Open Access

MicroRNA‑23a/27a/24‑2 cluster promotes gastric cancer cell proliferation synergistically

  • Authors:
    • Kate Hua
    • Yu‑Ting Chen
    • Chian‑Feng Chen
    • Ya‑Syuan Tang
    • Tzu‑Ting Huang
    • Yu‑Cheng Lin
    • Tien‑Shun Yeh
    • Kuo‑Hung Huang
    • Hsin‑Chen Lee
    • Ming‑Ta Hsu
    • Chin‑Wen Chi
    • Chew‑Wun Wu
    • Chi‑Hung Lin
    • Yueh‑Hsin Ping
  • View Affiliations

  • Published online on: June 7, 2018     https://doi.org/10.3892/ol.2018.8924
  • Pages: 2319-2325
  • Copyright: © Hua et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Previous studies have indicated that certain microRNAs (miRNAs/miRs) function as either tumor suppressors or oncogenes in human cancer. The present study identified the miR‑23a/27a/24‑2 cluster, containing miR‑23, miR‑27a and miR‑24, as an oncogene in gastric cancer. The expression of the miR‑23a/27a/24‑2 cluster was upregulated in clinical gastric cancer tissues. Transfection with inhibitors of miR‑23a, miR‑27a, or miR‑24, either independently or together, repressed in vitro colony formation and in vivo tumor formation. The miR23a/27a/24‑2 cluster inhibitors repressed the growth of gastric cancer cells in a synergistic manner. In addition, treatment with lower doses of the miRNA inhibitor mixture induced the formation of apoptotic bodies. According to computational predictions using TargetScan, suppressor of cytokine‑induced signaling 6 (SOCS6) was identified as one of the downstream target genes of the miR‑23a/27a/24‑2 cluster. The expression of SOCS6 was significantly lower in tumor tissues than in matched normal tissues (P<0.01) and was associated with poor survival (P<0.00001). Taken together, these results strongly suggested that the miR‑23a/27a/24‑2 cluster may mediate the progression of gastric cancer through the suppression of SOCS6 expression. The present study also provides a novel molecular target for the development of an anti‑gastric cancer agent.
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August-2018
Volume 16 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Hua K, Chen YT, Chen CF, Tang YS, Huang TT, Lin YC, Yeh TS, Huang KH, Lee HC, Hsu MT, Hsu MT, et al: MicroRNA‑23a/27a/24‑2 cluster promotes gastric cancer cell proliferation synergistically. Oncol Lett 16: 2319-2325, 2018.
APA
Hua, K., Chen, Y., Chen, C., Tang, Y., Huang, T., Lin, Y. ... Ping, Y. (2018). MicroRNA‑23a/27a/24‑2 cluster promotes gastric cancer cell proliferation synergistically. Oncology Letters, 16, 2319-2325. https://doi.org/10.3892/ol.2018.8924
MLA
Hua, K., Chen, Y., Chen, C., Tang, Y., Huang, T., Lin, Y., Yeh, T., Huang, K., Lee, H., Hsu, M., Chi, C., Wu, C., Lin, C., Ping, Y."MicroRNA‑23a/27a/24‑2 cluster promotes gastric cancer cell proliferation synergistically". Oncology Letters 16.2 (2018): 2319-2325.
Chicago
Hua, K., Chen, Y., Chen, C., Tang, Y., Huang, T., Lin, Y., Yeh, T., Huang, K., Lee, H., Hsu, M., Chi, C., Wu, C., Lin, C., Ping, Y."MicroRNA‑23a/27a/24‑2 cluster promotes gastric cancer cell proliferation synergistically". Oncology Letters 16, no. 2 (2018): 2319-2325. https://doi.org/10.3892/ol.2018.8924