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Article

RASEF expression correlates with hormone receptor status in breast cancer

  • Authors:
    • Masahiro Shibata
    • Mitsuro Kanda
    • Dai Shimizu
    • Haruyoshi Tanaka
    • Shinichi Umeda
    • Takashi Miwa
    • Masamichi Hayashi
    • Takahiro Inaishi
    • Noriyuki Miyajima
    • Yayoi Adachi
    • Yuko Takano
    • Kenichi Nakanishi
    • Dai Takeuchi
    • Sumiyo Noda
    • Yasuhiro Kodera
    • Toyone Kikumori
  • View Affiliations / Copyright

    Affiliations: Department of Breast and Endocrine Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Aichi 466‑8550, Japan, Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Aichi 466‑8550, Japan
  • Pages: 7223-7230
    |
    Published online on: October 3, 2018
       https://doi.org/10.3892/ol.2018.9542
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Abstract

Breast cancer (BC) is the most frequently diagnosed malignant tumor in women worldwide, and the development of new molecules associated with BC is essential for the management of this disease. RAS and EF‑hand domain‑containing (RASEF) encodes the GTPase enzyme that belongs to the Rab family. Although the effects of this gene have been reported in several malignant tumor types, the role of RASEF in BC has not been completely elucidated. The aim of the present study was to investigate the importance of RASEF expression in BC. RASEF mRNA expression levels were evaluated in BC and non‑cancerous mammary cell lines. The association between RASEF mRNA expression levels and clinicopathological factors in 167 patients with BC were then determined. Among the 13 examined BC cell lines, ER‑negative/HER2‑negative cell lines expressed lower RASEF mRNA levels, when compared with the other examined cell lines (P=0.014). Of the 167 patients examined, patients with negative hormone receptor status exhibited significantly lower RASEF mRNA expression levels (P<0.001). In addition low RASEF expression in BC tissues was associated with negative estrogen receptor status (P<0.001), negative progesterone receptor status (P<0.001), and triple‑negative status (P<0.001). Additionally, although the differences were not statistically significant, patients with low RASEF expression levels exhibited poorer disease‑free survival (P=0.123) and overall survival (P=0.086) than other patients. The results of the present study indicate that RASEF mRNA expression levels are associated with hormone receptor status in BC.
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Copy and paste a formatted citation
Spandidos Publications style
Shibata M, Kanda M, Shimizu D, Tanaka H, Umeda S, Miwa T, Hayashi M, Inaishi T, Miyajima N, Adachi Y, Adachi Y, et al: RASEF expression correlates with hormone receptor status in breast cancer. Oncol Lett 16: 7223-7230, 2018.
APA
Shibata, M., Kanda, M., Shimizu, D., Tanaka, H., Umeda, S., Miwa, T. ... Kikumori, T. (2018). RASEF expression correlates with hormone receptor status in breast cancer. Oncology Letters, 16, 7223-7230. https://doi.org/10.3892/ol.2018.9542
MLA
Shibata, M., Kanda, M., Shimizu, D., Tanaka, H., Umeda, S., Miwa, T., Hayashi, M., Inaishi, T., Miyajima, N., Adachi, Y., Takano, Y., Nakanishi, K., Takeuchi, D., Noda, S., Kodera, Y., Kikumori, T."RASEF expression correlates with hormone receptor status in breast cancer". Oncology Letters 16.6 (2018): 7223-7230.
Chicago
Shibata, M., Kanda, M., Shimizu, D., Tanaka, H., Umeda, S., Miwa, T., Hayashi, M., Inaishi, T., Miyajima, N., Adachi, Y., Takano, Y., Nakanishi, K., Takeuchi, D., Noda, S., Kodera, Y., Kikumori, T."RASEF expression correlates with hormone receptor status in breast cancer". Oncology Letters 16, no. 6 (2018): 7223-7230. https://doi.org/10.3892/ol.2018.9542
Copy and paste a formatted citation
x
Spandidos Publications style
Shibata M, Kanda M, Shimizu D, Tanaka H, Umeda S, Miwa T, Hayashi M, Inaishi T, Miyajima N, Adachi Y, Adachi Y, et al: RASEF expression correlates with hormone receptor status in breast cancer. Oncol Lett 16: 7223-7230, 2018.
APA
Shibata, M., Kanda, M., Shimizu, D., Tanaka, H., Umeda, S., Miwa, T. ... Kikumori, T. (2018). RASEF expression correlates with hormone receptor status in breast cancer. Oncology Letters, 16, 7223-7230. https://doi.org/10.3892/ol.2018.9542
MLA
Shibata, M., Kanda, M., Shimizu, D., Tanaka, H., Umeda, S., Miwa, T., Hayashi, M., Inaishi, T., Miyajima, N., Adachi, Y., Takano, Y., Nakanishi, K., Takeuchi, D., Noda, S., Kodera, Y., Kikumori, T."RASEF expression correlates with hormone receptor status in breast cancer". Oncology Letters 16.6 (2018): 7223-7230.
Chicago
Shibata, M., Kanda, M., Shimizu, D., Tanaka, H., Umeda, S., Miwa, T., Hayashi, M., Inaishi, T., Miyajima, N., Adachi, Y., Takano, Y., Nakanishi, K., Takeuchi, D., Noda, S., Kodera, Y., Kikumori, T."RASEF expression correlates with hormone receptor status in breast cancer". Oncology Letters 16, no. 6 (2018): 7223-7230. https://doi.org/10.3892/ol.2018.9542
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