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Article Open Access

RBBP7 is a prognostic biomarker in patients with esophageal squamous cell carcinoma

  • Authors:
    • Ning Yu
    • Peng Zhang
    • Li Wang
    • Xinjia He
    • Shanshan Yang
    • Haijun Lu
  • View Affiliations / Copyright

    Affiliations: Department of Ultrasonography, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China, Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China, Department of Nursing, The Affiliated Qingdao Hiser Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China, Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7204-7211
    |
    Published online on: October 3, 2018
       https://doi.org/10.3892/ol.2018.9543
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Abstract

Retinoblastoma‑binding protein 7 (RBBP7) is an important component of several complexes that regulate chromatin metabolism. It is overexpressed in certain cancer types and serves conflicting roles in tumor progression. In the present study, the expression and roles of RBBP7 were explored in esophageal squamous cell carcinoma (ESCC). Immunohistochemical staining was used to detect RBBP7 expression in ESCC tissues. The mRNA sequencing profiles from the Cancer Genome Atlas and Genotype‑Tissue Expression databases were mined to analyze the mRNA expression of RBBP7 in tissues. Proliferation, clone formation, apoptosis and Transwell invasion/migration assays were performed to explore the roles of RBBP7 in ESCC. RBBP7 was highly expressed in ESCC tissues. The protein and mRNA expression levels of RBBP7 were significantly elevated in tumor tissues compared with paired adjacent normal tissues. RBBP7 overexpression was associated with a poor overall survival in patients with ESCC. Furthermore, higher RBBP7 expression was significantly correlated with poor tumor differentiation, advanced regional lymph node involvement, and pathological TNM staging. Knockdown of RBBP7 in ESCC cells did not affect tumor apoptosis or tumor growth. However, the overexpression of RBBP7 significantly enhanced the invasion and migration of ESCC cells, whereas the knockdown of RBBP7 resulted in significantly decreased invasion and migration. The present study indicated that RBBP7 is a novel biomarker and prognosticator for patients with ESCC. Furthermore, RBBP7 serves crucial roles in promoting ESCC invasion and migration.
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View References

1 

Enzinger PC and Mayer RJ: Esophageal cancer. N Engl J Med. 349:2241–2252. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Kleinberg L and Forastiere AA: Chemoradiation in the management of esophageal cancer. J Clin Oncol. 25:4110–4117. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Wouters MW, Karim-Kos HE, le Cessie S, Wijnhoven BP, Stassen LP, Steup WH, Tilanus HW and Tollenaar RA: Centralization of esophageal cancer surgery: Does it improve clinical outcome? Ann Surg Oncol. 16:1789–1798. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Brücher BL, Swisher SG, Königsrainer A, Zieker D, Hartmann J, Stein H, Kitagawa Y, Law S and Ajani JA: Response to preoperative therapy in upper gastrointestinal cancers. Ann Surg Oncol. 16:878–886. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Morita M, Yoshida R, Ikeda K, Egashira A, Oki E, Sadanaga N, Kakeji Y, Yamanaka T and Maehara Y: Advances in esophageal cancer surgery in Japan: An analysis of 1000 consecutive patients treated at a single institute. Surgery. 143:499–508. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Allemani C, Matsuda T, Di Carlo V, Harewood R, Matz M, Nikšić M, Bonaventure A, Valkov M, Johnson CJ, Estève J, et al: Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): Analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet. 391:1023–1075. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Millard CJ, Fairall L and Schwabe JW: Towards an understanding of the structure and function of MTA1. Cancer Metastasis Rev. 33:857–867. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Wu H, Moshkina N, Min J, Zeng H, Joshua J, Zhou MM and Plotnikov AN: Structural basis for substrate specificity and catalysis of human histone acetyltransferase 1. Proc Natl Acad Sci USA. 109:8925–8930. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Millard CJ, Varma N, Saleh A, Morris K, Watson PJ, Bottrill AR, Fairall L, Smith CJ and Schwabe JW: The structure of the core NuRD repression complex provides insights into its interaction with chromatin. Elife. 5:e139412016. View Article : Google Scholar : PubMed/NCBI

10 

Christov CP, Dingwell KS, Skehel M, Wilkes HS, Sale JE, Smith JC and Krude T: A NuRD complex from xenopus laevis eggs is essential for DNA replication during early embryogenesis. Cell Rep. 22:2265–2278. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Xin J, Li J, Feng Y, Wang L, Zhang Y and Yang R: Downregulation of long noncoding RNA HOTAIRM1 promotes monocyte/dendritic cell differentiation through competitively binding to endogenous miR-3960. Onco Targets Ther. 10:1307–1315. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Balboula AZ, Stein P, Schultz RM and Schindler K: Knockdown of RBBP7 unveils a requirement of histone deacetylation for CPC function in mouse oocytes. Cell Cycle. 13:600–611. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Giri R, Yeh HH, Wu CH and Liu HS: SUMO-1 overexpression increases RbAp46 protein stability and suppresses cell growth. Anticancer Res. 28:3749–3756. 2008.PubMed/NCBI

14 

Chen GC, Guan LS, Yu JH, Li GC, Choi Kim HR and Wang ZY: Rb-associated protein 46 (RbAp46) inhibits transcriptional transactivation mediated by BRCA1. Biochem Biophys Res Commun. 284:507–514. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Zhang TF, Yu SQ, Loggie BW and Wang ZY: Inducible expression of RbAp46 activates c-Jun NH2-terminal kinase-dependent apoptosis and suppresses progressive growth of tumor xenografts in nude mice. Anticancer Res. 23:4621–4627. 2003.PubMed/NCBI

16 

Li GC, Guan LS and Wang ZY: Overexpression of RbAp46 facilitates stress-induced apoptosis and suppresses tumorigenicity of neoplastigenic breast epithelial cells. Int J Cancer. 105:762–768. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Rico M, Mukherjee A, Konieczkowski M, Bruggeman LA, Miller RT, Khan S, Schelling JR and Sedor JR: WT1-interacting protein and ZO-1 translocate into podocyte nuclei after puromycin aminonucleoside treatment. Am J Physiol Renal Physiol. 289:F431–F441. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Li GC and Wang ZY: Constitutive expression of RbAp46 induces epithelial-mesenchymal transition in mammary epithelial cells. Anticancer Res. 26:3555–3560. 2006.PubMed/NCBI

19 

Yeh HH, Tseng YF, Hsu YC, Lan SH, Wu SY, Raghavaraju G, Cheng DE, Lee YR, Chang TY, Chow NH, et al: Ras induces experimental lung metastasis through up-regulation of RbAp46 to suppress RECK promoter activity. BMC Cancer. 15:1722015. View Article : Google Scholar : PubMed/NCBI

20 

Fu J, Qin L, He T, Qin J, Hong J, Wong J, Liao L and Xu J: The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis. Cell Res. 21:275–289. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yu N, Zhang P, Wang L, He X, Yang S and Lu H: RBBP7 is a prognostic biomarker in patients with esophageal squamous cell carcinoma. Oncol Lett 16: 7204-7211, 2018.
APA
Yu, N., Zhang, P., Wang, L., He, X., Yang, S., & Lu, H. (2018). RBBP7 is a prognostic biomarker in patients with esophageal squamous cell carcinoma. Oncology Letters, 16, 7204-7211. https://doi.org/10.3892/ol.2018.9543
MLA
Yu, N., Zhang, P., Wang, L., He, X., Yang, S., Lu, H."RBBP7 is a prognostic biomarker in patients with esophageal squamous cell carcinoma". Oncology Letters 16.6 (2018): 7204-7211.
Chicago
Yu, N., Zhang, P., Wang, L., He, X., Yang, S., Lu, H."RBBP7 is a prognostic biomarker in patients with esophageal squamous cell carcinoma". Oncology Letters 16, no. 6 (2018): 7204-7211. https://doi.org/10.3892/ol.2018.9543
Copy and paste a formatted citation
x
Spandidos Publications style
Yu N, Zhang P, Wang L, He X, Yang S and Lu H: RBBP7 is a prognostic biomarker in patients with esophageal squamous cell carcinoma. Oncol Lett 16: 7204-7211, 2018.
APA
Yu, N., Zhang, P., Wang, L., He, X., Yang, S., & Lu, H. (2018). RBBP7 is a prognostic biomarker in patients with esophageal squamous cell carcinoma. Oncology Letters, 16, 7204-7211. https://doi.org/10.3892/ol.2018.9543
MLA
Yu, N., Zhang, P., Wang, L., He, X., Yang, S., Lu, H."RBBP7 is a prognostic biomarker in patients with esophageal squamous cell carcinoma". Oncology Letters 16.6 (2018): 7204-7211.
Chicago
Yu, N., Zhang, P., Wang, L., He, X., Yang, S., Lu, H."RBBP7 is a prognostic biomarker in patients with esophageal squamous cell carcinoma". Oncology Letters 16, no. 6 (2018): 7204-7211. https://doi.org/10.3892/ol.2018.9543
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