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Article Open Access

High expression of class III β‑tubulin in upper gastrointestinal cancer types

  • Authors:
    • Doris Höflmayer
    • Eray Öztürk
    • Cornelia Schroeder
    • Claudia Hube‑Magg
    • Niclas C. Blessin
    • Ronald Simon
    • Dagmar S. Lang
    • Emily Neubauer
    • Cosima Göbel
    • Marie‑Christine Heinrich
    • Christoph Fraune
    • Katharina Möller
    • Moritz Armbrust
    • Morton Freytag
    • Andrea Hinsch
    • Clara Lühr
    • Magdalena Noack
    • Viktor Reiswich
    • Sören Weidemann
    • Maximilian Bockhorn
    • Daniel Perez
    • Jakob R. Izbicki
    • Guido Sauter
    • Frank Jacobsen
  • View Affiliations / Copyright

    Affiliations: Institute of Pathology, University Medical Center Hamburg‑Eppendorf, D‑20246 Hamburg, Germany, General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg‑Eppendorf, D‑20246 Hamburg, Germany
    Copyright: © Höflmayer et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7139-7145
    |
    Published online on: September 25, 2018
       https://doi.org/10.3892/ol.2018.9502
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Abstract

Class III β‑tubulin (TUBB3) is a component of microtubules of neuronal cells that is upregulated in various cancer entities. To better understand the role of TUBB3 in upper gastrointestinal tract cancer types, the present study assessed TUBB3 expression in tissue microarrays including 189 gastric and 428 esophageal cancer. TUBB3 expression was detected in 62.4% of gastric cancer, 73.8% of esophageal adenocarcinoma and 88.7% of esophageal squamous cell cancer, while control samples of normal esophageal and gastric epithelium were TUBB3‑negative. TUBB3 positivity was not associated with the International Union Against Cancer classification, World Health Organization grading, lymph node involvement or distant metastasis in any entity. Of note, TUBB3 expression was associated with tumor localization and prognosis in gastric cancer, with the tumor stage in esophageal adenocarcinoma, and with the resection margin in esophageal squamous cell cancer. In conclusion, the substantial rate of positivity for TUBB3 already in early stages of gastric cancer in combination with the lack of a further increase in frequency with tumor stage, may suggest, that TUBB3 upregulation is rather relevant for cancer development than for cancer progression. TUBB3 might be a suitable prognostic biomarker in gastric cancer types.
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1 

Zhang Y: Epidemiology of esophageal cancer. World J Gastroenterol. 19:5598–5606. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Pasechnikov V, Chukov S, Fedorov E, Kikuste I and Leja M: Gastric cancer: Prevention, screening and early diagnosis. World J Gastroenterol. 20:13842–13862. 2014. View Article : Google Scholar : PubMed/NCBI

3 

CancerGenome Atlas Research Network; AnalysisWorking Group: Asan University; BC Cancer Agency; Brigham and Women's Hospital; Broad Institute; Brown University; Case Western Reserve University; Dana-Farber Cancer Institute; Duke University, et al, . Integrated genomic characterization of oesophageal carcinoma. Nature. 541:169–175. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Moro K, Nagahashi M, Naito T, Nagai Y, Katada T, Minagawa M, Hasegawa J, Tani T, Shimakage N, Usuda H, et al: Gastric adenosquamous carcinoma producing granulocyte-colony stimulating factor: A case of a rare malignancy. Surg Case Rep. 3:672017. View Article : Google Scholar : PubMed/NCBI

5 

Matsuda T and Saika K: The 5-year relative survival rate of stomach cancer in the USA, Europe and Japan. Jpn J Clin Oncol. 43:1157–1158. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Lewis SA, Lee MG and Cowan NJ: Five mouse tubulin isotypes and their regulated expression during development. J Cell Biol. 101:852–861. 1985. View Article : Google Scholar : PubMed/NCBI

7 

Yang YL, Luo XP and Xian L: The prognostic role of the class III β-tubulin in non-small cell lung cancer (NSCLC) patients receiving the taxane/vinorebine-based chemotherapy: A meta-analysis. PLoS One. 9:e939972014. View Article : Google Scholar : PubMed/NCBI

8 

Hinsch A, Chaker A, Burdelski C, Koop C, Tsourlakis MC, Steurer S, Rink M, Eichenauer TS, Wilczak W, Wittmer C, et al: βIII-tubulin overexpression is linked to aggressive tumor features and genetic instability in urinary bladder cancer. Hum Pathol. 61:210–220. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Lebok P, Öztürk M, Heilenkotter U, Jaenicke F, Müller V, Paluchowski P, Geist S, Wilke C, Burandt E, Lebeau A, et al: High levels of class III β-tubulin expression are associated with aggressive tumor features in breast cancer. Oncol Lett. 11:1987–1994. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Kavallaris M, Kuo DY, Burkhart CA, Regl DL, Norris MD, Haber M and Horwitz SB: Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes. J Clin Invest. 100:1282–1293. 1997. View Article : Google Scholar : PubMed/NCBI

11 

Ranganathan S, Benetatos CA, Colarusso PJ, Dexter DW and Hudes GR: Altered beta-tubulin isotype expression in paclitaxel-resistant human prostate carcinoma cells. Br J Cancer. 77:562–566. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Hwang JE, Hong JY, Kim K, Kim SH, Choi WY, Kim MJ, Jung SH, Shim HJ, Bae WK, Hwang EC, et al: Class III β-tubulin is a predictive marker for taxane-based chemotherapy in recurrent and metastatic gastric cancer. BMC Cancer. 13:4312013. View Article : Google Scholar : PubMed/NCBI

13 

Cao Y, Zhang G, Wang P, Zhou J, Gan W, Song Y, Huang L, Zhang Y, Luo G, Gong J and Zhang L: Clinical significance of UGT1A1 polymorphism and expression of ERCC1, BRCA1, TYMS, RRM1, TUBB3, STMN1 and TOP2A in gastric cancer. BMC Gastroenterol. 17:22017. View Article : Google Scholar : PubMed/NCBI

14 

Yu Y, Ding S, Liang Y, Zheng Y, Li W, Yang L, Zheng X and Jiang J: Expression of ERCC1, TYMS, TUBB3, RRM1 and TOP2A in patients with esophageal squamous cell carcinoma: A hierarchical clustering analysis. Exp Ther Med. 7:1578–1582. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Burkhart CA, Kavallaris M and Band Horwitz S: The role of beta-tubulin isotypes in resistance to antimitotic drugs. Biochim Biophys Acta. 1471:O1–O9. 2001.PubMed/NCBI

16 

Brierley JD, Gospodarowicz MK and Wittekind C: UICC TNM Classification of Malignant Tumours. 8th edition. Wiley Blackwell; New York, NY: 2017

17 

Kononen J, Bubendorf L, Kallioniemi A, Bärlund M, Schraml P, Leighton S, Torhorst J, Mihatsch MJ, Sauter G and Kallioniemi OP: Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med. 4:844–847. 1998. View Article : Google Scholar : PubMed/NCBI

18 

Mirlacher M and Simon R: Recipient block TMA technique. Methods Mol Biol. 664:37–44. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Urano N, Fujiwara Y, Doki Y, Kim SJ, Miyoshi Y, Noguchi S, Miyata H, Takiguchi S, Yasuda T, Yano M and Monden M: Clinical significance of class III beta-tubulin expression and its predictive value for resistance to docetaxel-based chemotherapy in gastric cancer. Int J Oncol. 28:375–381. 2006.PubMed/NCBI

20 

Nair KS, Naidoo R and Chetty R: Microsatellite analysis of the APC gene and immunoexpression of E-cadherin, catenin and tubulin in esophageal squamous cell carcinoma. Hum Pathol. 37:125–134. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Schlomm T, Iwers L, Kirstein P, Jessen B, Köllermann J, Minner S, Passow-Drolet A, Mirlacher M, Milde-Langosch K, Graefen M, et al: Clinical significance of p53 alterations in surgically treated prostate cancers. Mod Pathol. 21:1371–1378. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Panda D, Miller HP, Banerjee A, Ludueña RF and Wilson L: Microtubule dynamics in vitro are regulated by the tubulin isotype composition. Proc Natl Acad Sci USA. 91:11358–11362. 1994. View Article : Google Scholar : PubMed/NCBI

23 

Falconer MM, Echeverri CJ and Brown DL: Differential sorting of beta tubulin isotypes into colchicine-stable microtubules during neuronal and muscle differentiation of embryonal carcinoma cells. Cell Motil Cytoskeleton. 21:313–325. 1992. View Article : Google Scholar : PubMed/NCBI

24 

Tsourlakis MC, Weigand P, Grupp K, Kluth M, Steurer S, Schlomm T, Graefen M, Huland H, Salomon G, Steuber T, et al: βIII-tubulin overexpression is an independent predictor of prostate cancer progression tightly linked to ERG fusion status and PTEN deletion. Am J Pathol. 184:609–617. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Horak CE, Pusztai L, Xing G, Trifan OC, Saura C, Tseng LM, Chan S, Welcher R and Liu D: Biomarker analysis of neoadjuvant doxorubicin/cyclophosphamide followed by ixabepilone or Paclitaxel in early-stage breast cancer. Clin Cancer Res. 19:1587–1595. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Levallet G, Bergot E, Antoine M, Creveuil C, Santos AO, Beau-Faller M, de Fraipont F, Brambilla E, Levallet J, Morin F, et al: High TUBB3 expression, an independent prognostic marker in patients with early non-small cell lung cancer treated by preoperative chemotherapy, is regulated by K-Ras signaling pathway. Mol Cancer Ther. 11:1203–1213. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Zhang HL, Ruan L, Zheng LM, Whyte D, Tzeng CM and Zhou XW: Association between class III β-tubulin expression and response to paclitaxel/vinorebine-based chemotherapy for non-small cell lung cancer: a meta-analysis. Lung Cancer. 77:9–15. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Katsetos CD, Herman MM and Mörk SJ: Class III beta-tubulin in human development and cancer. Cell Motil Cytoskeleton. 55:77–96. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Gao S, Zhao X, Lin B, Hu Z, Yan L and Gao J: Clinical implications of REST and TUBB3 in ovarian cancer and its relationship to paclitaxel resistance. Tumour Biol. 33:1759–1765. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Carrara L, Guzzo F, Roque DM, Bellone S, Emiliano C, Sartori E, Pecorelli S, Schwartz PE, Rutherford TJ and Santin AD: Differential in vitro sensitivity to patupilone versus paclitaxel in uterine and ovarian carcinosarcoma cell lines is linked to tubulin-beta-III expression. Gynecol Oncol. 125:231–236. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Höflmayer D, Öztürk E, Schroeder C, Hube‑Magg C, Blessin NC, Simon R, Lang DS, Neubauer E, Göbel C, Heinrich MC, Heinrich MC, et al: High expression of class III β‑tubulin in upper gastrointestinal cancer types. Oncol Lett 16: 7139-7145, 2018.
APA
Höflmayer, D., Öztürk, E., Schroeder, C., Hube‑Magg, C., Blessin, N.C., Simon, R. ... Jacobsen, F. (2018). High expression of class III β‑tubulin in upper gastrointestinal cancer types. Oncology Letters, 16, 7139-7145. https://doi.org/10.3892/ol.2018.9502
MLA
Höflmayer, D., Öztürk, E., Schroeder, C., Hube‑Magg, C., Blessin, N. C., Simon, R., Lang, D. S., Neubauer, E., Göbel, C., Heinrich, M., Fraune, C., Möller, K., Armbrust, M., Freytag, M., Hinsch, A., Lühr, C., Noack, M., Reiswich, V., Weidemann, S., Bockhorn, M., Perez, D., Izbicki, J. R., Sauter, G., Jacobsen, F."High expression of class III β‑tubulin in upper gastrointestinal cancer types". Oncology Letters 16.6 (2018): 7139-7145.
Chicago
Höflmayer, D., Öztürk, E., Schroeder, C., Hube‑Magg, C., Blessin, N. C., Simon, R., Lang, D. S., Neubauer, E., Göbel, C., Heinrich, M., Fraune, C., Möller, K., Armbrust, M., Freytag, M., Hinsch, A., Lühr, C., Noack, M., Reiswich, V., Weidemann, S., Bockhorn, M., Perez, D., Izbicki, J. R., Sauter, G., Jacobsen, F."High expression of class III β‑tubulin in upper gastrointestinal cancer types". Oncology Letters 16, no. 6 (2018): 7139-7145. https://doi.org/10.3892/ol.2018.9502
Copy and paste a formatted citation
x
Spandidos Publications style
Höflmayer D, Öztürk E, Schroeder C, Hube‑Magg C, Blessin NC, Simon R, Lang DS, Neubauer E, Göbel C, Heinrich MC, Heinrich MC, et al: High expression of class III β‑tubulin in upper gastrointestinal cancer types. Oncol Lett 16: 7139-7145, 2018.
APA
Höflmayer, D., Öztürk, E., Schroeder, C., Hube‑Magg, C., Blessin, N.C., Simon, R. ... Jacobsen, F. (2018). High expression of class III β‑tubulin in upper gastrointestinal cancer types. Oncology Letters, 16, 7139-7145. https://doi.org/10.3892/ol.2018.9502
MLA
Höflmayer, D., Öztürk, E., Schroeder, C., Hube‑Magg, C., Blessin, N. C., Simon, R., Lang, D. S., Neubauer, E., Göbel, C., Heinrich, M., Fraune, C., Möller, K., Armbrust, M., Freytag, M., Hinsch, A., Lühr, C., Noack, M., Reiswich, V., Weidemann, S., Bockhorn, M., Perez, D., Izbicki, J. R., Sauter, G., Jacobsen, F."High expression of class III β‑tubulin in upper gastrointestinal cancer types". Oncology Letters 16.6 (2018): 7139-7145.
Chicago
Höflmayer, D., Öztürk, E., Schroeder, C., Hube‑Magg, C., Blessin, N. C., Simon, R., Lang, D. S., Neubauer, E., Göbel, C., Heinrich, M., Fraune, C., Möller, K., Armbrust, M., Freytag, M., Hinsch, A., Lühr, C., Noack, M., Reiswich, V., Weidemann, S., Bockhorn, M., Perez, D., Izbicki, J. R., Sauter, G., Jacobsen, F."High expression of class III β‑tubulin in upper gastrointestinal cancer types". Oncology Letters 16, no. 6 (2018): 7139-7145. https://doi.org/10.3892/ol.2018.9502
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