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JMJD3 promotes the epithelial‑mesenchymal transition and migration of glioma cells via the CXCL12/CXCR4 axis

  • Authors:
    • Shuang Zou
    • Dongchen Zhang
    • Zhongwei Xu
    • Xiaochang Wen
    • Yan Zhang
  • View Affiliations / Copyright

    Affiliations: Central Laboratory, Department of Medical Service, Logistics University of People's Armed Police Force, Tianjin 300309, P.R. China, Department of Dermatology, The First Central Hospital of Baoding, Baoding, Hebei 071000, P.R. China
    Copyright: © Zou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5930-5940
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    Published online on: October 9, 2019
       https://doi.org/10.3892/ol.2019.10972
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Abstract

Histone H3K27 demethylase Jumonji domain‑​containing protein 3 (JMJD3) is involved in somatic cell differentiation and tumor progression; however, the underlying mechanisms of JMJD3 in cancer progression are yet to be fully explored. To improve understanding regarding the function of JMJD3 in brain tumor cells, the present study investigated the effects of JMJD3 on the epithelial‑mesenchymal transition (EMT) and migration in glioma cells, and the underlying mechanisms involving the C‑X‑C motif chemokine ligand 12 (CXCL12)/C‑X‑C motif chemokine receptor 4 (CXCR4) axis. Immunohistochemical staining of a tissue microarray of glioma samples confirmed that JMJD3 overexpression could stratify highly metastatic glioma. The overexpression of JMJD3 induced a spindle‑shaped morphology, promoted N‑cadherin expression, inhibited E‑cadherin expression and enhanced the migration ability of U‑251MG and U‑87MG American Type Culture Collection cells. The expression of E‑cadherin and N‑cadherin were assessed by western blotting and reverse transcription‑quantitative polymerase chain reaction, and cell migration was evaluated using a Transwell migration assay and wound‑healing. The overexpression of JMJD3 upregulated CXCL12 expression in a demethylase activity‑dependent manner as ChIP assays revealed a decrease in H3K27 trimethylation at the CXCL12 promoter following overexpression of JMJD3 in U‑87MG ATCC cells. Accordingly, CXCL12 overexpression was sufficient to rescue the suppressive effects of JMJD3 inhibition on the EMT and migration in glioma cells. In addition, CXCR4 expression was not regulated by JMJD3, but the interruption of CXCR4 caused by the CXCR4 inhibitor AMD3100 abolished the promotional effect of JMJD3 on EMT and migration in glioma cells. Collectively, these results suggested that JMJD3 promoted EMT and migration in glioma cells via the CXCL12/CXCR4 axis. The present study described a novel epigenetic mechanism regulating tumor cell EMT and migration, and provided a novel direction for glioma diagnosis and treatment.
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View References

1 

Cloos PA, Christensen J, Agger K and Helin K: Erasing the methyl mark: Histone demethylases at the center of cellular differentiation and disease. Genes Dev. 22:1115–1140. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Yu SH, Zhu KY, Chen J, Liu XZ, Xu PF, Zhang W, Yan L, Guo HZ and Zhu J: JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML. Nat Commun. 9:33692018. View Article : Google Scholar : PubMed/NCBI

3 

Williams K, Christensen J, Rappsilber J, Nielsen AL, Johansen JV and Helin K: The histone lysine demethylase JMJD3/KDM6B is recruited to p53 bound promoters and enhancer elements in a p53 dependent manner. PLoS One. 9:e965452014. View Article : Google Scholar : PubMed/NCBI

4 

Hubner MR and Spector DL: Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation. Cold Spring Harb Symp Quant Biol. 75:43–49. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Agger K, Cloos PA, Rudkjaer L, Williams K, Andersen G, Christensen J and Helin K: The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence. Genes Dev. 23:1171–1176. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Barradas M, Anderton E, Acosta JC, Li S, Banito A, Rodriguez-Niedenführ M, Maertens G, Banck M, Zhou MM, Walsh MJ, et al: Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. Genes Dev. 23:1177–1182. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Sui A, Xu Y, Li Y, Hu Q, Wang Z, Zhang H, Yang J, Guo X and Zhao W: The pharmacological role of histone demethylase JMJD3 inhibitor GSK-J4 on glioma cells. Oncotarget. 8:68591–68598. 2017. View Article : Google Scholar : PubMed/NCBI

8 

De Santa F, Narang V, Yap ZH, Tusi BK, Burgold T, Austenaa L, Bucci G, Caganova M, Notarbartolo S, Casola S, et al: Jmjd3 contributes to the control of gene expression in LPS-activated macrophages. EMBO J. 28:3341–3352. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Przanowski P, Dabrowski M, Ellert-Miklaszewska A, Kloss M, Mieczkowski J, Kaza B, Ronowicz A, Hu F, Piotrowski A, Kettenmann H, et al: The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia. J Mol Med (Berl). 92:239–254. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Sherry-Lynes MM, Sengupta S, Kulkarni S and Cochran BH: Regulation of the JMJD3 (KDM6B) histone demethylase in glioblastoma stem cells by STAT3. PLoS One. 12:e01747752017. View Article : Google Scholar : PubMed/NCBI

11 

Perrigue PM, Silva ME, Warden CD, Feng NL, Reid MA, Mota DJ, Joseph LP, Tian YI, Glackin CA, Gutova M, et al: The histone demethylase jumonji coordinates cellular senescence including secretion of neural stem cell-attracting cytokines. Mol Cancer Res. 13:636–650. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Sasaki K, Natsugoe S, Ishigami S, Matsumoto M, Okumura H, Setoyama T, Uchikado Y, Kita Y, Tamotsu K, Sakurai T, et al: Expression of CXCL12 and its receptor CXCR4 correlates with lymph node metastasis in submucosal esophageal cancer. J Surg Oncol. 97:433–438. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Koishi K, Yoshikawa R, Tsujimura T, Hashimoto-Tamaoki T, Kojima S, Yanagi H, Yamamura T and Fujiwara Y: Persistent CXCR4 expression after preoperative chemoradiotherapy predicts early recurrence and poor prognosis in esophageal cancer. World J Gastroenterol. 12:7585–7590. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Pacitto R, Gaeta I, Swanson JA and Yoshida S: CXCL12-induced macropinocytosis modulates two distinct pathways to activate mTORC1 in macrophages. J Leukoc Biol. 101:683–692. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Patalano S, Rodriguez-Nieves J, Colaneri C, Cotellessa J, Almanza D, Zhilin-Roth A, Riley T and Macoska J: CXCL12/CXCR4-mediated procollagen secretion is coupled to Cullin-RING ubiquitin ligase activation. Sci Rep. 8:34992018. View Article : Google Scholar : PubMed/NCBI

16 

Du LL and Liu P: CXCL12/CXCR4 axis regulates neovascularization and lymphangiogenesis in sutured corneas in mice. Mol Med Rep. 13:4987–4994. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Li M, Hale JS, Rich JN, Ransohoff RM and Lathia JD: Chemokine CXCL12 in neurodegenerative diseases: An SOS signal for stem cell-based repair. Trends Neurosci. 35:619–628. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Xie S, Zeng W, Fan G, Huang J, Kang G, Geng Q, Cheng B, Wang W and Dong P: Effect of CXCL12/CXCR4 on increasing the metastatic potential of non-small cell lung cancer in vitro is inhibited through the downregulation of CXCR4 chemokine receptor expression. Oncol Lett. 7:941–947. 2014. View Article : Google Scholar : PubMed/NCBI

19 

He C, Zhang H, Wang B, He J and Ge G: SDF-1/CXCR4 axis promotes the growth and sphere formation of hypoxic breast cancer SP cells by c-Jun/ABCG2 pathway. Biochem Biophys Res Commun. 505:593–599. 2018. View Article : Google Scholar : PubMed/NCBI

20 

De-Colle C, Menegakis A, Monnich D, Welz S, Boeke S, Sipos B, Fend F, Mauz PS, Tinhofer I, Budach V, et al: SDF-1/CXCR4 expression is an independent negative prognostic biomarker in patients with head and neck cancer after primary radiochemotherapy. Radiother Oncol. 126:125–131. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Yu X, Shi W, Zhang Y, Wang X, Sun S, Song Z, Liu M, Zeng Q, Cui S and Qu X: CXCL12/CXCR4 axis induced miR-125b promotes invasion and confers 5-fluorouracil resistance through enhancing autophagy in colorectal cancer. Sci Rep. 7:422262017. View Article : Google Scholar : PubMed/NCBI

22 

Liu Y, Ren CC, Yang L, Xu YM and Chen YN: Role of CXCL12-CXCR4 axis in ovarian cancer metastasis and CXCL12-CXCR4 blockade with AMD3100 suppresses tumor cell migration and invasion in vitro. J Cell Physiol. 234:3897–3909. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Jeng KS, Jeng CJ, Jeng WJ, Chang CF and Sheen IS: Role of C-X-C chemokine ligand 12/C-X-C chemokine receptor 4 in the progression of hepatocellular carcinoma. Oncol Lett. 14:1905–1910. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Hugo H, Ackland ML, Blick T, Lawrence MG, Clements JA, Williams ED and Thompson EW: Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression. J Cell Physiol. 213:374–383. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Valastyan S and Weinberg RA: Tumor metastasis: Molecular insights and evolving paradigms. Cell. 147:275–292. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Yu Y, Xiao CH, Tan LD, Wang QS, Li XQ and Feng YM: Cancer-associated fibroblasts induce epithelial-mesenchymal transition of breast cancer cells through paracrine TGF-β signalling. Br J Cancer. 110:724–732. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Liao A, Shi R, Jiang Y, Tian S, Li P, Song F, Qu Y, Li J, Yun H and Yang X: SDF-1/CXCR4 axis regulates cell cycle progression and epithelial-mesenchymal transition via up-regulation of survivin in glioblastoma. Mol Neurobiol. 53:210–215. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Cheng Y, Song Y, Qu J, Che X, Song N, Fan Y, Wen T, Xu L, Gong J, Wang X, et al: The chemokine receptor CXCR4 and c-MET cooperatively promote epithelial-mesenchymal transition in gastric cancer cells. Transl Oncol. 11:487–497. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Zhang Y, Guo Q, Zhang Z, Bai N, Liu Z, Xiong M, Wei Y, Xiang R and Tan X: VDR status arbitrates the prometastatic effects of tumor-associated macrophages. Mol Cancer Res. 12:1181–1191. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Li X, Xu Y, Chen Y, Chen S, Jia X, Sun T, Liu Y, Li X, Xiang R and Li N: SOX2 promotes tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/beta-catenin signal network. Cancer Lett. 336:379–389. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Karicheva O, Rodriguez-Vargas JM, Wadier N, Martin-Hernandez K, Vauchelles R, Magroun N, Tissier A, Schreiber V and Dantzer F: PARP3 controls TGFβ and ROS driven epithelial-to-mesenchymal transition and stemness by stimulating a TG2-Snail-E-cadherin axis. Oncotarget. 7:64109–64123. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Yang ZC, Yi MJ, Ran N, Wang C, Fu P, Feng XY, Xu L and Qu ZH: Transforming growth factor-beta1 induces bronchial epithelial cells to mesenchymal transition by activating the Snail pathway and promotes airway remodeling in asthma. Mol Med Rep. 8:1663–1668. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Johnson JR, Nishioka M, Chakir J, Risse PA, Almaghlouth I, Bazarbashi AN, Plante S, Martin JG, Eidelman D and Hamid Q: IL-22 contributes to TGF-β1-mediated epithelial-mesenchymal transition in asthmatic bronchial epithelial cells. Respir Res. 14:1182013. View Article : Google Scholar : PubMed/NCBI

35 

Wendt MK, Tian M and Schiemann WP: Deconstructing the mechanisms and consequences of TGF-β-induced EMT during cancer progression. Cell Tissue Res. 347:85–101. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Shien K, Papadimitrakopoulou VA, Ruder D, Behrens C, Shen L, Kalhor N, Song J, Lee JJ, Wang J, Tang X, et al: JAK1/STAT3 activation through a proinflammatory cytokine pathway leads to resistance to molecularly targeted therapy in non-small cell lung cancer. Mol Cancer Ther. 16:2234–2245. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Cohen EN, Gao H, Anfossi S, Mego M, Reddy NG, Debeb B, Giordano A, Tin S, Wu Q, Garza RJ, et al: Inflammation mediated metastasis: Immune induced epithelial-to-mesenchymal transition in inflammatory breast cancer cells. PLoS One. 10:e01327102015. View Article : Google Scholar : PubMed/NCBI

38 

Aversa I, Zolea F, Ierano C, Bulotta S, Trotta AM, Faniello MC, De Marco C, Malanga D, Biamonte F, Viglietto G, et al: Epithelial-to-mesenchymal transition in FHC-silenced cells: The role of CXCR4/CXCL12 axis. J Exp Clin Cancer Res. 36:1042017. View Article : Google Scholar : PubMed/NCBI

39 

Wang X, Cao Y, Zhang S, Chen Z, Fan L, Shen X, Zhou S and Chen D: Stem cell autocrine CXCL12/CXCR4 stimulates invasion and metastasis of esophageal cancer. Oncotarget. 8:36149–36160. 2017.PubMed/NCBI

40 

Ramsey DM and McAlpine SR: Halting metastasis through CXCR4 inhibition. Bioorg Med Chem Lett. 23:20–25. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Agger K, Cloos PA, Christensen J, Pasini D, Rose S, Rappsilber J, Issaeva I, Canaani E, Salcini AE and Helin K: UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature. 449:731–734. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Zhang Y, Shen L, Stupack DG, Bai N, Xun J, Ren G, Han J, Li L, Luo Y, Xiang R and Tan X: JMJD3 promotes survival of diffuse large B-cell lymphoma subtypes via distinct mechanisms. Oncotarget. 7:29387–29399. 2016.PubMed/NCBI

43 

Ramadoss S, Chen X and Wang CY: Histone demethylase KDM6B promotes epithelial-mesenchymal transition. J Biol Chem. 287:44508–44517. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Li Q, Hou L, Ding G, Li Y, Wang J, Qian B, Sun J and Wang Q: KDM6B induces epithelial-mesenchymal transition and enhances clear cell renal cell carcinoma metastasis through the activation of SLUG. Int J Clin Exp Pathol. 8:6334–6344. 2015.PubMed/NCBI

45 

Xia M, Yao L, Zhang Q, Wang F, Mei H, Guo X and Huang W: Long noncoding RNA HOTAIR promotes metastasis of renal cell carcinoma by up-regulating histone H3K27 demethylase JMJD3. Oncotarget. 8:19795–19802. 2017.PubMed/NCBI

46 

Ene CI, Edwards L, Riddick G, Baysan M, Woolard K, Kotliarova S, Lai C, Belova G, Cam M, Walling J, et al: Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization. PLoS One. 7:e514072012. View Article : Google Scholar : PubMed/NCBI

47 

Zhao W, Li Q, Ayers S, Gu Y, Shi Z, Zhu Q, Chen Y, Wang HY and Wang RF: Jmjd3 inhibits reprogramming by upregulating expression of INK4a/Arf and targeting PHF20 for ubiquitination. Cell. 152:1037–1050. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Uygur B and Wu WS: SLUG promotes prostate cancer cell migration and invasion via CXCR4/CXCL12 axis. Mol Cancer. 10:1392011. View Article : Google Scholar : PubMed/NCBI

49 

Xue LJ, Mao XB, Ren LL and Chu XY: Inhibition of CXCL12/CXCR4 axis as a potential targeted therapy of advanced gastric carcinoma. Cancer Med. 6:1424–1436. 2017. View Article : Google Scholar : PubMed/NCBI

50 

Chatterjee S, Behnam Azad B and Nimmagadda S: The intricate role of CXCR4 in cancer. Adv Cancer Res. 124:31–82. 2014. View Article : Google Scholar : PubMed/NCBI

51 

Berning P, Schaefer C, Clemens D, Korsching E, Dirksen U and Potratz J: The CXCR4 antagonist plerixafor (AMD3100) promotes proliferation of Ewing sarcoma cell lines in vitro and activates receptor tyrosine kinase signaling. Cell Commun Signal. 16:212018. View Article : Google Scholar : PubMed/NCBI

52 

Zhu Y, Tang L, Zhao S, Sun B, Cheng L, Tang Y, Luo Z, Lin Z, Zhu J, Zhu W, et al: CXCR4-mediated osteosarcoma growth and pulmonary metastasis is suppressed by MicroRNA-613. Cancer Sci. 109:2412–2422. 2018. View Article : Google Scholar : PubMed/NCBI

53 

Xun J, Wang D, Shen L, Gong J, Gao R, Du L, Chang A, Song X, Xiang R and Tan X: JMJD3 suppresses stem cell-like characteristics in breast cancer cells by downregulation of Oct4 independently of its demethylase activity. Oncotarget. 8:21918–21929. 2017. View Article : Google Scholar : PubMed/NCBI

54 

Shen Y, Yu D, Qi P, Wang X, Guo X and Zhang A: Calcitriol induces cell senescence of kidney cancer through JMJD3 mediated histone demethylation. Oncotarget. 8:100187–100195. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zou S, Zhang D, Xu Z, Wen X and Zhang Y: JMJD3 promotes the epithelial‑mesenchymal transition and migration of glioma cells via the CXCL12/CXCR4 axis. Oncol Lett 18: 5930-5940, 2019.
APA
Zou, S., Zhang, D., Xu, Z., Wen, X., & Zhang, Y. (2019). JMJD3 promotes the epithelial‑mesenchymal transition and migration of glioma cells via the CXCL12/CXCR4 axis. Oncology Letters, 18, 5930-5940. https://doi.org/10.3892/ol.2019.10972
MLA
Zou, S., Zhang, D., Xu, Z., Wen, X., Zhang, Y."JMJD3 promotes the epithelial‑mesenchymal transition and migration of glioma cells via the CXCL12/CXCR4 axis". Oncology Letters 18.6 (2019): 5930-5940.
Chicago
Zou, S., Zhang, D., Xu, Z., Wen, X., Zhang, Y."JMJD3 promotes the epithelial‑mesenchymal transition and migration of glioma cells via the CXCL12/CXCR4 axis". Oncology Letters 18, no. 6 (2019): 5930-5940. https://doi.org/10.3892/ol.2019.10972
Copy and paste a formatted citation
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Spandidos Publications style
Zou S, Zhang D, Xu Z, Wen X and Zhang Y: JMJD3 promotes the epithelial‑mesenchymal transition and migration of glioma cells via the CXCL12/CXCR4 axis. Oncol Lett 18: 5930-5940, 2019.
APA
Zou, S., Zhang, D., Xu, Z., Wen, X., & Zhang, Y. (2019). JMJD3 promotes the epithelial‑mesenchymal transition and migration of glioma cells via the CXCL12/CXCR4 axis. Oncology Letters, 18, 5930-5940. https://doi.org/10.3892/ol.2019.10972
MLA
Zou, S., Zhang, D., Xu, Z., Wen, X., Zhang, Y."JMJD3 promotes the epithelial‑mesenchymal transition and migration of glioma cells via the CXCL12/CXCR4 axis". Oncology Letters 18.6 (2019): 5930-5940.
Chicago
Zou, S., Zhang, D., Xu, Z., Wen, X., Zhang, Y."JMJD3 promotes the epithelial‑mesenchymal transition and migration of glioma cells via the CXCL12/CXCR4 axis". Oncology Letters 18, no. 6 (2019): 5930-5940. https://doi.org/10.3892/ol.2019.10972
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