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Bioinformatics analysis of potential therapeutic targets among ARHGAP genes in breast cancer

  • Authors:
    • Wei‑Xian Chen
    • Ming Lou
    • Lin Cheng
    • Qi Qian
    • Ling‑Yun Xu
    • Li Sun
    • Yu‑Lan Zhu
    • Hong Dai
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, The Second Affiliated Changzhou People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China, Department of Graduate School, Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6017-6025
    |
    Published online on: October 2, 2019
       https://doi.org/10.3892/ol.2019.10949
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Abstract

GTPase activating proteins (RhoGAPs) serve significant roles in multiple aspects of tumor biology. Genes encoding RhoGAPs (ARHGAP), which switch off Rho‑like GTPases, are responsible for breast cancer biogenesis. However, the identification of suitable and novel biomarkers for precision treatment and prognosis remains challenging. The present study aimed to evaluate the expression of ARHGAP family genes in breast cancer and investigate the survival data using the Oncomine, Kaplan‑Meier Plotter, bcGenExMiner and cBioPortal online databases. The results demonstrated low expression of ARHGAP6, 7, 10, 14, 19, 23 and 24 and high expression of ARHGAP9, 11, 15, 18 and 30 in patients with breast cancer compared with that in healthy individuals. The survival analysis revealed that low expression levels of ARHGAP6, 7 and 19 were associated with poor relapse‑free survival (RFS) and overall survival (OS), whereas high expression levels of ARHGAP9, 15 and 30 were associated with preferable RFS and OS. Metastatic relapse data demonstrated that higher expression of ARHGAP9, 15, 18, 19, 25 and 30 were associated with better prognosis and increased expression of ARHGAP11A and 14 exerted negative effects on patient prognosis. The overlapping genes ARHGAP9, 15, 19 and 30 obtained from these bioinformatics analysis tools exhibited significant association with clinical parameters including age, the presence of estrogen receptor, progesterone receptor and epidermal growth factor receptor‑2, Scarff‑Bloom‑Richardson grade and Nottingham prognostic index. In conclusion, bioinformatics analysis revealed that ARHGAP9, 15, 19 and 30, but not other ARHGAP family genes may be promising targets with prognostic value and biological function for precision treatment of breast cancer.
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1 

Fan L, Strasser-Weippl K, Li JJ, St Louis J, Finkelstein DM, Yu KD, Chen WQ, Shao ZM and Goss PE: Breast cancer in China. Lancet Oncol. 15:e279–e289. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Vega FM and Ridley AJ: Rho GTPases in cancer cell biology. FEBS Lett. 582:2093–2101. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Etienne-Manneville S and Hall A: Rho GTPases in cell biology. Nature. 420:629–635. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Gökmen-Polar Y, True JD, Vieth E, Gu Y, Gu X, Qi GD, Mosley AL and Badve SS: Quantitative phosphoproteomic analysis identifies novel functional pathways of tumor suppressor DLC1 in estrogen receptor positive breast cancer. PLoS One. 13:e02046582018. View Article : Google Scholar : PubMed/NCBI

5 

Takagi K, Miki Y, Onodera Y, Ishida T, Watanabe M, Sasano H and Suzuki T: ARHGAP15 in human breast carcinoma: A potent tumor suppressor regulated by androgens. Int J Mol Sci. 19:E8042018. View Article : Google Scholar : PubMed/NCBI

6 

Aleskandarany MA, Sonbul S, Surridge R, Mukherjee A, Caldas C, Diez-Rodriguez M, Ashankyty I, Albrahim KI, Elmouna AM, Aneja R, et al: Rho-GTPase activating-protein 18: A biomarker associated with good prognosis in invasive breast cancer. Br J Cancer. 117:1176–1184. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A and Chinnaiyan AM: ONCOMINE: A cancer microarray database and integrated data-mining platform. Neoplasia. 6:1–6. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Györffy B, Lanczky A, Eklund AC, Denkert C, Budczies J, Li Q and Szallasi Z: An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast Cancer Res Treat. 123:725–731. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Jézéquel P, Frénel JS, Campion L, Guérin-Charbonnel C, Gouraud W, Ricolleau G and Campone M: bc-GenExMiner 3.0: New mining module computes breast cancer gene expression correlation analyses. Database (Oxford). 2013:bas0602013. View Article : Google Scholar : PubMed/NCBI

10 

Jézéquel P, Campone M, Gouraud W, Guérin-Charbonnel C, Leux C, Ricolleau G and Campion L: bc-GenExMiner: An easy-to-use online platform for gene prognostic analyses in breast cancer. Breast Cancer Res Treat. 131:765–775. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI

12 

Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Le Doussal V, Tubiana-Hulin M, Friedman S, Hacene K, Spyratos F and Brunet M: Prognostic value of histologic grade nuclear components of Scarff-Bloom-Richardson (SBR). An improved score modification based on a multivariate analysis of 1262 invasive ductal breast carcinomas. Cancer. 64:1914–1921. 1989. View Article : Google Scholar : PubMed/NCBI

14 

Haybittle JL, Blamey RW, Elston CW, Johnson J, Doyle PJ, Campbell FC, Nicholson RI and Griffiths K: A prognostic index in primary breast cancer. Br J Cancer. 45:361–366. 1982. View Article : Google Scholar : PubMed/NCBI

15 

Ang BK, Lim CY, Koh SS, Sivakumar N, Taib S, Lim KB, Ahmed S, Rajagopal G and Ong SH: ArhGAP9, a novel MAP kinase docking protein, inhibits Erk and p38 activation through WW domain binding. J Mol Signal. 2:12007. View Article : Google Scholar : PubMed/NCBI

16 

Furukawa Y, Kawasoe T, Daigo Y, Nishiwaki T, Ishiguro H, Takahashi M, Kitayama J and Nakamura Y: Isolation of a novel human gene, ARHGAP9, encoding a rho-GTPase activating protein. Biochem Biophys Res Commun. 284:643–649. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Zhang H, Tang QF, Sun MY, Zhang CY, Zhu JY, Shen YL, Zhao B, Shao ZY, Zhang LJ and Zhang H: ARHGAP9 suppresses the migration and invasion of hepatocellular carcinoma cells through up-regulating FOXJ2/E-cadherin. Cell Death Dis. 9:9162018. View Article : Google Scholar : PubMed/NCBI

18 

Wang T and Ha M: Silencing ARHGAP9 correlates with the risk of breast cancer and inhibits the proliferation, migration, and invasion of breast cancer. J Cell Biochem. 119:7747–7756. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Radu M, Rawat SJ, Beeser A, Iliuk A, Tao WA and Chernoff J: ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signaling. J Biol Chem. 288:21117–21125. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Seoh ML, Ng CH, Yong J, Lim L and Leung T: ArhGAP15, a novel human RacGAP protein with GTPase binding property. FEBS Lett. 539:131–137. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Pan S, Deng Y, Fu J, Zhang Y, Zhang Z, Ru X and Qin X: Decreased expression of ARHGAP15 promotes the development of colorectal cancer through PTEN/AKT/FOXO1 axis. Cell Death Dis. 9:6732018. View Article : Google Scholar : PubMed/NCBI

22 

Naji L, Pacholsky D and Aspenström P: ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion. Biochem Biophys Res Commun. 409:96–102. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Wang J, Qian J, Hu Y, Kong X, Chen H, Shi Q, Jiang L, Wu C, Zou W, Chen Y, et al: ArhGAP30 promotes p53 acetylation and function in colorectal cancer. Nat Commun. 5:47352014. View Article : Google Scholar : PubMed/NCBI

24 

David MD, Petit D and Bertoglio J: The RhoGAP ARHGAP19 controls cytokinesis and chromosome segregation in T lymphocytes. J Cell Sci. 127:400–410. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen WX, Lou M, Cheng L, Qian Q, Xu LY, Sun L, Zhu YL and Dai H: Bioinformatics analysis of potential therapeutic targets among ARHGAP genes in breast cancer. Oncol Lett 18: 6017-6025, 2019.
APA
Chen, W., Lou, M., Cheng, L., Qian, Q., Xu, L., Sun, L. ... Dai, H. (2019). Bioinformatics analysis of potential therapeutic targets among ARHGAP genes in breast cancer. Oncology Letters, 18, 6017-6025. https://doi.org/10.3892/ol.2019.10949
MLA
Chen, W., Lou, M., Cheng, L., Qian, Q., Xu, L., Sun, L., Zhu, Y., Dai, H."Bioinformatics analysis of potential therapeutic targets among ARHGAP genes in breast cancer". Oncology Letters 18.6 (2019): 6017-6025.
Chicago
Chen, W., Lou, M., Cheng, L., Qian, Q., Xu, L., Sun, L., Zhu, Y., Dai, H."Bioinformatics analysis of potential therapeutic targets among ARHGAP genes in breast cancer". Oncology Letters 18, no. 6 (2019): 6017-6025. https://doi.org/10.3892/ol.2019.10949
Copy and paste a formatted citation
x
Spandidos Publications style
Chen WX, Lou M, Cheng L, Qian Q, Xu LY, Sun L, Zhu YL and Dai H: Bioinformatics analysis of potential therapeutic targets among ARHGAP genes in breast cancer. Oncol Lett 18: 6017-6025, 2019.
APA
Chen, W., Lou, M., Cheng, L., Qian, Q., Xu, L., Sun, L. ... Dai, H. (2019). Bioinformatics analysis of potential therapeutic targets among ARHGAP genes in breast cancer. Oncology Letters, 18, 6017-6025. https://doi.org/10.3892/ol.2019.10949
MLA
Chen, W., Lou, M., Cheng, L., Qian, Q., Xu, L., Sun, L., Zhu, Y., Dai, H."Bioinformatics analysis of potential therapeutic targets among ARHGAP genes in breast cancer". Oncology Letters 18.6 (2019): 6017-6025.
Chicago
Chen, W., Lou, M., Cheng, L., Qian, Q., Xu, L., Sun, L., Zhu, Y., Dai, H."Bioinformatics analysis of potential therapeutic targets among ARHGAP genes in breast cancer". Oncology Letters 18, no. 6 (2019): 6017-6025. https://doi.org/10.3892/ol.2019.10949
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