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High efficacy and safety of VTD as an induction protocol in patients with newly diagnosed multiple myeloma eligible for high dose therapy and autologous stem cell transplantation: A report of the Polish Myeloma Study Group

  • Authors:
    • Iwona Hus
    • Joanna Mańko
    • Dariusz Jawniak
    • Artur Jurczyszyn
    • Grzegorz Charliński
    • Katarzyna Poniewierska‑Jasak
    • Lidia Usnarska‑Zubkiewicz
    • Mateusz Sawicki
    • Agnieszka Druzd‑Sitek
    • Alina Świderska
    • Anna Kopińska
    • Norbert Grząśko
    • Małgorzata Raźny
    • Aleksandra Wędłowska
    • Aleksander Perzyński
    • Aleksandra Gałązka
    • Dominik Dytfeld
    • Tadeusz Kubicki
    • Marek Rodzaj
    • Anna Waszczuk‑Gajda
    • Joanna Drozd‑Sokołowska
    • Bartłomiej Pogłódek
    • Anna Pasternak
    • Monika Długosz‑Danecka
    • Agnieszka Szymczyk
    • Anna Dmoszyńska
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Transplantology, Medical University of Lublin, 20-081 Lublin, Poland, Department of Hematooncology and Bone Marrow Transplantation, Medical University of Lublin, 20-081 Lublin, Poland, Department of Hematology, Collegium Medicum, Jagiellonian University, 30‑051 Cracow, Poland, Department of Hematology, Specialist Muncipial Hospital, 87‑100 Torun, Poland, Department of Hematology, Holycross Cancer Center, 25‑734 Kielce, Poland, Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, 50‑367 Wroclaw, Poland, Department of Lymphoid Malignancies, Institute of Oncology, 02‑781 Warsaw, Poland, Department of Hematology, University Hospital in Zielona Góra, 65‑046 Zielona Góra, Poland, Department of Hematology and Bone Marrow Transplantation, Medical University of Silesia, 40‑032 Katowice, Poland, Department of Hematology, St. John of Dukla Lublin Region Cancer Center, 20‑090 Lublin, Poland, Department of Hematology, Ludwik Rydygier Memorial Specialized Hospital, 31‑826 Cracow, Poland, Department of Hematology and Transplantology, Medical University of Gdansk, 80‑211 Gdansk, Poland, Department of Hematology, Institute of Hematology and Transfusion Medicine, 00‑791 Warsaw, Poland, Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, 60‑569 Poznan, Poland, Department of Hematology, Oncology and Internal Medicine, Medical University of Warsaw, 02‑097 Warsaw, Poland, Department of Oncologic Hematology, Specialist Hospital, 36‑200 Brzozów, Poland, Department of Hematology, Independent Public Health Care of Ministry of The Interior and Administration, 10‑228 Olsztyn, Poland
    Copyright: © Hus et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5811-5820
    |
    Published online on: September 27, 2019
       https://doi.org/10.3892/ol.2019.10929
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Abstract

The present retrospective analysis evaluated the efficacy and safety of the VTD (bortezomib, thalidomide, dexamethasone) regimen in 205 newly‑diagnosed patients with multiple myeloma (MM) eligible for high dose therapy and autologous stem cell transplantation (HDT/ASCT) in routine clinical practice. With a median of 6 cycles (range, 1‑8), at least partial response was achieved in 94.6% and at least very good partial response (VGPR) was achieved in 67.8% of patients. Peripheral neuropathy (PN) grade 2‑4 was observed in 28.7% of patients. In 72% of patients undergoing stem cell mobilization one apheresis allowed the number of stem cells sufficient for transplantation to be obtained. Following HDT/ASCT the sCR rate increased from 4.9 to 14.4% and CR from 27.8 to 35.6%. The results demonstrated that VTD as an induction regimen was highly efficient in transplant eligible patients with MM with increased at least VGPR rate following prolonged treatment (≥6 cycles). Therapy exhibited no negative impact on stem cell collection, neutrophils and platelets engraftment following ASCT. Therapy was generally well tolerated and PN was the most common reason of dose reduction or treatment discontinuation.
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Copy and paste a formatted citation
Spandidos Publications style
Hus I, Mańko J, Jawniak D, Jurczyszyn A, Charliński G, Poniewierska‑Jasak K, Usnarska‑Zubkiewicz L, Sawicki M, Druzd‑Sitek A, Świderska A, Świderska A, et al: High efficacy and safety of VTD as an induction protocol in patients with newly diagnosed multiple myeloma eligible for high dose therapy and autologous stem cell transplantation: A report of the Polish Myeloma Study Group. Oncol Lett 18: 5811-5820, 2019.
APA
Hus, I., Mańko, J., Jawniak, D., Jurczyszyn, A., Charliński, G., Poniewierska‑Jasak, K. ... Dmoszyńska, A. (2019). High efficacy and safety of VTD as an induction protocol in patients with newly diagnosed multiple myeloma eligible for high dose therapy and autologous stem cell transplantation: A report of the Polish Myeloma Study Group. Oncology Letters, 18, 5811-5820. https://doi.org/10.3892/ol.2019.10929
MLA
Hus, I., Mańko, J., Jawniak, D., Jurczyszyn, A., Charliński, G., Poniewierska‑Jasak, K., Usnarska‑Zubkiewicz, L., Sawicki, M., Druzd‑Sitek, A., Świderska, A., Kopińska, A., Grząśko, N., Raźny, M., Wędłowska, A., Perzyński, A., Gałązka, A., Dytfeld, D., Kubicki, T., Rodzaj, M., Waszczuk‑Gajda, A., Drozd‑Sokołowska, J., Pogłódek, B., Pasternak, A., Długosz‑Danecka, M., Szymczyk, A., Dmoszyńska, A."High efficacy and safety of VTD as an induction protocol in patients with newly diagnosed multiple myeloma eligible for high dose therapy and autologous stem cell transplantation: A report of the Polish Myeloma Study Group". Oncology Letters 18.6 (2019): 5811-5820.
Chicago
Hus, I., Mańko, J., Jawniak, D., Jurczyszyn, A., Charliński, G., Poniewierska‑Jasak, K., Usnarska‑Zubkiewicz, L., Sawicki, M., Druzd‑Sitek, A., Świderska, A., Kopińska, A., Grząśko, N., Raźny, M., Wędłowska, A., Perzyński, A., Gałązka, A., Dytfeld, D., Kubicki, T., Rodzaj, M., Waszczuk‑Gajda, A., Drozd‑Sokołowska, J., Pogłódek, B., Pasternak, A., Długosz‑Danecka, M., Szymczyk, A., Dmoszyńska, A."High efficacy and safety of VTD as an induction protocol in patients with newly diagnosed multiple myeloma eligible for high dose therapy and autologous stem cell transplantation: A report of the Polish Myeloma Study Group". Oncology Letters 18, no. 6 (2019): 5811-5820. https://doi.org/10.3892/ol.2019.10929
Copy and paste a formatted citation
x
Spandidos Publications style
Hus I, Mańko J, Jawniak D, Jurczyszyn A, Charliński G, Poniewierska‑Jasak K, Usnarska‑Zubkiewicz L, Sawicki M, Druzd‑Sitek A, Świderska A, Świderska A, et al: High efficacy and safety of VTD as an induction protocol in patients with newly diagnosed multiple myeloma eligible for high dose therapy and autologous stem cell transplantation: A report of the Polish Myeloma Study Group. Oncol Lett 18: 5811-5820, 2019.
APA
Hus, I., Mańko, J., Jawniak, D., Jurczyszyn, A., Charliński, G., Poniewierska‑Jasak, K. ... Dmoszyńska, A. (2019). High efficacy and safety of VTD as an induction protocol in patients with newly diagnosed multiple myeloma eligible for high dose therapy and autologous stem cell transplantation: A report of the Polish Myeloma Study Group. Oncology Letters, 18, 5811-5820. https://doi.org/10.3892/ol.2019.10929
MLA
Hus, I., Mańko, J., Jawniak, D., Jurczyszyn, A., Charliński, G., Poniewierska‑Jasak, K., Usnarska‑Zubkiewicz, L., Sawicki, M., Druzd‑Sitek, A., Świderska, A., Kopińska, A., Grząśko, N., Raźny, M., Wędłowska, A., Perzyński, A., Gałązka, A., Dytfeld, D., Kubicki, T., Rodzaj, M., Waszczuk‑Gajda, A., Drozd‑Sokołowska, J., Pogłódek, B., Pasternak, A., Długosz‑Danecka, M., Szymczyk, A., Dmoszyńska, A."High efficacy and safety of VTD as an induction protocol in patients with newly diagnosed multiple myeloma eligible for high dose therapy and autologous stem cell transplantation: A report of the Polish Myeloma Study Group". Oncology Letters 18.6 (2019): 5811-5820.
Chicago
Hus, I., Mańko, J., Jawniak, D., Jurczyszyn, A., Charliński, G., Poniewierska‑Jasak, K., Usnarska‑Zubkiewicz, L., Sawicki, M., Druzd‑Sitek, A., Świderska, A., Kopińska, A., Grząśko, N., Raźny, M., Wędłowska, A., Perzyński, A., Gałązka, A., Dytfeld, D., Kubicki, T., Rodzaj, M., Waszczuk‑Gajda, A., Drozd‑Sokołowska, J., Pogłódek, B., Pasternak, A., Długosz‑Danecka, M., Szymczyk, A., Dmoszyńska, A."High efficacy and safety of VTD as an induction protocol in patients with newly diagnosed multiple myeloma eligible for high dose therapy and autologous stem cell transplantation: A report of the Polish Myeloma Study Group". Oncology Letters 18, no. 6 (2019): 5811-5820. https://doi.org/10.3892/ol.2019.10929
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