The tumor suppressor role of miR‑155‑5p in gastric cancer

  • Authors:
    • Shiqing Li
    • Tao Zhang
    • Xiaoqing Zhou
    • Zonghan Du
    • Fumin Chen
    • Jun Luo
    • Qingsong Liu
  • View Affiliations

  • Published online on: June 8, 2018     https://doi.org/10.3892/ol.2018.8932
  • Pages: 2709-2714
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Abstract

Gastric cancer (GC) is the fifth most common type of malignant tumor worldwide and the most common cause of cancer‑associated mortality in China. Recent studies revealed that microRNAs (miRNAs) function in the pathogenesis of GC, and that miR‑155‑5p expression is downregulated in GC tissues. However, the function of miR‑155‑5p has not been fully identified. In the present study, it was demonstrated that overexpression of miR‑155‑5p inhibited GC‑cell proliferation and promoted apoptosis, while downregulation of miR‑155‑5p promoted GC‑cell proliferation and decreased the cisplatin sensitivity of GC cells. Mitogen‑activated protein kinase kinase kinase 10 was demonstrated to be a potential target gene of miR‑155‑5p. In conclusion, an antitumor role of miR‑155‑5p in gastric cancer was suggested.
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August-2018
Volume 16 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Li S, Zhang T, Zhou X, Du Z, Chen F, Luo J and Liu Q: The tumor suppressor role of miR‑155‑5p in gastric cancer. Oncol Lett 16: 2709-2714, 2018
APA
Li, S., Zhang, T., Zhou, X., Du, Z., Chen, F., Luo, J., & Liu, Q. (2018). The tumor suppressor role of miR‑155‑5p in gastric cancer. Oncology Letters, 16, 2709-2714. https://doi.org/10.3892/ol.2018.8932
MLA
Li, S., Zhang, T., Zhou, X., Du, Z., Chen, F., Luo, J., Liu, Q."The tumor suppressor role of miR‑155‑5p in gastric cancer". Oncology Letters 16.2 (2018): 2709-2714.
Chicago
Li, S., Zhang, T., Zhou, X., Du, Z., Chen, F., Luo, J., Liu, Q."The tumor suppressor role of miR‑155‑5p in gastric cancer". Oncology Letters 16, no. 2 (2018): 2709-2714. https://doi.org/10.3892/ol.2018.8932