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PACAP and PAC1 receptor expression in pancreatic ductal carcinoma

  • Authors:
    • Sandor Ferencz
    • Dora Reglodi
    • Balint Kaszas
    • Attila Bardosi
    • Denes Toth
    • Zsofia Vekony
    • Viktoria Vicena
    • Oszkar Karadi
    • Dezso Kelemen
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, University of Pécs, Medical School, Pécs 7622, Hungary, Department of Anatomy, MTA‑PTE PACAP Research Group, University of Pécs, Medical School, Pécs 7622, Hungary, Department of Pathology, University of Pécs, Medical School, Pécs 7622, Hungary, Center for Histology, Cytology and Molecular Diagnostics, and Proteopath GmbH, Trier 54296, Germany, Department of Forensic Medicine, University of Pécs, Medical School, Pécs 7622, Hungary, Department of Oncology, University of Pécs, Medical School, Pécs 7622, Hungary
    Copyright: © Ferencz et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5725-5730
    |
    Published online on: October 8, 2019
       https://doi.org/10.3892/ol.2019.10971
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Abstract

Pancreatic carcinoma is one of the most malignant diseases and is associated with a poor survival rate. Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide that acts on three different G protein‑coupled receptors: the specific PAC1 and the VPAC1/2 that also bind vasoactive intestinal peptide. PACAP is widely distributed in the body and has diverse physiological effects. Among other things, it acts as a trophic factor and influences proliferation and differentiation of several different cells both under normal circumstances and tumourous transformation. Changes of PACAP and its receptors have been shown in various tumour types. However, it is not known whether PACAP and its specific receptor are altered in pancreatic cancer. Perioperative data of patients with pancreas carcinoma was investigated over a five‑year period. Histological results showed Grade 2 or Grade 3 adenocarcinoma in most cases. PACAP and PAC1 receptor expression were investigated by immunohistochemistry. Staining intensity of PAC1 receptor was strong in normal tissues both in the exocrine and endocrine parts of the pancreas, the receptor staining was markedly weaker in the adenocarcinoma. PACAP immunostaining was weak in the exocrine part and very strong in the islets and nerve elements in non‑tumourous tissues. The PACAP immunostaining almost disappeared in the adenocarcinoma samples. Based on these findings a decrease or lack of the PAC1 receptor/PACAP signalling might have an influence on tumour growth and/or differentiation.
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1 

Pancreatic Cancer. Cancer Research UK, . https://www.cancerresearchuk.org/about-cancer/pancreatic-cancerMarch 21–2019

2 

Klaiber U, Leonhardt CS, Strobel O, Tjaden C, Hackert T and Neoptolemos JP: Neoadjuvant and adjuvant chemotherapy in pancreatic cancer. Langenbecks Arch Surg. 403:917–932. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Ling S, Feng T, Jia K, Tian Y and Li Y: Inflammation to cancer: The molecular biology in the pancreas (Review). Oncol Lett. 7:1747–1754. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Frampas E, David A, Regenet N, Touchefeu Y, Meyer J and Merla O: Pancreatic carcinoma: Key-points from diagnosis to treatment. Diagn Interv Imaging. 97:1207–1223. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Hirabayashi T, Nakamachi T and Shioda S: Discovery of PACAP and its receptors in the brain. J Headache Pain. 19:282018. View Article : Google Scholar : PubMed/NCBI

6 

Miyata A, Arimura A, Dahl RR, Minamino N, Uehara A, Jiang L, Culler MD and Coy DH: Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells. Biochem Biophys Res Commun. 164:567–574. 1989. View Article : Google Scholar : PubMed/NCBI

7 

Miyata A, Jiang L, Dahl RD, Kitada C, Kubo K, Fujino M, Minamino N and Arimura A: Isolation of a neuropeptide corresponding to the N-terminal 27 residues of the pituitary adenylate cyclase activating polypeptide with 38 residues (PACAP38). Biochem Biophys Res Commun. 170:643–648. 1990. View Article : Google Scholar : PubMed/NCBI

8 

Ojala J, Tooke K, Hsiang H, Girard BM, May V and Vizzard MA: PACAP/PAC1 expression and function in micturition pathways. J Mol Neurosci. 68:357–367. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Reglodi D, Illes A, Opper B, Schafer E, Tamas A and Horvath G: Presence and effects of pituitary adenylate cyclase activating polypeptide under physiological and pathological conditions in the stomach. Front Endocrinol (Lausanne). 9:902018. View Article : Google Scholar : PubMed/NCBI

10 

Lajko A, Meggyes M, Fulop BD, Gede N, Reglodi D and Szereday L: Comparative analysis of decidual and peripheral immune cells and immune-checkpoint molecules during pregnancy in wild-type and PACAP-deficient mice. Am J Reprod Immunol. 80:e130352018. View Article : Google Scholar : PubMed/NCBI

11 

Parsons RL and May V: PACAP-induced PAC1 receptor internalization and recruitment of endosomal signaling regulate cardiac neuron excitability. J Mol Neurosci. 68:340–347. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Sarszegi Z, Szabo D, Gaszner B, Konyi A, Reglodi D, Nemeth J, Lelesz B, Polgar B, Jungling A and Tamas A: Examination of pituitary adenylate cyclase-activating polypeptide (PACAP) as a potential biomarker in heart failure patients. J Mol Neurosci. 68:368–376. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Reglodi D and Tamas A: Pituitary Adenylate Cyclase Activating Polypeptide-PACAPCurr Topics Neurotox Springer Int. Switzerland: pp. 1–840. 2016

14 

Vaudry D, Falluel-Morel A, Bourgault S, Basille M, Burel D, Wurtz O, Fournier A, Chow BK, Hashimoto H, Galas L and Vaudry H: Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery. Pharmacol Rev. 61:283–357. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Elsås T, Uddman R and Sundler F: Pituitary adenylate cyclase-activating peptide-immunoreactive nerve fibers in the cat eye. Graefes Arch Clin Exp Ophthalmol. 234:573–580. 1996. View Article : Google Scholar : PubMed/NCBI

16 

Gaal V, Mark L, Kiss P, Kustos I, Tamas A, Kocsis B, Lubics A, Nemeth V, Nemeth A, Lujber L, et al: Investigation of the effects of PACAP on the composition of tear and endolymph proteins. J Mol Neurosci. 36:321–329. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Nakamachi T, Ohtaki H, Seki T, Yofu S, Kagami N, Hashimoto H, Shintani N, Baba A, Mark L, Lanekoff I, et al: PACAP suppresses dry eye signs by stimulating tear secretion. Nat Commun. 7:120342016. View Article : Google Scholar : PubMed/NCBI

18 

Pedersen AM, Dissing S, Fahrenkrug J, Hannibal J, Reibel J and Nauntofte B: Innervation pattern and Ca2+ signalling in labial salivary glands of healthy individuals and patients with primary Sjögren's syndrome (pSS). J Oral Pathol Med. 29:97–109. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Skakkebaek M, Hannibal J and Fahrenkrug J: Pituitary adenylate cyclase activating polypeptide (PACAP) in the rat mammary gland. Cell Tissue Res. 298:153–159. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Tobin G, Asztély A, Edwards AV, Ekström J, Håkanson R and Sundler F: Presence and effects of pituitary adenylate cyclase activating peptide in the submandibular gland of the ferret. Neuroscience. 66:227–235. 1995. View Article : Google Scholar : PubMed/NCBI

21 

Matoba Y, Nonaka N, Takagi Y, Imamura E, Narukawa M, Nakamachi T, Shioda S, Banks WA and Nakamura M: Pituitary adenylate cyclase-activating polypeptide enhances saliva secretion via direct binding to PACAP receptors of major salivary glands in mice. Anat Rec (Hoboken). 299:1293–1299. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Calvert PA, Heck PM and Edwards AV: Autonomic control of submandibular protein secretion in the anaesthetized calf. Exp Physiol. 83:545–556. 1998. View Article : Google Scholar : PubMed/NCBI

23 

Kamaishi H, Endoh T and Suzuki T: Multiple signal pathways coupling VIP and PACAP receptors to calcium channels in hamster submandibular ganglion neurons. Auton Neurosci. 111:15–26. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Mirfendereski S, Tobin G, Håkanson R and Ekström J: Pituitary adenylate cyclase activating peptide (PACAP) in salivary glands of the rat: Origin, and secretory and vascular effects. Acta Physiol Scand. 160:15–22. 1997. View Article : Google Scholar : PubMed/NCBI

25 

Schmidt WE, Seebeck J, Höcker M, Schwarzhoff R, Schäfer H, Fornefeld H, Morys-Wortmann C, Fölsch UR and Creutzfeldt W: PACAP and VIP stimulate enzyme secretion in rat pancreatic acini via interaction with VIP/PACAP-2 receptors: Additive augmentation of CCK/carbachol-induced enzyme release. Pancreas. 8:476–487. 1993. View Article : Google Scholar : PubMed/NCBI

26 

Sakurai Y, Shintani N, Hayata A, Hashimoto H and Baba A: Trophic effects of PACAP on pancreatic islets: A mini-review. J Mol Neurosci. 43:3–7. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Hamagami K, Sakurai Y, Shintani N, Higuchi N, Ikeda K, Hashimoto H, Suzuki A, Kiyama H and Baba A: Over-expression of pancreatic pituitary adenylate cyclase-activating polypeptide (PACAP) aggravates cerulein-induced acute pancreatitis in mice. J Pharmacol Sci. 110:451–458. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Jung S, Yi L, Jeong D, Kim J, An S, Oh TJ, Kim CH, Kim CJ, Yang Y, Kim KI, Lim JS and Lee MS: The role of ADCYAP1, adenylate cyclase activating polypeptide, as a methylation biomarker for the early detection of cervical cancer. Oncol Rep. 25:245–252. 2011.PubMed/NCBI

29 

Moody TW, Chan D, Fahrenkrug J and Jensen RT: Neuropeptides as autocrine growth factors in cancer cells. Curr Pharm Des. 9:495–509. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Moody TW, Nuche-Berenguer B and Jensen RT: Vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide, and their receptors and cancer. Curr Opin Endocrinol Diabetes Obes. 23:38–47. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Moody TW and Jensen RT: PACAP and cancerPituitary Adenylate Cyclase Activating Polypeptide-PACAP. Reglodi D and Tamas A: Springer Int.; Switzerland: pp. 795–814. 2016, View Article : Google Scholar

32 

Schulz S, Röcken C, Mawrin C, Weise W, Höllt V and Schulz S: Immunocytochemical identification of VPAC1, VPAC2, and PAC1 receptors in normal and neoplastic human tissues with subtype-specific antibodies. Clin Cancer Res. 10:8235–8242. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Schulz S, Mann A, Novakhov B, Piggins HD and Lupp A: VPAC2 receptor expression in human normal and neoplastic tissues: Evaluation of the novel MAB SP235. Endocr Connect. 4:18–26. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Wojcieszak J and Zawilska JB: PACAP38 and PACAP6-38 exert cytotoxic activity against human retinoblastoma Y79 cells. J Mol Neurosci. 54:463–468. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Schäfer H, Lettau P, Trauzold A, Banasch M and Schmidt WE: Human PACAP response gene 1 (p22/PRG1): Proliferation-associated expression in pancreatic carcinoma cells. Pancreas. 18:378–384. 1999. View Article : Google Scholar : PubMed/NCBI

36 

Schäfer H, Zheng J, Gundlach F, Günther R and Schmidt WE: PACAP stimulates transcription of c-Fos and c-Jun and activates the AP-1 transcription factor in rat pancreatic carcinoma cells. Biochem Biophys Res Commun. 221:111–116. 1996. View Article : Google Scholar : PubMed/NCBI

37 

Bardosi S, Bardosi A, Nagy Z and Reglodi D: Expression of PACAP and PAC1 receptor in normal human thyroid gland and in thyroid papillary carcinoma. J Mol Neurosci. 60:171–178. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Nakamura K, Nakamachi T, Endo K, Ito K, Machida T, Oka T, Hori M, Ishizaka K and Shioda S: Distribution of pituitary adenilate cyclase-activating polypeptide (PACAP) in the human testis and in testicular germ cell tumours. Andrologia. 46:465–471. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Ndlovu R, Deng LC, Wu J, Li XK and Zhang JS: Fibroblast growth factor 10 in pancreas development and pancreatic cancer. Front Genet. 9:4822018. View Article : Google Scholar : PubMed/NCBI

40 

Ishiwata T: Role of fibroblast growth factor receptor-2 splicing in normal and cancer cells. Front Biosci (Landmark Ed). 23:626–639. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Liu G, Xiong D, Xiao R and Huang Z: Prognostic role of fibroblast growth factor receptor 2 in human solid tumours: A systematic review and meta-analysis. Tumour Biol. 39:10104283177074242017. View Article : Google Scholar : PubMed/NCBI

42 

Saloman JL, Singhi AD, Hartman DJ, Normolle DP, Albers KM and Davis BM: Systemic depletion of nerve growth factor inhibits disease progression in a genetically engineered model of pancreatic ductal adenocarcinoma. Pancreas. 47:856–863. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Melzer C, Hass R, von der Ohe J, Lehnert H and Ungefroren H: The role of TGF-β and its crosstalk with RAC1/RAC1b signaling in breast and pancreas carcinoma. Cell Commun Signal. 15:192107. View Article : Google Scholar

44 

Chiramel J, Backen AC, Pihlak R, Lamarca A, Frizziero M, Tariq NU, Hubner RA, Valle JW, Amir E and McNamara MG: Targeting the epidermal growth factor receptor in addition to chemotherapy in patients with advanced pancreatic cancer: A systematic review and meta-analysis. Int J Mol Sci. 18:E9092017. View Article : Google Scholar : PubMed/NCBI

45 

Weiss GA, Rossi MR, Khushalani NI, Lo K, Gibbs JF, Bharthuar A, Cowell JK and Iyer R: Evaluation of phosphatidylinositol-3-kinase catalytic subunit (PIK3CA) and epidermal growth factor receptor (EGFR) gene mutations in pancreaticobiliary adenocarcinoma. J Gastrointest Onco. 4:20–29. 2013.

46 

Luo G, Long J, Qiu L, Liu C, Xu J and Yu X: Role of epidermal growth factor receptor expression on patient survival in pancreatic cancer: A meta-analysis. Pancreatology. 11:595–600. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Gong Y, Zhang B, Liao Y, Tang Y, Mai C, Chen T and Tang H: Serum insulin-like growth factor axis and the risk of pancreatic cancer: Systematic review and meta-analysis. Nutrients. 9:E3942017. View Article : Google Scholar : PubMed/NCBI

48 

Loosen SH, Neumann UP, Trautwein C, Roderburg C and Luedde T: Current and future biomarkers for pancreatic adenocarcinoma. Tumour Biol. 39:10104283176922312017. View Article : Google Scholar : PubMed/NCBI

49 

Yamaoka T, Ohba M and Ohmori T: Molecular-targeted therapies for epidermal growth factor receptor and its resistance mechanisms. Int J Mol Sci. 18:E24202017. View Article : Google Scholar : PubMed/NCBI

50 

Le N, Sund M and Vinci A; GEMS collaborating group of Pancreas 2000, : Prognostic and predictive markers in pancreatic adenocarcinoma. Dig Liver Dis. 48:223–230. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Fulop BD, Sandor B, Szentleleky E, Karanyicz E, Reglodi D, Gaszner B, Zakany R, Hashimoto H, Juhasz T and Tamas A: Altered notch signaling in developing molar teeth of pituitary adenylate cyclase-activating polypeptide (PACAP)-deficient mice. J Mol Neurosci. 68:377–388. 2019. View Article : Google Scholar : PubMed/NCBI

52 

Xu Z, Ohtaki H, Watanabe J, Miyamoto K, Murai N, Sasaki S, Matsumoto M, Hashimoto H, Hiraizumi Y, Numazawa S and Shioda S: Pituitary adenylate cyclase-activating polypeptide (PACAP) contributes to the proliferation of hematopoietic progenitor cells in murine bone marrow via PACAP-specific receptor. Sci Rep. 6:223732016. View Article : Google Scholar : PubMed/NCBI

53 

Sandor B, Fintor K, Reglodi D, Fulop DB, Helyes Z, Szanto I, Nagy P, Hashimoto H and Tamas A: Structural and morphometric comparison of lower incisors in PACAP-deficient and wild-type mice. J Mol Neurosci. 59:300–308. 2016. View Article : Google Scholar : PubMed/NCBI

54 

Zibara K, Zeidan A, Mallah K, Kassem N, Awad A, Mazurier F, Badran B and El-Zein N: Signaling pathways activated by PACAP in MCF-7 breast cancer cells. Cell Signal. 50:37–47. 2018. View Article : Google Scholar : PubMed/NCBI

55 

Maugeri G, D'Amico AG, Reitano R, Magro G, Cavallaro S, Salomone S and D'Agata V: PACAP and VIP inhibit the invasiveness of glioblastoma cells exposed to hypoxia through the regulation of HIFs and EGFR expression. Front Pharmacol. 7:1392016. View Article : Google Scholar : PubMed/NCBI

56 

Lee JH, Lee JY, Rho SB, Choi JS, Lee DG, An S, Oh T, Choi DC and Lee SH: PACAP inhibits tumour growth and interferes with clusterin in cervical carcinomas. FEBS Lett. 588:4730–4739. 2014. View Article : Google Scholar : PubMed/NCBI

57 

Juhász T, Matta C, Katona É, Somogyi C, Takács R, Hajdú T, Helgadottir SL, Fodor J, Csernoch L, Tóth G, et al: Pituitary adenylate cyclase-activating polypeptide (PACAP) signalling enhances osteogenesis in UMR-106 cell line. J Mol Neurosci. 54:555–573. 2014. View Article : Google Scholar : PubMed/NCBI

58 

Le SV, Yamaguchi DJ, McArdle CA, Tachiki K, Pisegna JR and Germano P: PAC1 and PACAP expression, signaling, and effect on the growth of HCT8, human colonic tumour cells. Regul Pept. 109:115–125. 2002. View Article : Google Scholar : PubMed/NCBI

59 

Farini D, Puglianiello A, Mammi C, Siracusa G and Moretti C: Dual effect of pituitary adenylate cyclase activating polypeptide on prostate tumour LNCaP cells: Short- and long-term exposure affect proliferation and neuroendocrine differentiation. Endocrinology. 144:1631–1643. 2003. View Article : Google Scholar : PubMed/NCBI

60 

Reubi JC, Läderach U, Waser B, Gebbers JO, Robberecht P and Laissue JA: Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor subtypes in human tumours and their tissues of origin. Cancer Res. 60:3105–3112. 2000.PubMed/NCBI

61 

Hessenius C, Bäder M, Meinhold H, Böhmig M, Faiss S, Reubi JC and Wiedenmann B: Vasoactive intestinal peptide receptor scintigraphy in patients with pancreatic adenocarcinomas or neuroendocrine tumours. Eur J Nucl Med. 27:1684–1693. 2000. View Article : Google Scholar : PubMed/NCBI

62 

Raderer M, Kurtaran A, Yang Q, Meghdadi S, Vorbeck F, Hejna M, Angelberger P, Kornek G, Pidlich J, Scheithauer W and Virgolini I: Iodine-123-vasoactive intestinal peptide receptor scanning in patients with pancreatic cancer. J Nucl Med. 39:1570–1575. 1998.PubMed/NCBI

63 

Tang C, Biemond I, Offerhaus GJ, Verspaget W and Lamers CB: Expression of receptors for gut peptides in human pancreatic adenocarcinoma and tumour-free pancreas. Br J Cancer. 75:1467–1473. 1997. View Article : Google Scholar : PubMed/NCBI

64 

Tamas A, Javorhazy A, Reglodi D, Sarlos DP, Banyai D, Semjen D, Nemeth J, Lelesz B, Fulop DB and Szanto Z: Examination of PACAP-like immunoreactivity in urogenital tumour samples. J Mol Neurosci. 59:177–183. 2016. View Article : Google Scholar : PubMed/NCBI

65 

Szanto Z, Sarszegi Z, Reglodi D, Nemeth J, Szabadfi K, Kiss P, Varga A, Banki E, Csanaky K, Gaszner B, et al: PACAP immunoreactivity in human malignant tumour samples and cardiac diseases. J Mol Neurosci. 48:667–673. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ferencz S, Reglodi D, Kaszas B, Bardosi A, Toth D, Vekony Z, Vicena V, Karadi O and Kelemen D: PACAP and PAC1 receptor expression in pancreatic ductal carcinoma. Oncol Lett 18: 5725-5730, 2019.
APA
Ferencz, S., Reglodi, D., Kaszas, B., Bardosi, A., Toth, D., Vekony, Z. ... Kelemen, D. (2019). PACAP and PAC1 receptor expression in pancreatic ductal carcinoma. Oncology Letters, 18, 5725-5730. https://doi.org/10.3892/ol.2019.10971
MLA
Ferencz, S., Reglodi, D., Kaszas, B., Bardosi, A., Toth, D., Vekony, Z., Vicena, V., Karadi, O., Kelemen, D."PACAP and PAC1 receptor expression in pancreatic ductal carcinoma". Oncology Letters 18.6 (2019): 5725-5730.
Chicago
Ferencz, S., Reglodi, D., Kaszas, B., Bardosi, A., Toth, D., Vekony, Z., Vicena, V., Karadi, O., Kelemen, D."PACAP and PAC1 receptor expression in pancreatic ductal carcinoma". Oncology Letters 18, no. 6 (2019): 5725-5730. https://doi.org/10.3892/ol.2019.10971
Copy and paste a formatted citation
x
Spandidos Publications style
Ferencz S, Reglodi D, Kaszas B, Bardosi A, Toth D, Vekony Z, Vicena V, Karadi O and Kelemen D: PACAP and PAC1 receptor expression in pancreatic ductal carcinoma. Oncol Lett 18: 5725-5730, 2019.
APA
Ferencz, S., Reglodi, D., Kaszas, B., Bardosi, A., Toth, D., Vekony, Z. ... Kelemen, D. (2019). PACAP and PAC1 receptor expression in pancreatic ductal carcinoma. Oncology Letters, 18, 5725-5730. https://doi.org/10.3892/ol.2019.10971
MLA
Ferencz, S., Reglodi, D., Kaszas, B., Bardosi, A., Toth, D., Vekony, Z., Vicena, V., Karadi, O., Kelemen, D."PACAP and PAC1 receptor expression in pancreatic ductal carcinoma". Oncology Letters 18.6 (2019): 5725-5730.
Chicago
Ferencz, S., Reglodi, D., Kaszas, B., Bardosi, A., Toth, D., Vekony, Z., Vicena, V., Karadi, O., Kelemen, D."PACAP and PAC1 receptor expression in pancreatic ductal carcinoma". Oncology Letters 18, no. 6 (2019): 5725-5730. https://doi.org/10.3892/ol.2019.10971
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