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Pathological tumor volume predicts survival outcomes in oral squamous cell carcinoma

  • Authors:
    • Nobuaki Mukoyama
    • Hidenori Suzuki
    • Nobuhiro Hanai
    • Michihiko Sone
    • Yasuhisa Hasegawa
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466‑8560, Japan, Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Aichi 464‑8681, Japan
    Copyright: © Mukoyama et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2471-2477
    |
    Published online on: June 12, 2018
       https://doi.org/10.3892/ol.2018.8951
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Abstract

The present study examined whether the pathological tumor volume (PTV) was correlated with the survival outcomes in patients with oral squamous cell carcinoma (SCC) and clinical lymph node metastasis. Forty‑seven patients who underwent radical surgery without preoperative treatment were enrolled. The PTV of the primary tumor, which was surgically resected without preoperative treatment, was calculated based on the diameters in three dimensions. A survival analysis was performed using a Cox proportional hazards model. A PTV of ≥18 cm3 was significantly correlated with shorter overall survival (P<0.01) and local recurrence‑free survival (P<0.01) in a univariate analysis. A multivariate analysis with adjustment for the pathological stage (stage I‑II/III‑IV), primary site (tongue/others) and positive surgical margin and/or extracapsular extension (absent/present) showed that a PTV of ≥18 cm3 was significantly correlated with shorter overall survival (P<0.01) and local recurrence‑free survival (P<0.01). The present findings suggested that PTV in oral SCC provides a prognostic parameter that may predict shorter or longer overall and local recurrence‑free survival.
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Copy and paste a formatted citation
Spandidos Publications style
Mukoyama N, Suzuki H, Hanai N, Sone M and Hasegawa Y: Pathological tumor volume predicts survival outcomes in oral squamous cell carcinoma. Oncol Lett 16: 2471-2477, 2018.
APA
Mukoyama, N., Suzuki, H., Hanai, N., Sone, M., & Hasegawa, Y. (2018). Pathological tumor volume predicts survival outcomes in oral squamous cell carcinoma. Oncology Letters, 16, 2471-2477. https://doi.org/10.3892/ol.2018.8951
MLA
Mukoyama, N., Suzuki, H., Hanai, N., Sone, M., Hasegawa, Y."Pathological tumor volume predicts survival outcomes in oral squamous cell carcinoma". Oncology Letters 16.2 (2018): 2471-2477.
Chicago
Mukoyama, N., Suzuki, H., Hanai, N., Sone, M., Hasegawa, Y."Pathological tumor volume predicts survival outcomes in oral squamous cell carcinoma". Oncology Letters 16, no. 2 (2018): 2471-2477. https://doi.org/10.3892/ol.2018.8951
Copy and paste a formatted citation
x
Spandidos Publications style
Mukoyama N, Suzuki H, Hanai N, Sone M and Hasegawa Y: Pathological tumor volume predicts survival outcomes in oral squamous cell carcinoma. Oncol Lett 16: 2471-2477, 2018.
APA
Mukoyama, N., Suzuki, H., Hanai, N., Sone, M., & Hasegawa, Y. (2018). Pathological tumor volume predicts survival outcomes in oral squamous cell carcinoma. Oncology Letters, 16, 2471-2477. https://doi.org/10.3892/ol.2018.8951
MLA
Mukoyama, N., Suzuki, H., Hanai, N., Sone, M., Hasegawa, Y."Pathological tumor volume predicts survival outcomes in oral squamous cell carcinoma". Oncology Letters 16.2 (2018): 2471-2477.
Chicago
Mukoyama, N., Suzuki, H., Hanai, N., Sone, M., Hasegawa, Y."Pathological tumor volume predicts survival outcomes in oral squamous cell carcinoma". Oncology Letters 16, no. 2 (2018): 2471-2477. https://doi.org/10.3892/ol.2018.8951
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