Mitotically‑associated long non‑coding RNA promotes cancer cell proliferation in hepatocellular carcinoma by downregulating miR‑122a

Zhang,Xuejing; Li,Hongling; Mao,Mingfeng; Wang,Xiangyang; Zheng,Jingjing; Yang,Shunshi

doi:10.3892/ol.2019.10947

Mitotically‑associated long non‑coding RNA promotes cancer cell proliferation in hepatocellular carcinoma by downregulating miR‑122a

Authors:
- Xuejing Zhang
- Hongling Li
- Mingfeng Mao
- Xiangyang Wang
- Jingjing Zheng
- Shunshi Yang
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Affiliations: Department of Medical Ultrasonics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, P.R. China, Department of Gastrointestinal Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, P.R. China
Published online on: October 2, 2019 https://doi.org/10.3892/ol.2019.10947
Pages: 6237-6242

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Abstract

Mitotically‑associated long non‑coding RNA (MANCR) is involved in malignant breast cancer. The present study analyzed the role of MANCR in hepatocellular carcinoma (HCC). MANCR was found to be upregulated in HCC and high expression level of MANCR in cancer tissues predicted poor survival of HCC patients. MicroRNA (miR)‑122a was downregulated HCC and was inversely correlated with MANCR only in cancer tissues. MANCR overexpression resulted in downregulation of miR‑122a, while miR‑122a overexpression showed no obvious effects on MANCR expression. MANCR overexpression showed no significant effects on HCC cell proliferation but led to promoted cell migration and invasion. miR‑122a overexpression led to inhibited migration and invasion of HCC cells and attenuated the effects of MANCR overexpression. Therefore, lncRNA MANCR may promote cancer cell proliferation in HCC by downregulating miR‑122a.

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