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Article

Hepatitis B virus infection and 1q21 amplification in multiple myeloma

  • Authors:
    • Dan Guo
    • Peipei Xu
    • Chaoyang Guan
    • Yong Xu
    • Yonggong Yang
    • Jingyan Xu
    • Rongfu Zhou
    • Bing Chen
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, P.R. China, Department of Hematology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
  • Pages: 6196-6206
    |
    Published online on: September 27, 2019
       https://doi.org/10.3892/ol.2019.10926
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Abstract

Hepatitis B virus (HBV) is a hepatotropic and a lymphotropic virus. An association between HBV and hematologic malignancies has been determined previously; however, the association between HBV infection and multiple myeloma (MM) remains controversial. The present study aimed to assess the prevalence of HBV infection in patients with MM, and investigate their characteristics and prognostic significance. The clinical data of 165 patients with MM who had received at least four cycles of chemotherapy between April 2008 and February 2017 at Nanjing Drum Tower Hospital (Nanjing, China) were collected. HBV markers were determined using ELISA. The rates of acute or chronic HBV infection and resolved HBV infection in patients with MM were 12.12 and 26.06%, respectively. The gain of 1q21 was significantly more prevalent in the patients who were classified as HBV‑positive compared with the patients who were classified as HBV‑negative (54 vs. 38.2%; P=0.048), and the level of alanine transaminase in patients who were classified as HBV‑positive was significantly increased compared with the non‑infected group (63.29 vs. 24.66 U/l; P=0.043). Lactate dehydrogenase, serum creatinine and serum calcium levels were additionally determined to be significant risk factors of overall survival. The progression‑free survival (PFS) of patients who were classified as HBV‑positive was decreased compared with patients who were classified as HBV‑negative (18.97 vs. 29.67 months; P=0.006), and being HBV‑positive was determined to be an independent prognostic factor of PFS. HBV infection may contribute to MM progression through 1q21 amplification, and improved monitoring of HBV markers in patients with MM may be required.
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Copy and paste a formatted citation
Spandidos Publications style
Guo D, Xu P, Guan C, Xu Y, Yang Y, Xu J, Zhou R and Chen B: Hepatitis B virus infection and 1q21 amplification in multiple myeloma. Oncol Lett 18: 6196-6206, 2019.
APA
Guo, D., Xu, P., Guan, C., Xu, Y., Yang, Y., Xu, J. ... Chen, B. (2019). Hepatitis B virus infection and 1q21 amplification in multiple myeloma. Oncology Letters, 18, 6196-6206. https://doi.org/10.3892/ol.2019.10926
MLA
Guo, D., Xu, P., Guan, C., Xu, Y., Yang, Y., Xu, J., Zhou, R., Chen, B."Hepatitis B virus infection and 1q21 amplification in multiple myeloma". Oncology Letters 18.6 (2019): 6196-6206.
Chicago
Guo, D., Xu, P., Guan, C., Xu, Y., Yang, Y., Xu, J., Zhou, R., Chen, B."Hepatitis B virus infection and 1q21 amplification in multiple myeloma". Oncology Letters 18, no. 6 (2019): 6196-6206. https://doi.org/10.3892/ol.2019.10926
Copy and paste a formatted citation
x
Spandidos Publications style
Guo D, Xu P, Guan C, Xu Y, Yang Y, Xu J, Zhou R and Chen B: Hepatitis B virus infection and 1q21 amplification in multiple myeloma. Oncol Lett 18: 6196-6206, 2019.
APA
Guo, D., Xu, P., Guan, C., Xu, Y., Yang, Y., Xu, J. ... Chen, B. (2019). Hepatitis B virus infection and 1q21 amplification in multiple myeloma. Oncology Letters, 18, 6196-6206. https://doi.org/10.3892/ol.2019.10926
MLA
Guo, D., Xu, P., Guan, C., Xu, Y., Yang, Y., Xu, J., Zhou, R., Chen, B."Hepatitis B virus infection and 1q21 amplification in multiple myeloma". Oncology Letters 18.6 (2019): 6196-6206.
Chicago
Guo, D., Xu, P., Guan, C., Xu, Y., Yang, Y., Xu, J., Zhou, R., Chen, B."Hepatitis B virus infection and 1q21 amplification in multiple myeloma". Oncology Letters 18, no. 6 (2019): 6196-6206. https://doi.org/10.3892/ol.2019.10926
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