Chromosome instability in neuroblastoma (Review)
- Pina Fusco
- Maria Rosaria Esposito
- Gian Paolo Tonini
Affiliations: Neuroblastoma Laboratory, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, I‑35127 Padua, Italy
- Published online on: October 3, 2018 https://doi.org/10.3892/ol.2018.9545
Copyright: © Fusco
et al. This is an open access article distributed under the
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Neuroblastoma is a neural crest‑derived tumor that accounts for 7‑10% of all malignancies in children and ~15% of all childhood cancer‑associated mortalities. Approximately 50% of patients are characterized as high‑risk (HR) and have an overall survival of <40% at 5 years from diagnosis. HR patients with unfavorable prognosis exhibit several structural copy number variations (CNVs), whereas localized tumors belonging to patients in the low‑ and intermediate‑risk classes, have favorable outcomes and display several numerical CNVs. Taken together these results are indicative of chromosome instability (CIN) in neuroblastoma tumor cells. The present review discusses multiple aspects of CIN including methods of measuring CIN, CIN targeting as a therapeutic strategy in cancer and the effects of CIN in neuroblastoma development and aggressiveness with particular emphasis on the CIN gene signature associated with HR neuroblastoma patients.