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Article Open Access

Integrated analysis of lncRNA CTD‑2357A8.3 expression and its potential roles in head and neck squamous cell carcinoma

  • Authors:
    • Bo Zou
    • Xin Guan
    • Wen Zhang
    • Dong Wang
    • Kai Xu
    • Dao‑Ying Yuan
    • Zhen Meng
    • Bin Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Liaocheng People's Hospital, Medical College of Liaocheng University, Liaocheng, Shandong 252000, P.R. China, Key Laboratory of Oral Maxillofacial‑Head and Neck Medical Biology of Shandong Province, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China
    Copyright: © Zou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6371-6378
    |
    Published online on: September 25, 2019
       https://doi.org/10.3892/ol.2019.10920
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Abstract

Head and neck squamous cell carcinoma (HNSCC), one of the most common malignant tumors, endangers human health. Recently, the incidence of HNSCC has kept increasing: However, its prognosis has not significantly improved. Understanding the molecular mechanism underlying HNSCC development will therefore provide new strategies for therapy. The present study attempted to identify differentially expressed (DE) long non‑coding (lnc)RNAs and investigated their functional role in HNSCC development. Expression profiles of HNSCC and normal samples were downloaded from The Cancer Genome Atlas (TCGA) database. DElncRNAs between the HNSCC and normal samples were highlighted and their potential functions were investigated through lncRNA‑micro (mi)RNA‑mRNA network by using Gene Expression Profiling Interactive Analysis, UALCAN, DIANA‑LncBase v.2 and miRWalk 3.0 databases. A total of 343 dysregulated lncRNAs were identified. Among these DElncRNAs, CTD‑2357A8.3 had the highest fold‑change and was significantly associated with poor overall survival in patients with HNSCC. Furthermore, CTD‑2357A8.3 was associated with ‘signaling pathways regulating stem cell pluripotency’, ‘proteoglycans in cancer’, ‘transcriptional misregulation in cancer’ and ‘chemokine signaling pathway’. Further analysis demonstrated that CTD‑2357A8.3 acted as a ‘sponge’ in order to competitively adsorb miRNA to regulate the expression of target gene caveolin 1 (CAV1) in HNSCC. In conclusion, CTD‑2357A8.3 may be considered a promising diagnosis biomarker or a therapeutic target for the treatment of HNSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Zou B, Guan X, Zhang W, Wang D, Xu K, Yuan DY, Meng Z and Zhang B: Integrated analysis of lncRNA CTD‑2357A8.3 expression and its potential roles in head and neck squamous cell carcinoma. Oncol Lett 18: 6371-6378, 2019.
APA
Zou, B., Guan, X., Zhang, W., Wang, D., Xu, K., Yuan, D. ... Zhang, B. (2019). Integrated analysis of lncRNA CTD‑2357A8.3 expression and its potential roles in head and neck squamous cell carcinoma. Oncology Letters, 18, 6371-6378. https://doi.org/10.3892/ol.2019.10920
MLA
Zou, B., Guan, X., Zhang, W., Wang, D., Xu, K., Yuan, D., Meng, Z., Zhang, B."Integrated analysis of lncRNA CTD‑2357A8.3 expression and its potential roles in head and neck squamous cell carcinoma". Oncology Letters 18.6 (2019): 6371-6378.
Chicago
Zou, B., Guan, X., Zhang, W., Wang, D., Xu, K., Yuan, D., Meng, Z., Zhang, B."Integrated analysis of lncRNA CTD‑2357A8.3 expression and its potential roles in head and neck squamous cell carcinoma". Oncology Letters 18, no. 6 (2019): 6371-6378. https://doi.org/10.3892/ol.2019.10920
Copy and paste a formatted citation
x
Spandidos Publications style
Zou B, Guan X, Zhang W, Wang D, Xu K, Yuan DY, Meng Z and Zhang B: Integrated analysis of lncRNA CTD‑2357A8.3 expression and its potential roles in head and neck squamous cell carcinoma. Oncol Lett 18: 6371-6378, 2019.
APA
Zou, B., Guan, X., Zhang, W., Wang, D., Xu, K., Yuan, D. ... Zhang, B. (2019). Integrated analysis of lncRNA CTD‑2357A8.3 expression and its potential roles in head and neck squamous cell carcinoma. Oncology Letters, 18, 6371-6378. https://doi.org/10.3892/ol.2019.10920
MLA
Zou, B., Guan, X., Zhang, W., Wang, D., Xu, K., Yuan, D., Meng, Z., Zhang, B."Integrated analysis of lncRNA CTD‑2357A8.3 expression and its potential roles in head and neck squamous cell carcinoma". Oncology Letters 18.6 (2019): 6371-6378.
Chicago
Zou, B., Guan, X., Zhang, W., Wang, D., Xu, K., Yuan, D., Meng, Z., Zhang, B."Integrated analysis of lncRNA CTD‑2357A8.3 expression and its potential roles in head and neck squamous cell carcinoma". Oncology Letters 18, no. 6 (2019): 6371-6378. https://doi.org/10.3892/ol.2019.10920
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