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Article

Propofol exhibits a tumor‑suppressive effect and regulates cell viability, migration and invasion in bladder carcinoma by targeting the microRNA‑10b/HOXD10 signaling pathway

Retraction in: /10.3892/ol.2024.14779
  • Authors:
    • Zongcai Qi
    • Lei Yuan
    • Nenghong Sun
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China, Department of Operating Room, The Seventh People's Hospital of Weifang City, Weifang, Shandong 261041, P.R. China
  • Pages: 6228-6236
    |
    Published online on: October 8, 2019
       https://doi.org/10.3892/ol.2019.10968
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Abstract

2,6‑diisopropylphenol (propofol) is a commonly used intravenous anesthetic drug, which has been reported to serve an antitumor role in human cancers. The current study aimed to assess the effects of propofol on the biological behaviors of human bladder cancer cells and to elucidate its potential molecular mechanism. The results of MTT, wound healing and Matrigel invasion assays demonstrated that propofol significantly inhibited the viability, migration and invasion of bladder cancer T24 cells in vitro. Reverse transcription‑quantitative PCR and western blotting revealed that propofol decreased the expression levels of microRNA (miR)‑10b and increased the expression levels of homeobox D10 (HOXD10) in T24 cells. Luciferase reporter assay revealed that HOXD10 was a direct target of miR‑10b in T24 cells. T24 cells transfected with a miR‑10b mimic significantly reduced the mRNA and protein expression levels of HOXD10. In addition, overexpression of miR‑10b partly reversed the inhibitory effect of propofol on T24 cell viability, migration and invasion induced by upregulation of HOXD10. In summary, the present study focused on the role of propofol in the treatment of bladder cancer and demonstrated that propofol may serve a tumor‑suppressive role and control cell viability, migration and invasion of T24 cells by targeting the miR‑10b/HOXD10 signaling pathway, which indicated that propofol may be used as an effective therapeutic drug for the treatment of bladder cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Qi Z, Yuan L and Sun N: Propofol exhibits a tumor‑suppressive effect and regulates cell viability, migration and invasion in bladder carcinoma by targeting the microRNA‑10b/HOXD10 signaling pathway Retraction in /10.3892/ol.2024.14779. Oncol Lett 18: 6228-6236, 2019.
APA
Qi, Z., Yuan, L., & Sun, N. (2019). Propofol exhibits a tumor‑suppressive effect and regulates cell viability, migration and invasion in bladder carcinoma by targeting the microRNA‑10b/HOXD10 signaling pathway Retraction in /10.3892/ol.2024.14779. Oncology Letters, 18, 6228-6236. https://doi.org/10.3892/ol.2019.10968
MLA
Qi, Z., Yuan, L., Sun, N."Propofol exhibits a tumor‑suppressive effect and regulates cell viability, migration and invasion in bladder carcinoma by targeting the microRNA‑10b/HOXD10 signaling pathway Retraction in /10.3892/ol.2024.14779". Oncology Letters 18.6 (2019): 6228-6236.
Chicago
Qi, Z., Yuan, L., Sun, N."Propofol exhibits a tumor‑suppressive effect and regulates cell viability, migration and invasion in bladder carcinoma by targeting the microRNA‑10b/HOXD10 signaling pathway Retraction in /10.3892/ol.2024.14779". Oncology Letters 18, no. 6 (2019): 6228-6236. https://doi.org/10.3892/ol.2019.10968
Copy and paste a formatted citation
x
Spandidos Publications style
Qi Z, Yuan L and Sun N: Propofol exhibits a tumor‑suppressive effect and regulates cell viability, migration and invasion in bladder carcinoma by targeting the microRNA‑10b/HOXD10 signaling pathway Retraction in /10.3892/ol.2024.14779. Oncol Lett 18: 6228-6236, 2019.
APA
Qi, Z., Yuan, L., & Sun, N. (2019). Propofol exhibits a tumor‑suppressive effect and regulates cell viability, migration and invasion in bladder carcinoma by targeting the microRNA‑10b/HOXD10 signaling pathway Retraction in /10.3892/ol.2024.14779. Oncology Letters, 18, 6228-6236. https://doi.org/10.3892/ol.2019.10968
MLA
Qi, Z., Yuan, L., Sun, N."Propofol exhibits a tumor‑suppressive effect and regulates cell viability, migration and invasion in bladder carcinoma by targeting the microRNA‑10b/HOXD10 signaling pathway Retraction in /10.3892/ol.2024.14779". Oncology Letters 18.6 (2019): 6228-6236.
Chicago
Qi, Z., Yuan, L., Sun, N."Propofol exhibits a tumor‑suppressive effect and regulates cell viability, migration and invasion in bladder carcinoma by targeting the microRNA‑10b/HOXD10 signaling pathway Retraction in /10.3892/ol.2024.14779". Oncology Letters 18, no. 6 (2019): 6228-6236. https://doi.org/10.3892/ol.2019.10968
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