MicroRNA‑21 and its impact on signaling pathways in cervical cancer (Review)

  • Authors:
    • Yong Wang
    • Shiying Zhou
    • Kefeng Fan
    • Chen Jiang
  • View Affiliations

  • Published online on: February 1, 2019     https://doi.org/10.3892/ol.2019.10002
  • Pages: 3066-3070
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Oncogenic microRNA‑21 (miR‑21/miRNA‑21) is a stable inhibitor of gene expression that is often upregulated in cervical cancer, a disease that affects the health of women and tends to transform and spread. Previous studies investigating miR‑21 in biopsies and cells from cervical cancer patients have identified that miR‑21 binds target mRNAs in signaling pathways or long non‑coding RNAs (lncRNA). Furthermore, studies have elucidated the molecular mechanisms of two tumor necrosis factor α (TNF‑α) signaling pathways that promote cell proliferation and inhibit cell apoptosis. miR‑21 inhibits the TNF receptor 1 (TNFR1) signaling pathway and activates the TNFR2 signaling pathway. Moreover, miR‑21 enhances cervical cancer cell proliferation by influencing the protein kinase B/mammalian target of rapamycin and RAS p21 protein activator 1 signaling pathways. The present review discusses the evidence that miR‑21 may impact cervical cancer through inhibiting apoptosis and enhancing proliferation, and may therefore be a target for clinical intervention.
View Figures
View References

Related Articles

Journal Cover

March-2019
Volume 17 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Zhou S, Fan K and Jiang C: MicroRNA‑21 and its impact on signaling pathways in cervical cancer (Review). Oncol Lett 17: 3066-3070, 2019
APA
Wang, Y., Zhou, S., Fan, K., & Jiang, C. (2019). MicroRNA‑21 and its impact on signaling pathways in cervical cancer (Review). Oncology Letters, 17, 3066-3070. https://doi.org/10.3892/ol.2019.10002
MLA
Wang, Y., Zhou, S., Fan, K., Jiang, C."MicroRNA‑21 and its impact on signaling pathways in cervical cancer (Review)". Oncology Letters 17.3 (2019): 3066-3070.
Chicago
Wang, Y., Zhou, S., Fan, K., Jiang, C."MicroRNA‑21 and its impact on signaling pathways in cervical cancer (Review)". Oncology Letters 17, no. 3 (2019): 3066-3070. https://doi.org/10.3892/ol.2019.10002