Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
March-2019 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2019 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association of estradiol and HPV/HPV16 infection with the occurrence of cervical squamous cell carcinoma

  • Authors:
    • Ling Ding
    • Chunliang Liu
    • Qin Zhou
    • Meijuan Feng
    • Jintao Wang
  • View Affiliations / Copyright

    Affiliations: Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China
  • Pages: 3548-3554
    |
    Published online on: February 1, 2019
       https://doi.org/10.3892/ol.2019.10005
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The associations between human papillomavirus (HPV) infection or hormonal exposure and cervical cancer risk are well established. However, to the best of our knowledge, the association between high endogenous estradiol levels in conjunction with HPV/HPV16 infection and the risk of cervical squamous cell carcinoma remains unknown. To investigate this, the current study conducted a matched case‑control study in Shanxi Province, China, in which clinical samples were obtained from 74 females with newly diagnosed uterine cervix squamous cell carcinoma and 74 matched healthy females who were selected from 582 healthy females according to age, place of residence, marital status and menopausal status. From all participants, DNA was extracted from cells obtained from a cervical smear and serum was separated from venous blood withdrawn during days 5‑8 of the menstrual cycle. HPV/HPV16 DNA and estradiol expression levels in the serum were measured by general polymerase chain reaction and enzyme‑linked immunosorbent assay, respectively. Significant differences were identified in the positive HPV and HPV16 DNA expression rates between patients and controls, with odds ratios (95% confidence interval) of 3.74 (1.84‑7.59) and 4.04 (1.97‑8.28), respectively. Expression levels of estradiol in patients were significantly higher compared with the controls (P<0.001), however, this was only identified when the HPV16 E2 or E6 oncogene status was negative. Considering 40 ng/ml as the cut‑off estradiol level, 78.38% of patients exhibited high estradiol levels, which was significantly higher than the percentage of controls (P<0.001). An additive interaction pattern was revealed between estradiol expression levels and HPV/HPV16 infection. The results suggest that among the various types of HPV, HPV16 may be most likely to cause uterine cervix squamous cell carcinoma and an abnormally high level of endogenous estradiol may further increase this risk. Therefore, estradiol therapy may represent a new treatment strategy for cases of cervical cancer associated with HPV infection.
View Figures

Figure 1

Figure 2

View References

1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Skinner RS, Wheeler CM, Romanowski B, Castellsagué X, Lazcano-Ponce E, Del Rosario-Raymundo RM, Vallejos C, Minkina G, Pereira Da Silva D, McNeil S, et al: Progression of HPV infection to detectable cervical lesions or clearance in adult women: Analysis of the control arm of the VIVIANE study. Int J Cancer. 138:2428–2438. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Madeleine MM, Anttila T, Schwartz SM, Saikku P, Leinonen M, Carter JJ, Wurscher M, Johnson LG, Galloway DA and Daling JR: Risk of cervical cancer associated with Chlamydia trachomatis antibodies by histology, HPV type and HPV cofactors. Int J Cancer. 120:650–655. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Choi YJ and Park JS: Clinical significance of human papillomavirus genotyping. J Gynecol Oncol. 7:e212016. View Article : Google Scholar

6 

Egawa N, Egawa K, Griffin H and Doorbar J: Human papillomaviruses: epithelial tropisms, and the development of neoplasia. Viruses. 7:3863–3890. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Bellanger S, Tan CL, Xue YZ, Teissier S and Thierry F: Tumor suppressor or oncogene? A critical role of the human papillomavirus (HPV) E2 protein in cervical cancer progression. Am J Cancer Res. 1:373–389. 2011.PubMed/NCBI

8 

Doorbar J, Egawa N, Griffin H, Kranjec C and Murakami I: Human papillomavirus molecular biology and disease association. Rev Med Virol. 25 (Suppl 1):S2–S23. 2015. View Article : Google Scholar

9 

Wang JT, Ding L, Gao ES and Cheng YY: Analysis on the expression of human papillomavirus type 16 E2 and E6 oncogenes and disruption of E2 in cervical cancer. Zhonghua Liu Xing Bing Xue Za Zhi. 28:968–971. 2007.(In Chinese). PubMed/NCBI

10 

Missaoui N, Trabelsi A, Landolsi H, Jaidaine L, Mokni M, Korbi S and Hmissa S: Cervical adenocarcinoma and squamous cell carcinoma incidence trends among Tunisian women. Asian Pac J Cancer Prev. 11:777–780. 2010.PubMed/NCBI

11 

Wang SS, Sherman ME, Hildesheim A, Lacey JV Jr and Devesa S: Cervical adenocarcinoma and squamous cell carcinoma incidence trends among white women and black women in the United States for 1976–2000. Cancer. 100:1035–1044. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Auborn KJ, Woodworth C, DiPaolo JA and Bradlow HL: The interaction between HPV infection and estrogen metabolism in cervical carcinogenesis. Int J Cancer. 49:867–869. 1991. View Article : Google Scholar : PubMed/NCBI

13 

Newfield L, Bradlow HL, Sepkovic DW and Auborn K: Estrogen metabolism and the malignant potential of human papillomavirus immortalized keratinocytes. Proc Soc Exp Biol Med. 217:322–326. 1998. View Article : Google Scholar : PubMed/NCBI

14 

Moodley M, Moodley J, Chetty R and Herrington CS: The role of steroid contraceptive hormones in the pathogenesis of invasive cervical cancer: A review. Int J Gynecol Cancer. 13:103–110. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Salazar EL, Sojo-Aranda I, Lopez R and Salcedo M: The evidence for an etiological relationship between oral contraceptive use and dysplastic change in cervical tissue. Gynecol Endocrinol. 15:23–28. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Muñoz N, Franceschi S, Bosetti C, Moreno V, Herrero R, Smith JS, Shah KV, Meijer CJ and Bosch FX;: International Agency for Research on Cancer (IARC) Multicentric Cervical Cancer Study Group: Role of parity and human papillomavirus in cervical cancer: The IARC multicentric case-control study. Lancet. 359:1093–1101. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Plapinger L and Bern HA: Adenosis-like lesions and other cervicovaginal abnormalities in mice treated perinatally with estrogen. J Natl Cancer Inst. 63:507–518. 1979.PubMed/NCBI

18 

McLachlan JA, Newbold RR and Bullock BC: Long-term effects on the female mouse genital tract associated with prenatal exposure to diethylstilbestrol. Cancer Res. 40:3988–3999. 1980.PubMed/NCBI

19 

Liu Y, Tian LB, Yang HY and Zhang HP: Effects of estradiol and progesterone on the growth of HeLa cervical cancer cells. Eur Rev Med Pharmacol Sci. 21:3959–3965. 2017.PubMed/NCBI

20 

Brake T and Lambert PF: Estrogen contributes to the onset, persistence, and malignant progression of cervical cancer in a human papillomavirus-transgenic mouse model. Proc Natl Acad Sci USA. 102:2490–2495. 2005. View Article : Google Scholar : PubMed/NCBI

21 

den Boon JA, Pyeon D, Wang SS, Horswill M, Schiffman M, Sherman M, Zuna RE, Wang Z, Hewitt SM, Pearson R, et al: Molecular transitions from papillomavirus infection to cervical precancer and cancer: Role of stromal estrogen receptor signaling. Proc Natl Acad Sci USA. 112:E3255–E3264. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Zhang SK, Kang LN, Chang IJ, Zhao FH, Hu SY, Chen W, Shi JF, Zhang X, Pan QJ, Li SM, et al: The natural history of cervical cancer in Chinese women: results from an 11-year follow-up study in china using a multistate model. Cancer Epidemiol Biomarkers Prev. 23:1298–1305. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Sambrook J and Russell DW: Purification of nucleic acids by extraction with phenol:chloroform. CSH Protoc. 2006(pii): pdb.prot4455. 2006.

24 

Yoshikawa H, Kawana T, Kitagawa K, Mizuno M, Yoshikura H and Iwamoto A: Detection and typing of multiple genital human papillomaviruses by DNA amplification with consensus primers. Jpn J Cancer Res. 82:524–531. 1991. View Article : Google Scholar : PubMed/NCBI

25 

Badaracco G, Venuti A, Sedati A and Marcante ML: HPV16 and HPV18 in genital tumors: Significantly different levels of viral integration and correlation to tumor invasiveness. J Med Virol. 67:574–582. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Knol MJ and VanderWeele TJ: Recommendations for presenting analyses of effect modification and interaction. Int J Epidemiol. 41:514–520. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Rothman KJ, Greenland S and Lash TL: Chapter 5 Concepts of Interaction. In: Modern epidemiology. Lippincott Williams & Wilkins. 2008.

28 

Goodman MT, Shvetsov YB, McDuffie K, Wilkens LR, Zhu X, Ning L, Killeen J, Kamemoto L and Hernandez BY: Acquisition of anal human papillomavirus (HPV) infection in women: The Hawaii HPV Cohort study. J Infect Dis. 197:957–966. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Shvetsov YB, Hernandez BY, McDuffie K, Wilkens LR, Zhu X, Ning L, Killeen J, Kamemoto L and Goodman MT: Duration and clearance of anal human papillomavirus (HPV) infection among women: The Hawaii HPV cohort study. Clin Infect Dis. 48:536–546. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Chen HC, Schiffman M, Lin CY, Pan MH, You SL, Chuang LC, Hsieh CY, Liaw KL, Hsing AW, Chen CJ, et al: Persistence of type-specific human papillomavirus infection and increased long-term risk of cervical cancer. J Natl Cancer Inst. 103:1387–1396. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Byun JM, Jeong DH, Kim YN, Jung EJ, Lee KB, Sung MS and Kim KT: Persistent HPV-16 infection leads to recurrence of high-grade cervical intraepithelial neoplasia. Medicine (Baltimore). 97:e136062018. View Article : Google Scholar : PubMed/NCBI

32 

Dai M, Bao YP, Li N, Clifford GM, Vaccarella S, Snijders PJ, Huang RD, Sun LX, Meijer CJ, Qiao YL and Franceschi S: Human papillomavirus infection in Shanxi Province, People's Republic of China: A population-based study. Br J Cancer. 95:96–101. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Guo J, Zhao F, Liu R and Mu Y: Prevalence and type distribution of human papillomavirus infection in women from Datong, China. Scand J Infect Dis. 42:72–75. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Briolat J, Dalstein V, Saunier M, Joseph K, Caudroy S, Prétet JL, Birembaut P and Clavel C: HPV prevalence, viral load and physical state of HPV-16 in cervical smears of patients with different grades of CIN. Int J Cancer. 121:2198–2204. 2010. View Article : Google Scholar

35 

Luhn P, Walker J, Schiffman M, Zuna RE, Dunn ST, Gold MA, Smith K, Mathews C, Allen RA, Zhang R, et al: The role of co-factors in the progression from human papillomavirus infection to cervical cancer. Gynecol Oncol. 128:265–270. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Moreno V, Bosch FX, Munoz N, Meijer CJ, Shah KV, Walboomers JM, Herrero R and Franceschi S;: International Agency for Research on Cancer. Multicentric Cervical Cancer Study Group: Effect of oral contraceptives on risk of cervical cancer in women with human papillomavirus infection: The IARC multicentric case-control study. Lancet. 359:1085–1092. 2002. View Article : Google Scholar : PubMed/NCBI

37 

Santos Filho MV, Gurgel AP, Lobo CD, Freitas AC, Silva-Neto JC and Silva LA: Prevalence of human papillomavirus (HPV), distribution of HPV types, and risk factors for infection in HPV-positive women. Genet Mol Res. 15:2016. View Article : Google Scholar : PubMed/NCBI

38 

Siristatidis C, Sergentanis TN, Kanavidis P, Trivella M, Sotiraki M, Mavromatis I, Psaltopoulou T, Skalkidou A and Petridou ET: Controlled ovarian hyperstimulation for IVF: Impact on ovarian, endometrial and cervical cancer-a systematic review and meta-analysis. Hum Reprod Update. 19:105–123. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Lundqvist M, Westin C, Lundkvist O, Simberg N, Strand A, Andersson S and Wilander E: Cytologic screening and human papilloma virus test in women undergoing artificial fertilization. Acta Obstet Gynecol Scand Oct. 81:949–953. 2002. View Article : Google Scholar

40 

International Collaboration of Epidemiological Studies of Cervical Cancer, ; Appleby P, Beral V, Berrington de González A, Colin D, Franceschi S, Goodhill A, Green J, Peto J, Plummer M and Sweetland S: Cervical cancer and hormonal contraceptives: collaborative reanalysis of individual data for 16,573 women with cervical cancer and 35,509 women without cervical cancer from 24 epidemiological studies. Lancet. 370:1609–1621. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Rinaldi S, Plummer M, Biessy C, Castellsagué X, Overvad K, Krüger Kjær S, Tjønneland A, Clavel-Chapelon F, Chabbert-Buffet N, Mesrine S, et al: Endogenous sex steroids and risk of cervical carcinoma: results from the EPIC study. Cancer Epidemiol Biomarkers Prev. 20:2532–2540. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Shields TS, Falk RT, Herrero R, Schiffman M, Weiss NS, Bratti C, Rodriguez AC, Sherman ME, Burk RD and Hildesheim A: A case-control study of endogenous hormones and cervical cancer. Br J Cancer. 90:146–152. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Spurgeon ME, den Boon JA, Horswill M, Barthakur S, Forouzan O, Rader JS, Beebe DJ, Roopra A, Ahlquist P and Lambert PF: Human papillomavirus oncogenes reprogram the cervical cancer microenvironment independently of and synergistically with estrogen. Proc Natl Acad Sci USA. 114:E9076–E9085. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Kuhl H: Pharmacology of estrogens and progestogens: Influence of different routes of administration. Climacteric. 8 (Suppl 1):S3–S63. 2005. View Article : Google Scholar

45 

Adurthi S, Kumar MM, Vinodkumar HS, Mukherjee G, Krishnamurthy H, Acharya KK, Bafna UD, Uma DK, Abhishekh B, Krishna S, et al: Oestrogen receptor-α binds the FOXP3 promoter and modulates regulatory T-cell function in human cervical cancer. Sci Rep. 7:172892017. View Article : Google Scholar : PubMed/NCBI

46 

Blachon S and Demeret C: The regulatory E2 proteins of human genital papillomaviruses are pro-apoptotic. Biochimie. 85:813–819. 2003. View Article : Google Scholar : PubMed/NCBI

47 

Riley RR, Duensing S, Brake T, Münger K, Lambert PF and Arbeit JM: Dissection of human papillomavirus E6 and E7 function in transgenic mouse models of cervical carcinogenesis. Cancer Res. 63:4862–4871. 2003.PubMed/NCBI

48 

Shai A, Brake T, Somoza C and Lambert PF: The human papillomavirus E6 oncogene dysregulates the cell cycle and contributes to cervical carcinogenesis through two independent activities. Cancer Res. 67:1626–1635. 2007. View Article : Google Scholar : PubMed/NCBI

49 

Arbeit JM, Howley PM and Hanahan D: Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice. Proc Natl Acad Sci USA. 93:2930–2935. 1996. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ding L, Liu C, Zhou Q, Feng M and Wang J: Association of estradiol and HPV/HPV16 infection with the occurrence of cervical squamous cell carcinoma. Oncol Lett 17: 3548-3554, 2019.
APA
Ding, L., Liu, C., Zhou, Q., Feng, M., & Wang, J. (2019). Association of estradiol and HPV/HPV16 infection with the occurrence of cervical squamous cell carcinoma. Oncology Letters, 17, 3548-3554. https://doi.org/10.3892/ol.2019.10005
MLA
Ding, L., Liu, C., Zhou, Q., Feng, M., Wang, J."Association of estradiol and HPV/HPV16 infection with the occurrence of cervical squamous cell carcinoma". Oncology Letters 17.3 (2019): 3548-3554.
Chicago
Ding, L., Liu, C., Zhou, Q., Feng, M., Wang, J."Association of estradiol and HPV/HPV16 infection with the occurrence of cervical squamous cell carcinoma". Oncology Letters 17, no. 3 (2019): 3548-3554. https://doi.org/10.3892/ol.2019.10005
Copy and paste a formatted citation
x
Spandidos Publications style
Ding L, Liu C, Zhou Q, Feng M and Wang J: Association of estradiol and HPV/HPV16 infection with the occurrence of cervical squamous cell carcinoma. Oncol Lett 17: 3548-3554, 2019.
APA
Ding, L., Liu, C., Zhou, Q., Feng, M., & Wang, J. (2019). Association of estradiol and HPV/HPV16 infection with the occurrence of cervical squamous cell carcinoma. Oncology Letters, 17, 3548-3554. https://doi.org/10.3892/ol.2019.10005
MLA
Ding, L., Liu, C., Zhou, Q., Feng, M., Wang, J."Association of estradiol and HPV/HPV16 infection with the occurrence of cervical squamous cell carcinoma". Oncology Letters 17.3 (2019): 3548-3554.
Chicago
Ding, L., Liu, C., Zhou, Q., Feng, M., Wang, J."Association of estradiol and HPV/HPV16 infection with the occurrence of cervical squamous cell carcinoma". Oncology Letters 17, no. 3 (2019): 3548-3554. https://doi.org/10.3892/ol.2019.10005
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team