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Prognostic significance of the expression of HER family members in primary osteosarcoma

  • Authors:
    • Sheng‑Lin Wang
    • Guang‑Xian Zhong
    • Xin‑Wen Wang
    • Feng‑Qiang Yu
    • Dan‑Feng Weng
    • Xin‑Xing Wang
    • Jian‑Hua Lin
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China, Department of Pathology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2185-2194
    |
    Published online on: June 8, 2018
       https://doi.org/10.3892/ol.2018.8931
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Abstract

The prognosis of patients with metastatic osteosarcoma is poor and has shown no significant improvement in nearly 20 years. The human epidermal growth factor (EGF) receptor (HER) family is frequently overexpressed in the majority of human carcinomas, and is involved in promoting the proliferation and survival of cancer cells. However, the role of EGFR and HER‑2 expression in osteosarcoma survival remains controversial and no previous study has simultaneously investigated the association of the expression of all the four HER family members with the prognostic significance of osteosarcoma. Therefore, the present study investigated the expression levels of the complete members of the HER family in osteosarcoma specimens, as well as their associations with the clinicopathological parameters, progression‑free survival (PFS) and overall survival (OS) time of patients with osteosarcoma. The expression of HER family members was detected in osteosarcoma tumor specimens from 60 patients using immunohistochemistry. The association of the expression of HER receptors in osteosarcoma with clinicopathological parameters was analyzed using χ2 test and Fishers exact test. Survival analyses were evaluated by Kaplan‑Meier method and Cox proportional hazards regression model. Overall, 18 (30%), 13 (22%), 23 (38%) and 19 (32%) patients presented with high expression of EGFR, HER‑2, HER‑3 and HER‑4, respectively, and the co‑expression of 2, 3 and all 4 members of the HER family was observed. High expression of EGFR and HER‑4 was associated with distant metastasis. High HER‑3 expression was significantly associated with an advanced Enneking stage and distant metastasis. Multivariate analysis demonstrated that the expression of EGFR, HER‑3, HER‑4, EGFR/HER‑3, EGFR/HER‑4 and HER‑3/HER‑4 was an independent predictor of poor PFS and OS time in osteosarcoma patients with stage I‑IIB disease. In patients with stage IIB osteosarcoma, the expression of HER‑4 and EGFR/HER‑4 demonstrated a more significant effect on PFS and OS time. In conclusion, therapies targeting EGFR, HER‑3 and HER‑4 may provide promising strategies for primary osteosarcoma.
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Copy and paste a formatted citation
Spandidos Publications style
Wang SL, Zhong GX, Wang XW, Yu FQ, Weng DF, Wang XX and Lin JH: Prognostic significance of the expression of HER family members in primary osteosarcoma. Oncol Lett 16: 2185-2194, 2018.
APA
Wang, S., Zhong, G., Wang, X., Yu, F., Weng, D., Wang, X., & Lin, J. (2018). Prognostic significance of the expression of HER family members in primary osteosarcoma. Oncology Letters, 16, 2185-2194. https://doi.org/10.3892/ol.2018.8931
MLA
Wang, S., Zhong, G., Wang, X., Yu, F., Weng, D., Wang, X., Lin, J."Prognostic significance of the expression of HER family members in primary osteosarcoma". Oncology Letters 16.2 (2018): 2185-2194.
Chicago
Wang, S., Zhong, G., Wang, X., Yu, F., Weng, D., Wang, X., Lin, J."Prognostic significance of the expression of HER family members in primary osteosarcoma". Oncology Letters 16, no. 2 (2018): 2185-2194. https://doi.org/10.3892/ol.2018.8931
Copy and paste a formatted citation
x
Spandidos Publications style
Wang SL, Zhong GX, Wang XW, Yu FQ, Weng DF, Wang XX and Lin JH: Prognostic significance of the expression of HER family members in primary osteosarcoma. Oncol Lett 16: 2185-2194, 2018.
APA
Wang, S., Zhong, G., Wang, X., Yu, F., Weng, D., Wang, X., & Lin, J. (2018). Prognostic significance of the expression of HER family members in primary osteosarcoma. Oncology Letters, 16, 2185-2194. https://doi.org/10.3892/ol.2018.8931
MLA
Wang, S., Zhong, G., Wang, X., Yu, F., Weng, D., Wang, X., Lin, J."Prognostic significance of the expression of HER family members in primary osteosarcoma". Oncology Letters 16.2 (2018): 2185-2194.
Chicago
Wang, S., Zhong, G., Wang, X., Yu, F., Weng, D., Wang, X., Lin, J."Prognostic significance of the expression of HER family members in primary osteosarcoma". Oncology Letters 16, no. 2 (2018): 2185-2194. https://doi.org/10.3892/ol.2018.8931
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