Open Access

Adenoid cystic carcinoma of the larynx in a 70-year-old patient: A case report

  • Authors:
    • Filippo Ricciardiello
    • Raffaele Addeo
    • Antonella Miriam Di Lullo
    • Teresa Abate
    • Salvatore Mazzone
    • Flavia Oliva
    • Giovanni Motta
    • Michelle Caraglia
    • Massimo Mesolella
  • View Affiliations

  • Published online on: June 18, 2018     https://doi.org/10.3892/ol.2018.8976
  • Pages: 2783-2788
  • Copyright: © Ricciardiello et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Adenoid cystic carcinoma (ACC) is a relatively rare tumor that accounts for <1% of all head and neck malignancies. Laryngeal localization of ACC, which is most commonly hypoglottic, is relatively rare, occurring in 0.07‑0.25% of all laryngeal tumors. ACC is characterized as a slow-growing tumor with a high recurrence rate, which often causes dyspnea and hoarseness. ACC exhibits a propensity for perineural invasion and thus, patients may experience pain as a late symptom of the disease. Distant metastasis occurs in 35-50% of cases and the lungs are the most common site of metastasis. Tumors are usually diagnosed by physical examination with fiberoscopy and computed tomography of the neck and chest, due to the high rate of lung metastases. The standard therapy for ACC is surgery followed by radiotherapy. In this study, a 70-year-old patient presented with laryngeal ACC, who underwent total laryngectomy with bilateral neck dissection and adjuvant radiotherapy, is presented. Follow‑up examination performed 2 years after surgery revealed no evidence of locoregional recurrence or distant metastases. Previously published literature regarding ACC of the larynx was also reviewed.

Introduction

Adenoid cystic carcinoma (ACC) is a malignant neoplasm of the epithelium, which occurs in the major and minor salivary glands (1). In 1859, Billroth used the term ‘cylindroma’ to describe the standard histology of salivary gland tumors, however, this was replaced by the term ‘ACC’ in 1953 (2,3).

ACC is a relatively rare tumor, accounting for <1% of all head and neck malignancies and 7.5–10% of all salivary gland neoplasms (36).

Laryngeal localization of ACC, which is most frequently hypoglottic, is relatively rare, occurring in 0.07–0.25% of all laryngeal tumors (5,7,8). ACC tumors arise from submucosal minor salivary glands, in which laryngotracheal mucosa is sparse (5,9). The majority of the minor salivary glands are located in the subglottis (60%), however, they are also identified in the supraglottis, false vocal cords, aryepiglottic folds and caudal aspect of the epiglottis (5,7,10). Tumors of the minor salivary glands are usually malignant and ACC presents the most common tumor type (5,7). These tumors most frequently occur in the oral cavity, particularly in the hard palate, however, tumors are less common in the nasal cavity, paranasal sinuses, pharynx and larynx (5,11), due to the distribution of minor salivary glands in these regions. ACC most commonly occurs in patients aged between 50 and 60 years old with no gender predilection (11). Laryngeal ACC is characterized as a slowly-growing tumor with symptoms that are dependent on the location of the tumor. For example, certain patients present with dyspnea, while patients with lesions that involve the true vocal cords present with hoarseness and dysphagia that is associated with ear pain (12). Distant metastasis is observed in 35–50% of ACC cases and most commonly occurs in the lungs (2). Diagnostic modalities include physical examination with fiberoscopy and computed tomography of the neck and chest in order to identify lung metastases, which are extremely common (13). At present, surgery followed by radiotherapy is the standard treatment for ACC (10). Approximately 50% of ACC patients experience recurrence within 5 years of diagnosis, however, ACC exhibits a fairly good prognosis, with a 5-year overall survival rate of 70% (14).

To the best of our knowledge, in the last 15 years a total of 81 cases of ACC of the larynx have been reported in the literature (Table I). In this study, a case of laryngeal ACC in a 70-year-old man, which was a candidate for total laryngectomy with bilateral neck dissection and adjuvant radiotherapy, is presented.

Table I.

Previous case reports of adenoid cystic carcinoma arising in the larynx reported in the English language literature over the last 15 years.

Table I.

Previous case reports of adenoid cystic carcinoma arising in the larynx reported in the English language literature over the last 15 years.

First author/s, yearCase(s), nPrimary tumor localizationRecurrence sites (local-regional/ distant metastases)SurvivalRef.
Javadi et al, 20021SubglottisNDND(1)
Saraydaroglu et al, 20111 Supraglottis-glottisNDND(5)
Ganly et al, 200612LarynxNDND(7)
Lee et al, 20031LarynxNDND(15)
Del Negro et al, 20071SubglottisNDND(16)
Amit et al, 20146LarynxNDNED - Follow-up period 3–288 months (median, 64 months)(17)
Qian et al, 20141SupraglottisRegional recurrence [supraglottis, glottis and subglottis (1 cm)]NED-42 months follow-up(18)
Misiukiewicz et al, 20131TransglotticDistant metastases (pulmonary metastases at 54 months)Alive, 112 months follow-up(19)
1GlottisNoneNED - 60 months follow-up
Testa et al, 20131 Glottis-subglottisNDNED - 36 months follow-up(20)
Murray et al, 20101LarynxLung metastasis and splenic lesionND(21)
Zvrko and Golubović, 20091SubglottisNDNED - 6 months follow-up(22)
Wang et al, 20091SubglottisNDNED - 6 months follow-up(23)
Zeng et al, 200910 Supraglottis/SubglottisNDND(24)
Maukarbel et al, 200815Supraglottis (2; 13.3%), glottis (1; 6.6%), subglottis (9; 60%) and transglottis (3; 20%)Distant metastases (7), local/distant (2), local residual (1), none (3) and regional (2)6 patients alive (1 NED), 9 patients succumbed (7 from their disease. 6.9 years follow-up (range, 1.3–22.3 years)(25)
Aydin et al, 20081SubglottisNoneNED - 6 years(26)
Messaoudi et al, 20071SubglottisNoneNED - 6 months(27)
Khan et al, 20061SubglottisNDND(28)
Pino Rivero et al, 20061LarynxPulmonary metastasesNED - 1 year(29)
Natarajan et al, 20041LarynxNDND(30)
Adachi et al, 20031LarynxChoroidal/optic disc metastasisND(31)
Dexemple et al, 20032LarynxNDND(32)
Mahlstedt et al, 20026LarynxNDND(33)
Issing et al, 20023LarynxNDND(34)
Altaf, 20011LarynxNDND(35)
Szmeja et al, 20011LarynxNDND(36)
Lucioni et al, 20158Supraglottis (2), transglottis (1) and subglottis (5)Regional metastases (2)NED - 41 months median follow-up (range, 14–301 months)(37)

[i] NED, no evidence of disease; ND, not determined.

Case report

In May 2012, a 70-year-old man presented to the Department of Otolaryngology-Head and Neck Surgery at ‘Federico II’ University (Naples, Italy) with ear pain, dysphonia, a 1-year history of dysphagia and a 1-month history of dyspnea. The patient was a former smoker (80 cigarettes/day for 50 years) and had previously been diagnosed with diabetes mellitus and chronic renal failure, which had been managed with dialysis for 10 years.

Laryngoscopy revealed a bulging mass in the left true vocal cord and left ventricle, which extended to the subglottic area with lack of mobility of the left larynx (Fig. 1). In the neck, left lymph nodes were palpable (level III). Total body positron emission tomography-computed tomography (PET-CT) with contrast medium revealed hyperaccumulation of tracer in the left laryngeal region (standardized uptake volume, 7.9) (Fig. 2). Magnetic resonance imaging (MRI) of the neck with contrast medium revealed asymmetric reduction of the laryngeal glottic plane and the presence of a solid, inhomogeneous lesion with evidence of increased perfusion predominantly in the left true vocal cord (28×37 mm).

This lesion laterally destroyed the paraglottic space, upward interesting the ipsilateral false vocal cord and anteriorly reaching the anterior commissure; posteriorly and inferiorly it was associated with mixed structural alteration mainly thickening of the left arytenoid cartilage, especially in his vocal process, and the posterosuperior and lateral portion of the cricoid cartilage, which exhibited moderate and uniform contrast enhancement suggesting infiltrative growth into nearby structures (Fig. 3). In addition, neck MRI revealed an enlarged left cervical lymph node, measuring 1.8 cm in diameter. Clinical staging was T3N1M0 (stage III, according to the Union for International Cancer Control/American Joint Committee on Cancer staging system) (38).

Biopsy of the tumor mass by direct microlaryngoscopy in suspension revealed a cellular neoplasm with prominent cribriform architecture, which was composed of small, bland hyperchromatic cells with a high nuclear-to-cytoplasmic ratio. The neoplastic cells surrounding the pseudoglandular spaces were filled with basement membrane-like material and mucin (Fig. 4).

Subsequently, the patient underwent total laryngectomy with bilateral selective neck dissection (levels II–IV, left side; levels II–III, right side).

Tissue sections (3–5 µm) from each specimen were mounted on glass slides and dried overnight at 37°C. All sections were deparaffinized in xylene, rehydrated through a graded alcohol series and washed in phosphate-buffered saline. Tissue sections were processed using the standard streptavidin-biotin-immunoperoxidase method (Dako LSAB2 Universal Kit; Dako, Carpinteria, CA, USA). Rabbit polyclonal anti-human c-kit antibody (CD117; catalog no. 34–8800; Dako) at 1:50 dilution was used according to the manufacturer's protocols. Hematoxylin and eosin (Sigma-Aldrich; Merck KGaA, Damrstadt, Germany) stain was used as the final chromogen. Histological examination identified the presence of ACC, which exhibited focal solid areas and infiltration of the cartilage and fibroadipose perilaryngeal tissues with perineural invasion. All dissected neck lymph nodes were free of metastases. Immunohistochemical analysis of ACC cells revealed positivity for the c-kit protein. Subsequently, the tumor was pathologically staged as ACC T3N0M0 (stage III).

The patient was administered adjuvant radiotherapy (66 Gy) for 6 weeks according to recent guidelines (39). Follow-up examinations were performed every 6 months and follow-up 2 years after surgery revealed no evidence of locoregional recurrence or distant metastases.

Discussion

ACC of the larynx most commonly occurs in patients aged between 40 and 60 years-old (5,11,15). However, in the present case, ACC of the larynx was diagnosed in a 70-year-old patient. In the last 15 years, a total of 81 laryngeal ACCs have been reported and well-documented in the English literature (Table I). ACC is the predominant histological type among malignancies of the minor salivary glands, with a frequency of 10–20%, representing only 2–4% of all head and neck malignancies. ACC of the larynx is incredibly rare (0.07–0.25% of all laryngeal tumours, 1% of all ACC) as there are few salivary glands in the mucosa of laryngeal-tracheal tract (5). These tumors are predominantly subglottic (64%), such as in the present case. Moreover, their prevalence is 25% for the supra-glottic region, 5% for the glottic region and 6% for the trans-glottic area. This pattern of distribution in the anatomical laryngeal subsites is due to their origin from submucosal glands, which are more frequently found in the subglottic region of the larynx (1,5,7,1). These tumors grow slowly with perineural diffusion (37). So the evolution prognosis of this disease is caused by lung, bone and brain metastases or by local recurrence (20,37).

ACC of the larynx develops in a similar manner to ACC of other head and neck sites. It is considered a slowly growing but highly invasive cancer with a high recurrence rate.

In the laryngeal region, symptoms depend on the tumor location. Patients with subglottic cancer show dyspnea, whereas common symptoms of glottis implications are dyspnea and a hoarse voice. Subglottic tumors are rare and associated with stridor and airway obstruction (12). In the present clinical case, an initial glottic and supraglottic lesion infiltrating the left true vocal cord and left ventricle caused hoarseness (due to vocal cord compromise) and dysphagia associated with ear pain for 1 year (10), and subsequently, the major extension of the lesion to the subglottic region resulted in dyspnea (due to airway obstruction) over the last month.

In the present case, physical and radiological examinations identified an enlarged left cervical lymph node, 1.8 cm in diameter with no evidence of distant metastasis. Previously it has been reported that nodal metastasis is a common cause of treatment failure in ACC patients (16), however, metastasis to the cervical lymph nodes is rare in ACC, occurring in 10–20% of patients with head and neck ACC (38). Notably, the metastasis rates of ACC located in the base of the tongue (19.2%), mobile tongue (17.6%) and mouth floor (15.3%) are higher than that of ACC of the larynx (15). In addition, clinical investigations have shown that the incidence of ACC with distant metastasis ranges from 35 to 50%, and leads to 5-year survival rates ranging from 12–17% following surgery (12). The lungs are the most common site of distant metastasis from ACC (15).

We recommend that neck dissection is performed in all ACC patients with pre-operative evidence of nodal metastases, as indicated by physical examination and imaging studies including CT, MRI and/or PET-CT, since occult cervical metastases of head and neck ACC occurs in 10–20% of cases (38).

The prognostic factors of ACC are dependent on tumor site, tumor stage and microscopic tumor pattern. Other prognostic factors are an age >60 years, a solid histological subtype, an advanced clinical stage and the presence of perineural invasion (5,40).

In the patient of the present case, the ACC tumor was mainly localized to the glottis and supraglottic area, causing hoarseness and dysphagia; however, major extension of the lesion to the subglottic region resulted in dyspnea leading to a late diagnosis. In the larynx, tumor occurrence in the minor salivary glands is rare, accounting for <1% laryngeal tumors (5). The tumors arise from submucosal minor salivary glands, which exhibit a distinct anatomical distribution in the larynx. The majority of minor salivary glands are concentrated in the subglottis, however, they may also be identified in the supraglottis in the false vocal cords, aryepiglottic folds and caudal aspect of the epiglottis (5). The anatomical site in which laryngeal submucosal minor salivary glands are located explains the evolution of the symptoms in the present clinical case.

The patient in the present case was initially diagnosed with clinical stage III (cT3N1M0) disease, as tumor extension to the vocal cords with emilaryngeal lack of mobility (T3) and a metastatic omolateral lymph node (N1) were observed with no evidence of distant metastases (M0) (5). Tumor staging was postoperatively confirmed as T3N0M0 since all dissected neck lymph nodes were free of metastases.

According to the World Health Organization Classification of Tumors (41), ACC may be divided into three microscopic grades: Tubular (well-differentiated/grade I), which exhibits the best prognosis; cribriform (moderately-differentiated/grade II), which is the most common; and solid (poorly-differentiated/grade III), which is the least common with the worst prognosis (5,16,17). ACC tumors often exhibit a mixture of the three histological growth patterns and thus, tumors are classified according to the predominant pattern (42). The tumor in the present case exhibited a classic cribriform pattern and thus was defined as low-grade (grade II).

Generally, neoplastic ACC cells exhibit myoepithelial and ductal differentiation, with positivity for p63, S100 protein, smooth muscle actin and cytokeratins (43). Typically, the most peripheral cells of the tumor nests and glands are arranged in a cribriform pattern and exhibit myoepithelial differentiation that is accompanied by the abundant production of extracellular matrix and basement membrane components, such as laminin (43). Loss of laminin or reduced expression may occur during transformation to a more aggressive malignancy (3,44). In the present case, immunochemistry revealed positivity for c-kit protein, a class III transmembrane receptor tyrosine kinase. C-kit is a proto-oncogene encoded by a gene located on the human chromosome segment 4q11, which leads to activation of specific intracellular signal transduction cascades that contribute to the cellular growth and differentiation that subsequently confers a worse prognosis (11). Thus, further investigation is required to characterize c-kit functional pathways in salivary gland tumors and to evaluate potential therapeutic effects of small molecule inhibitors of c-kit, such as imatinib mesylate (42). In ACC, c-kit expression is limited to the inner epithelial cells, whereas epidermal growth factor receptor (EGFR) is typically expressed in myoepithelial cells. EGFR, which facilitates carcinogenesis in humans via the blockade of apoptosis and promotion of angiogenesis, may be modified by anti-EGFR agents, including cetuximab and erlotinib. In addition, recent studies have reported that cytogenetically, ACC is characterized by the tumor-type specific translocation, t(6;9) (q22-23;p23-24), which has been identified as the sole anomaly in certain cases. This traslocation results in the fusion of the MYB proto-oncogene and the transcription factor gene nuclear factor I-B (NFIB), leading to the formation of the MYB-NFIB fusion oncogene, which is highly overexpressed in ACC; thus, it may be considered a useful biomarker for the disease (3,11).

At present, surgery followed by radiotherapy is the standard treatment for ACC due to the risk of perineural and hematogenous spread. According to the literature, surgical excision of the lesion is recommended due to the relative radioresistance of these tumors. Surgical excision should be performed with bilateral selective neck dissection in cases where frozen sections reveal negative lymph nodes (no tumoral infiltration) (pN0) and with radical neck dissection in cases whereby frozen sections reveal positive lymph nodes (pN+) (39).

The patient in the present case underwent total laryngectomy associated with bilateral selective neck dissection (levels II–IV, left side; levels II–III, right side). Furthermore, frozen biopsy sections revealed that negative lymph nodes were negative for metastasis (pN0) and thus adjuvant radiotherapy (66 Gy) was administered according to recent guidelines (39).

Postoperative radiation is recommended in certain cases, as radiotherapy has been demonstrated to result in tumor regression and symptomatic relief (16). However, the use of chemotherapy for ACC remains controversial. Certain studies have demonstrated positive patient responses to chemotherapy and thus, it is recommended as palliative therapy in advanced cases (5,17).

However, currently, the identification of molecular abnormalities underlying ACC, such as those of c-kit and EGFR, is paramount for the development of specific targeted therapies.

Previous case reports of ACC in the larynx during the last 14 years are listed in Table I (1,5,7,1).

After 2 years of post-operative follow-up, performed every 6 months, the patient in the current study remained free of locoregional recurrence and/or distant metastases.

In conclusion, ACC is a relatively rare tumor comprising <1% of all malignancies of the head and neck area. ACC of the larynx occurs more commonly in middle-aged or older patients, evolving slowly and with patients mainly developing dyspnea. In addition, it is considered a highly invasive cancer with a high recurrence rate and an incidence of distant metastasis ranging from 35 to 50%, resulting in a low long-term survival rate (12). It has been well-documented that the most common site of distant metastasis from ACC is the lung. In localized ACC, the gold-standard therapy is surgery followed by adjuvant radiotherapy. Novel therapeutic frontiers will focus on the identification of molecular abnormalities underlying ACC, such as c-kit and EGFR, to develop specific targeted therapies.

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Ricciardiello F, Addeo R, Di Lullo AM, Abate T, Mazzone S, Oliva F, Motta G, Caraglia M and Mesolella M: Adenoid cystic carcinoma of the larynx in a 70-year-old patient: A case report. Oncol Lett 16: 2783-2788, 2018
APA
Ricciardiello, F., Addeo, R., Di Lullo, A.M., Abate, T., Mazzone, S., Oliva, F. ... Mesolella, M. (2018). Adenoid cystic carcinoma of the larynx in a 70-year-old patient: A case report. Oncology Letters, 16, 2783-2788. https://doi.org/10.3892/ol.2018.8976
MLA
Ricciardiello, F., Addeo, R., Di Lullo, A. M., Abate, T., Mazzone, S., Oliva, F., Motta, G., Caraglia, M., Mesolella, M."Adenoid cystic carcinoma of the larynx in a 70-year-old patient: A case report". Oncology Letters 16.3 (2018): 2783-2788.
Chicago
Ricciardiello, F., Addeo, R., Di Lullo, A. M., Abate, T., Mazzone, S., Oliva, F., Motta, G., Caraglia, M., Mesolella, M."Adenoid cystic carcinoma of the larynx in a 70-year-old patient: A case report". Oncology Letters 16, no. 3 (2018): 2783-2788. https://doi.org/10.3892/ol.2018.8976