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Experimental and clinicopathological analysis of HOXB9 in gastric cancer

  • Authors:
    • Fumihiko Kato
    • Norihito Wada
    • Tetsu Hayashida
    • Kazumasa Fukuda
    • Rieko Nakamura
    • Tsunehiro Takahashi
    • Hirofumi Kawakubo
    • Hiroya Takeuchi
    • Yuko Kitagawa
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Keio University School of Medicine, Tokyo 160‑8582, Japan
    Copyright: © Kato et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3097-3102
    |
    Published online on: February 4, 2019
       https://doi.org/10.3892/ol.2019.10008
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Abstract

The association between homeobox (HOX)B9 expression and tumor malignancy was identified recently. It was reported that HOXB9 induced tumor angiogenesis, and associated with poor prognosis in patients with breast and colon cancer. On the other hand, regional lymph nodes are the most common site of tumor spread, and lymph node metastasis is a major prognostic factor in gastric cancer. It was hypothesized that HOXB9 promotes tumor lymphangiogenesis and induces tumor progression, invasion and metastasis in gastric cancer. The aim of the present study was to evaluate the correlation between HOXB9 expression, prognosis and clinicopathologic factors in patients with gastric cancer, and to assess the contribution of HOXB9 expression to tumor cell lymphangiogenesis in vitro. HOXB9 expression was evaluated by immunohistochemistry in resected tumor tissues from 58 patients with gastric cancer, and the association between prognosis and clinicopathologic factors was determined. HOXB9 gene was overexpressed in human gastric cancer TMK‑1 cells and the effect of HOXB9 overexpression on the expression of vascular endothelial growth factor (VEGF)‑C, VEGF‑D and VEGF receptor (R)‑3 was determined. It was demonstrated that the depth of tumor invasion, the number of node metastases, lymphatic invasion and vascular invasion were significantly associated with HOXB9 expression. Overall survival was decreased in patients with HOXB9 expression. The mRNA expression of VEGF‑D but not of VEGF‑C and VEGFR‑3 was increased in HOXB9‑overexpressing TMK‑1 cells compared with control cells. In conclusion, HOXB9 expression was positively correlated with gastric cancer progression and lymphangiogenesis marker expression. HOXB9 may be associated with lymphogenic metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Kato F, Wada N, Hayashida T, Fukuda K, Nakamura R, Takahashi T, Kawakubo H, Takeuchi H and Kitagawa Y: Experimental and clinicopathological analysis of HOXB9 in gastric cancer. Oncol Lett 17: 3097-3102, 2019.
APA
Kato, F., Wada, N., Hayashida, T., Fukuda, K., Nakamura, R., Takahashi, T. ... Kitagawa, Y. (2019). Experimental and clinicopathological analysis of HOXB9 in gastric cancer. Oncology Letters, 17, 3097-3102. https://doi.org/10.3892/ol.2019.10008
MLA
Kato, F., Wada, N., Hayashida, T., Fukuda, K., Nakamura, R., Takahashi, T., Kawakubo, H., Takeuchi, H., Kitagawa, Y."Experimental and clinicopathological analysis of HOXB9 in gastric cancer". Oncology Letters 17.3 (2019): 3097-3102.
Chicago
Kato, F., Wada, N., Hayashida, T., Fukuda, K., Nakamura, R., Takahashi, T., Kawakubo, H., Takeuchi, H., Kitagawa, Y."Experimental and clinicopathological analysis of HOXB9 in gastric cancer". Oncology Letters 17, no. 3 (2019): 3097-3102. https://doi.org/10.3892/ol.2019.10008
Copy and paste a formatted citation
x
Spandidos Publications style
Kato F, Wada N, Hayashida T, Fukuda K, Nakamura R, Takahashi T, Kawakubo H, Takeuchi H and Kitagawa Y: Experimental and clinicopathological analysis of HOXB9 in gastric cancer. Oncol Lett 17: 3097-3102, 2019.
APA
Kato, F., Wada, N., Hayashida, T., Fukuda, K., Nakamura, R., Takahashi, T. ... Kitagawa, Y. (2019). Experimental and clinicopathological analysis of HOXB9 in gastric cancer. Oncology Letters, 17, 3097-3102. https://doi.org/10.3892/ol.2019.10008
MLA
Kato, F., Wada, N., Hayashida, T., Fukuda, K., Nakamura, R., Takahashi, T., Kawakubo, H., Takeuchi, H., Kitagawa, Y."Experimental and clinicopathological analysis of HOXB9 in gastric cancer". Oncology Letters 17.3 (2019): 3097-3102.
Chicago
Kato, F., Wada, N., Hayashida, T., Fukuda, K., Nakamura, R., Takahashi, T., Kawakubo, H., Takeuchi, H., Kitagawa, Y."Experimental and clinicopathological analysis of HOXB9 in gastric cancer". Oncology Letters 17, no. 3 (2019): 3097-3102. https://doi.org/10.3892/ol.2019.10008
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