Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2019 Volume 18 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2019 Volume 18 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

KIFC1 promotes the proliferation of hepatocellular carcinoma in vitro and in vivo

Retraction in: /10.3892/ol.2023.13931
  • Authors:
    • Xing Wang
    • Meng Wang
    • Xing‑Yue Li
    • Jian Li
    • Dian‑Peng Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261031, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5739-5746
    |
    Published online on: October 14, 2019
       https://doi.org/10.3892/ol.2019.10985
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Hepatocellular carcinoma (HCC) is a common type of malignant tumor worldwide with a high mortality rate. In the past 20 years, the morbidity rate of HCC has increased. Progress has been made in the clinical diagnosis and therapy for HCC. However, due to the high heterogeneity and metastasis targeted therapy for HCC exhibits great promise, and novel therapeutic targets for HCC are urgently required. Kinesin family member C1 (KIFC1) is a member of the kinesin superfamily of proteins. Previous studies have indicated a potential association between KIFC1 and cancer progression. However, the potential role of KIFC1 in the development of HCC remains unclear. The present study aimed to explore the function of KIFC1 in HCC. Immunohistochemical (IHC) assays were performed to explore the KIF15 expression levels in 74 samples of HCC and corresponding non‑tumor tissues. The potential association between KIF15 expression levels and clinical features was analyzed, and the effects of KIF15 on cell proliferation of HCC were detected by colony formation and MTT assays. In addition, the proliferation‑related proteins Ki67 and PCNA were detected by western blotting. The possible effects of KIF15 on tumor growth were measured in mice. The results demonstrated that a high expression level of KIFC1 was associated with poor prognosis of HCC. Further results indicated that KIFC1 promoted cell proliferation of HCC in vitro. In addition, knockdown of KIFC1 suppressed tumor formation and growth in mice. Therefore, these results provide a potential therapeutic target for the treatment of HCC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Dhanasekaran R and Talwalkar JA: Quality of cancer care in patients with cirrhosis and hepatocellular carcinoma. Curr Gastroenterol Rep. 17:342015. View Article : Google Scholar : PubMed/NCBI

2 

Lertpipopmetha K and Auewarakul CU: High incidence of hepatitis B infection-associated cirrhosis and hepatocellular carcinoma in the Southeast Asian patients with portal vein thrombosis. BMC Gastroenterol. 11:662011. View Article : Google Scholar : PubMed/NCBI

3 

Ziogas IA and Tsoulfas G: Advances and challenges in laparoscopic surgery in the management of hepatocellular carcinoma. World J Gastrointest Surg. 9:233–245. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Schietroma I, Scheri GC, Pinacchio C, Statzu M, Petruzziello A and Vullo V: Hepatitis C virus and hepatocellular carcinoma: Pathogenetic mechanisms and impact of direct-acting antivirals. Open Virol J. 12:16–25. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Kim D, Li AA, Perumpail BJ, Gadiparthi C, Kim W, Cholankeril G, Glenn JS, Harrison SA, Younossi ZM and Ahmed A: Changing trends in etiology-based and ethnicity-based annual mortality rates of cirrhosis and hepatocellular carcinoma in the United States. Hepatology. 69:1064–1074. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Lee HY, Jung JH, Kang YS, Kim YS, Moon HS, Park KO, Lee YS, Kim SM, Seo SW, Lee SW, et al: Clinical significance of transiently elevated serum AFP level in developing hepatocellular carcinoma in HBsAg positive-liver cirrhosis. Korean J Gastroenterol. 43:252–259. 2004.(In Korean). PubMed/NCBI

7 

Rasool M, Rashid S, Arooj M, Ansari SA, Khan KM, Malik A, Naseer MI, Zahid S, Manan A, Asif M, et al: New possibilities in hepatocellular carcinoma treatment. Anticancer Res. 34:1563–1571. 2014.PubMed/NCBI

8 

Ando E, Tanaka M, Yamashita F, Kuromatsu R, Takada A, Fukumori K, Yano Y, Sumie S, Okuda K, Kumashiro R and Sata M: Diagnostic clues for recurrent hepatocellular carcinoma: Comparison of tumour markers and imaging studies. Eur J Gastroenterol Hepatol. 15:641–648. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Aggarwal M, Arain A and Jin Z: Systemic treatment for hepatocellular carcinoma. Chronic Dis Transl Med. 4:148–155. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Huang A, Zhao X, Yang XR, Li FQ, Zhou XL, Wu K, Zhang X, Sun QM, Cao Y, Zhu HM, et al: Circumventing intratumoral heterogeneity to identify potential therapeutic targets in hepatocellular carcinoma. J Hepatol. 67:293–301. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Ma DD, Pan MY, Hou CC, Tan FQ and Yang WX: KIFC1 and myosin Va: Two motors for acrosomal biogenesis and nuclear shaping during spermiogenesis of Portunus trituberculatus. Cell Tissue Res. 369:625–640. 2017. View Article : Google Scholar : PubMed/NCBI

12 

She ZY, Pan MY, Tan FQ and Yang WX: Minus end-directed kinesin-14 KIFC1 regulates the positioning and architecture of the Golgi apparatus. Oncotarget. 8:36469–36483. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Kim N and Song K: KIFC1 is essential for bipolar spindle formation and genomic stability in the primary human fibroblast IMR-90 cell. Cell Struct Funct. 38:21–30. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Lee SH, Joo K, Jung EJ, Hong H, Seo J and Kim J: Export of membrane proteins from the Golgi complex to the primary cilium requires the kinesin motor, KIFC1. FASEB J. 32:957–968. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Yang WX and Sperry AO: C-terminal kinesin motor KIFC1 participates in acrosome biogenesis and vesicle transport. Biol Reprod. 69:1719–1729. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Hou CC and Yang WX: Acroframosome-dependent KIFC1 facilitates acrosome formation during spermatogenesis in the caridean shrimp Exopalaemon modestus. PLoS One. 8:e760652013. View Article : Google Scholar : PubMed/NCBI

17 

Liu Y, Zhan P, Zhou Z, Xing Z, Zhu S, Ma C, Li Q, Zhu Q, Miao Y, Zhang J, et al: The overexpression of KIFC1 was associated with the proliferation and prognosis of non-small cell lung cancer. J Thorac Dis. 8:2911–2923. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Li G, Chong T, Yang J, Li H and Chen H: Kinesin motor protein KIFC1 is a target protein of miR-338-3p and associated with poor prognosis and progression of renal cell carcinoma. Oncol Res. 27:125–137. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Li Y, Lu W, Chen D, Boohaker RJ, Zhai L, Padmalayam I, Wennerberg K, Xu B and Zhang W: KIFC1 is a novel potential therapeutic target for breast cancer. Cancer Biol Ther. 16:1316–1322. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Sekino Y, Oue N, Shigematsu Y, Ishikawa A, Sakamoto N, Sentani K, Teishima J, Matsubara A and Yasui W: KIFC1 induces resistance to docetaxel and is associated with survival of patients with prostate cancer. Urol Oncol. 35:31.e13–31.e20. 2017. View Article : Google Scholar

21 

Xiao YX and Yang WX: KIFC1: A promising chemotherapy target for cancer treatment? Oncotarget. 7:48656–48670. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Han J, Wang F, Lan Y, Wang J, Nie C, Liang Y, Song R, Zheng T, Pan S, Pei T, et al: KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling. Oncogene. 38:406–420. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Seino S, Tsuchiya A, Watanabe Y, Kawata Y, Kojima Y, Ikarashi S, Yanai H, Nakamura K, Kumaki D, Hirano M, et al: Clinical outcome of hepatocellular carcinoma can be predicted by the expression of hepatic progenitor cell markers and serum tumour markers. Oncotarget. 9:21844–21860. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Hiraoka A, Michitaka K, Kumada T and Kudo M: ALBI score as a novel tool in staging and treatment planning for hepatocellular carcinoma: Advantage of ALBI grade for universal assessment of hepatic function. Liver Cancer. 6:377–379. 2017. View Article : Google Scholar : PubMed/NCBI

25 

DeLeon TT, Ahn DH, Bogenberger JM, Anastasiadis PZ, Arora M, Ramanathan RK, Aqel BA, Vasmatzis G, Truty MJ, Oklu R, et al: Novel targeted therapy strategies for biliary tract cancers and hepatocellular carcinoma. Future Oncol. 14:553–566. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Cancer Genome Atlas Research Network. Electronic address: wheeler@bcm.edu, . Cancer Genome Atlas Research Network: Comprehensive and integrative genomic characterization of hepatocellular carcinoma. Cell. 169:1327–1341.e23. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Gao HJ, Zhao MC, Zhang YJ, Zhou DS, Xu L, Li GB, Chen MS and Liu J: Monocarboxylate transporter 4 predicts poor prognosis in hepatocellular carcinoma and is associated with cell proliferation and migration. J Cancer Res Clin Oncol. 141:1151–1162. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Xiao YX, Shen HQ, She ZY, Sheng L, Chen QQ, Chu YL, Tan FQ and Yang WX: C-terminal kinesin motor KIFC1 participates in facilitating proper cell division of human seminoma. Oncotarget. 8:61373–61384. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Mittal K, Choi DH, Klimov S, Pawar S, Kaur R, Mitra AK, Gupta MV, Sams R, Cantuaria G, Rida PCG and Aneja R: A centrosome clustering protein, KIFC1, predicts aggressive disease course in serous ovarian adenocarcinomas. J Ovarian Res. 9:172016. View Article : Google Scholar : PubMed/NCBI

30 

Marsman M, Jordens I, Kuijl C, Janssen L and Neefjes J: Dynein-mediated vesicle transport controls intracellular Salmonella replication. Mol Biol Cell. 15:2954–2964. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Huang X, Liu F, Zhu C, Cai J, Wang H, Wang X, He S, Liu C, Yao L, Ding Z, et al: Suppression of KIF3B expression inhibits human hepatocellular carcinoma proliferation. Dig Dis Sci. 59:795–806. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Yang T, Zhang XB and Zheng ZM: Suppression of KIF14 expression inhibits hepatocellular carcinoma progression and predicts favorable outcome. Cancer Sci. 104:552–557. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Wang J, Ma S, Ma R, Qu X, Liu W, Lv C, Zhao S and Gong Y: KIF2A silencing inhibits the proliferation and migration of breast cancer cells and correlates with unfavorable prognosis in breast cancer. BMC Cancer. 14:4612014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang X, Wang M, Li XY, Li J and Zhao DP: KIFC1 promotes the proliferation of hepatocellular carcinoma in vitro and in vivo Retraction in /10.3892/ol.2023.13931. Oncol Lett 18: 5739-5746, 2019.
APA
Wang, X., Wang, M., Li, X., Li, J., & Zhao, D. (2019). KIFC1 promotes the proliferation of hepatocellular carcinoma in vitro and in vivo Retraction in /10.3892/ol.2023.13931. Oncology Letters, 18, 5739-5746. https://doi.org/10.3892/ol.2019.10985
MLA
Wang, X., Wang, M., Li, X., Li, J., Zhao, D."KIFC1 promotes the proliferation of hepatocellular carcinoma in vitro and in vivo Retraction in /10.3892/ol.2023.13931". Oncology Letters 18.6 (2019): 5739-5746.
Chicago
Wang, X., Wang, M., Li, X., Li, J., Zhao, D."KIFC1 promotes the proliferation of hepatocellular carcinoma in vitro and in vivo Retraction in /10.3892/ol.2023.13931". Oncology Letters 18, no. 6 (2019): 5739-5746. https://doi.org/10.3892/ol.2019.10985
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Wang M, Li XY, Li J and Zhao DP: KIFC1 promotes the proliferation of hepatocellular carcinoma in vitro and in vivo Retraction in /10.3892/ol.2023.13931. Oncol Lett 18: 5739-5746, 2019.
APA
Wang, X., Wang, M., Li, X., Li, J., & Zhao, D. (2019). KIFC1 promotes the proliferation of hepatocellular carcinoma in vitro and in vivo Retraction in /10.3892/ol.2023.13931. Oncology Letters, 18, 5739-5746. https://doi.org/10.3892/ol.2019.10985
MLA
Wang, X., Wang, M., Li, X., Li, J., Zhao, D."KIFC1 promotes the proliferation of hepatocellular carcinoma in vitro and in vivo Retraction in /10.3892/ol.2023.13931". Oncology Letters 18.6 (2019): 5739-5746.
Chicago
Wang, X., Wang, M., Li, X., Li, J., Zhao, D."KIFC1 promotes the proliferation of hepatocellular carcinoma in vitro and in vivo Retraction in /10.3892/ol.2023.13931". Oncology Letters 18, no. 6 (2019): 5739-5746. https://doi.org/10.3892/ol.2019.10985
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team