Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
March-2019 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2019 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Establishment of multiple diagnosis models for colorectal cancer with artificial neural networks

  • Authors:
    • Qiang Wang
    • Jianchang Wei
    • Zhuanpeng Chen
    • Tong Zhang
    • Junbin Zhong
    • Bingzheng Zhong
    • Ping Yang
    • Wanglin Li
    • Jie Cao
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Guangzhou Digestive Disease Centre, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong 510000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3314-3322
    |
    Published online on: February 4, 2019
       https://doi.org/10.3892/ol.2019.10010
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The current study aimed to develop multiple diagnosis models for colorectal cancer (CRC) based on data from The Cancer Genome Atlas database and analysis with artificial neural networks in order to enhance CRC diagnosis methods. A genetic algorithm and mean impact value were used to select genes to be used as numerical encoded parameters to reflect cancer metastasis or aggression. Back propagation and learning vector quantization neural networks were used to build four diagnosis models: Cancer/Normal, M0/M1, carcinoembryonic antigen (CEA) <5/≥5 and Clinical stage I‑II/III‑IV. The performance of each model was evaluated by predictive accuracy (ACC), the area under the receiver operating characteristic curve (AUC) and a 10‑fold cross‑validation test. The ACC and AUC of the Cancer/Normal, M0/M1, CEA and Clinical stage models were 100%, 1.000; 87.14%, 0.670; 100%, 1.000; and 100%, 1.000, respectively. The 10‑fold cross‑validation test of the ACC values and sensitivity for each test were 93.75‑99.39%, 1.0000; 80.58‑88.24%, 0.9286‑1.0000; 67.21‑92.31%, 0.7091‑1.0000; and 59.13‑68.85%, 0.6017‑0.6585, respectively. The diagnosis models developed in the current study combined gene expression profiling data and artificial intelligence algorithms to create tools for improved diagnosis of CRC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Chen W, Zheng R, Zhang S, Zeng H, Xia C, Zuo T, Yang Z, Zou X and He J: Cancer incidence and mortality in China, 2013. Cancer Letters. 401:63–71. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Quah HM, Chou JF, Gonen M, Shia J, Schrag D, Landmann RG, Guillem JG, Paty PB, Temple LK, Wong WD and Weiser MR: Identification of patients with high-risk stage II colon cancer for adjuvant therapy. Dis Colon Rectum. 51:503–507. 2008. View Article : Google Scholar : PubMed/NCBI

5 

de Gramont A, Hubbard J, Shi Q, O'Connell MJ, Buyse M, Benedetti J, Bot B, O'Callaghan C, Yothers G, Goldberg RM, et al: Association between disease-free survival and overall survival when survival is prolonged after recurrence in patients receiving cytotoxic adjuvant therapy for colon cancer: Simulations based on the 20,800 Patient ACCENT Data Set. J Clin Oncol Official. 28:460–465. 2010. View Article : Google Scholar

6 

Saghapour E and Sehhati M: Prediction of metastasis in advanced colorectal carcinomas using CGH data. J Theor Biol. 429:116–123. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Chen YD, Zheng S, Yu JK and Hu X: Artificial neural networks analysis of surface-enhanced laser desorption/ionization mass spectra of serum protein pattern distinguishes colorectal cancer from healthy population. Clin Cancer Res. 10:8380–8385. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Hagan MT, Demuth HB and Beale M: Neural network design. InWseas International Conference on Circuits. 357:1997.

9 

Kuan CM: Artificial Neural Networks. Ieas Working Paper Academic Research. 1:1–23. 2006.

10 

Shi HY, Lee KT, Wang JJ, Sun DP, Lee HH and Chiu CC: Artificial neural network model for predicting 5-year mortality after surgery for hepatocellular carcinoma: A nationwide study. J Gastrointest Surg. 16:2126–2131. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Spelt L, Nilsson J, Andersson R and Andersson B: Artificial neural networks-a method for prediction of survival following liver resection for colorectal cancer metastases. Eur J Surg Oncol. 39:648–654. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Tsao CW, Liu CY, Cha TL, Wu ST, Sun GH, Yu DS, Chen HI, Chang SY, Chen SC and Hsu CY: Artificial neural network for predicting pathological stage of clinically localized prostate cancer in a Taiwanese population. J Chin Med Assoc. 77:513–518. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Hu HP, Niu ZJ, Bai YP and Tan XH: Cancer classification based on gene expression using neural networks. Genet Mol Res. 14:17605–17611. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Peng JH, Fang YJ, Li CX, Ou QJ, Jiang W, Lu SX, Lu ZH, Li PX, Yun JP, Zhang RX, et al: A scoring system based on artificial neural network for predicting 10-year survival in stage II A colon cancer patients after radical surgery. Oncotarget. 7:22939–22947. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Cancer Genome Atlas Network: Comprehensive molecular characterization of human colon and rectal cancer. Nature. 487:330–337. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Whitley D: A genetic algorithm tutorial. Stat Comput. 4:65–85. 1994. View Article : Google Scholar

17 

Shaefer CG: Genetic algorithm. Springer. (New York, NY). 8191993.

18 

Mitchell M, Forrest S and Holland JH: The royal road for genetic algorithms: Fitness landscapes and GA Performance. In: Proceedings of the First European Conference on Artificial Life. MIT Press. (Cambridge, MA). 245–254. 1992.PubMed/NCBI

19 

Zhang X, Zhang X, Li Q, Sun Z, Song L and Sun T: Support vector machine applied to study on quantitative structure-retention relationships of polybrominated diphenyl ether congeners. Chromatographia. 77:1387–1398. 2014. View Article : Google Scholar

20 

Jalaliheravi M and Kyani A: Application of genetic algorithm-kernel partial least square as a novel nonlinear feature selection method: Activity of carbonic anhydrase II inhibitors. Eur J Med Chem. 42:649–659. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Fu ZG, Qi MF and Jing Y: Regression forecast of main steam flow based on mean impact value and support vector regression. In: Proceedings of Asia Pacific Power and Energy Engineering Conference. IEEE. (Shanghai). 1–5. 2012.

22 

Jiang JL, Su X, Zhang H, Zhang XH and Yuan YJ: A novel approach to active compounds identification based on support vector regression model and mean impact value. Chem Biol Drug Des. 81:650–657. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Hagan MT and Beale M: Neural network design China Machine Press. 2002.

24 

Hassoun MH: Fundamentals of artificial neural networks. Proceedings of the IEEE. 84:9061996. View Article : Google Scholar

25 

Boubaker M, Khalifa KB, Girau B, Dogui M and Bedoui MH: On-line arithmetic based reprogrammable hardware implementation of LVQ neural network for alertness classification. IJCSNS Int J Comput Science Netw Secur. 8:260–266. 2008.

26 

Jiang FN, He HC, Zhang YQ, Yang DL, Huang JH, Zhu YX, Mo RJ, Chen G, Yang SB, Chen YR, et al: An integrative proteomics and interaction network-based classifier for prostate cancer diagnosis. PLoS One. 8:e639412013. View Article : Google Scholar : PubMed/NCBI

27 

Baldi P, Brunak S, Chauvin Y, Andersen CA and Nielsen H: Assessing the accuracy of prediction algorithms for classification: An overview. Bioinformatics. 16:412–424. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Sun Y and Goodison S: Optimizing molecular signatures for predicting prostate cancer recurrence. Prostate. 69:1119–1127. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Heinzerling JH, Anthony T, Livingston EH and Huerta S: Predictors of distant metastasis and mortality in patients with stage II colorectal cancer. Am Surg. 73:230–238. 2007.PubMed/NCBI

30 

He F, Chen H, Yang P. Wu Q, Zhang T, Wang C, Wei J, Chen Z, Hu H, Li W and Cao J: Gankyrin sustains PI3K/GSK-3β/β-catenin signal activation and promotes colorectal cancer aggressiveness and progression. Oncotarget. 7:81156–81171. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Akkoca AN, Yanık S, Ozdemir ZT, Cihan FG, Sayar S, Cincin TG, Cam A and Ozer C: TNM and modified dukes staging along with the demographic characteristics of patients with colorectal carcinoma. Int J Clin Exp Med. 7:2828–2835. 2014.PubMed/NCBI

32 

Ullenhag GJ, Frödin JE, Jeddi-Tehrani M, Strigard K, Eriksson E, Samanci A, Choudhury A, Nilsson B, Rossmann ED, Mosolits S and Mellstedt H: Durable carcinoembryonic antigen (CEA)-specific humoral and cellular immune responses in colorectal carcinoma patients vaccinated with recombinant CEA and granulocyte/macrophage colony-stimulating factor. Clin Cancer Res. 10:3273–3281. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Spindler KLG, Christensen IJ, Nielsen HJ, Jakobsen A and Brünner N: TIMP-1 and CEA as biomarkers in third-line treatment with irinotecan and cetuximab for metastatic colorectal cancer. Tumour Biol. 36:4301–4308. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Aldulaymi B, Christensen IJ, Sölétormos G, Jess P, Nielsen SE, Brünner N and Nielsen HJ: Changes in soluble CEA and TIMP-1 levels during adjuvant chemotherapy for stage III colon cancer. Anticancer Res. 30:233–237. 2010.PubMed/NCBI

35 

Liu LG, Yan XB, Xie RT, Jin ZM and Yang Y: Stromal expression of vimentin predicts the clinical outcome of stage II colorectal cancer for high-risk patients. Med Sci Monit. 23:28972017. View Article : Google Scholar : PubMed/NCBI

36 

Lee KW, Lee SS, Kim SB, Sohn BH, Lee HS, Jang HJ, Park YY, Kopetz S, Kim SS, Oh SC and Lee JS: Significant association of oncogene YAP1 with poor prognosis and cetuximab resistance in colorectal cancer patients. Clin Cancer Res. 21:357–364. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang Q, Wei J, Chen Z, Zhang T, Zhong J, Zhong B, Yang P, Li W and Cao J: Establishment of multiple diagnosis models for colorectal cancer with artificial neural networks. Oncol Lett 17: 3314-3322, 2019.
APA
Wang, Q., Wei, J., Chen, Z., Zhang, T., Zhong, J., Zhong, B. ... Cao, J. (2019). Establishment of multiple diagnosis models for colorectal cancer with artificial neural networks. Oncology Letters, 17, 3314-3322. https://doi.org/10.3892/ol.2019.10010
MLA
Wang, Q., Wei, J., Chen, Z., Zhang, T., Zhong, J., Zhong, B., Yang, P., Li, W., Cao, J."Establishment of multiple diagnosis models for colorectal cancer with artificial neural networks". Oncology Letters 17.3 (2019): 3314-3322.
Chicago
Wang, Q., Wei, J., Chen, Z., Zhang, T., Zhong, J., Zhong, B., Yang, P., Li, W., Cao, J."Establishment of multiple diagnosis models for colorectal cancer with artificial neural networks". Oncology Letters 17, no. 3 (2019): 3314-3322. https://doi.org/10.3892/ol.2019.10010
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Q, Wei J, Chen Z, Zhang T, Zhong J, Zhong B, Yang P, Li W and Cao J: Establishment of multiple diagnosis models for colorectal cancer with artificial neural networks. Oncol Lett 17: 3314-3322, 2019.
APA
Wang, Q., Wei, J., Chen, Z., Zhang, T., Zhong, J., Zhong, B. ... Cao, J. (2019). Establishment of multiple diagnosis models for colorectal cancer with artificial neural networks. Oncology Letters, 17, 3314-3322. https://doi.org/10.3892/ol.2019.10010
MLA
Wang, Q., Wei, J., Chen, Z., Zhang, T., Zhong, J., Zhong, B., Yang, P., Li, W., Cao, J."Establishment of multiple diagnosis models for colorectal cancer with artificial neural networks". Oncology Letters 17.3 (2019): 3314-3322.
Chicago
Wang, Q., Wei, J., Chen, Z., Zhang, T., Zhong, J., Zhong, B., Yang, P., Li, W., Cao, J."Establishment of multiple diagnosis models for colorectal cancer with artificial neural networks". Oncology Letters 17, no. 3 (2019): 3314-3322. https://doi.org/10.3892/ol.2019.10010
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team