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Article Open Access

FKBP51 promotes migration and invasion of papillary thyroid carcinoma through NF‑κB‑dependent epithelial‑to‑mesenchymal transition

  • Authors:
    • Ying Gao
    • Elham Elamin
    • Rongfang Zhou
    • Huili Yan
    • Shuang Liu
    • Shengnan Hu
    • Jing Dong
    • Muyun Wei
    • Linying Sun
    • Yueran Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Central Lab, Shandong Provincial Hospital Affiliated to Shandong University, Shandong, Jinan 250021, P.R. China, Department of Medicine and Life Science, University of Jinan‑Shandong Academy of Medical Sciences, Shandong, Jinan 250062, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7020-7028
    |
    Published online on: September 27, 2018
       https://doi.org/10.3892/ol.2018.9517
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Abstract

FK506‑binding protein 51 (FKBP51) is a member of the immunophilin family, with relevant roles in multiple signaling pathways, tumorigenesis and chemoresistance. However, the function of FKBP51 in papillary thyroid carcinoma (PTC) remains largely unknown. In the present study, increased FKBP51 expression was detected in PTC tissues as compared with adjacent normal tissues, and the expression level was associated with clinical tumor, node and metastasis stage. Using FKBP51‑overexpressing K1 cells and FKBP51‑knockdown TPC‑1 cells, both human PTC cell lines, it was identified that FKBP51 promoted the migration and invasion of PTC, without affecting cell proliferation. Further investigation revealed that FKBP51 activated the NF‑κB pathway and epithelial‑to‑mesenchymal transition (EMT) genes, and EMT was suppressed when NF‑κB was inhibited. It was also assessed whether FKBP51 promoted the formation of cytoskeleton to promote migration and invasion of PTC using a tubulin tracker; however, no evidence of such an effect was observed. These results suggested that FKBP51 promotes migration and invasion through NF‑κB‑dependent EMT.
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Copy and paste a formatted citation
Spandidos Publications style
Gao Y, Elamin E, Zhou R, Yan H, Liu S, Hu S, Dong J, Wei M, Sun L, Zhao Y, Zhao Y, et al: FKBP51 promotes migration and invasion of papillary thyroid carcinoma through NF‑κB‑dependent epithelial‑to‑mesenchymal transition. Oncol Lett 16: 7020-7028, 2018.
APA
Gao, Y., Elamin, E., Zhou, R., Yan, H., Liu, S., Hu, S. ... Zhao, Y. (2018). FKBP51 promotes migration and invasion of papillary thyroid carcinoma through NF‑κB‑dependent epithelial‑to‑mesenchymal transition. Oncology Letters, 16, 7020-7028. https://doi.org/10.3892/ol.2018.9517
MLA
Gao, Y., Elamin, E., Zhou, R., Yan, H., Liu, S., Hu, S., Dong, J., Wei, M., Sun, L., Zhao, Y."FKBP51 promotes migration and invasion of papillary thyroid carcinoma through NF‑κB‑dependent epithelial‑to‑mesenchymal transition". Oncology Letters 16.6 (2018): 7020-7028.
Chicago
Gao, Y., Elamin, E., Zhou, R., Yan, H., Liu, S., Hu, S., Dong, J., Wei, M., Sun, L., Zhao, Y."FKBP51 promotes migration and invasion of papillary thyroid carcinoma through NF‑κB‑dependent epithelial‑to‑mesenchymal transition". Oncology Letters 16, no. 6 (2018): 7020-7028. https://doi.org/10.3892/ol.2018.9517
Copy and paste a formatted citation
x
Spandidos Publications style
Gao Y, Elamin E, Zhou R, Yan H, Liu S, Hu S, Dong J, Wei M, Sun L, Zhao Y, Zhao Y, et al: FKBP51 promotes migration and invasion of papillary thyroid carcinoma through NF‑κB‑dependent epithelial‑to‑mesenchymal transition. Oncol Lett 16: 7020-7028, 2018.
APA
Gao, Y., Elamin, E., Zhou, R., Yan, H., Liu, S., Hu, S. ... Zhao, Y. (2018). FKBP51 promotes migration and invasion of papillary thyroid carcinoma through NF‑κB‑dependent epithelial‑to‑mesenchymal transition. Oncology Letters, 16, 7020-7028. https://doi.org/10.3892/ol.2018.9517
MLA
Gao, Y., Elamin, E., Zhou, R., Yan, H., Liu, S., Hu, S., Dong, J., Wei, M., Sun, L., Zhao, Y."FKBP51 promotes migration and invasion of papillary thyroid carcinoma through NF‑κB‑dependent epithelial‑to‑mesenchymal transition". Oncology Letters 16.6 (2018): 7020-7028.
Chicago
Gao, Y., Elamin, E., Zhou, R., Yan, H., Liu, S., Hu, S., Dong, J., Wei, M., Sun, L., Zhao, Y."FKBP51 promotes migration and invasion of papillary thyroid carcinoma through NF‑κB‑dependent epithelial‑to‑mesenchymal transition". Oncology Letters 16, no. 6 (2018): 7020-7028. https://doi.org/10.3892/ol.2018.9517
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