of GBM with epithelioid features, 1 exhibited a BRAF V600E mutation, while the other cases did not. IHC staining was positive in 3 out of the 8 conventional GBMs. Vemurafenib is a targeted therapy that has mainly been used for the treatment of melanoma patients for several years, and as a possible alternative treatment for cases of GBM harboring BRAF mutations, its existence may make testing for BRAF status important.
View Figures
View References

Related Articles

Journal Cover

August-2018
Volume 16 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Tosuner Z, Geçer MÖ, Hatiboğlu MA, Abdallah A and Turna S: BRAF V600E mutation and BRAF VE1 immunoexpression profiles in different types of glioblastoma. Oncol Lett 16: 2402-2408, 2018
APA
Tosuner, Z., Geçer, M.Ö., Hatiboğlu, M.A., Abdallah, A., & Turna, S. (2018). BRAF V600E mutation and BRAF VE1 immunoexpression profiles in different types of glioblastoma. Oncology Letters, 16, 2402-2408. https://doi.org/10.3892/ol.2018.8919
MLA
Tosuner, Z., Geçer, M. Ö., Hatiboğlu, M. A., Abdallah, A., Turna, S."BRAF V600E mutation and BRAF VE1 immunoexpression profiles in different types of glioblastoma". Oncology Letters 16.2 (2018): 2402-2408.
Chicago
Tosuner, Z., Geçer, M. Ö., Hatiboğlu, M. A., Abdallah, A., Turna, S."BRAF V600E mutation and BRAF VE1 immunoexpression profiles in different types of glioblastoma". Oncology Letters 16, no. 2 (2018): 2402-2408. https://doi.org/10.3892/ol.2018.8919