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Identification of biomarkers and construction of a microRNA‑mRNA regulatory network for ependymoma using integrated bioinformatics analysis

  • Authors:
    • Biao Yang
    • Jun‑Xi Dai
    • Yuan‑Bo Pan
    • Yan‑Bin Ma
    • Sheng‑Hua Chu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201999, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6079-6089
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    Published online on: September 30, 2019
       https://doi.org/10.3892/ol.2019.10941
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Abstract

Ependymomas (EPNs) are one of the most common types of malignant neuroepithelial tumors. In an effort to identify potential biomarkers involved in the pathogenesis of EPN, the mRNA expression profiles of the GSE25604, GSE50161, GSE66354, GSE74195 and GSE86574 datasets, in addition to the microRNA (miRNA/miR) expression profiles of GSE42657 were downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) and differentially expressed miRNAs (DEMs) between EPN and normal brain tissue samples were identified using the Limma package in R and GEO2R, respectively. Functional and pathway enrichment analyses were conducted using the Database for Annotation, Visualization and Integrated Discovery. A protein‑protein interaction network was constructed using the Search Tool for Retrieval of Interacting Genes database, which was visualized using Cytoscape. The targeted genes of DEMs were predicted using miRWalk2.0 and a miRNA‑mRNA regulatory network was constructed. Following analysis, a total of 948 DEGs and 129 DEMs were identified. Functional enrichment analysis revealed that 609 upregulated DEGs were significantly enriched in ‘PI3K‑Akt signaling pathway’, while 339 downregulated DEGs were primarily involved in ‘cell junction’ and ‘retrograde endocannabinoid signaling’. In addition, 6 hub genes [cyclin dependent kinase 1, CD44 molecule (Indian blood group) (CD44), proliferating cell nuclear antigen (PCNA), MYC, synaptotagmin 1 (SYT1) and kinesin family member 4A] and 6 crucial miRNAs [homo sapiens (hsa)‑miR‑34a‑5p, hsa‑miR‑449a, hsa‑miR‑106a‑5p, hsa‑miR‑124‑3p, hsa‑miR‑128‑3p and hsa‑miR‑330‑3p] were identified as biomarkers and potential therapeutic targets for EPN. Furthermore, a microRNA‑mRNA regulatory network was constructed to highlight the interactions between DEMs and their target DEGs; this included the hsa‑miR‑449a‑SYT1, hsa‑miR‑34a‑5p‑SYT1, hsa‑miR‑330‑3p‑CD44 and hsa‑miR‑124‑3p‑PCNA pairs, whose expression levels were confirmed using reverse transcription‑quantitative polymerase chain reaction. In conclusion, the present study may provide important data for the investigation of the molecular mechanisms of EPN pathogenesis.
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1 

Ostrom QT, Gittleman H, de Blank PM, Finlay JL, Gurney JG, McKean-Cowdin R, Stearns DS, Wolff JE, Liu M, Wolinsky Y, et al: American brain tumor association adolescent and young adult primary brain and central nervous system tumors diagnosed in the united states in 2008–2012. Neuro Oncol. 18 (Suppl 1):i1–i50. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Kilday JP, Rahman R, Dyer S, Ridley L, Lowe J, Coyle B and Grundy R: Pediatric ependymoma: Biological perspectives. Mol Cancer Res. 7:765–786. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Li AM, Dunham C, Tabori U, Carret AS, McNeely PD, Johnston D, Lafay-Cousin L, Wilson B, Eisenstat DD, Jabado N, et al: EZH2 expression is a prognostic factor in childhood intracranial ependymoma: A Canadian Pediatric Brain Tumor Consortium study. Cancer. 121:1499–1507. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P and Ellison DW: The 2016 world health organization classification of tumors of the central nervous system: A summary. Acta neuropathol. 131:803–820. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Vera-Bolanos E, Aldape K, Yuan Y, Wu J, Wani K, Necesito-Reyes MJ, Colman H, Dhall G, Lieberman FS, Metellus P, et al: Clinical course and progression-free survival of adult intracranial and spinal ependymoma patients. Neuro Oncol. 17:440–447. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Zhang B, Pan X and Anderson TA: MicroRNA: A new player in stem cells. J Cell Physiol. 209:266–269. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Fabian MR, Sonenberg N and Filipowicz W: Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem. 79:351–379. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Margolin-Miller Y, Yanichkin N, Shichrur K, Toledano H, Ohali A, Tzaridis T, Michowitz S, Fichman-Horn S, Feinmesser M, Pfister SM, et al: Prognostic relevance of miR-124-3p and its target TP53INP1 in pediatric ependymoma. Genes Chromosomes Cancer. 56:639–650. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Liang ML, Hsieh TH, Liu YR, Chen YW, Lee YY, Chang FC, Lin SC, Huang MC, Donald Ming-Tak H, Wong TT, et al: Significance of cyclin D1 overexpression in progression and radio-resistance of pediatric ependymomas. Oncotarget. 9:2527–2542. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Benjamini Y and Hochberg Y: Controlling the false discovery rate: A practical and powerful approach to multiple testing. J Royal Statistical Soc. 57:289–300. 1995.

11 

Huang da W, Sherman BT and Lempicki RA: Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37:1–13. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Kanehisa M: The KEGG database. Novartis Found Symp. 247:91–103, 119-128, 244–152. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Fabregat A, Sidiropoulos K, Garapati P, Gillespie M, Hausmann K, Haw R, Jassal B, Jupe S, Korninger F, McKay S, et al: The Reactome pathway Knowledgebase. Nucleic Acids Res. 44:D481–487. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Szklarczyk D, Franceschini A, Kuhn M, Simonovic M, Roth A, Minguez P, Doerks T, Stark M, Muller J, Bork P, et al: The STRING database in 2011: Functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res. 39:D561–D568. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Bader GD and Hogue CW: An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics. 4:22003. View Article : Google Scholar : PubMed/NCBI

17 

Chin CH, Chen SH, Wu HH, Ho CW, Ko MT and Lin CY: cytoHubba: Identifying hub objects and sub-networks from complex interactome. BMC Syst Biol. 8 (Suppl 4):S112014. View Article : Google Scholar : PubMed/NCBI

18 

Janky R, Verfaillie A, Imrichova H, Van de Sande B, Standaert L, Christiaens V, Hulselmans G, Herten K, Naval Sanchez M, Potier D, et al: iRegulon: From a gene list to a gene regulatory network using large motif and track collections. PLoS Comput Biol. 10:e10037312014. View Article : Google Scholar : PubMed/NCBI

19 

Maragkakis M, Vergoulis T, Alexiou P, Reczko M, Plomaritou K, Gousis M, Kourtis K, Koziris N, Dalamagas T and Hatzigeorgiou AG: Hatzigeorgiou DIANA-microT Web server upgrade supports Fly and Worm miRNA target prediction and bibliographic miRNA to disease association. Nucleic Acids Res. 39:W145–W158. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Paraskevopoulou MD, Georgakilas G, Kostoulas N, Vlachos IS, Vergoulis T, Reczko M, Filippidis C, Dalamagas T and Hatzigeorgiou AG: DIANA-microT web server v5.0: Service integration into miRNA functional analysis workflows. Nucleic Acids Res. 41:W169–W173. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Betel D, Wilson M, Gabow A, Marks DS and Sander C: The microRNA.org resource: Targets and expression. Nucleic Acids Res. 36:D149–D53. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Tsang JS, Ebert MS and van Oudenaarden A: Genome-wide dissection of microRNA functions and cotargeting networks using gene set signatures. Mol Cell. 38:140–153. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Wong N and Wang X: miRDB: An online resource for microRNA target prediction and functional annotations. Nucleic Acids Res. 43:D146–D152. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Vejnar CE, Blum M and Zdobnov EM: miRmap web: Comprehensive microRNA target prediction online. Nucleic Acids Res. 41:W165–W168. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Hsu PW, Huang HD, Hsu SD, Lin LZ, Tsou AP, Tseng CP, Stadler PF, Washietl S and Hofacker IL: miRNAMap: Genomic maps of microRNA genes and their target genes in mammalian genomes. Nucleic Acids Res. 34:D135–D139. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Krek A, Grün D, Poy MN, Wolf R, Rosenberg L, Epstein EJ, MacMenamin P, da Piedade I, Gunsalus KC, Stoffel M and Rajewsky N: Combinatorial microRNA target predictions. Nat Genet. 37:495–500. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Kertesz M, Iovino N, Unnerstall U, Gaul U and Segal E: The role of site accessibility in microRNA target recognition. Nat Genet. 39:1278–1284. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Miranda KC, Huynh T, Tay Y, Ang YS, Tam WL, Thomson AM, Lim B and Rigoutsos I: A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. Cell. 126:1203–1217. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Krüger J and Rehmsmeier M: RNAhybrid: microRNA target prediction easy, fast and flexible. Nucleic Acids Res. 34:W451–W454. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Garcia DM, Baek D, Shin C, Bell GW, Grimson A and Bartel DP: Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs. Nat Struct Mol Biol. 18:1139–1146. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Li X, Wu C, Chen N, Gu H, Yen A, Cao L, Wang E and Wang L: PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma. Oncotarget. 7:33440–33450. 2016.PubMed/NCBI

33 

Dimitrova V and Arcaro A: Targeting the PI3K/AKT/mTOR signaling pathway in medulloblastoma. Curr Mol Med. 15:82–93. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Verstegen MJ, Leenstra DT, Ijlst-Keizers H and Bosch DA: Proliferation- and apoptosis-related proteins in intracranial ependymomas: An immunohistochemical analysis. J Neurooncol. 56:21–28. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Gupta RK, Sharma MC, Suri V, Kakkar A, Singh M and Sarkar C: Study of chromosome 9q gain, Notch pathway regulators and Tenascin-C in ependymomas. J Neurooncol. 116:267–274. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Faria C, Miguens J, Antunes JL, Salgado D, Nunes S, Barroso C, Martins Mdo C, Nunes VM and Roque L: Pediatric brain tumors: Genetics and clinical outcome. J Neurosurg Pediatr. 5:263–270. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Chen X, Zhang FH, Chen QE, Wang YY, Wang YL, He JC and Zhou J: The clinical significance of CDK1 expression in oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal. 20:e7–12. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Chen H, Huang Q, Zhai DZ, Dong J, Wang AD and Lan Q: CDK1 expression and effects of CDK1 silencing on the malignant phenotype of glioma cells. Zhonghua Zhong Liu Za Zhi. 29:484–488. 2007.(In Chinese). PubMed/NCBI

39 

Brown DV, Daniel PM, D'Abaco GM, Gogos A, Ng W, Morokoff AP and Mantamadiotis T: Coexpression analysis of CD133 and CD44 identifies proneural and mesenchymal subtypes of glioblastoma multiforme. Oncotarget. 6:6267–6280. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Yang J, Hou Z, Wang C, Wang H and Zhang H: Gene expression profiles reveal key genes for early diagnosis and treatment of adamantinomatous craniopharyngioma. Cancer Gene Ther. 25:227–239. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Zhong S, Wu B, Dong X, Han Y, Jiang S, Zhang Y, Bai Y, Luo SX, Chen Y, Zhang H and Zhao G: Identification of driver genes and key pathways of glioblastoma shows JNJ-7706621 as a novel antiglioblastoma drug. World Neurosurg. 109:e329–e342. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Gao J, Li N, Dong Y, Li S, Xu L, Li X, Li Y, Li Z, Ng SS, Sung JJ, et al: miR-34a-5p suppresses colorectal cancer metastasis and predicts recurrence in patients with stage II/III colorectal cancer. Oncogene. 34:4142–4152. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Pu Y, Zhao F, Wang H, Cai W, Gao J, Li Y and Cai S: MiR-34a-5p promotes the multi-drug resistance of osteosarcoma by targeting the CD117 gene. Oncotarget. 7:28420–28434. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Yao Y, Ma J, Xue Y, Wang P, Li Z, Li Z, Hu Y, Shang X and Liu Y: MiR-449a exerts tumor-suppressive functions in human glioblastoma by targeting Myc-associated zinc-finger protein. Mol Oncol. 9:640–656. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Zhi F, Zhou G, Shao N, Xia X, Shi Y, Wang Q, Zhang Y, Wang R, Xue L, Wang S, et al: miR-106a-5p inhibits the proliferation and migration of astrocytoma cells and promotes apoptosis by targeting FASTK. PLoS One. 8:e723902013. View Article : Google Scholar : PubMed/NCBI

46 

Zhi F, Chen X, Wang S, Xia X, Shi Y, Guan W, Shao N, Qu H, Yang C, Zhang Y, et al: The use of hsa-miR-21, hsa-miR-181b and hsa-miR-106a as prognostic indicators of astrocytoma. Eur J Cancer. 46:1640–1649. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Mao G, Ren P, Wang G, Yan F and Zhang Y: MicroRNA-128-3p protects mouse against cerebral ischemia through reducing p38α mitogen-activated protein kinase activity. J Mol Neurosci. 61:152–158. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Zhang R, Liu C, Niu Y, Jing Y, Zhang H, Wang J, Yang J, Zen K, Zhang J, Zhang CY and Li D: MicroRNA-128-3p regulates mitomycin C-induced DNA damage response in lung cancer cells through repressing SPTAN1. Oncotarget. 8:58098–58107. 2017.PubMed/NCBI

49 

Mets E, Van Peer G, Van der Meulen J, Boice M, Taghon T, Goossens S, Mestdagh P, Benoit Y, De Moerloose B, Van Roy N, et al: MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia. Haematologica. 99:1326–1333. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Huang CY, Huang XP, Zhu JY, Chen ZG, Li XJ, Zhang XH, Huang S, He JB, Lian F, Zhao YN, et al: miR-128-3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients. Oncol Rep. 33:2889–2898. 2015. View Article : Google Scholar : PubMed/NCBI

51 

Meng H, Wang K, Chen X, Guan X, Hu L, Xiong G, Li J and Bai Y: MicroRNA-330-3p functions as an oncogene in human esophageal cancer by targeting programmed cell death 4. Am J Cancer Res. 5:1062–1075. 2015.PubMed/NCBI

52 

Pantaleo MA, Ravegnini G, Astolfi A, Simeon V, Nannini M, Saponara M, Urbini M, Gatto L, Indio V, Sammarini G, et al: Integrating miRNA and gene expression profiling analysis revealed regulatory networks in gastrointestinal stromal tumors. Epigenomics. 8:1347–1366. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang B, Dai JX, Pan YB, Ma YB and Chu SH: Identification of biomarkers and construction of a microRNA‑mRNA regulatory network for ependymoma using integrated bioinformatics analysis. Oncol Lett 18: 6079-6089, 2019.
APA
Yang, B., Dai, J., Pan, Y., Ma, Y., & Chu, S. (2019). Identification of biomarkers and construction of a microRNA‑mRNA regulatory network for ependymoma using integrated bioinformatics analysis. Oncology Letters, 18, 6079-6089. https://doi.org/10.3892/ol.2019.10941
MLA
Yang, B., Dai, J., Pan, Y., Ma, Y., Chu, S."Identification of biomarkers and construction of a microRNA‑mRNA regulatory network for ependymoma using integrated bioinformatics analysis". Oncology Letters 18.6 (2019): 6079-6089.
Chicago
Yang, B., Dai, J., Pan, Y., Ma, Y., Chu, S."Identification of biomarkers and construction of a microRNA‑mRNA regulatory network for ependymoma using integrated bioinformatics analysis". Oncology Letters 18, no. 6 (2019): 6079-6089. https://doi.org/10.3892/ol.2019.10941
Copy and paste a formatted citation
x
Spandidos Publications style
Yang B, Dai JX, Pan YB, Ma YB and Chu SH: Identification of biomarkers and construction of a microRNA‑mRNA regulatory network for ependymoma using integrated bioinformatics analysis. Oncol Lett 18: 6079-6089, 2019.
APA
Yang, B., Dai, J., Pan, Y., Ma, Y., & Chu, S. (2019). Identification of biomarkers and construction of a microRNA‑mRNA regulatory network for ependymoma using integrated bioinformatics analysis. Oncology Letters, 18, 6079-6089. https://doi.org/10.3892/ol.2019.10941
MLA
Yang, B., Dai, J., Pan, Y., Ma, Y., Chu, S."Identification of biomarkers and construction of a microRNA‑mRNA regulatory network for ependymoma using integrated bioinformatics analysis". Oncology Letters 18.6 (2019): 6079-6089.
Chicago
Yang, B., Dai, J., Pan, Y., Ma, Y., Chu, S."Identification of biomarkers and construction of a microRNA‑mRNA regulatory network for ependymoma using integrated bioinformatics analysis". Oncology Letters 18, no. 6 (2019): 6079-6089. https://doi.org/10.3892/ol.2019.10941
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