Clinicopathological features of T1 colorectal carcinomas with skip lymphovascular invasion

Sato,Yuta; Kudo,Shin‑Ei; Ichimasa,Katsuro; Matsudaira,Shingo; Kouyama,Yuta; Kato,Kazuki; Baba,Toshiyuki; Wakamura,Kunihiko; Hayashi,Takemasa; Kudo,Toyoki; Ogata,Noriyuki; Mori,Yuichi; Misawa,Masashi; Toyoshima,Naoya; Ishigaki,Tomoyuki; Yagawa,Yusuke; Nakamura,Hiroki; Sakurai,Tatsuya; Shakuo,Yukiko; Suzuki,Kenichi; Kudo,Yui; Hamatani,Shigeharu; Ishida,Fumio; Miyachi,Hideyuki

doi:10.3892/ol.2018.9527

Clinicopathological features of T1 colorectal carcinomas with skip lymphovascular invasion

Authors:
- Yuta Sato
- Shin‑Ei Kudo
- Katsuro Ichimasa
- Shingo Matsudaira
- Yuta Kouyama
- Kazuki Kato
- Toshiyuki Baba
- Kunihiko Wakamura
- Takemasa Hayashi
- Toyoki Kudo
- Noriyuki Ogata
- Yuichi Mori
- Masashi Misawa
- Naoya Toyoshima
- Tomoyuki Ishigaki
- Yusuke Yagawa
- Hiroki Nakamura
- Tatsuya Sakurai
- Yukiko Shakuo
- Kenichi Suzuki
- Yui Kudo
- Shigeharu Hamatani
- Fumio Ishida
- Hideyuki Miyachi
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Affiliations: Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224‑8503, Japan, Endoscopic Division, Kudo Clinic, Akita 010‑0001, Japan, Department of Pathology, Jikei University School of Medicine, Tokyo 105‑8471, Japan
Published online on: September 28, 2018 https://doi.org/10.3892/ol.2018.9527
Pages: 7264-7270

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Abstract

With recent advances in endoscopic treatment, many T1 colorectal carcinomas (CRCs) are resected endoscopically with a negative margin. However, some lesions exhibit skip lymphovascular invasion (SLVI), which is defined as the discontinuous foci of the tumor cells within the colon wall. The aim of the present study was to reveal the clinicopathological features of T1 CRCs with SLVI and validate the Japanese guidelines regarding SLVI. A total of 741 patients with T1 CRCs that were resected surgically between April 2001 and October 2016 in our hospital were divided into two groups: With SLVI and without SLVI. Clinicopathological features compared between the two groups were patient's gender, age, tumor size, location, morphology, lymphovascular invasion, tumor differentiation, tumor budding and lymph node metastasis. The incidence of T1 CRCs with SLVI was 0.9% (7/741). All cases with SLVI were found in the sigmoid colon or rectum. T1 CRCs with SLVI showed significantly higher rates of lymphovascular invasion than those without SLVI (P<0.01). In conclusion, lymphovascular invasion was a significant risk factor for SLVI in T1 CRCs, and for which surgical colectomy was necessary. The Japanese guidelines are appropriate regarding SLVI. Registered in the University Hospital Medical Network Clinical Trials Registry (UMIN000027097).

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