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Article Open Access

The core genes involved in the promotion of depression in patients with ovarian cancer

  • Authors:
    • Yuexiong Yi
    • Yanyan Liu
    • Kejia Wu
    • Wanrong Wu
    • Wei Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China
    Copyright: © Yi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5995-6007
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    Published online on: September 30, 2019
       https://doi.org/10.3892/ol.2019.10934
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Abstract

The present study aimed to identify the core genes and pathways involved in depression in patients with ovarian cancer (OC) who suffer from high or low‑grade depression. The dataset GSE9116 from Gene Expression Omnibus database was analyzed to identify differentially expressed genes (DEGs) in these patients. To elucidate how certain genes could promote depression in patients with OC, pathway crosstalk, protein‑protein interaction (PPI) and comprehensive gene‑pathway analyses were determined using WebGestalt, ToppGene and Search Tool for the Retrieval of Interacting Genes and gene ontology analysis. Key genes and pathways were extracted from the gene‑pathway network, and gene expression and survival analysis were evaluated. A total of 93 DEGs were identified from GSE9116 dataset, including 84 upregulated genes and nine downregulated genes. The PPI, pathway crosstalk and comprehensive gene‑pathway analyses highlighted C‑C motif chemokine ligand 2 (CCL2), Fos proto‑oncogene, AP‑1 transcription factor subunit (FOS), serpin family E member 1 (SERPINE1) and serpin family G member 1 (SERPING1) as core genes involved in the promotion of depression in patients with OC. These core genes were involved in the following four pathways ‘Ensemble of genes encoding ECM‑associated proteins including ECM‑affiliated proteins’, ‘ECM regulators and secreted factors’, ‘Ensemble of genes encoding extracellular matrix and extracellular matrix‑associated proteins’ and ‘MAPK signaling pathway and IL‑17 signaling pathway’. The results from gene expression and survival analysis demonstrated that these four key genes were upregulated in patients with OC and high‑grade depression and could worsen patients' survival. These results suggested that CCL2, FOS, SERPINE1 and SERPING1 may serve a crucial role in the promotion of depression in patients with OC. This finding may provide novel markers for predicting and treating depression in patients with OC; however, the underlying mechanisms remain unknown and require further investigation.
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1 

Reid BM, Permuth JB and Sellers TA: Epidemiology of ovarian cancer: A review. Cancer Biol Med. 14:9–32. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in china. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Zhang L, Luo M, Yang H, Zhu S, Cheng X and Qing C: Next-generation sequencing-based genomic profiling analysis reveals novel mutations for clinical diagnosis in chinese primary epithelial ovarian cancer patients. J Ovarian Res. 12:192019. View Article : Google Scholar : PubMed/NCBI

5 

Carlson LE, Angen M, Cullum J, Goodey E, Koopmans J, Lamont L, MacRae JH, Martin M, Pelletier G and Robinson J: High levels of untreated distress and fatigue in cancer patients. Br J Cancer. 90:2297–2304. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Sellick SM and Crooks DL: Depression and cancer: An appraisal of the literature for prevalence, detection, and practice guideline development for psychological interventions. Psychooncology. 8:315–333. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Zabora J, BrintzenhofeSzoc K, Curbow B, Hooker C and Piantadosi S: The prevalence of psychological distress by cancer site. Psychooncology. 10:19–28. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Greimel E, Thiel I, Peintinger F, Cegnar I and Pongratz E: Prospective assessment of quality of life of female cancer patients. Gynecol Oncol. 85:140–147. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Lutgendorf SK, Slavich GM, Degeest K, Goodheart M, Bender D, Thaker PH, Penedo F, Zimmerman B, Lucci J III, Mendez L, et al: Non-cancer life stressors contribute to impaired quality of life in ovarian cancer patients. Gynecol Oncol. 131:667–673. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Watts S, Prescott P, Mason J, McLeod N and Lewith G: Depression and anxiety in ovarian cancer: A systematic review and meta-analysis of prevalence rates. BMJ Open. 5:e0076182015. View Article : Google Scholar : PubMed/NCBI

11 

Huang T, Poole EM, Okereke OI, Kubzansky LD, Eliassen AH, Sood AK, Wang M and Tworoger SS: Depression and risk of epithelial ovarian cancer: Results from two large prospective cohort studies. Gynecol Oncol. 139:481–486. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Mielcarek P, Nowicka-Sauer K and Kozaka J: Anxiety and depression in patients with advanced ovarian cancer: A prospective study. J Psychosom Obstet Gynaecol. 37:57–67. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Wu C, Zhao Y, Liu Y, Yang X, Yan M, Min Y, Pan Z, Qiu S, Xia S, Yu J, et al: Identifying miRNA-mRNA regulation network of major depressive disorder in ovarian cancer patients. Oncol Lett. 16:5375–5382. 2018.PubMed/NCBI

14 

Rahman MR, Islam T, Al-Mamun MA, Zaman T, Karim MR and Moni MA: The influence of depression on ovarian cancer: Discovering molecular pathways that identify novel biomarkers and therapeutic targets. Informatics Med Unlocked. 16:1002072019. View Article : Google Scholar

15 

Watson M, Haviland JS, Greer S, Davidson J and Bliss JM: Influence of psychological response on survival in breast cancer: A population-based cohort study. Lancet. 354:1331–1336. 1999. View Article : Google Scholar : PubMed/NCBI

16 

DiMatteo MR, Lepper HS and Croghan TW: Depression is a risk factor for noncompliance with medical treatment: Meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med. 160:2101–2107. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Yamamoto T, Yanagimoto H, Satoi S, Toyokawa H, Hirooka S, Yamaki S, Yui R, Yamao J, Kim S and Kwon AH: Circulating CD4+CD25+ regulatory T cells in patients with pancreatic cancer. Pancreas. 41:409–415. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Lutgendorf SK, DeGeest K, Sung CY, Arevalo JM, Penedo F, Lucci J III, Goodheart M, Lubaroff D, Farley DM, Sood AK and Cole SW: Depression, social support, and beta-adrenergic transcription control in human ovarian cancer. Brain Behav Immun. 23:176–183. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Cole SW, Arevalo JMG, Takahashi R, Sloan EK, Lutgendorf SK, Sood AK, Sheridan JF and Seeman TE: Computational identification of gene-social environment interaction at the human IL6 locus. Proc Natl Acad Sci. 107:5681–5686. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Wang J, Vasaikar S, Shi Z, Greer M and Zhang B: WebGestalt 2017: A more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit. Nucleic Acids Res. 45:W130–W137. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Chen J, Bardes EE, Aronow BJ and Jegga AG: ToppGene Suite for gene list enrichment analysis and candidate gene prioritization. Nucleic Acids Res. 37:W305–W311. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, et al: NCBI GEO: Archive for functional genomics data sets-update. Nucleic Acids Res. 41:D991–D995. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Radloff LS: The CES-D scale: A self-report depression scale for research in the general population. Appl Psychol Meas. 1:385–401. 1977. View Article : Google Scholar

24 

Cutroa CE and Rusell DW: The provisions of social relationships and adaptation to stress. Adv Pers Relationships. 1:37–67. 1987.

25 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

26 

Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, et al: STRING v10: Protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 43:D447–D452. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Shannon P, Markiel A, Owen O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Scardoni G, Petterlini M and Laudanna C: Analyzing biological network parameters with centiScaPe. Bioinformatics. 25:2857–2859. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Ogata H, Goto S, Sato K, Fujibuchi W, Bono H and Kanehisa M: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 27:29–34. 1999. View Article : Google Scholar : PubMed/NCBI

30 

Fox R: A view from the web. J R Soc Med. 90:4731997. View Article : Google Scholar

31 

Jia P, Kao CF, Kuo PH and Zhao Z: A comprehensive network and pathway analysis of candidate genes in major depressive disorder. BMC Syst Biol. 5 (Suppl 3):S122011. View Article : Google Scholar : PubMed/NCBI

32 

Hu Y, Pan Z, Hu Y, Zhang L and Wang J: Network and pathway-based analyses of genes associated with parkinson's disease. Mol Neurobiol. 54:4452–4465. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Niwattanakul S, Singthongchai J, Naenudorn E and Wanapu S: Using of jaccard coefficient for keywords similarity. Proc Int Multiconference Eng Comput Sci. 1:13–15. 2013.

34 

Mizuno S, Yamaguchi T, Fukushima A, Matsuyama Y and Ohashi Y: Overlap coefficient for assessing the similarity of pharmacokinetic data between ethnically different populations. Clin Trials. 2:174–181. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Gyorffy B, Lánczky A and Szállási Z: Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients. Endocr Relat Cancer. 19:197–208. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Cancer Genome Atlas Research Network, ; Weinstein JN, Collisson EA, Mills GB, Shaw KR, Ozenberger BA, Ellrott K, Shmulevich I, Sander C and Stuart JM: The cancer genome atlas pan-cancer analysis project. Nat Genet. 45:1113–1120. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Denkert C, Budczies J, Darb-Esfahani S, Györffy B, Sehouli J, Könsgen D, Zeillinger R, Weichert W, Noske A, Buckendahl AC, et al: A prognostic gene expression index in ovarian cancer-validation across different independent data sets. J Pathol. 218:273–280. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Ahmed AA, Mills AD, Ibrahim AE, Temple J, Blenkiron C, Vias M, Massie CE, Iyer NG, McGeoch A, Crawford R, et al: The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel. Cancer Cell. 12:514–527. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Mok SC, Bonome T, Vathipadiekal V, Bell A, Johnson ME, Wong KK, Park DC, Hao K, Yip DK, Donninger H, et al: A gene signature predictive for outcome in advanced ovarian cancer identifies a survival factor: Microfibril-associated glycoprotein 2. Cancer Cell. 16:521–532. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Konstantinopoulos PA, Spentzos D, Karlan BY, Taniguchi T, Fountzilas E, Francoeur N, Levine DA and Cannistra SA: Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelial ovarian cancer. J Clin Oncol. 28:3555–3561. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Marchion DC, Cottrill HM, Xiong Y, Chen N, Bicaku E, Fulp WJ, Bansal N, Chon HS, Stickles XB, Kamath SG, et al: BAD phosphorylation determines ovarian cancer chemosensitivity and patient survival. Clin Cancer Res. 17:6356–6366. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Gentric G, Kieffer Y, Mieulet V, Goundiam O, Bonneau C, Nemati F, Hurbain I, Raposo G, Popova T, Stern MH, et al: PML-regulated mitochondrial metabolism enhances chemosensitivity in human ovarian cancers. Cell Metab. 29:156–173. 2019. View Article : Google Scholar : PubMed/NCBI

43 

Mateescu B, Batista L, Cardon M, Gruosso T, de Feraudy Y, Mariani O, Nicolas A, Meyniel JP, Cottu P, Sastre-Garau X and Mechta-Grigoriou F: MiR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response. Nat Med. 17:1627–1635. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Bonome T, Levine DA, Shih J, Randonovich M, Pise-Masison CA, Bogomolniy F, Ozbun L, Brady J, Barrett JC, Boyd J and Birrer MJ: A gene signature predicting for survival in suboptimally debulked patients with ovarian cancer. Cancer Res. 68:5478–5486. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Vathipadiekal V, Wang V, Wei W, Waldron L, Drapkin R, Gillette M, Skates S and Birrer M: Creation of a human secretome: A novel composite library of human secreted proteins: Validation using ovarian cancer gene expression data and a virtual secretome array. Clin Cancer Res. 21:4960–4969. 2015. View Article : Google Scholar : PubMed/NCBI

46 

King ER, Tung CS, Tsang YT, Zu Z, Lok GT, Deavers MT, Malpica A, Wolf JK, Lu KH, Birrer MJ, et al: The anterior gradient homolog 3 (AGR3) gene is associated with differentiation and survival in ovarian cancer. Am J Surg Pathol. 35:904–912. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Ferriss JS, Kim Y, Duska L, Birrer M, Levine DA, Moskaluk C, Theodorescu D and Lee JK: Multi-gene expression predictors of single drug responses to adjuvant chemotherapy in ovarian carcinoma: Predicting platinum resistance. PLoS One. 7:e305502012. View Article : Google Scholar : PubMed/NCBI

48 

Bild AH, Yao G, Chang JT, Wang Q, Potti A, Chasse D, Joshi MB, Harpole D, Lancaster JM, Berchuck A, et al: Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature. 439:353–357. 2006. View Article : Google Scholar : PubMed/NCBI

49 

Koti M, Gooding RJ, Nuin P, Haslehurst A, Crane C, Weberpals J, Childs T, Bryson P, Dharsee M and Evans K: Identification of the IGF1/PI3K/NF κB/ERK gene signalling networks associated with chemotherapy resistance and treatment response in high-grade serous epithelial ovarian cancer. BMC Cancer. 13:5492013. View Article : Google Scholar : PubMed/NCBI

50 

Lisowska KM, Olbryt M, Dudaladava V, Pamuła-Piłat J, Kujawa K, Grzybowska E, Jarząb M, Student S, Rzepecka IK, Jarząb B and Kupryjańczyk J: Gene expression analysis in ovarian cancer-faults and hints from DNA microarray study. Front Oncol. 4:62014. View Article : Google Scholar : PubMed/NCBI

51 

Uehara Y, Oda K, Ikeda Y, Koso T, Tsuji S, Yamamoto S, Asada K, Sone K, Kurikawa R, Makii C, et al: Integrated copy number and expression analysis identifies profiles of whole-arm chromosomal alterations and subgroups with favorable outcome in ovarian clear cell carcinomas. PLoS One. 10:e01280662015. View Article : Google Scholar : PubMed/NCBI

52 

Tothill RW, Tinker AV, George J, Brown R, Fox SB, Lade S, Johnson DS, Trivett MK, Etemadmoghadam D, Locandro B, et al: Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome. Clin Cancer Res. 14:5198–5208. 2008. View Article : Google Scholar : PubMed/NCBI

53 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. 394–424. 2018.PubMed/NCBI

54 

Chaturvedi SK: Psychiatric oncology: Cancer in mind. Indian J Psychiatry. 54:111–118. 2012. View Article : Google Scholar : PubMed/NCBI

55 

Pasquini M and Biondi M: Depression in cancer patients: A critical review. Clin Pract Epidemiol Ment Health. 3:22007. View Article : Google Scholar : PubMed/NCBI

56 

Prasad SM, Eggener SE, Lipsitz SR, Irwin MR, Ganz PA and Hu JC: Effect of depression on diagnosis, treatment, and mortality of men with clinically localized prostate cancer. J Clin Oncol. 32:2471–2478. 2014. View Article : Google Scholar : PubMed/NCBI

57 

Colombo N, Lorusso D and Scollo P: Impact of recurrence of ovarian cancer on quality of life and outlook for the future. Int J Gynecol Cancer. 27:1134–1140. 2017. View Article : Google Scholar

58 

Leighton SP, Nerurkar L, Krishnadas R, Johnman C, Graham GJ and Cavanagh J: Chemokines in depression in health and in inflammatory illness: A systematic review and meta-analysis. Mol Psychiatry. 23:48–58. 2018. View Article : Google Scholar : PubMed/NCBI

59 

Eyre HA, Air T, Pradhan A, Johnston J, Lavretsky H, Stuart MJ and Baune BT: A meta-analysis of chemokines in major depression. Prog Neuropsychopharmacol Biol Psychiatry. 68:1–8. 2016. View Article : Google Scholar : PubMed/NCBI

60 

Chen K, Pociask DA, McAleer JP, Chan YR, Alcorn JF, Kreindler JL, Keyser MR, Shapiro SD, Houghton AM, Kolls JK and Zheng M: IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke. PLoS One. 6:e203332011. View Article : Google Scholar : PubMed/NCBI

61 

Lim SY, Yuzhalin AE, Gordon-Weeks AN and Muschel RJ: Targeting the CCL2-CCR2 signaling axis in cancer metastasis. Oncotarget. 7:28697–28710. 2016. View Article : Google Scholar : PubMed/NCBI

62 

Yu T, Guo M, Garza J, Rendon S, Sun X, Zhang W and Lu XY: Cognitive and neural correlates of depression-like behaviour in socially defeated mice: An animal model of depression with cognitive dysfunction. Int J Neuropsychopharmacol. 14:303–317. 2011. View Article : Google Scholar : PubMed/NCBI

63 

Kung JC, Chen TC, Shyu BC, Hsiao S and Huang AC: Anxiety- and depressive-like responses and c-fos activity in preproenkephalin knockout mice: Oversensitivity hypothesis of enkephalin deficit-induced posttraumatic stress disorder. J Biomed Sci. 17:292010. View Article : Google Scholar : PubMed/NCBI

64 

Yokoyama K, Hiyama A, Arai F, Nukaga T, Sakai D and Mochida J: C-Fos regulation by the MAPK and PKC pathways in intervertebral disc cells. PLoS One. 8:1–14. 2013. View Article : Google Scholar

65 

Whitmarsh AJ: Regulation of gene transcription by mitogen-activated protein kinase signaling pathways. Biochim Biophys Acta. 1773:1285–1298. 2007. View Article : Google Scholar : PubMed/NCBI

66 

Li JK, Nie L, Zhao YP, Zhang YQ, Wang X, Wang SS, Liu Y, Zhao H and Cheng L: IL-17 mediates inflammatory reactions via p38/c-Fos and JNK/c-Jun activation in an AP-1-dependent manner in human nucleus pulposus cells. J Transl Med. 14:772016. View Article : Google Scholar : PubMed/NCBI

67 

Ma X, Reynolds SL, Baker BJ, Li X, Benveniste EN and Qin H: IL-17 enhancement of the IL-6 signaling cascade in astrocytes. J Immunol. 184:4898–4906. 2010. View Article : Google Scholar : PubMed/NCBI

68 

Hayashi KG, Ushizawa K, Hosoe M and Takahashi T: Differential gene expression of serine protease inhibitors in bovine ovarian follicle: Possible involvement in follicular growth and atresia. Reprod Biol Endocrinol. 9:722011. View Article : Google Scholar : PubMed/NCBI

69 

Lassila M, Fukami K, Jandeleit-Dahm K, Semple T, Carmeliet P, Cooper ME and Kitching AR: Plasminogen activator inhibitor-1 production is pathogenetic in experimental murine diabetic renal disease. Diabetologia. 50:1315–1326. 2007. View Article : Google Scholar : PubMed/NCBI

70 

Yamamoto K, Takeshita K, Shimokawa T, Yi H, Isobe K, Loskutoff DJ and Saito H: Plasminogen activator inhibitor-1 is a major stress-regulated gene: Implications for stress-induced thrombosis in aged individuals. Proc Natl Acad Sci. 99:890–895. 2002. View Article : Google Scholar : PubMed/NCBI

71 

Eskandari F, Mistry S, Martinez PE, Torvik S, Kotila C, Sebring N, Drinkard BE, Levy C, Reynolds JC, Csako G, et al: Younger, premenopausal women with major depressive disorder have more abdominal fat and increased serum levels of prothrombotic factors: Implications for greater cardiovascular risk. Metabolism. 54:918–924. 2005. View Article : Google Scholar : PubMed/NCBI

72 

Lahlou-Laforet K, Alhenc-Gelas M, Pornin M, Bydlowski S, Seigneur E, Benetos A, Kierzin JM, Scarabin PY, Ducimetiere P, Aiach M, et al: Relation of depressive mood to plasminogen activator inhibitor, tissue plasminogen activator, and fibrinogen levels in patients with versus without coronary heart disease. Am J Cardiol. 97:1287–1291. 2006. View Article : Google Scholar : PubMed/NCBI

73 

Tsai SJ, Hong CJ, Liou YJ, Yu YW and Chen TJ: Plasminogen activator inhibitor-1 gene is associated with major depression and antidepressant treatment response. Pharmacogenet Genomics. 18:869–875. 2008. View Article : Google Scholar : PubMed/NCBI

74 

Fang Y, Zhang L, Zeng Z, Lian Y, Jia Y, Zhu H and Xu Y: Promoter polymorphisms of SERPINE1 are associated with the antidepressant response to depression in alzheimer's disease. Neurosci Lett. 516:217–220. 2012. View Article : Google Scholar : PubMed/NCBI

75 

Haslund D, Ryø LB, Seidelin Majidi S, Rose I, Skipper KA, Fryland T, Bohn AB, Koch C, Thomsen MK, Palarasah Y, et al: Dominant-negative SERPING1 variants cause intracellular retention of C1 inhibitor in hereditary angioedema. J Clin Invest. 129:388–405. 2019. View Article : Google Scholar : PubMed/NCBI

76 

Madsen DE, Hansen S, Gram J, Bygum A, Drouet C and Sidelmann JJ: Presence of C1-inhibitor polymers in a subset of patients suffering from hereditary angioedema. PLoS One. 9:e1120512014. View Article : Google Scholar : PubMed/NCBI

77 

Lumry WR, Craig T, Zuraw B, Longhurs H, Baker J, Li HH, Bernstein JA, Anderson J, Riedl MA, Manning ME, et al: Health-related quality of life with subcutaneous C1-inhibitor for prevention of attacks of hereditary angioedema. J Allergy Clin Immunol Pract. 112:1733–1741. 2018. View Article : Google Scholar

78 

Fouche AS, Saunders EF and Craig T: Depression and anxiety in patients with hereditary angioedema. Ann Allergy Asthma Immunol. 112:371–375. 2014. View Article : Google Scholar : PubMed/NCBI

79 

Varga L, Széplaki G, Laki J, Kocsis A, Kristóf K, Gál P, Bajtay Z, Wieslander J, Daha MR, Garred P, et al: Depressed activation of the lectin pathway of complement in hereditary angioedema. Clin Exp Immunol. 153:68–74. 2008. View Article : Google Scholar : PubMed/NCBI

80 

Ditzen C, Tang N, Jastorff AM, Teplytska L, Yassouridis A, Maccarrone G, Uhr M, Bronisch T, Miller CA, Holsboer F and Turck CW: Cerebrospinal fluid biomarkers for major depression confirm relevance of associated pathophysiology. Neuropsychopharmacology. 37:1013–1025. 2012. View Article : Google Scholar : PubMed/NCBI

81 

Liu RM: Oxidative stress, plasminogen activator inhibitor 1, and lung fibrosis. Antioxid Redox Signal. 10:303–319. 2008. View Article : Google Scholar : PubMed/NCBI

82 

Oh CK, Ariue B, Alban RF, Shaw B and Cho SH: PAI-1 promotes extracellular matrix deposition in the airways of a murine Asthma model. Biochem Biophys Res Commun. 294:1155–1160. 2002. View Article : Google Scholar : PubMed/NCBI

83 

Singer M and Jones AM: Bench-to-bedside review: The role of C1-esterase inhibitor in sepsis and other critical illnesses. Crit Care. 15:2032011. View Article : Google Scholar : PubMed/NCBI

84 

Davis AE III, Lu F and Mejia P: C1 inhibitor, a multi-functional serine protease inhibitor. Thromb Haemost. 104:886–893. 2010. View Article : Google Scholar : PubMed/NCBI

85 

Green TA, Alibhai IN, Unterberg S, Neve RL, Ghose S, Tamminga CA and Nestler EJ: Induction of activating transcription factors (ATFs) ATF2, ATF3, and ATF4 in the nucleus accumbens and their regulation of emotional behavior. J Neurosci. 28:2025–2032. 2008. View Article : Google Scholar : PubMed/NCBI

86 

Turner CA, Sharma V, Hagenauer MH, Chaudhury S, O'Connor AM, Hebda-Bauer EK, Thompson RC, Myers RM, Bunney WE and Barchas JD: Connective tissue growth factor is a novel prodepressant. Biol Psychiatry. 84:555–562. 2018. View Article : Google Scholar : PubMed/NCBI

87 

Giese-Davis J, Collie K, Rancourt KM, Neri E, Kraemer HC and Spiegel D: Decrease in depression symptoms is associated with longer survival in patients with metastatic breast cancer: A secondary analysis. J Clin Oncol. 29:413–420. 2011. View Article : Google Scholar : PubMed/NCBI

88 

Raison CL and Miller AH: The evolutionary significance of depression in pathogen host defense (PATHOS-D). Mol Psychiatry. 18:15–37. 2013. View Article : Google Scholar : PubMed/NCBI

89 

Wojnarowicz P, Gambaro K, de Ladurantaye M, Quinn MC, Provencher D, Mes-Masson AM and Tonin PN: Overexpressing the CCL2 chemokine in an epithelial ovarian cancer cell line results in latency of in vivo tumourigenicity. Oncogenesis. 1:e272012. View Article : Google Scholar : PubMed/NCBI

90 

Mahner S, Baasch C, Schwarz J, Hein S, Wölber L, Jänicke F and Milde-Langosch K: C-Fos expression is a molecular predictor of progression and survival in epithelial ovarian carcinoma. Br J Cancer. 99:1269–1275. 2008. View Article : Google Scholar : PubMed/NCBI

91 

Andreasen PA, Kjøller L, Christensen L and Duffy MJ: The urokinase-type plasminogen activator system in cancer metastasis: A review. Int J cancer. 72:1–22. 1997. View Article : Google Scholar : PubMed/NCBI

92 

Klein RM, Bernstein D, Higgins SP, Higgins CE and Higgins PJ: SERPINE1 expression discriminates site-specific metastasis in human melanoma. Exp Dermatol. 21:551–554. 2012. View Article : Google Scholar : PubMed/NCBI

93 

Peng S, Du T, Wu W, Chen X, Lai Y, Zhu D, Wang Q, Ma X, Lin C, Li Z, et al: Decreased expression of serine protease inhibitor family G1 (SERPING1) in prostate cancer can help distinguish high-risk prostate cancer and predicts malignant progression. Urol Oncol. 36:366.e1–366.e9. 2018. View Article : Google Scholar

94 

Mejia P, Diez-Silva M, Kamena F, Lu F, Fernandes SM, Seeberger PH, Davis AE III and Mitchell JR: Human C1-inhibitor suppresses malaria parasite invasion and cytoadhesion via binding to parasite glycosylphosphatidylinositol and host cell receptors. J Infect Dis. 213:80–89. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yi Y, Liu Y, Wu K, Wu W and Zhang W: The core genes involved in the promotion of depression in patients with ovarian cancer. Oncol Lett 18: 5995-6007, 2019.
APA
Yi, Y., Liu, Y., Wu, K., Wu, W., & Zhang, W. (2019). The core genes involved in the promotion of depression in patients with ovarian cancer. Oncology Letters, 18, 5995-6007. https://doi.org/10.3892/ol.2019.10934
MLA
Yi, Y., Liu, Y., Wu, K., Wu, W., Zhang, W."The core genes involved in the promotion of depression in patients with ovarian cancer". Oncology Letters 18.6 (2019): 5995-6007.
Chicago
Yi, Y., Liu, Y., Wu, K., Wu, W., Zhang, W."The core genes involved in the promotion of depression in patients with ovarian cancer". Oncology Letters 18, no. 6 (2019): 5995-6007. https://doi.org/10.3892/ol.2019.10934
Copy and paste a formatted citation
x
Spandidos Publications style
Yi Y, Liu Y, Wu K, Wu W and Zhang W: The core genes involved in the promotion of depression in patients with ovarian cancer. Oncol Lett 18: 5995-6007, 2019.
APA
Yi, Y., Liu, Y., Wu, K., Wu, W., & Zhang, W. (2019). The core genes involved in the promotion of depression in patients with ovarian cancer. Oncology Letters, 18, 5995-6007. https://doi.org/10.3892/ol.2019.10934
MLA
Yi, Y., Liu, Y., Wu, K., Wu, W., Zhang, W."The core genes involved in the promotion of depression in patients with ovarian cancer". Oncology Letters 18.6 (2019): 5995-6007.
Chicago
Yi, Y., Liu, Y., Wu, K., Wu, W., Zhang, W."The core genes involved in the promotion of depression in patients with ovarian cancer". Oncology Letters 18, no. 6 (2019): 5995-6007. https://doi.org/10.3892/ol.2019.10934
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