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Review

The roles of estrogen and estrogen receptors in gastrointestinal disease (Review)

  • Authors:
    • Changmei Chen
    • Xiang Gong
    • Xiaoxu Yang
    • Xianhui Shang
    • Qian Du
    • Qiushi Liao
    • Rui Xie
    • Yuanshou Chen
    • Jingyu Xu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China, Institute of Burns, Tongren Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Pediatric Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China, Department of Physiology, Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China
  • Pages: 5673-5680
    |
    Published online on: October 11, 2019
       https://doi.org/10.3892/ol.2019.10983
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Abstract

Estrogen is an important sex steroid hormone which serves an important role in the regulation of a number of biological functions, including regulating bone density, brain function, cholesterol mobilization, electrolyte balance, skin physiology, the cardiovascular system, the central nervous system and female reproductive organs. Estrogen exhibits various functions through binding to its specific receptors, estrogen receptor α, estrogen receptor β and G protein‑coupled estrogen receptor 1. In recent years, researchers have demonstrated that estrogen and its receptors serve an important role in the gastrointestinal (GI) tract and contribute to the progression of a number of GI diseases, including gastroesophageal reflux, esophageal cancer, peptic ulcers, gastric cancer, inflammatory bowel disease, irritable bowel syndrome and colon cancer. The aim of this review is to provide an overview of estrogen and its receptors in GI disease, and highlight potential avenues for the prevention and treatment of GI diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Chen C, Gong X, Yang X, Shang X, Du Q, Liao Q, Xie R, Chen Y and Xu J: The roles of estrogen and estrogen receptors in gastrointestinal disease (Review). Oncol Lett 18: 5673-5680, 2019.
APA
Chen, C., Gong, X., Yang, X., Shang, X., Du, Q., Liao, Q. ... Xu, J. (2019). The roles of estrogen and estrogen receptors in gastrointestinal disease (Review). Oncology Letters, 18, 5673-5680. https://doi.org/10.3892/ol.2019.10983
MLA
Chen, C., Gong, X., Yang, X., Shang, X., Du, Q., Liao, Q., Xie, R., Chen, Y., Xu, J."The roles of estrogen and estrogen receptors in gastrointestinal disease (Review)". Oncology Letters 18.6 (2019): 5673-5680.
Chicago
Chen, C., Gong, X., Yang, X., Shang, X., Du, Q., Liao, Q., Xie, R., Chen, Y., Xu, J."The roles of estrogen and estrogen receptors in gastrointestinal disease (Review)". Oncology Letters 18, no. 6 (2019): 5673-5680. https://doi.org/10.3892/ol.2019.10983
Copy and paste a formatted citation
x
Spandidos Publications style
Chen C, Gong X, Yang X, Shang X, Du Q, Liao Q, Xie R, Chen Y and Xu J: The roles of estrogen and estrogen receptors in gastrointestinal disease (Review). Oncol Lett 18: 5673-5680, 2019.
APA
Chen, C., Gong, X., Yang, X., Shang, X., Du, Q., Liao, Q. ... Xu, J. (2019). The roles of estrogen and estrogen receptors in gastrointestinal disease (Review). Oncology Letters, 18, 5673-5680. https://doi.org/10.3892/ol.2019.10983
MLA
Chen, C., Gong, X., Yang, X., Shang, X., Du, Q., Liao, Q., Xie, R., Chen, Y., Xu, J."The roles of estrogen and estrogen receptors in gastrointestinal disease (Review)". Oncology Letters 18.6 (2019): 5673-5680.
Chicago
Chen, C., Gong, X., Yang, X., Shang, X., Du, Q., Liao, Q., Xie, R., Chen, Y., Xu, J."The roles of estrogen and estrogen receptors in gastrointestinal disease (Review)". Oncology Letters 18, no. 6 (2019): 5673-5680. https://doi.org/10.3892/ol.2019.10983
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