Open Access

MicroRNA-1294 inhibited oral squamous cell carcinoma growth by targeting c-Myc

  • Authors:
    • Zuojun Wang
    • Jinsheng Yan
    • Tingqian Zou
    • Hui Gao
  • View Affiliations

  • Published online on: June 13, 2018     https://doi.org/10.3892/ol.2018.8967
  • Pages: 2243-2250
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Oral squamous cell carcinoma (OSCC) is the predominant histological type of oral cancer. The 5-year survival rate of OSCC is only ~50%. c-Myc is a known oncogene and target gene in various cancer types, including OSCC. The presnet study revealed that c-Myc is one of the target genes of miR-1294. Results indicated lower levels of miR-1294 in OSCC tissues samples collected from 24 patients with OSCC. Notably, overexpression of miR-1294 inhibited proliferation and migration in OSCC cell lines and inhibition of miR-1294 promoted cell growth and migration in OSCC cell lines. Moreover, miR-1294 can target the 3'UTR of c-Myc, as we identified a negative correlation between c-Myc mRNA expression and miR-1294 expression in 24 OSCC tissues. In conclusion, the data demonstrate the tumor suppressive role of miR-1294 in OSCC.
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August-2018
Volume 16 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wang Z, Yan J, Zou T and Gao H: MicroRNA-1294 inhibited oral squamous cell carcinoma growth by targeting c-Myc. Oncol Lett 16: 2243-2250, 2018.
APA
Wang, Z., Yan, J., Zou, T., & Gao, H. (2018). MicroRNA-1294 inhibited oral squamous cell carcinoma growth by targeting c-Myc. Oncology Letters, 16, 2243-2250. https://doi.org/10.3892/ol.2018.8967
MLA
Wang, Z., Yan, J., Zou, T., Gao, H."MicroRNA-1294 inhibited oral squamous cell carcinoma growth by targeting c-Myc". Oncology Letters 16.2 (2018): 2243-2250.
Chicago
Wang, Z., Yan, J., Zou, T., Gao, H."MicroRNA-1294 inhibited oral squamous cell carcinoma growth by targeting c-Myc". Oncology Letters 16, no. 2 (2018): 2243-2250. https://doi.org/10.3892/ol.2018.8967