Open Access

High expression of class III β‑tubulin in upper gastrointestinal cancer types

  • Authors:
    • Doris Höflmayer
    • Eray Öztürk
    • Cornelia Schroeder
    • Claudia Hube‑Magg
    • Niclas C. Blessin
    • Ronald Simon
    • Dagmar S. Lang
    • Emily Neubauer
    • Cosima Göbel
    • Marie‑Christine Heinrich
    • Christoph Fraune
    • Katharina Möller
    • Moritz Armbrust
    • Morton Freytag
    • Andrea Hinsch
    • Clara Lühr
    • Magdalena Noack
    • Viktor Reiswich
    • Sören Weidemann
    • Maximilian Bockhorn
    • Daniel Perez
    • Jakob R. Izbicki
    • Guido Sauter
    • Frank Jacobsen
  • View Affiliations

  • Published online on: September 25, 2018     https://doi.org/10.3892/ol.2018.9502
  • Pages: 7139-7145
  • Copyright: © Höflmayer et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Class III β‑tubulin (TUBB3) is a component of microtubules of neuronal cells that is upregulated in various cancer entities. To better understand the role of TUBB3 in upper gastrointestinal tract cancer types, the present study assessed TUBB3 expression in tissue microarrays including 189 gastric and 428 esophageal cancer. TUBB3 expression was detected in 62.4% of gastric cancer, 73.8% of esophageal adenocarcinoma and 88.7% of esophageal squamous cell cancer, while control samples of normal esophageal and gastric epithelium were TUBB3‑negative. TUBB3 positivity was not associated with the International Union Against Cancer classification, World Health Organization grading, lymph node involvement or distant metastasis in any entity. Of note, TUBB3 expression was associated with tumor localization and prognosis in gastric cancer, with the tumor stage in esophageal adenocarcinoma, and with the resection margin in esophageal squamous cell cancer. In conclusion, the substantial rate of positivity for TUBB3 already in early stages of gastric cancer in combination with the lack of a further increase in frequency with tumor stage, may suggest, that TUBB3 upregulation is rather relevant for cancer development than for cancer progression. TUBB3 might be a suitable prognostic biomarker in gastric cancer types.
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December-2018
Volume 16 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Höflmayer D, Öztürk E, Schroeder C, Hube‑Magg C, Blessin NC, Simon R, Lang DS, Neubauer E, Göbel C, Heinrich MC, Heinrich MC, et al: High expression of class III β‑tubulin in upper gastrointestinal cancer types. Oncol Lett 16: 7139-7145, 2018
APA
Höflmayer, D., Öztürk, E., Schroeder, C., Hube‑Magg, C., Blessin, N.C., Simon, R. ... Jacobsen, F. (2018). High expression of class III β‑tubulin in upper gastrointestinal cancer types. Oncology Letters, 16, 7139-7145. https://doi.org/10.3892/ol.2018.9502
MLA
Höflmayer, D., Öztürk, E., Schroeder, C., Hube‑Magg, C., Blessin, N. C., Simon, R., Lang, D. S., Neubauer, E., Göbel, C., Heinrich, M., Fraune, C., Möller, K., Armbrust, M., Freytag, M., Hinsch, A., Lühr, C., Noack, M., Reiswich, V., Weidemann, S., Bockhorn, M., Perez, D., Izbicki, J. R., Sauter, G., Jacobsen, F."High expression of class III β‑tubulin in upper gastrointestinal cancer types". Oncology Letters 16.6 (2018): 7139-7145.
Chicago
Höflmayer, D., Öztürk, E., Schroeder, C., Hube‑Magg, C., Blessin, N. C., Simon, R., Lang, D. S., Neubauer, E., Göbel, C., Heinrich, M., Fraune, C., Möller, K., Armbrust, M., Freytag, M., Hinsch, A., Lühr, C., Noack, M., Reiswich, V., Weidemann, S., Bockhorn, M., Perez, D., Izbicki, J. R., Sauter, G., Jacobsen, F."High expression of class III β‑tubulin in upper gastrointestinal cancer types". Oncology Letters 16, no. 6 (2018): 7139-7145. https://doi.org/10.3892/ol.2018.9502